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Articles

The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

Miranda J. Melis, Muska Miller, Vera B.M. Peters, Mervyn Singer

Clin Sci (Lond) (2023) 137 (9): 707–725.

DOI: https://doi.org/10.1042/CS20220709

Published: 05 May 2023

... of University College London in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. hormones immune response mitochondria organ dysfunction sepsis stress response Sepsis is defined as a dysregulated host...

View article titled, The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

Articles

Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Zhipeng Tao, Zhiyong Cheng

Clin Sci (Lond) (2023) 137 (6): 415–434.

DOI: https://doi.org/10.1042/CS20210519

Published: 21 March 2023

... with Portland Press and the Biochemical Society under a transformative agreement with Individual. autophagy estrogen Insulin metabolic disease metabolism mitochondria Since the definition of hormone by the British physiologist Ernest Starling in 1905 [ 1 ], hormone research has advanced...

View article titled, Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Articles

Correction: Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway -Application to a biomarker for atherosclerosis

Clin Sci (Lond) (2023) 137 (5): 353.

DOI: https://doi.org/10.1042/CS-2022-0525_COR

Published: 01 March 2023

...). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarker cell-free DNA cGAS-STING DNA damage mitochondria ...

View article titled, Correction: Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway -Application to a biomarker for atherosclerosis

Articles

Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD

Lynne Faherty, Sarah Kenny, Suzanne M. Cloonan

Clin Sci (Lond) (2023) 137 (3): 219–237.

DOI: https://doi.org/10.1042/CS20210504

Published: 02 February 2023

... that mitochondria, the central players in cellular iron utilisation, are dysfunctional in respiratory cells in individuals with COPD, with alterations in mitochondrial bioenergetics and dynamics driving disease progression. Understanding the molecular mechanisms underlying the dysfunction of mitochondria...

View article titled, Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD

Articles

Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis

Keitaro Ueda, Chiemi Sakai, Takafumi Ishida, Kosuke Morita, Yusuke Kobayashi, Yasunori Horikoshi, Akiko Baba, Yuma Okazaki, Masao Yoshizumi, Satoshi Tashiro, Mari Ishida

Clin Sci (Lond) (2023) 137 (2): 163–180.

DOI: https://doi.org/10.1042/CS20220525

Published: 24 January 2023

... level of cell-free DNA (cfDNA), a result of mitochondrial and/or genomic DNA damage, as a biomarker for atherosclerosis. Cigarette smoke extract (CSE) increased DNA damage in the nucleus and mitochondria in human endothelial cells. Mitochondrial damage induced minority mitochondrial outer membrane...

View article titled, Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis

Includes: Supplementary data

Articles

Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases

Gourabamani Swalsingh, Punyadhara Pani, Naresh C. Bal

Clin Sci (Lond) (2022) 136 (24): 1851–1871.

DOI: https://doi.org/10.1042/CS20220636

Published: 22 December 2022

... a high level of metabolic flexibility, which is reduced in several metabolic diseases, including obesity and Type 2 diabetes (T2D). Skeletal muscle health is highly dependent on optimally functioning mitochondria that exist in a highly integrated network with the sarcoplasmic reticulum and sarcolemma...

View article titled, Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases

Articles

Targeting skeletal muscle mitochondrial health in obesity

Chantal A. Pileggi, Breana G. Hooks, Ruth McPherson, Robert R.M. Dent, Mary-Ellen Harper

Clin Sci (Lond) (2022) 136 (14): 1081–1110.

DOI: https://doi.org/10.1042/CS20210506

Published: 27 July 2022

... 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . metabolic disorders metabolic regulation mitochondria oxidative...

View article titled, Targeting skeletal muscle mitochondrial health in obesity

Articles

Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection

Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Apiwan Arinno, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Wichwara Nawara, Siriporn C. Chattipakorn, Nipon Chattipakorn

Clin Sci (Lond) (2022) 136 (11): 841–860.

DOI: https://doi.org/10.1042/CS20220074

Published: 01 June 2022

... investigated whether treatment with Mdivi-1 and M1 protects the heart against DOX-induced cardiotoxicity via mitochondria-targeted pathways. Male Wistar rats ( n =40) received DOX (3 mg/kg, six doses, n =32) or 3% dimethylsulfoxide (DMSO) in the normal saline solution (NSS) ( n =8) as a control. DOX-injected...

View article titled, Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection

Articles

Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Maria V. Irazabal, Alejandro R. Chade, Alfonso Eirin

Clin Sci (Lond) (2022) 136 (5): 345–360.

