1-42 of 42
Keywords: microRNA
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Clin Sci (Lond) (2022) CS20220216.
Published: 27 July 2022
.... Biomolecules secreted or shuttled within extracellular vesicles, such as exosomes, may participate in the concerted response. We investigated the exosome´s microRNAs due to their capacity to fine-tune gene expression, potentially affecting the multicellular repair response. We profiled and quantified rat ASC...
Articles
Clin Sci (Lond) (2022) 136 (12): 911–934.
Published: 20 June 2022
... transcription factor family and microRNAs on the regulation of positive and negative cell cycle factors is discussed. This review also highlights seminal studies that identified the coordination of signaling mechanisms that can potently activate CM cell cycle re-entry including the Wnt/Ctnnb1, Hippo, Pi3K-Akt...
Articles
Clin Sci (Lond) (2022) 136 (8): 621–637.
Published: 27 April 2022
... Correspondence: Boyoung Joung ( cby6908@yuhs.ac ) or Young-Nam Youn ( ynyoun@yuhs.ac ) AF atrial fibrillation AF-sEVs sEVs were isolated from patients with persistent AF CaMKII calcium/calmodulin-dependent protein kinase II miRNA microRNA non-AF-sEVs sEVs were isolated from...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (8): 579–597.
Published: 21 April 2022
...) components such as such as collagen. Recent years have seen huge increases in our understanding of the functions of microRNAs (miRNAs) in wound repair. Concomitantly, there has been growing recognition of miRNA roles in circadian processes, either as regulators or targets of clock activity or direct...
Articles
Clin Sci (Lond) (2022) 136 (5): 345–360.
Published: 09 March 2022
... with altered expression of mitochondria-related microRNAs (mitomiRs), which localize in mitochondria and regulate the expression of mtDNA and nucleus-encoded mitochondrial genes. This review summarizes relevant evidence regarding the involvement of renal mitochondrial injury and dysfunction in frequent forms...
Articles
Clin Sci (Lond) (2022) 136 (5): 323–328.
Published: 02 March 2022
...Carlos J. Pirola; Silvia Sookoian MicroRNAs (miRNAs), which are regarded as crucial regulators of gene expression and diverse aspects of cell biology, can be present in various body fluids as highly stable molecules. It is also known that miRNAs exert tissue-specific regulation of gene...
Articles
Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...
Articles
Clin Sci (Lond) (2020) 134 (21): 2893–2895.
Published: 13 November 2020
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . microRNA renal physiology therapeutics The renal tubular epithelial cell (rTEC) has been well-characterised with respect to its ability to release and take up extracellular RNA (exRNA) and EVs [ 1...
Articles
Clin Sci (Lond) (2020) 134 (8): 1001–1025.
Published: 27 April 2020
...Sonya Frazier; Martin W. McBride; Helen Mulvana; Delyth Graham Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR...
Articles
Clin Sci (Lond) (2020) 134 (8): 955–959.
Published: 21 April 2020
... the adhesion of neighboring metastatic cells: Role of microRNA-210 . Cancer Biol. Ther. 17 , 1062 – 1069 10.1080/15384047.2016.1219815 27611932 10. Liu H. , Liu Y. , Sun P. , Leng K. , Xu Y. , Mei L. et al . ( 2020 ) Colorectal cancer-derived exosomal miR-106b...
Articles
Clin Sci (Lond) (2020) 134 (2): 169–192.
Published: 23 January 2020
... for the development of biomarkers to identify at-risk asymptomatic carotid plaque prior to disease progression and stroke. Further, it would aid in creation of therapeutics to stabilize carotid plaque. MicroRNAs (miRNAs) have been implicated as key protagonists in various stages of atherosclerotic plaque initiation...
Articles
Clin Sci (Lond) (2020) 134 (2): 87–101.
Published: 21 January 2020
... coronary syndrome microRNA preeclampsia RNA sequencing Preeclampsia (PE) is estimated to affect up to 8% of all pregnancies worldwide, and thus represents a substantial burden on the cardiovascular health of millions of women [ 1 ]. While the high blood pressure and proteinuria associated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (1): 39–51.
Published: 06 January 2020
... males and females. Besides the action of estrogen, sex chromosome gene expression and programming effects also provoke this sexual dimorphism. MicroRNAs (miRNAs) have emerged as regulators of endothelial cell function and dysfunction. We here hypothesized distinct miRNA expression patterns in male...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (21): 2217–2220.
