... FXa signaling was shown to be implicated in a myriad of diseases, such as atherosclerosis, neurodegeneration, and inflammatory disorders [ 67 ]. Therefore, the coagulation-independent activities of FXa and the widely reported functions of PARs have driven investigations into a wide range...

... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 blood brain barrier epilepsy glial cell neurodegeneration pericytes traumatic brain injury Accumulating evidence advocates for a role of cerebrovascular dysfunction in central...

... of the Biochemical Society 2018 autonomic nervous system neurodegeneration sympathetic nervous system Pure autonomic failure (PAF) is a rare sporadic disorder characterized by profound orthostatic hypotension in association with other features of autonomic failure, but in the absence of neurological...

... brain copper neurodegeneration Parkinson's disease therapy A complex and self-perpetuating cascade of events, including oxidative stress, protein aggregation, mitochondrial dysfunction and inflammation are responsible for neuronal death in Parkinson's disease [ 1 ]. Changes in brain...

... and signs of neurodegeneration. Given the importance of both apoptosis and autophagy for neuronal survival in adult neurons, understanding how BCL-2 homologues co-ordinately regulate these processes will allow a better understanding of the cellular processes leading to neurodegeneration. In the present...

... ( Table 1 ). clinical trial gene therapy Huntington's disease neurodegeneration neurotransplantation stem cell treatment HD (Huntington's disease) is an inherited neurodegenerative disorder, with the most common age of onset between 30–50 years of age, and with a mean disease duration...

...) lentivirus neurodegeneration ocular disease retinal disorder viral vector In terms of long-term expression of a therapeutic transgene, retroviral- and lentiviral-based vectors provide the most promising gene therapy vehicles, since the viral genome is stably integrated into that of the host cell...