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Keywords: muscle
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Clin Sci (Lond) (2020) 134 (13): 1659–1673.
Published: 01 July 2020
... to muscles to offset the supposed benefit of reduced body weight gain on insulin signalling in this major site for glucose tolerance (or insulin action). The study was conducted in mice exposed to chronic CS followed by either a chow (CH) diet or a high-fat (HF) diet. CS increased triglyceride (TG) levels...
Includes: Supplementary data
Clin Sci (Lond) (2009) 116 (2): 157–164.
Published: 15 December 2008
...Marlies Bosselaar; Paul Smits; Cees J. Tack Ischaemia, like muscle contraction, has been reported to induce skeletal muscle glucose uptake in in vitro models. This stimulating effect appears independent of insulin and is probably mediated by activation of AMPK (AMP-activated protein kinase...
Clin Sci (Lond) (2005) 109 (1): 117–123.
Published: 23 June 2005
...Jacqueline BASTIAANSE; Dick W. SLAAF; Mirjam G. A. oude EGBRINK; Gary L. ANDERSON; Hans VINK; Brigitte E. P. A. van der HEIJDEN; Moshe KON Hypothermia is an important preservation method for tissues and solid organs. The aim of the present study was to assess in rat cremaster muscle the effect...
Clin Sci (Lond) (2003) 104 (2): 127–141.
Published: 10 January 2003
...-constant infusions of p -aminohippurate and 3 H-labelled isotopes were used to measure glucose, amino acid and protein metabolism across the portal-drained viscera, liver and hindquarters (to represent muscle) at 0 and 24h of endotoxaemia. Whole-body protein and glucose flux were increased during...
Clin Sci (Lond) (2001) 101 (3): 295–304.
Published: 15 August 2001
...Michael J. O'LEARY; Colin N. FERGUSON; Michael J. RENNIE; Charles J. HINDS; John H. COAKLEY; Victor R. PREEDY We have investigated sequential changes in skeletal muscle and hepatic protein synthesis following sepsis, and their relationship to changes in circulating and tissue glutamine...
Clin Sci (Lond) (2000) 99 (3): 181–187.
Published: 01 August 2000
...Cheng-Hui FANG; Bing-Guo LI; David R. FISCHER; Jing Jing WANG; Herbert A. RUNNELS; John J. MONACO; Per-Olof HASSELGREN There is evidence that burn injury stimulates ubiquitin–proteasome-dependent protein breakdown in skeletal muscle. In this proteolytic pathway, protein substrates are conjugated...
Clin Sci (Lond) (1999) 96 (6): 639–646.
Published: 11 May 1999
... and intracellular muscle glutamine depletion. Under these conditions, decreased intramuscular glutamine concentration correlates with reduced rates of protein synthesis. It has therefore been hypothesized that intracellular muscle glutamine levels have a regulatory role in muscle protein turnover rates...
Clin Sci (Lond) (1999) 96 (6): 647–657.
Published: 11 May 1999
...N. J. FULLER; C. R. HARDINGHAM; M. GRAVES; N. SCREATON; A. K. DIXON; L. C. WARD; M. ELIA Magnetic resonance imaging (MRI) was used to evaluate and compare with anthropometry a fundamental bioelectrical impedance analysis (BIA) method for predicting muscle and adipose tissue composition in the lower...
Clin Sci (Lond) (1998) 95 (3): 339–346.
Published: 01 September 1998
... the proportion of glutamine appearing in plasma directly due to its release from protein. 3. The glutamine tracer entered muscle, but the rise in intramuscular glutamine enrichment was small, presumably as a result of the enormous size of the intramuscular glutamine pool and the limited speed of entry...
Clin Sci (Lond) (1998) 95 (2): 225–233.
Published: 01 August 1998
...Cheng-Hui FANG; Jing Jing WANG; Scott HOBLER; Bing Guo LI; Josef E. FISCHER; Per-Olof HASSELGREN 1. Burn injury stimulates ubiquitin-dependent protein breakdown in skeletal muscle. The 20S proteasome is the proteolytic core of the 26S proteasome that degrades ubiquitin conjugates. We examined...