DOI: https://doi.org/10.1042/CS20210512

Published: 09 March 2022

... progression towards end-stage renal disease (ESRD). Renal tubular cells are populated with a high number of mitochondria, which produce cellular energy and modulate several important cellular processes, including generation of reactive oxygen species (ROS), calcium homeostasis, proliferation, and apoptosis...

View article titled, Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Articles

Platelets: the peripheral donor of mitochondria for diabetes-induced cognitive impairment

Shaimaa Nasr Amin

Clin Sci (Lond) (2021) 135 (4): 593–595.

DOI: https://doi.org/10.1042/CS20201297

Published: 18 February 2021

...Shaimaa Nasr Amin This commentary highlights the research entitled: Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice, presented by Ma et al. appearing in Clinical Science (2020) 134 (16), https://doi.org/10.1042/CS20200530...

View article titled, Platelets: the peripheral donor of mitochondria for diabetes-induced cognitive impairment

Articles

AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle

Miao Chen, Caoyu Ji, Qingchen Yang, Shuya Gao, Yue Peng, Zhe Li, Xingyu Gao, Yaoting Li, Nan Jiang, Yubin Zhang, Xiaohong Bian, Caiping Chen, Kaidi Zhang, Daniel Sanchis, Fangrong Yan, Junmei Ye

Clin Sci (Lond) (2020) 134 (17): 2381–2398.

DOI: https://doi.org/10.1042/CS20191320

Published: 16 September 2020

... ( daniel.sanchis@cmb.udl.cat ) * These authors contributed equally to this work. 09 01 2020 02 09 2020 03 09 2020 03 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 AKT2 AMPK glucose metabolism mitochondria...

View article titled, AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle

Includes: Supplementary data

Articles

Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Runa S.J. Lindblom, Gavin C. Higgins, Tuong-Vi Nguyen, Maryann Arnstein, Darren C. Henstridge, Cesare Granata, Matthew Snelson, Vicki Thallas-Bonke, Mark E. Cooper, Josephine M. Forbes, Melinda T. Coughlan

Clin Sci (Lond) (2020) 134 (2): 239–259.

DOI: https://doi.org/10.1042/CS20190787

Published: 29 January 2020

... nephropathy mitochondria mitochondrial permeability transition pores Chronic kidney disease (CKD) is recognised as a leading cause of morbidity and mortality amongst the 425 million people estimated to have diabetes globally [ 1 ]. This represents a significant burden to healthcare systems...

View article titled, Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Includes: Supplementary data

Articles

Processes exacerbating apoptosis in non-alcoholic steatohepatitis

Marta B. Afonso, Rui E. Castro, Cecília M. P. Rodrigues

Clin Sci (Lond) (2019) 133 (22): 2245–2264.

DOI: https://doi.org/10.1042/CS20190068

Published: 19 November 2019

... importance. In turn, the liver houses a very high number of mitochondria, crucial metabolic unifiers of both extrinsic and intrinsic signals that converge in apoptosis activation. The role of lifestyle options is also dissected, highlighting the management of modifiable risk factors, such as obesity...

View article titled, Processes exacerbating apoptosis in non-alcoholic steatohepatitis

Articles

Exosomal microRNA-122 mediates obesity-related cardiomyopathy through suppressing mitochondrial ADP-ribosylation factor-like 2

Yongshun Wang, Pianpian Jin, Jingjin Liu, Xiang Xie

Clin Sci (Lond) (2019) 133 (17): 1871–1881.

DOI: https://doi.org/10.1042/CS20190558

Published: 10 September 2019

... ]. Besides, miR-122 determined the metabolic gene profiles of hepatic mitochondria in hepatocellular carcinoma [ 13 ]. Therefore, miR-122 might be a potential mediator of obesity-induced cardiac mitochondrial dysfunction. To explore the potential pathophysiological role of liver-secreted miR-122...

View article titled, Exosomal microRNA-122 mediates obesity-related cardiomyopathy through suppressing mitochondrial ADP-ribosylation factor-like 2

Includes: Supplementary data

Articles

Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition

Yujia Yuan, Younan Chen, Tianqing Peng, Lan Li, Wuzheng Zhu, Fei Liu, Shuyun Liu, Xingxing An, Ruixi Luo, Jingqiu Cheng, Jingping Liu, Yanrong Lu

Clin Sci (Lond) (2019) 133 (15): 1759–1777.

DOI: https://doi.org/10.1042/CS20190672

Published: 14 August 2019

... Commons Attribution License 4.0 (CC BY-NC-ND) . autophagy diabetes lysosome mitochondria macrophage polarization In the last several decades, the increased prevalence of diabetes and its associated complications have been a serious health problem worldwide [ 1 , 2 ]. Diabetic...