Published: 13 November 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease fibrosis microRNA Cardiovascular disease (CVD) is the leading cause of death worldwide, with over 17.6 million deaths per year [ 1 ]. Cardiomyopathy is a type of CVD and cardiac fibrosis is an important...
Articles
Clin Sci (Lond) (2019) 133 (4): 583–595.
Published: 22 February 2019
...; Yuishin Izumi; Toshitaka Kawarai; Ryuji Kaji; Takeshi Kimura; Haruhisa Inoue; Koh Ono Recent reports, including ours, have indicated that microRNA (miR)-33 located within the intron of sterol regulatory element binding protein (SREBP) 2 controls cholesterol homeostasis and can be a potential therapeutic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (1): 23–40.
Published: 03 January 2019
... carried out in humans. adipocytes exosomes MicroRNA metabolism non-coding RNAs Obesity is a worldwide epidemic that arises as a chronic long-term imbalance between calorie intake and energy expenditure. Despite nutritional interventions and physical education programmes, the prevalence...
Articles
Clin Sci (Lond) (2018) 132 (22): 2451–2467.
Published: 30 November 2018
... Limited on behalf of the Biochemical Society 2018 exosomes Insulin sensitivity microRNA pregnancy type 2 diabetes Maternal metabolism undergoes dynamic changes in pregnancy to ensure an adequate supply of metabolites for the growth and development of the fetus. This involves an increase...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2437–2449.
Published: 22 November 2018
...Jasmin Strutz; Silvija Cvitic; Hubert Hackl; Karl Kashofer; Hannah M. Appel; Andrea Thüringer; Gernot Desoye; Pieter Koolwijk; Ursula Hiden MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important, epigenetic regulators of endothelial function. Metabolic disturbances such as diabetes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2423–2436.
Published: 22 November 2018
... contributed equally to this work. 02 08 2018 31 10 2018 01 11 2018 02 11 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 atherosclerosis endothelial dysfunction inflammation microRNA Atherosclerosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (17): 1875–1888.
Published: 05 September 2018
... on behalf of the Biochemical Society 2018 atherosclerosis microRNA platelet adhesion and activation Platelet activation leads to the release of CCL5 and its deposition on the surface of endothelial cells where it triggers monocyte and T-cell arrest and their subsequent transmigration [ 115...
Articles
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
... on behalf of the Biochemical Society 2018 biomarkers cardiovascular disease microRNA non-coding RNA physical exercise therapeutics The social and economic burden of cardiovascular disease (CVD) due to premature deaths and reduced quality of life is tremendous. CVD has remained the leading...
Articles
Clin Sci (Lond) (2017) 131 (24): 2885–2900.
Published: 04 December 2017
...@enders.tch.harvard.edu ) 18 09 2017 01 11 2017 03 11 2017 03 11 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 adipocytes cardiac hypertrophy dyslipidemia high fat diet microRNA obesity The incidence of obesity has...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (23): 2813–2834.
Published: 28 November 2017
... 16 10 2017 23 10 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 microRNA resistant hypertension Signaling Pathways Resistant hypertension (RH) is characterized by a condition in which the patient requires four...
Articles
Clin Sci (Lond) (2017) 131 (18): 2397–2408.
Published: 08 September 2017
... response to ischaemia and increased thrombogenicity due to platelet aggregation and adhesion. cardiovascular disease hypercholesterolaemia microRNA miR-200c miR-33 oxidative stress paediatrics Zinc Finger E-box-Binding Homeobox 1 Each quantificative variable was checked for normality...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 2007–2017.
Published: 13 July 2017
... ( satohm@iwate-med.ac.jp ) 24 03 2017 07 06 2017 23 06 2017 23 06 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Atherosclerosis cardiovascular events microRNA peripheral blood mononuclear cell statins telomere...
Articles
Clin Sci (Lond) (2017) 131 (15): 1923–1940.
Published: 13 July 2017
..., a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability...
Articles
Clin Sci (Lond) (2017) 131 (14): 1649–1667.
Published: 30 June 2017
... Stenvinkel ( peter.stenvinkel@ki.se ) 09 12 2016 17 04 2017 19 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 chronic kidney disease DNA methylation epigenetics microRNA Chronic kidney disease (CKD...
Articles
Clin Sci (Lond) (2014) 127 (11): 615–634.
Published: 25 July 2014
... proliferative disease. Although the main molecular and cellular mechanisms underlying restenosis have been well described, new signalling molecules and cell types controlling the progress of restenosis are continuously being discovered. In particular, microRNAs and vascular progenitor cells have recently been...
