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Keywords: mitochondria
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Clin Sci (Lond) (2023) 137 (9): 707–725.
Published: 05 May 2023
... activation can result in tissue injury and can paradoxically render the host more vulnerable to subsequent infection, especially if the inflammatory state is both severe and prolonged [ 4 , 24 , 25 ]. hormones immune response mitochondria organ dysfunction sepsis stress response Sepsis...
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Clin Sci (Lond) (2023) 137 (6): 415–434.
Published: 21 March 2023
... with Portland Press and the Biochemical Society under a transformative agreement with Individual. autophagy estrogen Insulin metabolic disease metabolism mitochondria Since the definition of hormone by the British physiologist Ernest Starling in 1905 [ 1 ], hormone research has advanced...
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Clin Sci (Lond) (2023) 137 (3): 219–237.
Published: 02 February 2023
... that mitochondria, the central players in cellular iron utilisation, are dysfunctional in respiratory cells in individuals with COPD, with alterations in mitochondrial bioenergetics and dynamics driving disease progression. Understanding the molecular mechanisms underlying the dysfunction of mitochondria...
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Clin Sci (Lond) (2022) 136 (24): 1851–1871.
Published: 22 December 2022
... a high level of metabolic flexibility, which is reduced in several metabolic diseases, including obesity and Type 2 diabetes (T2D). Skeletal muscle health is highly dependent on optimally functioning mitochondria that exist in a highly integrated network with the sarcoplasmic reticulum and sarcolemma...
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Clin Sci (Lond) (2022) 136 (14): 1081–1110.
Published: 27 July 2022
... disorders metabolic regulation mitochondria oxidative phosphorylation skeletal muscle According to the World Health Organization, more than 1 billion adults are overweight and an additional 650 million adults are living with obesity. The global prevalence of obesity has tripled since the 1970s...
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Clin Sci (Lond) (2022) 136 (5): 345–360.
Published: 09 March 2022
... progression towards end-stage renal disease (ESRD). Renal tubular cells are populated with a high number of mitochondria, which produce cellular energy and modulate several important cellular processes, including generation of reactive oxygen species (ROS), calcium homeostasis, proliferation, and apoptosis...
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Clin Sci (Lond) (2021) 135 (4): 593–595.
Published: 18 February 2021
...Shaimaa Nasr Amin This commentary highlights the research entitled: Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice, presented by Ma et al. appearing in Clinical Science (2020) 134 (16), https://doi.org/10.1042/CS20200530...
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Clin Sci (Lond) (2020) 134 (17): 2381–2398.
Published: 16 September 2020
... ( daniel.sanchis@cmb.udl.cat ) * These authors contributed equally to this work. 09 01 2020 02 09 2020 03 09 2020 03 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 AKT2 AMPK glucose metabolism mitochondria...
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Clin Sci (Lond) (2019) 133 (22): 2245–2264.
Published: 19 November 2019
... importance. In turn, the liver houses a very high number of mitochondria, crucial metabolic unifiers of both extrinsic and intrinsic signals that converge in apoptosis activation. The role of lifestyle options is also dissected, highlighting the management of modifiable risk factors, such as obesity...
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Clin Sci (Lond) (2019) 133 (17): 1871–1881.
Published: 10 September 2019
... process. For instance, both miR-194 and miR-29a could modulate cardiac mitochondrial biogenesis and activities in vitro and in vivo [ 11 , 12 ]. Besides, miR-122 determined the metabolic gene profiles of hepatic mitochondria in hepatocellular carcinoma [ 13 ]. Therefore, miR-122 might be a potential...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (23): 2509–2518.
Published: 05 December 2018
..., affecting brain functions and morphology. Future studies will address whether these central metabolic alterations are relayed to PBMC mitochondria via non-cellular, blood-borne circulating factors that are potentially released from the brain, altering PBMC mitochondrial bioenergetics. To our knowledge...