View article titled, Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition

Includes: Supplementary data

Articles

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

Gargi Mahapatra, S. Carrie Smith, Timothy M. Hughes, Benjamin Wagner, Joseph A. Maldjian, Barry I. Freedman, Anthony J. A. Molina

Clin Sci (Lond) (2018) 132 (23): 2509–2518.

DOI: https://doi.org/10.1042/CS20180690

Published: 05 December 2018

... that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology. bioenergetics diabetes mitochondria neuroimaging Type 2 diabetes...

View article titled, Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

Articles

Inhibition of mitochondrial fission as a novel therapeutic strategy to reduce mortality upon myocardial infarction

Hannah A. Cooper, Satoru Eguchi

Clin Sci (Lond) (2018) 132 (20): 2163–2167.

DOI: https://doi.org/10.1042/CS20180671

Published: 19 October 2018

... of the Biochemical Society 2018 cardiomyocytes ischaemia-reperfusion injury mitochondria The authors declare that there are no competing interests associated with the manuscript. Drp1 dynamin-related protein 1 I/R ischemia/reperfusion LV left ventricle Mdivi-1...

View article titled, Inhibition of mitochondrial fission as a novel therapeutic strategy to reduce mortality upon myocardial infarction

Articles

Perturbations in mitochondrial dynamics by p66Shc lead to renal tubular oxidative injury in human diabetic nephropathy

Ming Zhan, Irtaza Usman, Jingbo Yu, Liemin Ruan, Xueyan Bian, Jun Yang, Shikun Yang, Lin Sun, Yashpal S. Kanwar

Clin Sci (Lond) (2018) 132 (12): 1297–1314.

DOI: https://doi.org/10.1042/CS20180005

Published: 26 June 2018

... dynamics were investigated by confocal microscopy of HK2 cells (human proximal tubular cell lines) stained with Mitotracker red or green dye along with Western blotting of the relevant proteins that modulate mitochondrial dynamics. Filamentous morphologic characteristic of mitochondria was readily...

View article titled, Perturbations in mitochondrial dynamics by p66Shc lead to renal tubular oxidative injury in human diabetic nephropathy

Includes: Supplementary data

Articles

Mitochondrial Sirtuins in cardiometabolic diseases

Xiaoqiang Tang, Xiao-Feng Chen, Hou-Zao Chen, De-Pei Liu

Clin Sci (Lond) (2017) 131 (16): 2063–2078.

DOI: https://doi.org/10.1042/CS20160685

Published: 24 July 2017

...Xiaoqiang Tang; Xiao-Feng Chen; Hou-Zao Chen; De-Pei Liu Mitochondria are heterogeneous and essentially contribute to cellular functions and tissue homeostasis. Mitochondrial dysfunction compromises overall cell functioning, tissue damage, and diseases. The advances in mitochondrion biology...

View article titled, Mitochondrial Sirtuins in cardiometabolic diseases

Articles

Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease

Gareth A. Nye, Giorgos K. Sakellariou, Hans Degens, Adam P. Lightfoot

Clin Sci (Lond) (2017) 131 (15): 1919–1922.

DOI: https://doi.org/10.1042/CS20160940

Published: 07 July 2017

...Gareth A. Nye; Giorgos K. Sakellariou; Hans Degens; Adam P. Lightfoot Mitochondria are no longer solely regarded as the cellular powerhouse; instead, they are now implicated in mediating a wide-range of cellular processes, in the context of health and disease. A recent article in Clinical Science...

View article titled, Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease

Articles

Mitochondria: a central target for sex differences in pathologies

Renée Ventura-Clapier, Maryline Moulin, Jérôme Piquereau, Christophe Lemaire, Mathias Mericskay, Vladimir Veksler, Anne Garnier

Clin Sci (Lond) (2017) 131 (9): 803–822.

DOI: https://doi.org/10.1042/CS20160485

Published: 19 April 2017

...Renée Ventura-Clapier; Maryline Moulin; Jérôme Piquereau; Christophe Lemaire; Mathias Mericskay; Vladimir Veksler; Anne Garnier It is increasingly acknowledged that a sex and gender specificity affects the occurrence, development, and consequence of a plethora of pathologies. Mitochondria...

View article titled, Mitochondria: a central target for sex differences in pathologies

Articles

Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis

Jerome Morel, Iain Hargreaves, David Brealey, Viruna Neergheen, Janne T. Backman, Sandro Lindig, Marcus Bläss, Michael Bauer, Daniel F. McAuley, Mervyn Singer

Clin Sci (Lond) (2017) 131 (8): 747–758.

