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Keywords: metabolism
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Clin Sci (Lond) (2022) 136 (8): 639–642.
Published: 27 April 2022
... advance when published and why there is still much to be learned from this paper half a century later. 25-hydroxyvitamin D adipose bile cholecalciferol metabolism This year is the 100th anniversary of the first use of the term vitamin D to describe a fat-soluble factor that cured rickets...
Clin Sci (Lond) (2022) 136 (8): 557–577.
Published: 21 April 2022
... is a major clinical challenge. Metabolic acidosis is both a consequence and a possible driver of CKD progression. Alkali therapy counteracts these effects in CKD patients, but underlying mechanisms remain incompletely understood. Here we show that bicarbonate supplementation protected renal function...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (11): 1389–1408.
Published: 04 June 2021
...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...
Clin Sci (Lond) (2020) 134 (12): 1357–1376.
Published: 18 June 2020
... proximal tubular epithelial cells (mPTCs). Moreover, impaired cellular metabolism was reported as a crucial pathogenic factor in CKD. By metabolomics analysis, we found that KD025 restored the metabolic disturbance, including the impaired glutathione metabolism in TGF-β1-stimulated tubular epithelial cells...
Clin Sci (Lond) (2019) 133 (22): 2245–2264.
Published: 19 November 2019
.... We focus on processes triggering and exacerbating apoptotic signalling in the liver of NAFLD patients and their metabolic and pathological implications. Indeed, liver injury and inflammation are cardinal histopathological features of NASH, a duo in which derailment of apoptosis is of paramount...
Clin Sci (Lond) (2019) 133 (20): 2107–2119.
Published: 25 October 2019
...Tongxing Song; Shihuan Kuang Adipose tissues collectively as an endocrine organ and energy storage are crucial for systemic metabolic homeostasis. The major cell type in the adipose tissue, the adipocytes or fat cells, are remarkably plastic and can increase or decrease their size and number...
Clin Sci (Lond) (2019) 133 (9): 1085–1096.
Published: 09 May 2019
...Xue-liang Zhou; Zhi-bo Liu; Rong-rong Zhu; Huang Huang; Qi-rong Xu; Hua Xu; Liang Zeng; Yun-yun Li; Cha-hua Huang; Qi-cai Wu; Ji-chun Liu Nuclear receptor binding SET domain 2 (NSD2)-mediated metabolic reprogramming has been demonstrated to regulate oncogenesis via catalyzing the methylation...
Clin Sci (Lond) (2019) 133 (2): 253–267.
Published: 25 January 2019
...Yi-Cheng Wang; Ming-Tsung Wu; Feng-Yao Tang; Der-Yuan Chen; Hsin-An Ko; Barry Shane; Wen-Nan Huang; En-Pei Isabel Chiang Objective: Currently, no guidelines are established for pharmacogenomic testing involving folate metabolic genes in long-term disease-modifying antirheumatic drugs’ (DMARD...
Clin Sci (Lond) (2019) 133 (1): 23–40.
Published: 03 January 2019
...Silvia Lorente-Cebrián; Pedro González-Muniesa; Fermín I. Milagro; J. Alfredo Martínez Obesity is a metabolic condition usually accompanied by insulin resistance (IR), type 2 diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation and related to white adipose tissue...
Clin Sci (Lond) (2017) 131 (16): 2079–2094.
Published: 24 July 2017
... but less oxygen efficient fuel compared with glucose. The pathways involved in myocardial FA metabolism are regulated at various subcellular levels, and can be divided into sarcolemmal FA uptake, cytosolic activation and storage, mitochondrial uptake and β-oxidation. An understanding of the critical...
Clin Sci (Lond) (2017) 131 (2): 105–111.
Published: 14 December 2016
... are autosomal dominant and can be roughly divided into four major groups: muscle diseases, peripheral neuronal diseases, accelerated aging disorders and metabolic diseases including Dunnigan type familial partial lipodystrophy (FLPD), acquired partial lipodystrophy (APL) and autosomal dominant leucodystrophy...
Clin Sci (Lond) (2016) 130 (12): 1005–1016.
Published: 06 May 2016
... on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target. Women have a lower...
Clin Sci (Lond) (2016) 130 (12): 1017–1025.
Published: 06 May 2016
... of humans. The objective of this project was to examine the isolated and combined effects of experimental short-term mild heat exposure and metabolic level on glucoregulation. Two experimental randomized crossover studies were conducted. Ten healthy young men participated in study A, which comprises four...
Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
... (Seahorse XF System) in 10 6 lymphocytes sampled from matched lymphopenic and non-lymphopenic patients in the same assay plate and under identical experimental conditions; ≥5 measures were made per patient sample. Metabolic measurements were made in a subset of patients preoperatively and 72 h after...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (10): 715–721.
Published: 10 March 2015
... and the metabolic syndrome, and how its sundry modifications can affect its function. Such studies could reveal how NUCKS could be a link between physiological cues and human ailments. Correspondence : Dr Weiping Han (email weiping_han@sbic.a-star.edu.sg ) or Dr Vinay Tergaonkar (email vinayt@imcb.a...
Clin Sci (Lond) (2015) 128 (1): 57–67.
Published: 29 August 2014
... study was to investigate the dose–response effect of intravenous arginine supplementation in post-absorptive patients with septic shock on arginine-NO and protein metabolism and on global and regional haemodynamics. Eight critically ill patients with a diagnosis of septic shock participated...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (7): 417–427.
Published: 07 June 2012
... effects. In the present review, we briefly outline the new findings on the role of magnesium in angiogenesis and metastatization, and focus on the relationship between tumour cell proliferation and metabolic reprogramming, discussing how magnesium and its transporters are involved in these processes...
Clin Sci (Lond) (2012) 122 (6): 253–270.
Published: 11 November 2011
... status activates AMPK (AMP-activated protein kinase), a cellular metabolic sensor, providing a generally accepted mechanism for the action of metformin on hepatic gluconeogenesis. The demonstration that respiratory chain complex I, but not AMPK, is the primary target of metformin was recently...
Clin Sci (Lond) (2011) 121 (5): 191–203.
Published: 20 May 2011
... as potential treatments. In the present review, we describe the functions of sirtuins in cell survival, inflammation, energy metabolism, cancer and differentiation, and their impact on diseases. We also discuss the organ-specific functions of sirtuins, focusing on the brain and blood vessels...
Clin Sci (Lond) (2011) 120 (2): 65–72.
Published: 08 October 2010
... in metabolism. In turn, key metabolic enzymes and transcription activators interact with and affect the core clock mechanism. Animals with mutations in clock genes that disrupt cellular rhythmicity have provided evidence to the relationship between the circadian clock and metabolic homoeostasis. The present...
Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
... availability may be a specific feature of the presence of tumour. As arginine is important in post-operative repair, we hypothesized that abnormalities in arginine metabolism in cancer lead to an aberrant post-operative response in arginine and NO metabolism. To investigate this, we studied post-operative...
Clin Sci (Lond) (2005) 109 (5): 447–455.
Published: 24 October 2005
... changes in gene expression of BRIN-BD11 cells. Sixty-six genes were up-regulated >1.8-fold, including many involved in cellular signalling, metabolism, gene regulation, protein synthesis, apoptosis and the cellular stress response. Subsequent functional experiments confirmed that L -alanine provided...
Includes: Supplementary data
Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
... identify novel targets for future diabetes therapies. Mitochondrial metabolism is crucial for the coupling of amino acid and glucose recognition to the exocytosis of the insulin granules. This is illustrated by in vitro and in vivo observations discussed in the present review. Mitochondria generate ATP...
Clin Sci (Lond) (2003) 104 (2): 153–162.
Published: 17 January 2003
...-mail L.vanLoon@HB.Unimaas.nl ). 18 6 2002 13 9 2002 14 11 2002 The Biochemical Society and the Medical Research Society © 2003 2003 creatine phosphate ergogenic aids functional foods metabolism oxidative capacity skeletal muscle substrate utilization 153Clinical Science...
Clin Sci (Lond) (2000) 98 (5): 587–592.
Published: 11 April 2000
...Patrick SCHRAUWEN; Ellen E. BLAAK; Dorien P. C. van AGGEL-LEIJSSEN; Lars B. BORGHOUTS; Anton J. M. WAGENMAKERS When using 13 C or 14 C tracers to study substrate metabolism, an acetate correction factor should be applied to correct for loss of label in the exchange pathways of the tricarboxylic...
Clin Sci (Lond) (1998) 94 (3): 279–286.
Published: 01 March 1998
...D. Bendahan; M. Badier; Y. Jammes; S. Confort-Gouny; A. M. Salvan; C. Guillot; P. J. Cozzone 1. Failure of muscle force during sustained fatiguing contraction is associated with myoelectrical and metabolic alterations. However, the inter-relationships between these two types of events remain...
Clin Sci (Lond) (1996) 91 (5): 627–631.