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Clin Sci (Lond) (2018) 132 (20): 2163–2167.
Published: 19 October 2018
... of the study, potential molecular mechanisms of mitochondrial fission, consequences of the fission, and future research directions. cardiomyocytes ischaemia-reperfusion injury mitochondria Correspondence: Satoru Eguchi ( seguchi@temple.edu ) 21 08 2018 13 09 2018 24 09 2018...
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Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... dynamics were investigated by confocal microscopy of HK2 cells (human proximal tubular cell lines) stained with Mitotracker red or green dye along with Western blotting of the relevant proteins that modulate mitochondrial dynamics. Filamentous morphologic characteristic of mitochondria was readily...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (16): 2063–2078.
Published: 24 July 2017
...Xiaoqiang Tang; Xiao-Feng Chen; Hou-Zao Chen; De-Pei Liu Mitochondria are heterogeneous and essentially contribute to cellular functions and tissue homeostasis. Mitochondrial dysfunction compromises overall cell functioning, tissue damage, and diseases. The advances in mitochondrion biology...
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Clin Sci (Lond) (2017) 131 (15): 1919–1922.
Published: 07 July 2017
...Gareth A. Nye; Giorgos K. Sakellariou; Hans Degens; Adam P. Lightfoot Mitochondria are no longer solely regarded as the cellular powerhouse; instead, they are now implicated in mediating a wide-range of cellular processes, in the context of health and disease. A recent article in Clinical Science...
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Clin Sci (Lond) (2017) 131 (9): 803–822.
Published: 19 April 2017
...Renée Ventura-Clapier; Maryline Moulin; Jérôme Piquereau; Christophe Lemaire; Mathias Mericskay; Vladimir Veksler; Anne Garnier It is increasingly acknowledged that a sex and gender specificity affects the occurrence, development, and consequence of a plethora of pathologies. Mitochondria...
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Clin Sci (Lond) (2017) 131 (1): 1–2.
Published: 21 November 2016
... organelles. Here, endothelial cell dysfunction induced by T-lymphocyte derived microparticles activated a signalling cascade which involved temporal cross-talk between the ER and the mitochondria leading to loss of bioavailable nitric oxide and impaired vasoregulation [ 14 ]. This study offers new...
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Clin Sci (Lond) (2016) 130 (14): 1179–1184.
Published: 01 June 2016
...Cathal Michael McCarthy; Louise Clare Kenny Mitochondria are extensively identified for their bioenergetic capacities; however, recently these metabolic hubs are increasingly being appreciated as critical regulators of numerous cellular signalling systems. Mitochondrial reactive oxygen species have...
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Clin Sci (Lond) (2016) 130 (9): 711–720.
Published: 18 March 2016
... by mitochondria, which are dynamic organelles, constantly fusing and dividing to maintain kidney homoeostasis. In diabetic kidney disease (DKD), mitochondria appear dysfunctional, but the temporal development of diabetes-induced adaptations in mitochondrial structure and bioenergetics have not been previously...
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Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
.... This hypometabolic phenotype triggered by glucocorticoid-induced mitochondrial dysfunction activating the NLRP1 inflammasome prevents normal lymphocyte functionality and increases apoptosis. apoptosis inflammasome lymphocyte metabolism mitochondria sepsis • The mechanism underlying...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
... between NADPH oxidase and mitochondria, the main ROS sources in hypertension, which may represent a vicious feed-forward cycle of ROS production. In recent years, there is experimental evidence showing a relationship between ROS and COX-derived products. Thus ROS can activate COX and the COX/PG...
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Clin Sci (Lond) (2008) 114 (1): 27–35.
Published: 30 November 2007
... Biochemical Society 2008 apoptosis cell proliferation cell cycle energy metabolism magnesium transport mitochondria Mg (magnesium; referring to both bound and free forms) is referred to as the intracellular divalent cation par excellence . Its biological role is extremely versatile...