Articles
Clin Sci (Lond) (2014) 127 (5): 341–350.
Published: 15 May 2014
... microRNA miR-29 stricture • Intestinal fibrosis and stricture formation is a frequent serious complication in CD. Understanding its aetiology is a significant unmet need, as current medical therapies are unable to reverse fibrosis, which remains the main indication for surgery...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (4): 233–242.
Published: 10 April 2014
... (email silvano.bosari@unimi.it or). 12 9 2013 11 2 2014 17 2 2014 17 2 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 breast carcinoma microRNA neoplasm metastasis and recurrence prognosis Scribble • Despite breast cancer being...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (2): 77–89.
Published: 17 March 2014
...Amutha Selvamani; Madison H. Williams; Rajesh C. Miranda; Farida Sohrabji Small non-coding RNA [miRNA (microRNA)] found in the circulation have been used successfully as biomarkers and mechanistic targets for chronic and acute disease. The present study investigated the impact of age and sex...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (6): 417–423.
Published: 15 November 2013
..., which is characterized by an immunological reaction against gluten and transglutaminase in genetically predisposed subjects. However, the molecular determinants underpinning CD pathogenesis are yet to be fully elucidated and little data are available about the involvement of miRNAs (microRNAs) in CD...
Articles
Clin Sci (Lond) (2014) 126 (6): 377–400.
Published: 15 November 2013
... drugs. Correspondence: Dr Helen Maddock ( apx281@coventry.ac.uk ). 16 11 2012 22 8 2013 23 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biomarker cancer-therapy-induced cardiotoxicity early clinical assessment microRNA subclinical...
Articles
Clin Sci (Lond) (2014) 126 (2): 123–138.
Published: 13 September 2013
... 2014 Biochemical Society 2014 endometriosis epigenetics epithelial progenitor cell mesenchymal stromal cell microRNA stem cell marker Human endometrium is the mucosal lining of the cavity of the uterus. It is composed of two layers: the outer is defined as “functionalis...
Articles
Clin Sci (Lond) (2013) 125 (4): 151–166.
Published: 26 April 2013
...Enzo R. Porrello Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent...
Articles
Clin Sci (Lond) (2013) 124 (1): 27–40.
Published: 07 September 2012
... study was performed to determine the function of miR-29b (microRNA-29b) in trophoblast cells and its underlying role in the pathogenesis of PE. The prediction of miR-29b target genes was performed using computer-based programs, including Targetscan, Pictar and miRBase. The function of these target genes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (11): 611–625.
Published: 01 August 2012
...Katarzyna Goljanek-Whysall; Dylan Sweetman; Andrea E. Münsterberg miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several miRNAs, expressed exclusively in muscle, play important roles during muscle development, growth and regeneration; other ubiquitously expressed...
Articles
Clin Sci (Lond) (2011) 121 (10): 437–447.
Published: 25 July 2011
...Tengfei Zhang; Qiming Wang; Dan Zhao; Yaling Cui; Bangrong Cao; Liping Guo; Shih Hsin Lu miR-31 (microRNA-31) is frequently altered in numerous cancers. The aim of the present study was to investigate the role of miR-31 in ESCC (oesophageal squamous cell carcinoma). We measured miR-31 in 45 paired...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 121 (4): 141–158.
Published: 20 April 2011
.... Gene expression profiling based on mRNA has led to further refinement of the classification and diagnosis of cancer. More recently, miRNAs (microRNAs), among other small non-coding RNA molecules, have been discovered and found to be major players in cell biology. miRNAs, having both oncogenic...
Articles
Clin Sci (Lond) (2011) 120 (5): 183–193.
Published: 19 November 2010
...Junhao Gui; Yaping Tian; Xinyu Wen; Wenhui Zhang; Pengjun Zhang; Jing Gao; Wei Run; Liyuan Tian; Xingwang Jia; Yanhong Gao Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate the feasibility of using...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 119 (2): 87–95.
Published: 20 April 2010
...Yunhui Cheng; Ning Tan; Jian Yang; Xiaojun Liu; Xiaopei Cao; Pengcheng He; Xiaoli Dong; Shanshan Qin; Chunxiang Zhang miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively...
Articles
Clin Sci (Lond) (2008) 114 (12): 699–706.
Published: 14 May 2008
...Chunxiang Zhang miRNAs (microRNAs) comprise a novel class of endogenous, small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have demonstrated that miRNAs are highly expressed in the cardiovascular system...