Clin Sci (Lond) (1998) 95 (1): 3–17.
Published: 01 July 1998
... muscle by insulin, catecholamines, β 2 -agonists or theophylline increases the intracellular uptake of K + and accounts for the hypokalaemia elicited by these agents. Conversely, digitalis intoxication elicits hyperkalaemia via acute inhibition of the Na + ,K + -pump. 2. Simple and accurate methods have...
Clin Sci (Lond) (1997) 92 (4): 391–396.
Published: 01 April 1997
...A. M. Forsberg; J. Bergström; B. Lindholm; E. Hultman 1. A method is described that enables the calculation of resting membrane potential from the electrolyte and water contents in blood plasma and in a sample of human muscle tissue obtained by the percutaneous needle-biopsy technique...
Clin Sci (Lond) (1996) 91 (6): 685–690.
Published: 01 December 1996
...Alison L. Armstrong; Janet Oborne; Carol A. C. Coupland; Marion B. MacPherson; E. Joan Bassey; W. Angus Wallace 1. A randomized controlled trial of the effect of oral hormone replacement therapy plus calcium compared with calcium alone on balance, muscle performance and falls was conducted over 48...
Clin Sci (Lond) (1996) 90 (6): 467–472.
Published: 01 June 1996
...T. R. Helliwell; P. A. MacLennan; A. McArdle; R. H. T. Edwards; M. J. Jackson 1. The effects of fasting for 48 h were investigated in CS7BL/10 (wild type) and age-matched C57BL/10 dystrophin-deficient ( mdx ) mice. 2. Fasting resulted in an increased percentage of necrotic fibres in muscles from...
Clin Sci (Lond) (1996) 90 (5): 323–335.
Published: 01 May 1996
...Norman L. Jones; George J. F. Heigenhauser © 1996 The Biochemical Society and the Medical Research Society 1996 acid-base, blood carbon dioxide stores muscle physicochemical approach Clinical Science (1996) 90, 323-335 (Printed in Great Britain) Editorial Review 323 Getting rid...
Clin Sci (Lond) (1996) 90 (5): 409–415.
Published: 01 May 1996
...Simon W. Coppack; Rachel M. Fisher; Sandy M. Humphreys; Mo L. Clark; Jennifer J. Pointon; Keith N. Frayn 1. To examine whether insulin resistance in vivo is manifest equally in both muscle and adipose tissues, we measured arteriovenous glucose and lactate fluxes across forearm (muscle...
Clin Sci (Lond) (1994) 87 (2): 187–192.
Published: 01 August 1994
...Jan Pigon; Jan Karlsson; Claes-Göran Östenson 1. We have assessed insulin secretion, insulin sensitivity, exercise capacity and muscle fibre composition in healthy men with a low insulin response to glucose (low insulin responders and endurance-trained subjects) and in healthy men with a normally...
Clin Sci (Lond) (1994) 87 (2): 213–224.
Published: 01 August 1994
...Z. A. H. Yayha; D. Joe Millward 1. We report here studies of the interrelationship of bone and muscle growth in the rat and the regulatory role of dietary protein. Two experiments were undertaken. In experiment 1, growth inhibition was induced by ad libitum feeding of low protein diets containing 7...
Clin Sci (Lond) (1994) 86 (3): 339–345.
Published: 01 March 1994
...M. A. McNurlan; S. D. Heys; K. G. M. Park; J. Broom; D. S. Brown; O. Eremin; P. J. Garlick 1 Rates of protein synthesis have been measured from the incorporation of 57 mg of l-[1- 13 C]leucine/kg for 90 min into muscle tissue and colorectal tumours removed at surgery from cancer patients. 2...
Clin Sci (Lond) (1994) 86 (2): 169–175.
