... gut barrier integrity and microbiome. Studies were carried out in Young (3–4 months) and old (20–24 months) male mice. Ang-(1–7) was administered by using osmotic pumps. Outcome measures included expressions of ACE, ACE2, AT1R, and MasR, intestinal permeability by using FITC-dextran...

... that develops independently, and its presence could be recognized by the detection, in blood, of lipopolysaccharides and (1→3)-β-D-glucan (major components of gut microbiota). Gut-dysbiosis is the consequence of a reduction in some bacterial species in the gut microbiome, as a consequence of intestinal mucosal...

...Fergus Shanahan; Tarini S. Ghosh; Michael G. Molloy; Paul W. O’Toole The microbiome contributes to human development and maturation, and is essential for maintenance of health and prevention of disease. While the human genome encodes one’s identity, the microbiome – also individually unique...

... of the Biochemical Society 2022 cirrhosis microbiome portal hypertension Sinusoidal portal hypertension (PH) is the major cause of morbidity and mortality in cirrhosis. While the pathophysiology through which PH develops is complex, changes in portal vein pressure can be expressed as a function...

... understood at present. Herein, we used a mouse (8 weeks) OA model of destabilization of the medial meniscus (DMM) and gut microbiome dysbiosis induced by antibiotic treatment with ampicillin and neomycin for 8 weeks. The results show that antibiotic-induced intestinal microbiota dysbiosis reduced the serum...

...Michael Weis The gut microbiome functions like an endocrine organ, generating enzymes and bioactive metabolites, which affect host physiology. In addition metabolism-independent processes like impaired intestinal barrier function may result in bacterial translocation and an increased inflammation...

...Seungbum Kim; Ruby Goel; Ashok Kumar; Yanfei Qi; Gil Lobaton; Koji Hosaka; Mohammed Mohammed; Eileen M. Handberg; Elaine M. Richards; Carl J. Pepine; Mohan K. Raizada Recent evidence indicates a link between gut pathology and microbiome with hypertension (HTN) in animal models. However, whether...

...Wei Ling Lau; Javad Savoj; Michael B. Nakata; Nosratola D. Vaziri In chronic kidney disease (CKD), influx of urea and other retained toxins exerts a change in the gut microbiome. There is decreased number of beneficial bacteria that produce short-chain fatty acids, an essential nutrient...

... and endocrine symptoms. Several microbiome studies have described alterations in the bacterial component of the microbiome (dysbiosis) consistent with a possible role in disease development. However, in focusing on the bacterial components of the microbiome, these studies have neglected the viral constituent...

... Limited on behalf of the Biochemical Society 2018 alcohol dependence brain gut barrier inflammation liver disease microbiome Alcohol abuse is a major public health problem worldwide causing a wide range of preventable morbidity and mortality [ 1 – 3 ]. Subjects drinking up to two drinks...

... 2015 25 8 2015 © 2015 Authors; published by Portland Press Limited 2015 antibiotics insulin resistance glucose metabolic inflammation microbiome Bacteria inhabit many niches, including multicellular animals. The assemblage of a bacterial community is termed the microbiota...