DOI: https://doi.org/10.1042/CS20160802

Published: 06 April 2017

..., reflecting experiences in patient studies. Correspondence: Mervyn Singer ( m.singer@ucl.ac.uk ) 9 11 2016 2 2 2017 15 2 2017 15 2 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 mitochondria organ dysfunction...

View article titled, Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis

Includes: Supplementary data

Articles

Organelles in health and diseases

Satoru Eguchi, Victor Rizzo

Clin Sci (Lond) (2017) 131 (1): 1–2.

DOI: https://doi.org/10.1042/CS20160610

Published: 21 November 2016

... cellular organelles ER exosomes microparticles mitochondria Cellular organelles have their own critical functions. For example, mitochondria are a power source to maintain cellular and tissue energy demand. However, recent expansion of pharmacological, molecular and genetic tools have allowed us...

View article titled, Organelles in health and diseases

Articles

Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease

Marie-Claude Denis, Denis Roy, Pantea Rahmani Yeganeh, Yves Desjardins, Thibault Varin, Nour Haddad, Devendra Amre, Alain Théophile Sané, Carole Garofalo, Alexandra Furtos, Natalie Patey, Edgard Delvin, Eric Tremblay, André Marette, Jean-François Beaulieu, Emile Levy

Clin Sci (Lond) (2016) 130 (23): 2217–2237.

DOI: https://doi.org/10.1042/CS20160524

Published: 31 October 2016

...). published by Portland Press Limited on behalf of the Biochemical Society 2016 inflammation mitochondria peroxidation polyphenol • Apple peel polyphenols represent an efficient functional food for the prevention and treatment of inflammatory bowel diseases. • Apple peel polyphenols...

View article titled, Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease

Includes: Supplementary data

Articles

Mitochondrial DNA disturbances and deregulated expression of oxidative phosphorylation and mitochondrial fusion proteins in sporadic inclusion body myositis

Marc Catalán-García, Glòria Garrabou, Constanza Morén, Mariona Guitart-Mampel, Adriana Hernando, Àngels Díaz-Ramos, Ingrid González-Casacuberta, Diana-Luz Juárez, Maria Bañó, Jennifer Enrich-Bengoa, Sonia Emperador, José César Milisenda, Pedro Moreno, Ester Tobías, Antonio Zorzano, Julio Montoya, Francesc Cardellach, Josep Maria Grau

Clin Sci (Lond) (2016) 130 (19): 1741–1751.

DOI: https://doi.org/10.1042/CS20160080

Published: 31 August 2016

...@clinic.ub.es ). 3 2 2016 5 7 2016 13 7 2016 13 7 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 In this study, we describe the role of mitochondria in sIBM, demonstrating that deregulated mitochondrial dynamics...

View article titled, Mitochondrial DNA disturbances and deregulated expression of oxidative phosphorylation and mitochondrial fusion proteins in sporadic inclusion body myositis

Includes: Supplementary data

Articles

Mitochondrial [dys]function; culprit in pre-eclampsia?

Cathal Michael McCarthy, Louise Clare Kenny

Clin Sci (Lond) (2016) 130 (14): 1179–1184.

DOI: https://doi.org/10.1042/CS20160103

Published: 01 June 2016

...Cathal Michael McCarthy; Louise Clare Kenny Mitochondria are extensively identified for their bioenergetic capacities; however, recently these metabolic hubs are increasingly being appreciated as critical regulators of numerous cellular signalling systems. Mitochondrial reactive oxygen species have...

View article titled, Mitochondrial [dys]function; culprit in pre-eclampsia?

Articles

Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease

Dennis Dahlmans, Alexandre Houzelle, Patrick Schrauwen, Joris Hoeks

Clin Sci (Lond) (2016) 130 (11): 843–852.

DOI: https://doi.org/10.1042/CS20150780

Published: 22 April 2016

...Dennis Dahlmans; Alexandre Houzelle; Patrick Schrauwen; Joris Hoeks The western dietary habits and sedentary lifestyle largely contributes to the growing epidemic of obesity. Mitochondria are at the front line of cellular energy homoeostasis and are implicated in the pathophysiology of obesity...

View article titled, Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease

Articles

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

Melinda T. Coughlan, Tuong-Vi Nguyen, Sally A. Penfold, Gavin C. Higgins, Vicki Thallas-Bonke, Sih Min Tan, Nicole J. Van Bergen, Karly C. Sourris, Brooke E. Harcourt, David R. Thorburn, Ian A. Trounce, Mark E. Cooper, Josephine M. Forbes

Clin Sci (Lond) (2016) 130 (9): 711–720.