Published: 01 November 1996
... vasoconstriction and metabolic heat production were measured. 3. The α-adrenoceptor antagonist caused a dose-dependent inhibition of vasoconstriction in the elderly but did not impair vasoconstriction in the young subjects at the doses that were given. Shivering and metabolic heat production were unaffected by α...
Clin Sci (Lond) (1996) 91 (1): 79–86.
Published: 01 July 1996
... to investigate impaired methionine metabolism, especially of the trans-sulphuration pathway, but most studies have focused on changes in homocysteine. 2. We investigated the effect of methionine excess on total plasma homocysteine, 5-methyltetrahydrofolate (which is the active form of folate in the remethylation...
Clin Sci (Lond) (1995) 89 (6): 591–599.
Published: 01 December 1995
... in tryptophan metabolism in the two groups. 3. Tryptophan, kynurenine, kynurenic acid, xanthurenic acid, 3-hydroxyanthranilic acid, 5-hydroxyanthranilic acid, 5-hydroxytryptophan and anthranilic acid were measured by HPLC with dual electrochemical and programmable wavelength fluorescence detection. Fasting...
Clin Sci (Lond) (1995) 89 (3): 219–225.
Published: 01 September 1995
..., mean skin-surface temperature, fingertip capillary blood flow and metabolic heat production were measured. Dose—response curves were plotted for all measured variables, and males and females were compared to identify potential gender differences. 3. Core temperature decreased with all doses...
Clin Sci (Lond) (1993) 85 (4): 437–444.
Published: 01 October 1993
... were reduced by 50% at day 4, no changes in intestinal amino acid and ammonia metabolism were observed. 3. In the liver, glutamine consumption was reduced and ammonia uptake was increased, but urea synthesis was not changed. The decreased intracellular glutamine, glutamate, aspartate and ammonia...
Clin Sci (Lond) (1993) 84 (3): 247–256.
Published: 01 March 1993
...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...
Clin Sci (Lond) (1993) 84 (2): 177–183.
Published: 01 February 1993
... rate. Clinical Science (1993) 84, 177-183 (Printed in Great Britain) I77 Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique David L. CHINKES, Judah ROSENBLATT and Robert R. WOLFE Metabolism Unit, Shriners Burns...
Clin Sci (Lond) (1992) 83 (5): 589–592.
Published: 01 November 1992
.... All this speaks for a role of metabolic factors in the development and maintenance of obesity, although the extent of their importance is not yet clear. Lipolysis, the release of free fatty acids and glycerol from adipocytes, is stimulated by 8-adreno- ceptors and inhibited by a-adrenoceptors, insulin...
Clin Sci (Lond) (1992) 83 (3): 295–299.
Published: 01 September 1992
.... Lysine potently inhibits tubular peptide uptake, and may thus depress the uptake and metabolism of aprotinin. This was investigated in 14 glomerulonephritic patients with normal renal function and variable proteinuria and in one healthy subject. 2. 99m Tc-labelled aprotinin was given intravenously alone...
Clin Sci (Lond) (1992) 82 (6): 709–716.
Published: 01 June 1992
...M. Salleh; M. Ardawi 1. The hepatic metabolism of glutamine, alanine, ammonia, urea, glutathione and glucose was studied in rats made septic by caecal ligation and puncture and was compared with that in rats that had undergone sham operation (laparotomy). 2. Sepsis resulted in increases...
Clin Sci (Lond) (1992) 82 (5): 573–580.
Published: 01 May 1992
.... It is concluded that the administration of glutamine- supplemented parenteral nutrition, with or without epi- dermal growth factor, is beneficial to the small bowel of septic rats. INTRODUCTION The gastrointestinal tract is the most metabolically active cell mass in the entire body, regenerating its entire...
Clin Sci (Lond) (1991) 81 (6): 799–802.
Published: 01 December 1991
...-802 799 Metabolic balance studies of mineral supplementation in osteoporosis TREVOR STAMP, MONICA KATAKITY, A. J. GOLDSTEIN, M. V. JENKINS, C. R. KELSEY AND G. A. ROSE Department of Bone and Mineral Metabolism, Royal National Orthopaedic Hospital and Institute of Orthopaedics, Stanmore, Middlesex, U.K...
Clin Sci (Lond) (1991) 81 (6): 751–758.
Published: 01 December 1991
...-' while the animals were breathing 10% oxygen. Hypoxaemia alone (arterial partial Key words: antidiuretic hormone, cardiac output, hypoxia, metabolism, oxygen consumption, regional blood flows. pressure of oxygen 4.67 kPa) decreased whole-body oxygen delivery by 30%. The fall in whole-body oxygen...