Published: 01 February 1994
... within the muscle and those delivered in the blood. Among the former, glycogen is the most important, with muscle triacylglycerol (TG) becoming important at high intensities [l]. Among blood-borne fuels, glucose and non-esterified fatty I 69 acids (NEFA) predominate. It is usually considered...
Clin Sci (Lond) (1993) 85 (4): 373–384.
Published: 01 October 1993
...Keith N. Frayn; Patricia Lund; Mark Walker © 1993 The Biochemical Society and the Medical Research Society 1993 adipose tissue arteriovenous differences carbon dioxide indirect calorimetry muscle oxygen respiratory quotient substrate oxidation Clinical S c i i e (1993) 85, 373...
Clin Sci (Lond) (1993) 85 (3): 337–342.
Published: 01 September 1993
...Peter E. Ballmer; Margaret A. McNurlan; Ian Grant; Peter J. Garlick 1. The influence of an acute-phase reaction on the ability of protein synthesis rates in liver and three different muscles (gastrocnemius, soleus and heart) to respond to a short intravenous infusion of nutrients (glucose plus...
Clin Sci (Lond) (1993) 84 (2): 177–183.
Published: 01 February 1993
.... The traditional equation gives a maximal value for the fractional synthesis rate. 3. When data from the literature are considered, the fractional synthesis rate of muscle protein as calculated by the constant infusion technique falls between the values of fractional synthesis rate calculated by the two flooding...
Clin Sci (Lond) (1993) 84 (1): 99–104.
Published: 01 January 1993
...M. Elia; K. Khan; G. Calder; A. Kurpad 1. Whole-body kinetics and regional exchange of glycerol across forearm muscle were assessed in eight lean subjects by a combination of a tracer method (infusion of [ 2 H 5 ]glycerol) and arteriovenous catheterization. 2. During an apparent steady state...
Clin Sci (Lond) (1992) 83 (5): 607–614.
Published: 01 November 1992
... metabolism possibly represents an indication of increased substrate utilization by the immune system. Clinical Science (1992) 83, 607-614 (Printed in Great Britain) Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs N. E. P. DEUTZ, P. L. M. REIJVEN, G...
Clin Sci (Lond) (1992) 83 (4): 391–397.
Published: 01 October 1992
...Larry C. Lands; George J. F. Heigenhauser; Norman L. Jones 1. Maximal exercise capacity in cystic fibrosis is influenced by both pulmonary and nutritional factors: lung disease by limiting maximal achievable ventilation, and malnutrition through a loss of muscle mass. The associated reduction...
Clin Sci (Lond) (1992) 83 (3): 367–374.
Published: 01 September 1992
...Roger C. Harris; Karin Söderlund; Eric Hultman 1. The present study was undertaken to test whether creatine given as a supplement to normal subjects was absorbed, and if continued resulted in an increase in the total creatine pool in muscle. An additional effect of exercise upon uptake into muscle...
Clin Sci (Lond) (1992) 82 (4): 455–459.
Published: 01 April 1992
...A. McArdle; R. H. T. Edwards; M. J. Jackson 1. Accumulation of calcium by extensor digitorum longus muscles from dystrophin-deficient mdx and control C57BL/10 mice has been studied in vitro by measurements of total muscle calcium and by following the retention of 45 Ca resulting from the incubation...
Clin Sci (Lond) (1991) 81 (5): 669–676.
Published: 01 November 1991
...V. H. F. Mak; F. Chapman; C. James; S. G. Spiro 1. The maximum rate of relaxation of stimulated twitches (twitch maximum relaxation rate) of the sternomastoid muscle was compared with its frequency-force curve (expressed as the ratio of force produced at a stimulation frequency of 20 Hz...
Clin Sci (Lond) (1991) 81 (s25): 557–564.
Published: 01 October 1991
...M. A. McNurlan; P. Essen; S. D. Heys; V. Buchan; P. J. Garlick; J. Wernerman 1. The rate of protein synthesis in quadriceps muscle of healthy subjects estimated from the incorporation of l -[1- 13 C]leucine given by continuous infusion was 1.1%/day. The estimate of protein synthesis from...