DOI: https://doi.org/10.1042/CS20150838

Published: 18 March 2016

... by mitochondria, which are dynamic organelles, constantly fusing and dividing to maintain kidney homoeostasis. In diabetic kidney disease (DKD), mitochondria appear dysfunctional, but the temporal development of diabetes-induced adaptations in mitochondrial structure and bioenergetics have not been previously...

View article titled, Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

Articles

Metabolic dysfunction in lymphocytes promotes postoperative morbidity

Mark R. Edwards, Pervez Sultan, Ana Gutierrez del Arroyo, John Whittle, Shamir N. Karmali, S. Ramani Moonesinghe, Fares S. Haddad, Michael G. Mythen, Mervyn Singer, Gareth L. Ackland

Clin Sci (Lond) (2015) 129 (5): 423–437.

DOI: https://doi.org/10.1042/CS20150024

Published: 11 June 2015

.... This hypometabolic phenotype triggered by glucocorticoid-induced mitochondrial dysfunction activating the NLRP1 inflammasome prevents normal lymphocyte functionality and increases apoptosis. apoptosis inflammasome lymphocyte metabolism mitochondria sepsis • The mechanism underlying a potential...

View article titled, Metabolic dysfunction in lymphocytes promotes postoperative morbidity

Includes: Supplementary data

Articles

Activation of intracellular angiotensin AT 2 receptors induces rapid cell death in human uterine leiomyosarcoma cells

Yi Zhao, Ulf Lützen, Jürgen Fritsch, Maaz Zuhayra, Stefan Schütze, Ulrike M. Steckelings, Chiara Recanti, Pawel Namsoleck, Thomas Unger, Juraj Culman

Clin Sci (Lond) (2015) 128 (9): 567–578.

DOI: https://doi.org/10.1042/CS20140627

Published: 11 February 2015

...Yi Zhao; Ulf Lützen; Jürgen Fritsch; Maaz Zuhayra; Stefan Schütze; Ulrike M. Steckelings; Chiara Recanti; Pawel Namsoleck; Thomas Unger; Juraj Culman The presence of angiotensin type 2 (AT 2 ) receptors in mitochondria and their role in NO generation and cell aging were recently demonstrated...

View article titled, Activation of intracellular angiotensin AT 2 receptors induces rapid cell death in human uterine leiomyosarcoma cells

Articles

Prevention of oxidative stress, inflammation and mitochondrial dysfunction in the intestine by different cranberry phenolic fractions

Marie-Claude Denis, Yves Desjardins, Alexandra Furtos, Valérie Marcil, Stéphanie Dudonné, Alain Montoudis, Carole Garofalo, Edgard Delvin, André Marette, Emile Levy

Clin Sci (Lond) (2015) 128 (3): 197–212.

DOI: https://doi.org/10.1042/CS20140210

Published: 03 October 2014

... to reduce intestinal oxidative stress and inflammation while improving mitochondrial dysfunction. antioxidant cyclo-oxygenase inflammation mitochondria peroxidation polyphenol transcription factor • Inflammation is the central component in inflammatory bowel diseases...

View article titled, Prevention of oxidative stress, inflammation and mitochondrial dysfunction in the intestine by different cranberry phenolic fractions

Includes: Supplementary data

Articles

New roles for old pathways? A circuitous relationship between reactive oxygen species and cyclo-oxygenase in hypertension

Raquel Hernanz, Ana M. Briones, Mercedes Salaices, María J. Alonso

Clin Sci (Lond) (2014) 126 (2): 111–121.

DOI: https://doi.org/10.1042/CS20120651

Published: 13 September 2013

... between NADPH oxidase and mitochondria, the main ROS sources in hypertension, which may represent a vicious feed-forward cycle of ROS production. In recent years, there is experimental evidence showing a relationship between ROS and COX-derived products. Thus ROS can activate COX and the COX/PG...

View article titled, New roles for old pathways? A circuitous relationship between reactive oxygen species and cyclo-oxygenase in hypertension

Articles

Cell (patho)physiology of magnesium

Federica I. Wolf, Valentina Trapani

Clin Sci (Lond) (2008) 114 (1): 27–35.

DOI: https://doi.org/10.1042/CS20070129

Published: 30 November 2007

... Biochemical Society 2008 apoptosis cell proliferation cell cycle energy metabolism magnesium transport mitochondria Mg (magnesium; referring to both bound and free forms) is referred to as the intracellular divalent cation par excellence . Its biological role is extremely versatile...

