... ) 23 04 2018 22 07 2018 26 07 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 atherosclerosis diabetic complications inflammation nephropathy Oxidative stress The rising prevalence of diabetes and associated...

...Christine Maric-Bilkan Vascular complications are a leading cause of morbidity and mortality in both men and women with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus, however the prevalence, progression and pathophysiology of both microvascular (nephropathy, neuropathy and retinopathy...

... as nuclear receptor binding. In the renal vasculature, Ang-(1–7) has vasodilatory properties and it opposes growth-stimulatory signalling in tubular epithelial cells. In several kidney diseases, including hypertensive and diabetic nephropathy, glomerulonephritis, tubulointerstitial fibrosis, pre-eclampsia...

...Jeffrey J. Olearczyk; Jeffrey E. Quigley; Bradford C. Mitchell; Tatsuo Yamamoto; In-Hae Kim; John W. Newman; Ayala Luria; Bruce D. Hammock; John D. Imig Hypertension and Type 2 diabetes are co-morbid diseases that lead to the development of nephropathy. sEH (soluble epoxide hydrolase) inhibitors...

... by SEH (soluble epoxide hydrolase) [ 10 ]. The balance between COX and CYP450 metabolites can influence renal vascular function, and an improper balance during disease states could contribute to the progression of nephropathy. Although the role of arachidonic acid metabolites in the pathogenesis...

...) nephropathy proteomics Type II diabetes Renal disease in patients with Type II diabetes mellitus has become the leading cause of terminal renal failure and a major healthcare problem in all Western countries [ 1 ]. Several observers have documented that, beyond genetic factors, a number...

...Tahseen A. CHOWDHURY; Philip H. DYER; Sudhesh KUMAR; Anthony H. BARNETT; Stephen C. BAIN Diabetic nephropathy is the most serious complication of diabetes mellitus. Progression of the condition leads to end-stage renal failure, and other complications of diabetes are also common in this group...

... blood flow in hypertensive Type I diabetes patients with diabetic nephropathy. 2. We performed a 1-year double-blind, double-dummy randomized controlled study comparing nisoldipine (20–40 mg once daily) with lisinopril (10–20 mg once daily) in 48 hypertensive Type I diabetes patients with diabetic...

... work load (W/kg body weight) during exercise reveals blood pressure differences otherwise not noted. A diabetic patient with blood pressure above the 97.5% confidence limit during exercise seems to have a higher risk of developing incipient nephropathy 5 years later. 28 9 1993 19 10 1993...

...Peter A. Rutherford; Trevor H. Thomas; Susan J. Carr; Roy Taylor; Robert Wilkinson 1. It has been proposed that raised erythrocyte sodium-lithium countertransport activity in type 1 diabetic patients is associated with an increased risk of developing diabetic nephropathy. Diabetic patients...