Clin Sci (Lond) (1991) 81 (2): 215–222.
Published: 01 August 1991
... nutrition resulted in improved nitrogen balance in septic rats: the cumulative nitrogen balance over the 4 days of treatment was the least negative as compared with other groups of septic rats. 4. The rate of loss of intracellular glutamine in skeletal muscle was markedly decreased ( P < 0.001...
Clin Sci (Lond) (1991) 81 (2): 267–270.
Published: 01 August 1991
...R. G. Cooper; C. M. Taylor; J. J. Choo; J. B. Weiss 1. Capillary density is greater in skeletal muscles comprised of predominantly oxidative (type I) fibres than in those comprised of mainly glycolytic (type II) fibres. In order to investigate further the angiogenic mechanisms involved in muscle...
Clin Sci (Lond) (1991) 81 (1): 123–128.
Published: 01 July 1991
...-containing metabolites of normal human skeletal muscle in vivo in four normal subjects. 2. Insulin and glucose were infused for 120 min. Plasma insulin increased approximately 10-fold over pre-clamp levels (5.6 ± 0.9 m-units/l pre-clamp and 54 ± 5 m-units/l over the last hour of infusion; mean ± sem , n = 4...
Clin Sci (Lond) (1990) 79 (5): 491–497.
Published: 01 November 1990
...C. R. K. Dudley; D. J. Taylor; L. L. Ng; G. J. Kemp; P. J. Ratcliffe; G. K. Radda; J. G. G. Ledingham 1. Exercise-induced pH changes in skeletal muscle were studied in a group of eight subjects with essential hypertension by using 31 P n.m.r. spectroscopy. 2. Leucocyte Na + /H + antiport activity...
Clin Sci (Lond) (1990) 79 (4): 331–337.
Published: 01 October 1990
...J. Bergström; P. Fürst; E. Vinnars 1. The effect of a protein-free meal and a protein-rich meal on the concentration of free amino acids in plasma and muscle tissue was studied in eight healthy subjects. The energy content of the protein-free meal was 3800 kJ. The protein-rich meal was identical...
Clin Sci (Lond) (1990) 79 (2): 139–147.
Published: 01 August 1990
...M. Salleh M. Ardawi; Yasir S. Jamal 1. The effect of dexamethasone (30 μg day −-1 100 g −-1 body weight) on the regulation of glutamine metabolism was studied in skeletal muscles of rats after 9 days of treatment. 2. Dexamethasone resulted in negative nitrogen balance, and produced increases...
Clin Sci (Lond) (1990) 78 (6): 579–584.
Published: 01 June 1990
...%). At 30–36 h and 60–66 h of starvation, essentially all the non-protein energy was derived from the oxidation of fat (directly plus indirectly via ketone bodies). 3. After an overnight fast, acetoacetate and 3-hydroxybutyrate were taken up by forearm muscle at a rate which could account for 5...
Clin Sci (Lond) (1990) 78 (5): 515–519.
Published: 01 May 1990
... phosphocreatine (PCr) depletion in the working skeletal muscles of the arm. We have studied the importance of the work necessary to reach a similar PCr depletion {[PCr]/([PCr] + [P i ]) = 0.5} in calf muscle. Our results show significantly lower values for patients with congestive heart failure in both aerobic...
Clin Sci (Lond) (1989) 77 (6): 663–670.
Published: 01 December 1989
... the adipose tissue showed marked positive carbon balance (net substrate deposition). 7 6 1989 23 6 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 adipose tissue free fatty acids glucose glycerol insulin lactate muscle triacylglycerol Clinical Science...
Clin Sci (Lond) (1989) 77 (4): 413–416.
Published: 01 October 1989
.... These observations support the concept that short-chain acylcarnitine (largely acetylcarnitine) contributes to the flux of metabolic fuels from the liver to muscle in the fasted state, although to a limited extent in comparison with 3-hydroxybutyrate (< 5% on a molar basis). 14 3 1989 31 3 1989...
Clin Sci (Lond) (1989) 77 (3): 329–336.
Published: 01 September 1989
... with the tracer to minimize differences in isotopic enrichment of the free amino acid in plasma and tissue compartments. This approach has been investigated in human muscle by taking biopsies from postabsorptive male volunteers given [1- 13 C]leucine. 2. Intravenous injection of 4 g of unlabelled leucine resulted...
Clin Sci (Lond) (1988) 75 (3): 257–261.
Published: 01 September 1988
...Priscilla M. Clarkson; Cara Ebbeling 1. The present study examined if the presence of creatine kinase (CK) inhibitors might explain the large variability in blood levels of CK among subjects after exercise-induced muscle damage. 2. Twenty-four women performed an eccentric exercise with the forearm...
Clin Sci (Lond) (1988) 74 (5): 461–466.
Published: 01 May 1988
...Victor R. Preedy; Timothy J. Peters 1. The effects of a single dose of ethanol (75 mmol/kg body weight) on rates of muscle protein synthesis were examined in young rats. Fractional rates of protein synthesis were measured in the soleus, plantaris, gastrocnemius, diaphragm and stomach by the large...
Clin Sci (Lond) (1988) 74 (1): 85–89.
Published: 01 January 1988
... of reversing loss of muscle strength through increased daily activity. 15 5 1987 07 7 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 age factors muscle Clinical Science (1988) 74,85-89 85 Muscle strength in the triceps surae and objectively measured...
Clin Sci (Lond) (1987) 72 (4): 475–482.
Published: 01 April 1987
...S. P. T. Sinkeler; R. A. Binkhorst; E. M. G. Joosten; R. A. Wevers; M. M. Coerwinkel; T. L. Oei 1. Muscle biopsies were taken from 10 control subjects and five AMP deaminase (AMPD) deficient individuals before and after an ischaemic isometric exercise test and analysed for purine nucleotide, NAD...
Clin Sci (Lond) (1986) 71 (6): 729–735.
Published: 01 December 1986
..., at rest, from the flexor digitorum superficialis muscle of hypophosphataemic patients with vitamin D-resistant rickets, and patients with Paget's disease of bone before and after they had been made hyperphosphataemic by treatment with the drug ethylidene-1-hydroxy-1,1-bisphosphonate. Changes...
Clin Sci (Lond) (1986) 71 (3): 283–290.
Published: 01 September 1986
...L. J. Hands; P. J. Bore; G. Galloway; P. J. Morris; G. K. Radda 1. Eleven men with claudication and ten control subjects had calf muscle metabolism studied at rest and during exercise and the subsequent recovery period by 31 P nuclear magnetic resonance (n.m.r.) spectroscopy. 2. The muscle...
Clin Sci (Lond) (1986) 70 (3): 285–293.
Published: 01 March 1986
... increased zinc loss without affecting calcium balance. 30 9 1985 22 10 1985 © 1986 The Biochemical Society and the Medical Research Society 1986 body weight calcium diet reducing muscle tri-iodothyronine zinc Clinical Science (1986).70, 285-293 285 Changes in bone and muscle...
Clin Sci (Lond) (1984) 66 (2): 173–178.
Published: 01 February 1984
...K. Gohil; D. A. Jones; R. H. T. Edwards 1. Activities for the oxidation of palmitoyl-carnitine, of palmitoyl-CoA and of carnitine palmitoyltransferase were measured in mitochondria prepared from needle biopsy samples of human skeletal muscle. Results are presented for nine normal subjects and 18...
Clin Sci (Lond) (1983) 65 (5): 491–498.
Published: 01 November 1983
... role in the disposal of leucine. 19 5 1983 7 6 1983 © 1983 The Biochemical Society and the Medical Research Society 1983 glucose insulin leucine muscle somatostatin splanchnic Clinical Science (1983) 65,491-498 49 1 Leucine uptake by splanchnic and leg tissues in man...