... on behalf of the Biochemical Society 2022 DNA methylation epitranscriptomics histone modifications lncRNA m6A miRNA Epigenetics can be defined as a heritable mechanism to regulate gene expression that does not change the underlying genomic sequence, therefore, epigenetics is a vital...

... in db/db mice. In conclusion, the HDAC2/SP1/miR-205 feedback loop may be crucial for the pathogenesis of DKD. We hypothesized that changes in miRNA expression due to chromatin remodeling by HDAC2 may play a key role in DKD. To test this hypothesis, we overexpressed HDAC2 and identified dysregulated...

..., we analyze some emerging circulating biomarkers related to inflammation, ECM and lipid infiltration, angiogenesis, metalloproteinases and microRNA (miRNA), as possible diagnostic and prognostic indicators of plaque vulnerability. Correspondence: Silvana Balzan ( balzan@ifc.cnr.it ) 20 04...

... of the cyclin-dependent kinase that drives cell-cycle progression, governs the secretion and relative proportion of secreted non-coding RNA subtypes (miRNA, rRNA, tRNA, CDBox, scRNA, HAcaBox. scaRNA, piRNA) in human breast cancer. Cyclin D1 induced the secretion of miRNA governing the tumor immune response...

... gestational diabetes mellitus (GDM). This is a complex condition influenced by genetic, environment and potentially epigenetic factors in association with a range of altered developmental outcomes. A recent study, published in Clinical Science, explores miRNAs as a molecular mechanism underpinning the altered...

...Jeanie B. Tryggestad; Anu Vishwanath; Shaoning Jiang; Ashwini Mallappa; April M. Teague; Yusuke Takahashi; David M. Thompson; Steven D. Chernausek We aimed to identify miRNAs whose expression levels in fetal tissues are altered by exposure to a diabetic milieu and elucidate the impact on target...

...Hongmei Shen; Zheng Li The identification and functional delineation of miRNAs (a class of small non-coding RNAs) have added a new layer of complexity to our understanding of the molecular mechanisms underlying synaptic plasticity. Genome-wide association studies in conjunction with investigations...

... glucose metabolism, male fertility, blood cell production and calcium/phosphate metabolism. Many of the genes regulating these functions are specific to bone cells. Some of these genes can be wrongly expressed by other malfunctioning cells, driving the generation of disease. The miRNAs are a class of non...

... therapeutic agent for the treatment of coronary atherosclerosis. The present review summarizes the cellular and molecular mechanism of statins against coronary atherosclerosis. atherosclerosis endothelial progenitor cells miRNA SIRT-1 telomere toll-like receptor 4 A recent study has reported...

...Bing Feng; Kai Zhang; Rui Wang; Longbang Chen Lung cancer is the leading cause of cancer-related death worldwide, with approximately 80–85% of cases being non-small-cell lung cancer (NSCLC). The miRNAs are small non-coding RNAs that regulate gene expression at a post-transcriptional level by either...

..., the median overall survival (OS) benefit is only ~3 months, and sufficient biomarkers predicting treatment response are not available. The aim of the present study was to evaluate miRNA expression patterns from HCC tissue biopsies as potential biomarkers in patients under sorafenib treatment. Nineteen...

...Rick F. J. Kwekkeboom; Zhiyong Lei; Pieter A. Doevendans; René J. P. Musters; Joost P. G. Sluijter Dysregulation of miRNA expression has been associated with many cardiovascular diseases in animal models, as well as in patients. In the present review, we summarize recent findings on the role...

... II). Changes in the levels of ACE2 have been observed in a number of pathologies, including cardiovascular disease, but little is known of the mechanisms regulating its expression. In the present study, therefore, the potential role of miRNAs in the regulation of ACE2 expression in primary human...

...Hui-juan Wang; Bao-zeng Wang; Peng-jun Zhang; Jie Deng; Zhi-rui Zhao; Xin Zhang; Kun Xiao; Dan Feng; Yan-hong Jia; You-ning Liu; Li-xin Xie The goal of the present study was to identify novel protein biomarkers from the target genes of six serum miRNAs that we identified previously in patients...

...Erik Biros; Corey S. Moran; Yutang Wang; Philip J. Walker; John Cardinal; Jonathan Golledge AAA (abdominal aortic aneurysm) is a potentially life-threatening late-onset degenerative condition. miRNAs (microRNAs), the small non-coding RNA molecules that regulate gene expression, have been shown...