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Keywords: microRNA
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Articles
Clin Sci (Lond) (2023) 137 (16): 1311–1332.
Published: 31 August 2023
... for this article was enabled by the participation of University of Queensland in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. Extracellular Vesicles insulin resistance microRNA Pregnancy skeletal muscle...
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Clin Sci (Lond) (2022) 136 (18): 1341–1346.
Published: 21 September 2022
...Jessica L. Faulkner; Jennifer C. Sullivan MicroRNA (miRNA) are small, single strand non-coding RNA molecules involved in the post-transcriptional regulation of target genes. Since their discovery in 1993, over 2000 miRNAs have been identified in humans and there is growing interest in both...
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Clin Sci (Lond) (2022) 136 (17): 1281–1301.
Published: 05 September 2022
... response. Biomolecules secreted or shuttled within extracellular vesicles, such as exosomes, may participate in the concerted response. We investigated the exosome’s microRNAs due to their capacity to fine-tune gene expression, potentially affecting the multicellular repair response. We profiled...
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Clin Sci (Lond) (2022) 136 (12): 911–934.
Published: 20 June 2022
... transcription factor family and microRNAs on the regulation of positive and negative cell cycle factors is discussed. This review also highlights seminal studies that identified the coordination of signaling mechanisms that can potently activate CM cell cycle re-entry including the Wnt/Ctnnb1, Hippo, Pi3K-Akt...
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Clin Sci (Lond) (2022) 136 (8): 621–637.
Published: 27 April 2022
... 2021 21 03 2022 11 04 2022 12 04 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 atrial fibrillation microRNA small extracellular vesicles Atrial fibrillation (AF) is the most sustained cardiac arrhythmia...
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Clin Sci (Lond) (2022) 136 (8): 579–597.
Published: 21 April 2022
...) components such as such as collagen. Recent years have seen huge increases in our understanding of the functions of microRNAs (miRNAs) in wound repair. Concomitantly, there has been growing recognition of miRNA roles in circadian processes, either as regulators or targets of clock activity or direct...
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Clin Sci (Lond) (2022) 136 (5): 345–360.
Published: 09 March 2022
... with altered expression of mitochondria-related microRNAs (mitomiRs), which localize in mitochondria and regulate the expression of mtDNA and nucleus-encoded mitochondrial genes. This review summarizes relevant evidence regarding the involvement of renal mitochondrial injury and dysfunction in frequent forms...
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Clin Sci (Lond) (2022) 136 (5): 323–328.
Published: 02 March 2022
...Carlos J. Pirola; Silvia Sookoian MicroRNAs (miRNAs), which are regarded as crucial regulators of gene expression and diverse aspects of cell biology, can be present in various body fluids as highly stable molecules. It is also known that miRNAs exert tissue-specific regulation of gene...
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Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...
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Clin Sci (Lond) (2020) 134 (21): 2893–2895.
Published: 13 November 2020
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Figure 1 Protective role of microRNA in the kidney ( A ) Conclusions from Yu and co-workers . Under hypoxic conditions in vitro , renal tubular cells released EVs enriched in microRNAs that were...
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Clin Sci (Lond) (2020) 134 (8): 955–959.
Published: 21 April 2020
...-mediated microRNA (miRNA) exchange [ 10 ]. In the last decade, many data have been produced in favor of the role of extracellular vesicles (EVs) in cancer. These particles are considered key intercellular communicators delivering both tumorigenic and pro-metastatic signals within the tumor...
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Clin Sci (Lond) (2020) 134 (2): 169–192.
Published: 23 January 2020
... for the development of biomarkers to identify at-risk asymptomatic carotid plaque prior to disease progression and stroke. Further, it would aid in creation of therapeutics to stabilize carotid plaque. MicroRNAs (miRNAs) have been implicated as key protagonists in various stages of atherosclerotic plaque initiation...
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Clin Sci (Lond) (2020) 134 (2): 87–101.
Published: 21 January 2020
... microRNA preeclampsia RNA sequencing Preeclampsia (PE) is estimated to affect up to 8% of all pregnancies worldwide, and thus represents a substantial burden on the cardiovascular health of millions of women [ 1 ]. While the high blood pressure and proteinuria associated with PE usually resolve...
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Clin Sci (Lond) (2019) 133 (21): 2217–2220.
Published: 13 November 2019
... in mouse models of neointimal hyperplasia where c-myb is up-regulated [ 24 ]. These contrasting findings might be explained by differences in temporospatial expression of microRNA-143/145 or negative regulation of Dicer processing of miR-143/145 in the context of atherosclerosis [ 24 ]. To serve...
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Clin Sci (Lond) (2018) 132 (22): 2423–2436.
Published: 22 November 2018
... dysfunction inflammation microRNA Atherosclerosis and the presence of unstable plaques at carotid bifurcation is responsible for approximately 15–20% of all cerebrovascular events [ 1 ]. Vulnerable or rupture-prone plaques are characterised by a large cholesterol-rich core, are poor in calcium...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (17): 1875–1888.
