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Keywords: microRNA (miRNA)
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Articles

miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling

Bo Wang, Kevin Yao, Andrea F. Wise, Ricky Lau, Hsin-Hui Shen, Greg H. Tesch, Sharon D. Ricardo
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (5): 411–423.
DOI: https://doi.org/10.1042/CS20160571
Published: 17 February 2017
... 12 2016 3 1 2017 4 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic nephropathy kidney fibrosis mesangial cells microRNA (miRNA) transforming growth factor-β (TGF-β1) • Diabetic nephropathy (DN...
View article titled, miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling
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Includes: Supplementary data
Articles

In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease

Casper F.T. van der Ven, Pin-Jou Wu, Mark W. Tibbitt, Alain van Mil, Joost P.G. Sluijter, Robert Langer, Elena Aikawa
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (3): 181–195.
DOI: https://doi.org/10.1042/CS20160378
Published: 05 January 2017
...-looking review of 3D CAVD models, miRNA-based therapeutics and controlled drug-delivery strategies. aortic valve calcification 3D model drug delivery microRNA (miRNA) • Employing human 3D in vitro models of CAVD for identifying the underlying mechanisms and potential targets...
View article titled, In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease
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Articles

Role of microRNAs in cancers of the female reproductive tract: insights from recent clinical and experimental discovery studies

Monica Logan, Shannon M. Hawkins
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (3): 153–180.
DOI: https://doi.org/10.1042/CS20140087
Published: 03 October 2014
...Monica Logan; Shannon M. Hawkins microRNAs (miRNAs) are small RNA molecules that represent the top of the pyramid of many tumorigenesis cascade pathways as they have the ability to affect multiple, intricate, and still undiscovered downstream targets. Understanding how miRNA molecules serve...
View article titled, Role of microRNAs in cancers of the female reproductive tract: insights from recent clinical and experimental discovery studies
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Articles

microRNAs in the onset and development of cardiovascular disease

Kasey C. Vickers, Kerry-Anne Rye, Fatiha Tabet
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (3): 183–194.
DOI: https://doi.org/10.1042/CS20130203
Published: 01 October 2013
... 2013 12 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cardiovascular disease diabetes dyslipidaemia hypertension microRNA (miRNA) miRNAs (microRNAs) are short (~19–25 nucleotides in length) single-stranded non-encoding RNAs that are well conserved...
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Articles

microRNA in the development of diabetic complications

Aaron D. McClelland, Phillip Kantharidis
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (2): 95–110.
DOI: https://doi.org/10.1042/CS20130079
Published: 13 September 2013
..., a novel class of non-coding RNA, microRNA (miRNA), have emerged as being important regulators of numerous biological functions. Among these functions are basic maintenance of cell signalling and tissue architecture. Disruption of miRNA levels can contribute not only to the development of the chronic...
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Articles

Translational study of microRNAs and its application in kidney disease and hypertension research

Alison J. Kriegel, Domagoj Mladinov, Mingyu Liang
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (10): 439–447.
DOI: https://doi.org/10.1042/CS20110159
Published: 20 January 2012
... be sifted through with experimental validation. Correspondence: Dr Mingyu Liang (email mliang@mcw.edu ). 25 3 2011 11 10 2011 1 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 diagnosis hypertension kidney microRNA (miRNA) therapy...
View article titled, Translational study of microRNAs and its application in kidney disease and hypertension research
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Articles

Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin–angiotensin system blockade and statins on miRNA-146a / b and Toll-like receptor 4 levels

Yuji Takahashi, Mamoru Satoh, Yoshitaka Minami, Tsuyoshi Tabuchi, Tomonori Itoh, Motoyuki Nakamura
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (9): 395–405.
DOI: https://doi.org/10.1042/CS20100003
Published: 23 July 2010
... Journal compilation © 2010 Biochemical Society 2010 angiotensin-converting enzyme inhibitor (ACEI) angiotensin II receptor blocker (ARB) atherosclerosis interleukin-1-receptor-associated kinase 1 (IRAK1) microRNA (miRNA) Toll-like receptor 4 (TLR4) tumour-necrosis-factor-receptor-associated...
View article titled, Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin–angiotensin system blockade and statins on miRNA-146a / b and Toll-like receptor 4 levels
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Articles

Gene expression profiling in whole blood of patients with coronary artery disease

Chiara Taurino, William H. Miller, Martin W. McBride, John D. McClure, Raya Khanin, María U. Moreno, Jane A. Dymott, Christian Delles, Anna F. Dominiczak
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (8): 335–343.
DOI: https://doi.org/10.1042/CS20100043
Published: 06 July 2010
... microRNA (miRNA) mitochondrion oxidative phosphorylation rehabilitation programme CAD (coronary artery disease) is caused by multiple genetic and environmental factors and the interaction between them. Microarray analysis is a powerful technique for high-throughput global transcriptomic...
View article titled, Gene expression profiling in whole blood of patients with coronary artery disease
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Includes: Supplementary data