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Keywords: mitochondrial function
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Clin Sci (Lond) (2021) 135 (7): 979–990.
Published: 16 April 2021
... in skeletal muscle cells and increased after exercise training. Then, IGF2 deficiency in myotubes from C2C12 and primary skeletal muscle cells (PMSCs) led to impaired mitochondrial function, reduced mitochondria-related protein content, and decreased mitochondrial biogenesis. Furthermore, we explored...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (24): 2431–2447.
Published: 16 December 2019
...) fed groups. After feeding with either ND or HFD for 12 weeks, rats in each dietary group were divided into groups to receive either the vehicle, Mdivi1 (1.2 mg/kg, i.p.), M1 (2 mg/kg, i.p.) or combined treatment for 14 days. The cardiac function, cardiac mitochondrial function, metabolic...
Clin Sci (Lond) (2018) 132 (19): 2103–2115.
Published: 02 October 2018
... groups was observed regarding oxidative stress markers. HbSS mice displayed a higher intramuscular acidosis during the ischemic period while their mitochondrial function was impaired as compared with their HbAA and HbAS counterparts. These metabolic abnormalities could worsen the complications related...
Clin Sci (Lond) (2016) 130 (18): 1641–1653.
Published: 08 August 2016
... was partly abolished by 3-MA ( Figure 5 A). ΔΨ m was dramatically reduced in NRCs exposed to H/R, and partially restored by PD. However, the effect of PD was abolished by Baf ( Figures 5 B and 5 C). Figure 5 Effects of PD treatment on mitochondrial function in NRCs exposed to H/R ( A ) TEM pictures...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (11): 931–941.
Published: 29 April 2016
... , 14 ] and their relationship to altered placental function and fetal programming [ 15 ]. We have shown that mitochondrial function/oxidative phosphorylation is significantly reduced in the placenta with increasing maternal adiposity [ 16 , 17 ]. Recently, it was shown that mitochondrial protein...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (7): 589–599.
Published: 14 July 2015
...Joaquin Perez-Schindler; Andrew Philp Skeletal muscle metabolism is highly dependent on mitochondrial function, with impaired mitochondrial biogenesis associated with the development of metabolic diseases such as insulin resistance and type 2 diabetes. Mitochondria display substantial plasticity...
Clin Sci (Lond) (2014) 127 (12): 655–663.
Published: 08 August 2014
... by lipid deposition within the liver [intrahepatocellular lipid (IHCL)], is associated with insulin resistance and the metabolic syndrome (MS). It has been suggested that impaired skeletal muscle mitochondrial function may contribute to ectopic lipid deposition, and the associated MS, by altering post...
Clin Sci (Lond) (2010) 119 (7): 293–301.
Published: 25 June 2010
... concurrently. Statin intake may blunt mitochondrial function and the adaptive response to exercise training. Thus combining exercise training with statin administration may have adverse effects. We examined whether improvements in cardiometabolic risk factors, insulin sensitivity and mitochondrial function...
Includes: Supplementary data
Clin Sci (Lond) (2006) 111 (2): 135–143.
Published: 13 July 2006
... 13 CO 2 for ketoisocaproate at 60 min was associated with the highest prediction (positive predictive value, 0.90; negative predictive value, 0.73) for NASH, yielding an overall sensitivity of 68% and specificity of 94%. In conclusion, both microsomal and mitochondrial functions are disturbed in NASH...
Clin Sci (Lond) (1987) 73 (6): 593–599.
Published: 01 December 1987
... and cardiac adenosine triphosphatase activities or renal cortical mitochondrial function. 4. The adenosine triphosphate content of kidney cortex and cardiac mitochondrial function were significantly depressed in CBDL rats. 5. The results demonstrate that jaundice in CBDL rats is associated with functional...