Published: 05 September 2018
... in the cytoplasm or generated de novo upon platelet activation. atherosclerosis microRNA platelet adhesion and activation Platelets play an important role in the control of vascular homeostasis. Indeed, beyond their function in hemostasis, they can transmit inflammatory signals and secrete...
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Clin Sci (Lond) (2017) 131 (23): 2813–2834.
Published: 28 November 2017
... 2017 microRNA resistant hypertension Signaling Pathways Resistant hypertension (RH) is characterized by a condition in which the patient requires four or more antihypertensive medications, including a diuretic, regardless of blood pressure (BP) control. RH patients can be classified...
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Clin Sci (Lond) (2017) 131 (15): 1923–1940.
Published: 13 July 2017
..., a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability...
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Clin Sci (Lond) (2017) 131 (14): 1649–1667.
Published: 30 June 2017
... Stenvinkel ( peter.stenvinkel@ki.se ) 09 12 2016 17 04 2017 19 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 chronic kidney disease DNA methylation epigenetics microRNA Chronic kidney disease (CKD...
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Clin Sci (Lond) (2014) 127 (11): 615–634.
Published: 25 July 2014
... proliferative disease. Although the main molecular and cellular mechanisms underlying restenosis have been well described, new signalling molecules and cell types controlling the progress of restenosis are continuously being discovered. In particular, microRNAs and vascular progenitor cells have recently been...
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Clin Sci (Lond) (2014) 127 (4): 233–242.
Published: 10 April 2014
...) or strong (3) expressors. breast carcinoma microRNA neoplasm metastasis and recurrence prognosis Scribble • Despite breast cancer being a deeply characterized neoplasia with disclosed molecular signatures, it remains the second largest cause of cancer death in women. Deregulation...
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Clin Sci (Lond) (2014) 127 (2): 77–89.
Published: 17 March 2014
...Amutha Selvamani; Madison H. Williams; Rajesh C. Miranda; Farida Sohrabji Small non-coding RNA [miRNA (microRNA)] found in the circulation have been used successfully as biomarkers and mechanistic targets for chronic and acute disease. The present study investigated the impact of age and sex...
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Clin Sci (Lond) (2014) 126 (2): 123–138.
Published: 13 September 2013
....it ). 27 2 2013 24 6 2013 15 7 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 endometriosis epigenetics epithelial progenitor cell mesenchymal stromal cell microRNA stem cell marker There is well-established evidence that, although endometriosis...
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Clin Sci (Lond) (2013) 125 (4): 151–166.
Published: 26 April 2013
...Enzo R. Porrello Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent...
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Clin Sci (Lond) (2013) 124 (1): 27–40.
Published: 07 September 2012
... study was performed to determine the function of miR-29b (microRNA-29b) in trophoblast cells and its underlying role in the pathogenesis of PE. The prediction of miR-29b target genes was performed using computer-based programs, including Targetscan, Pictar and miRBase. The function of these target genes...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 123 (11): 611–625.
Published: 01 August 2012
...Katarzyna Goljanek-Whysall; Dylan Sweetman; Andrea E. Münsterberg miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several miRNAs, expressed exclusively in muscle, play important roles during muscle development, growth and regeneration; other ubiquitously expressed...
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Clin Sci (Lond) (2011) 121 (10): 437–447.
Published: 25 July 2011
...Tengfei Zhang; Qiming Wang; Dan Zhao; Yaling Cui; Bangrong Cao; Liping Guo; Shih Hsin Lu miR-31 (microRNA-31) is frequently altered in numerous cancers. The aim of the present study was to investigate the role of miR-31 in ESCC (oesophageal squamous cell carcinoma). We measured miR-31 in 45 paired...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 121 (4): 141–158.
Published: 20 April 2011
.... Gene expression profiling based on mRNA has led to further refinement of the classification and diagnosis of cancer. More recently, miRNAs (microRNAs), among other small non-coding RNA molecules, have been discovered and found to be major players in cell biology. miRNAs, having both oncogenic...
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Clin Sci (Lond) (2011) 120 (5): 183–193.
Published: 19 November 2010
...Junhao Gui; Yaping Tian; Xinyu Wen; Wenhui Zhang; Pengjun Zhang; Jing Gao; Wei Run; Liyuan Tian; Xingwang Jia; Yanhong Gao Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate the feasibility of using...
Includes: Supplementary data
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Clin Sci (Lond) (2010) 119 (2): 87–95.
Published: 20 April 2010
...Yunhui Cheng; Ning Tan; Jian Yang; Xiaojun Liu; Xiaopei Cao; Pengcheng He; Xiaoli Dong; Shanshan Qin; Chunxiang Zhang miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively...
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Clin Sci (Lond) (2008) 114 (12): 699–706.
Published: 14 May 2008
...Chunxiang Zhang miRNAs (microRNAs) comprise a novel class of endogenous, small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have demonstrated that miRNAs are highly expressed in the cardiovascular system...