View article titled, Cell (patho)physiology of magnesium

Articles

How does endothelin induce vascular oxidative stress in mineralocorticoid hypertension?

David M. Pollock

Clin Sci (Lond) (2006) 110 (2): 205–206.

DOI: https://doi.org/10.1042/CS20050359

Published: 17 January 2006

... mitochondria to generate reactive oxygen species in the vascular wall during mineralocorticoid-induced hypertension in the rat. These studies open a new line of investigation that could be important for the development of therapeutic strategies; however, there still remains a great deal of uncertainty about...

View article titled, How does endothelin induce vascular oxidative stress in mineralocorticoid hypertension?

Articles

New insights into amino acid metabolism, β-cell function and diabetes

Philip NEWSHOLME, Lorraine BRENNAN, Blanca RUBI, Pierre MAECHLER

Clin Sci (Lond) (2005) 108 (3): 185–194.

DOI: https://doi.org/10.1042/CS20040290

Published: 18 February 2005

... identify novel targets for future diabetes therapies. Mitochondrial metabolism is crucial for the coupling of amino acid and glucose recognition to the exocytosis of the insulin granules. This is illustrated by in vitro and in vivo observations discussed in the present review. Mitochondria generate ATP...

View article titled, New insights into amino acid metabolism, β-cell function and diabetes

Articles

Effects of indomethacin on energy metabolism in rat and human jejunal tissue in vitro

Molly JACOB, Ingvar BJARNASON, Robert J. SIMPSON

Clin Sci (Lond) (2001) 101 (5): 493–498.

DOI: https://doi.org/10.1042/cs1010493

Published: 25 September 2001

... and energy charge were less conclusive. These findings suggest that indomethacin affects mitochondria and thereby impairs energy metabolism in jejunal tissue. Correspondence: Dr R. J. Simpson, Department of Endocrinology, Diabetes and Internal Medicine, King's College Denmark Hill Campus, Bessemer Rd...

View article titled, Effects of indomethacin on energy metabolism in rat and human jejunal tissue in vitro

Articles

Stimulation of apoptosis by sulindac and piroxicam

William R. WADDELL

Clin Sci (Lond) (1998) 95 (3): 385–388.

DOI: https://doi.org/10.1042/cs0950385

Published: 01 September 1998

... form of the drug with protons in the intermembrane space of mitochondria to disrupt the potential across the inner mitochondrial membrane and thereby initiate apoptosis. Normal cells are not affected. Present address: P.O. Box 289, Silver City, NM 88062, U.S.A. 13 10 1997 20 1 1998...

View article titled, Stimulation of apoptosis by sulindac and piroxicam

Articles

Mitochondrial DNA Defects: A Widening Clinical Spectrum of Disorders

Emma J. Sherratt, Andrew W. Thomas, John C. Alcolado

Clin Sci (Lond) (1997) 92 (3): 225–235.

DOI: https://doi.org/10.1042/cs0920225

Published: 01 March 1997

... and nerve deafness. 6. Nuclear gene defects may result in mitochondrial disorders by predisposing to multiple mitochondrial DNA deletions or quantitative depletions of mitochondrial DNA content. © 1997 The Biochemical Society and the Medical Research Society 1997 diabetes genetics mitochondria...

View article titled, Mitochondrial DNA Defects: A Widening Clinical Spectrum of Disorders

Articles

Non-Invasive Measurement of Cardiac Oxygenation and Haemodynamics during Transient Episodes of Coronary Artery Occlusion and Reperfusion in the Pig

M. S. Thorniley, A. Lahiri, B. Glenville, C. Shurey, G. Baker, U. Ravel, J. Crawley, C. J. Green

Clin Sci (Lond) (1996) 91 (1): 51–58.

DOI: https://doi.org/10.1042/cs0910051

Published: 01 July 1996

... absorption properties of two key biochemical com- ponents, namely haemoglobin and myoglobin [2, 3, 81. The oxygenation status of haemoglobin and Key words: cardiac, cytochrome oo3, haemodynamics, ischaemia, mitochondria, spectrophotometry. Abbreviations: HbD. oxygenation index; HbO,, oxygenated haemoglobin...

View article titled, Non-Invasive Measurement of Cardiac Oxygenation and Haemodynamics during Transient Episodes of Coronary Artery Occlusion and Reperfusion in the Pig

Articles

Investigation by Polymerase Chain Reaction of Enteroviral Infection in Patients with Chronic Fatigue Syndrome

A. McArdle, F. McArdle, M. J. Jackson, S. F. Page, I. Fahal, R. H. T. Edwards

Clin Sci (Lond) (1996) 90 (4): 295–300.