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Clin Sci (Lond) (2006) 110 (2): 205–206.
Published: 17 January 2006
... mitochondria to generate reactive oxygen species in the vascular wall during mineralocorticoid-induced hypertension in the rat. These studies open a new line of investigation that could be important for the development of therapeutic strategies; however, there still remains a great deal of uncertainty about...
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Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
... identify novel targets for future diabetes therapies. Mitochondrial metabolism is crucial for the coupling of amino acid and glucose recognition to the exocytosis of the insulin granules. This is illustrated by in vitro and in vivo observations discussed in the present review. Mitochondria generate ATP...
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Clin Sci (Lond) (2001) 101 (5): 493–498.
Published: 25 September 2001
... and energy charge were less conclusive. These findings suggest that indomethacin affects mitochondria and thereby impairs energy metabolism in jejunal tissue. Correspondence: Dr R. J. Simpson, Department of Endocrinology, Diabetes and Internal Medicine, King's College Denmark Hill Campus, Bessemer Rd...
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Clin Sci (Lond) (1998) 95 (3): 385–388.
Published: 01 September 1998
... form of the drug with protons in the intermembrane space of mitochondria to disrupt the potential across the inner mitochondrial membrane and thereby initiate apoptosis. Normal cells are not affected. Present address: P.O. Box 289, Silver City, NM 88062, U.S.A. 13 10 1997 20 1 1998...
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Clin Sci (Lond) (1997) 92 (3): 225–235.
Published: 01 March 1997
... and nerve deafness. 6. Nuclear gene defects may result in mitochondrial disorders by predisposing to multiple mitochondrial DNA deletions or quantitative depletions of mitochondrial DNA content. © 1997 The Biochemical Society and the Medical Research Society 1997 diabetes genetics mitochondria...
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Clin Sci (Lond) (1996) 90 (4): 295–300.
Published: 01 April 1996
... by reverse transcriptase-polymerase chain reaction techniques in relation to functional studies of muscle mitochondria and the muscle RNA/DNA ratio. 3. Fifty-eight percent of patients reported an uncharacterized ‘viral infection’ before the onset of their illness, but none of the muscle samples from 34...
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Clin Sci (Lond) (1985) 69 (2): 153–163.
Published: 01 August 1985
... individuals. 2. The subsarcolemmal mitochondria were released by gentle homogenization, with a recovery of 32-37%, and the intermyofibrillar by enzymic digestion and further mechanical disintegration, recovery 18-21%. The subsarcolemmal mitochondria were morphologically defined as those located within 2 μm...
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Clin Sci (Lond) (1984) 66 (2): 173–178.
Published: 01 February 1984
...K. Gohil; D. A. Jones; R. H. T. Edwards 1. Activities for the oxidation of palmitoyl-carnitine, of palmitoyl-CoA and of carnitine palmitoyltransferase were measured in mitochondria prepared from needle biopsy samples of human skeletal muscle. Results are presented for nine normal subjects and 18...
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Clin Sci (Lond) (1980) 59 (6): 457–462.
Published: 01 December 1980
... a major peak (modal density, 1.17) with a small subsidiary peak (modal density 1.24). 3. The following organelles, characterized by their marker enzymes, were located in the density gradients; plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes (β- N...
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Clin Sci (Lond) (1980) 59 (1): 7–12.
Published: 01 July 1980
... lysosomes mitochondria plasma membrane Pompe's disease subcellular fractionation © 1980 The Biochemical Society and the Medical Research Society 1980 6 11 1979 13 2 1980 Clinical Science (1 980) 59,7- 12 7 Subcellular fractionation studies on hepatic tissue from a patient...
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Clin Sci (Lond) (1980) 59 (1): 1–6.
Published: 01 July 1980
... density 1.18) and a substantial shoulder extending into the denser regions of the gradient. 3. The following organelles, characterized by their marker enzymes, were located in the density gradients: plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes...