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Keywords: myocardial remodeling
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Articles

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

In Collection
Cardiovascular-Oncology
Daniel N. Meijles, Joshua J. Cull, Susanna T.E. Cooper, Thomais Markou, Michelle A. Hardyman, Stephen J. Fuller, Hajed O. Alharbi, Zoe H.R. Haines, Viridiana Alcantara-Alonso, Peter E. Glennon, Mary N. Sheppard, Peter H. Sugden, Angela Clerk
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1631–1647.
DOI: https://doi.org/10.1042/CS20210192
Published: 23 July 2021
... or not to use? J. Am. Coll. Cardiol. 71 , 1474 – 1482 10.1016/j.jacc.2018.01.058 29598869 15. Tarone G. , Balligand J.L. , Bauersachs J. , Clerk A. , De Windt, L. , Heymans S. et al . ( 2014 ) Targeting myocardial remodelling to develop novel therapies for heart...
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Articles

Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease

Andrew Geissler, Sergey Ryzhov, Douglas B. Sawyer
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2623–2643.
DOI: https://doi.org/10.1042/CS20200230
Published: 14 October 2020
... under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . epidermal growth factor receptor growth factors heart failure myocardial remodeling Neuregulins (NRG) are polypeptide growth factors belonging to the epidermal growth factor family that signal through receptor tyrosine...
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Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction

Darnel Prakoso, Miles J. De Blasio, Chengxue Qin, Sarah Rosli, Helen Kiriazis, Hongwei Qian, Xiao-Jun Du, Kate L. Weeks, Paul Gregorevic, Julie R. McMullen, Rebecca H. Ritchie
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1345–1360.
DOI: https://doi.org/10.1042/CS20170063
Published: 07 June 2017
... 01 2017 21 04 2017 08 05 2017 09 05 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic cardiomyopathy gene therapy myocardial remodeling phosphoinositide 3-kinase reactive oxygen species superoxides...
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Includes: Supplementary data