DOI: https://doi.org/10.1042/cs0900295

Published: 01 April 1996

... by reverse transcriptase-polymerase chain reaction techniques in relation to functional studies of muscle mitochondria and the muscle RNA/DNA ratio. 3. Fifty-eight percent of patients reported an uncharacterized ‘viral infection’ before the onset of their illness, but none of the muscle samples from 34...

View article titled, Investigation by Polymerase Chain Reaction of Enteroviral Infection in Patients with Chronic Fatigue Syndrome

Articles

Calf Muscle Mitochondrial and Glycogenolytic Atp Synthesis in Patients with Claudication Due to Peripheral Vascular Disease Analysed Using 31 P Magnetic Resonance Spectroscopy

G. J. Kemp, L. J. Hands, G. Ramaswami, D. J. Taylor, A. Nicolaides, A. Amato, G. K. Radda

Clin Sci (Lond) (1995) 89 (6): 581–590.

DOI: https://doi.org/10.1042/cs0890581

Published: 01 December 1995

... consequence of reduced blood flow, and may be related to change in muscle fibre type. 4 7 1995 1 9 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 arterial disease ATP synthesis bioenergetics glycogenolysis mitochondria occlusive oxidative metabolism 31...

View article titled, Calf Muscle Mitochondrial and Glycogenolytic Atp Synthesis in Patients with Claudication Due to Peripheral Vascular Disease Analysed Using 31 P Magnetic Resonance Spectroscopy

Articles

Ammonium Chloride Inhibits Pyruvate Oxidation in Rat Liver Mitochondria: A Possible Cause of Fatty Liver in Reye's Syndrome and Urea Cycle Defects

Vaddanahally T. Maddaiah, Uday Kumbar

Clin Sci (Lond) (1994) 87 (5): 499–503.

DOI: https://doi.org/10.1042/cs0870499

Published: 01 November 1994

... and salicylate on ADP-induced O 2 consumption by mitochondria (State 3 rate) respiring on pyruvate, and oxidation of [1- 14 C]- and [2- 14 C]-pyruvate to 14 CO 2 . 2. The rate of State 3 respiration was inhibited and plateaued at 45% with 10 mmol/l NH 4 Cl. 3. Oxidation of [1- 14 C]pyruvate was not significantly...

View article titled, Ammonium Chloride Inhibits Pyruvate Oxidation in Rat Liver Mitochondria: A Possible Cause of Fatty Liver in Reye's Syndrome and Urea Cycle Defects

Articles

Electron paramagnetic resonance spectroscopy of stable free radicals in the liver compared with ultrastructural and functional damage in a rat model of alcohol- and iron-overload

Graham P. Butcher, Nigel Deighton, Roger M. Batt, Boliang Ding, Susan Haywood, John Hoffman, Malcolm J. Jackson, Martyn C. R. Symons, Jonathan M. Rhodes

Clin Sci (Lond) (1993) 84 (3): 339–348.

DOI: https://doi.org/10.1042/cs0840339

Published: 01 March 1993

... The Biochemical Society and the Medical Research Society 1993 alcohol free radical iron liver mitochondria peroxisome electron paramagnetic resonance spectroscopy subcellular fractionation Clinical Science (1993) 84, 339-348 (Printed in Great Britain) 339 Electron paramagnetic resonance...

View article titled, Electron paramagnetic resonance spectroscopy of stable free radicals in the liver compared with ultrastructural and functional damage in a rat model of alcohol- and iron-overload

Articles

ATP production in isolated muscle mitochondria from haemodialysis patients: effects of correction of anaemia with erythropoietin

Peter Bárány, Rolf Wibom, Eric Hultman, Jonas Bergström

Clin Sci (Lond) (1991) 81 (5): 645–653.

DOI: https://doi.org/10.1042/cs0810645

Published: 01 November 1991

...Peter Bárány; Rolf Wibom; Eric Hultman; Jonas Bergström 1. The ATP production rate in isolated skeletal muscle mitochondria was measured with a bioluminescence method, before and during erythropoietin treatment, in 21 anaemic haemodialysis patients. In addition, the concentrations of ATP...

View article titled, ATP production in isolated muscle mitochondria from haemodialysis patients: effects of correction of anaemia with erythropoietin

Articles

Changes in concentrations of respiratory components and cytochrome oxidase activity in mitochondria obtained from carbon tetrachloride-induced cirrhotic rat liver

Taisuke Morimoto, Akira Tanaka, Yoshiro Taki, Masashi Noguchi, Naoki Yokoo, Tomohiko Nishihira, Katsuhide Nishikawa, Shunji Yamamoto, Naoki Nitta, Akira Jikkoh, Yasuo Kamiyama, Yoshio Yamaoka, Kazue Ozawa

Clin Sci (Lond) (1988) 74 (5): 485–489.