Clin Sci (Lond) (1991) 81 (5): 603–609.
Published: 01 November 1991
...M. Salleh M. Ardawi 1. The metabolism of glutamine and alanine in the lung was studied in rats made septic by a caecal ligation and puncture technique. 2. The blood glucose concentration was not significantly different in septic rats, but blood pyruvate, lactate, glutamine and alanine...
Clin Sci (Lond) (1991) 81 (s25): 557–564.
Published: 01 October 1991
...- 13 C]leucine (mean difference 0.16%/day) and l -[1- 13 C]phenylalanine (mean difference 0.2%/day). 15 3 1991 29 5 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 flooding technique leucine mass spectrometry metabolism muscle protein protein...
Clin Sci (Lond) (1991) 81 (3): 347–355.
Published: 01 September 1991
...M. Salleh M. Ardawi; Sawsan M. Jalalah 1. The metabolism of glucose and glutamine was studied in the small intestine and the colon of rats after 4–5 weeks of hypothyroidism. 2. Hypothyroidism resulted in increases in the plasma concentrations of ketone bodies ( P < 0.05), cholesterol ( P...
Clin Sci (Lond) (1991) 81 (2): 215–222.
Published: 01 August 1991
... nutrition on septic rats M. SALLEH M. ARDAWI Department of Clinical Biochemistry, College of Medicine and Allied Sciences, King Abdulaziz University, Jeddah, Saudi Arabia (Received 26 October 1990/7 February 1991; accepted 4 March 1991) SUMMARY metabolic abnormalities: altered glucose dynamics, 1...
Clin Sci (Lond) (1991) 81 (1): 37–42.
Published: 01 July 1991
...M. Salleh; M. Ardawi 1. The effect of dexamethasone (30 μg day −1 100 g −1 body weight) on the regulation of glutamine metabolism was studied in the lungs of rats after 9 days of treatment. 2. Dexamethasone resulted in a negative nitrogen balance, and produced decreases in the blood concentrations...
Clin Sci (Lond) (1990) 79 (5): 457–466.
Published: 01 November 1990
... amino acid kinetics branched-chain amino acids leucine metabolism protein proteolysis skeletal muscle Clinical Science (1990) 79,457-466 457 Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man RITA J. LOUARD, EUGENE J. BARRETT AND ROBERT A. GELFAND...
Clin Sci (Lond) (1990) 79 (2): 139–147.
Published: 01 August 1990
...M. Salleh M. Ardawi; Yasir S. Jamal 1. The effect of dexamethasone (30 μg day −-1 100 g −-1 body weight) on the regulation of glutamine metabolism was studied in skeletal muscles of rats after 9 days of treatment. 2. Dexamethasone resulted in negative nitrogen balance, and produced increases...
Clin Sci (Lond) (1990) 78 (2): 239–245.
Published: 01 February 1990
..., but not further metabolism, was impaired in phosphoribosylpyrophosphate synthetase-mutant cells. The Lesch–Nyhan and phosphoribosylpyrophosphate synthetase-mutant cells were unusual in that both showed no further stimulation of nucleotide synthesis at 18 mmol/l P i compared with 1 mmol/l. 3. At the high substrate...
Clin Sci (Lond) (1988) 75 (5): 499–502.
Published: 01 November 1988
...A. W. Johnson; J. M. Berrington; I. Walker; A. Manning; M. S. Losowsky 1. The measurement of the intestinal metabolism of the nitrogen moiety of glutamic acid has been investigated by oral ingestion of l -[ 15 N]glutamic acid and sampling of arterialized blood. 2. Measurements have been made in six...
Clin Sci (Lond) (1988) 75 (1): 93–100.
Published: 01 July 1988
...M. Salleh M. Ardawi; May F. Majzoub; Eric A. Newsholme 1. The effect of dexamethasone (30 μg day −1 100 g −1 body wt.) on the metabolism of glucose and glutamine was studied in the small intestine of rats after 9 days of treatment. 2. Dexamethasone treatment resulted in negative nitrogen balance...
Clin Sci (Lond) (1988) 74 (4): 377–384.
Published: 01 April 1988
... and methylxanthines. The majority of the metabolites were excreted in the first 24 h period and only 2.0 ± 1.4% of the administered caffeine was excreted unchanged. 3. Patients with compensated cirrhosis ( n = 10) metabolized caffeine similarly to the control subjects. Thus the mean serum caffeine clearance was 1.4...