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1-15 of 15
Keywords: miRNA
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (7): 473–492.
Published: 06 April 2022
... on behalf of the Biochemical Society 2022 DNA methylation epitranscriptomics histone modifications lncRNA m6A miRNA Epigenetics can be defined as a heritable mechanism to regulate gene expression that does not change the underlying genomic sequence, therefore, epigenetics is a vital...
Articles
Zongji Zheng, Shuting Zhang, Jiaqi Chen, Meina Zou, Yanlin Yang, Wen Lu, Shijing Ren, Xiangyu Wang, Wenhui Dong, Zikun Zhang, Ling Wang, Meiping Guan, Gladys L.Y. Cheing, Yaoming Xue, Yijie Jia
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (3): 223–238.
Published: 07 February 2022
... in db/db mice. In conclusion, the HDAC2/SP1/miR-205 feedback loop may be crucial for the pathogenesis of DKD. We hypothesized that changes in miRNA expression due to chromatin remodeling by HDAC2 may play a key role in DKD. To test this hypothesis, we overexpressed HDAC2 and identified dysregulated...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (16): 1981–1997.
Published: 20 August 2021
..., we analyze some emerging circulating biomarkers related to inflammation, ECM and lipid infiltration, angiogenesis, metalloproteinases and microRNA (miRNA), as possible diagnostic and prognostic indicators of plaque vulnerability. Correspondence: Silvana Balzan ( balzan@ifc.cnr.it ) 20 04...
Articles
Jinhui Lü, Qian Zhao, Xin Ding, Yuefan Guo, Yuan Li, Zhen Xu, Shujun Li, Zhongrui Wang, Lei Shen, Huang-wen Chen, Zuoren Yu, Richard G. Pestell
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 791–805.
Published: 09 April 2020
... of the cyclin-dependent kinase that drives cell-cycle progression, governs the secretion and relative proportion of secreted non-coding RNA subtypes (miRNA, rRNA, tRNA, CDBox, scRNA, HAcaBox. scaRNA, piRNA) in human breast cancer. Cyclin D1 induced the secretion of miRNA governing the tumor immune response...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 315–319.
Published: 25 January 2019
... gestational diabetes mellitus (GDM). This is a complex condition influenced by genetic, environment and potentially epigenetic factors in association with a range of altered developmental outcomes. A recent study, published in Clinical Science, explores miRNAs as a molecular mechanism underpinning the altered...
Articles
Jeanie B. Tryggestad, Anu Vishwanath, Shaoning Jiang, Ashwini Mallappa, April M. Teague, Yusuke Takahashi, David M. Thompson, Steven D. Chernausek
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (21): 1955–1967.
Published: 22 September 2016
...Jeanie B. Tryggestad; Anu Vishwanath; Shaoning Jiang; Ashwini Mallappa; April M. Teague; Yusuke Takahashi; David M. Thompson; Steven D. Chernausek We aimed to identify miRNAs whose expression levels in fetal tissues are altered by exposure to a diabetic milieu and elucidate the impact on target...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1137–1146.
Published: 01 June 2016
...Hongmei Shen; Zheng Li The identification and functional delineation of miRNAs (a class of small non-coding RNAs) have added a new layer of complexity to our understanding of the molecular mechanisms underlying synaptic plasticity. Genome-wide association studies in conjunction with investigations...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (10): 863–873.
Published: 28 August 2015
... glucose metabolism, male fertility, blood cell production and calcium/phosphate metabolism. Many of the genes regulating these functions are specific to bone cells. Some of these genes can be wrongly expressed by other malfunctioning cells, driving the generation of disease. The miRNAs are a class of non...
Articles
Mamoru Satoh, Yuji Takahashi, Tsuyoshi Tabuchi, Yoshitaka Minami, Makiko Tamada, Kan Takahashi, Tomonori Itoh, Yoshihiro Morino, Motoyuki Nakamura
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (2): 93–105.
Published: 24 April 2015
... therapeutic agent for the treatment of coronary atherosclerosis. The present review summarizes the cellular and molecular mechanism of statins against coronary atherosclerosis. atherosclerosis endothelial progenitor cells miRNA SIRT-1 telomere toll-like receptor 4 A recent study has reported...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (10): 619–634.
Published: 20 February 2015
...Bing Feng; Kai Zhang; Rui Wang; Longbang Chen Lung cancer is the leading cause of cancer-related death worldwide, with approximately 80–85% of cases being non-small-cell lung cancer (NSCLC). The miRNAs are small non-coding RNAs that regulate gene expression at a post-transcriptional level by either...
Articles
Jan Peveling-Oberhag, Claudia Döring, Sylvia Hartmann, Natalie Filmann, Angelika Mertens, Albrecht Piiper, Eva Herrmann, Martin-Leo Hansmann, Stefan Zeuzem, Jörg Trojan, Martin-Walter Welker
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (1): 29–37.
Published: 27 August 2014
..., the median overall survival (OS) benefit is only ~3 months, and sufficient biomarkers predicting treatment response are not available. The aim of the present study was to evaluate miRNA expression patterns from HCC tissue biopsies as potential biomarkers in patients under sorafenib treatment. Nineteen...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (6): 351–365.
Published: 21 May 2014
...Rick F. J. Kwekkeboom; Zhiyong Lei; Pieter A. Doevendans; René J. P. Musters; Joost P. G. Sluijter Dysregulation of miRNA expression has been associated with many cardiovascular diseases in animal models, as well as in patients. In the present review, we summarize recent findings on the role...
Articles
Daniel W. Lambert, Louise A. Lambert, Nicola E. Clarke, Nigel M. Hooper, Karen E. Porter, Anthony J. Turner
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (4): 243–249.
Published: 10 April 2014
... II). Changes in the levels of ACE2 have been observed in a number of pathologies, including cardiovascular disease, but little is known of the mechanisms regulating its expression. In the present study, therefore, the potential role of miRNAs in the regulation of ACE2 expression in primary human...
Articles
Hui-juan Wang, Bao-zeng Wang, Peng-jun Zhang, Jie Deng, Zhi-rui Zhao, Xin Zhang, Kun Xiao, Dan Feng, Yan-hong Jia, You-ning Liu, Li-xin Xie
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (12): 857–867.
Published: 05 March 2014
...Hui-juan Wang; Bao-zeng Wang; Peng-jun Zhang; Jie Deng; Zhi-rui Zhao; Xin Zhang; Kun Xiao; Dan Feng; Yan-hong Jia; You-ning Liu; Li-xin Xie The goal of the present study was to identify novel protein biomarkers from the target genes of six serum miRNAs that we identified previously in patients...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (11): 795–803.
Published: 21 February 2014
...Erik Biros; Corey S. Moran; Yutang Wang; Philip J. Walker; John Cardinal; Jonathan Golledge AAA (abdominal aortic aneurysm) is a potentially life-threatening late-onset degenerative condition. miRNAs (microRNAs), the small non-coding RNA molecules that regulate gene expression, have been shown...
Includes: Supplementary data