DOI: https://doi.org/10.1042/cs0740485

Published: 01 May 1988

..., the cytochrome oxidase activity of mitochondria and the hepatic adenylate energy charge level ( in situ ) were studied in cirrhotic rat liver induced by carbon tetrachloride (CCl 4 ). 2. In the cirrhotic liver mitochondria, concentrations of cytochrome a (+ a 3 ), cytochrome b , coenzyme Q 9 and coenzyme Q 10...

View article titled, Changes in concentrations of respiratory components and cytochrome oxidase activity in mitochondria obtained from carbon tetrachloride-induced cirrhotic rat liver

Articles

Biochemical and Morphometric Properties of Mitochondrial Populations in Human Muscle Fibres

Anna Elander, Michael Sjöström, Fredrik Lundgren, Tore Scherstén, Ann-Christin Bylund-Fellenius

Clin Sci (Lond) (1985) 69 (2): 153–163.

DOI: https://doi.org/10.1042/cs0690153

Published: 01 August 1985

... individuals. 2. The subsarcolemmal mitochondria were released by gentle homogenization, with a recovery of 32-37%, and the intermyofibrillar by enzymic digestion and further mechanical disintegration, recovery 18-21%. The subsarcolemmal mitochondria were morphologically defined as those located within 2 μm...

View article titled, Biochemical and Morphometric Properties of Mitochondrial Populations in Human Muscle Fibres

Articles

Fatty Acid Oxidation in Mitochondria from Needle Biopsy Samples of Human Skeletal Muscle

K. Gohil, D. A. Jones, R. H. T. Edwards

Clin Sci (Lond) (1984) 66 (2): 173–178.

DOI: https://doi.org/10.1042/cs0660173

Published: 01 February 1984

...K. Gohil; D. A. Jones; R. H. T. Edwards 1. Activities for the oxidation of palmitoyl-carnitine, of palmitoyl-CoA and of carnitine palmitoyltransferase were measured in mitochondria prepared from needle biopsy samples of human skeletal muscle. Results are presented for nine normal subjects and 18...

View article titled, Fatty Acid Oxidation in Mitochondria from Needle Biopsy Samples of Human Skeletal Muscle

Articles

Subcellular Fractionation Studies of Human Rectal Mucosa; Localization of the Mucosal Peptide Hormones

J. Dawson, M. G. Bryant, S. R. Bloom, T. J. Peters

Clin Sci (Lond) (1980) 59 (6): 457–462.

DOI: https://doi.org/10.1042/cs0590457

Published: 01 December 1980

... a major peak (modal density, 1.17) with a small subsidiary peak (modal density 1.24). 3. The following organelles, characterized by their marker enzymes, were located in the density gradients; plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes (β- N...

View article titled, Subcellular Fractionation Studies of Human Rectal Mucosa; Localization of the Mucosal Peptide Hormones

Articles

Subcellular Fractionation Studies on Hepatic Tissue from a Patient with Pompe's Disease (Type II Glycogen-Storage Disease)

T. J. Peters, W. Jenkins, V. Dubowitz

Clin Sci (Lond) (1980) 59 (1): 7–12.

DOI: https://doi.org/10.1042/cs0590007

Published: 01 July 1980

... lysosomes mitochondria plasma membrane Pompe's disease subcellular fractionation © 1980 The Biochemical Society and the Medical Research Society 1980 6 11 1979 13 2 1980 Clinical Science (1 980) 59,7- 12 7 Subcellular fractionation studies on hepatic tissue from a patient...

View article titled, Subcellular Fractionation Studies on Hepatic Tissue from a Patient with Pompe's Disease (Type II Glycogen-Storage Disease)

Articles

Subcellular Fractionation Studies of Human Gastric Antrum: Localization of the Mucosal Peptide Hormones

J. Dawson, M. G. Bryant, S. R. Bloom, T. J. Peters

Clin Sci (Lond) (1980) 59 (1): 1–6.

DOI: https://doi.org/10.1042/cs0590001

Published: 01 July 1980

... density 1.18) and a substantial shoulder extending into the denser regions of the gradient. 3. The following organelles, characterized by their marker enzymes, were located in the density gradients: plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes...

View article titled, Subcellular Fractionation Studies of Human Gastric Antrum: Localization of the Mucosal Peptide Hormones

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