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Articles

Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Zhipeng Tao, Zhiyong Cheng

Clin Sci (Lond) (2023) 137 (6): 415–434.

DOI: https://doi.org/10.1042/CS20210519

Published: 21 March 2023

...Zhipeng Tao; Zhiyong Cheng Hormonal signaling plays key roles in tissue and metabolic homeostasis. Accumulated evidence has revealed a great deal of insulin and estrogen signaling pathways and their interplays in the regulation of mitochondrial, cellular remodeling, and macronutrient metabolism...

View article titled, Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Articles

There is more to life than serum vitamin D: a lesson from the past

Martin Hewison

Clin Sci (Lond) (2022) 136 (8): 639–642.

DOI: https://doi.org/10.1042/CS20211176

Published: 27 April 2022

... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . 25-hydroxyvitamin D adipose bile cholecalciferol metabolism This year is the 100th anniversary of the first use of the term vitamin D to describe a fat-soluble...

View article titled, There is more to life than serum vitamin D: a lesson from the past

Articles

Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

... is a major clinical challenge. Metabolic acidosis is both a consequence and a possible driver of CKD progression. Alkali therapy counteracts these effects in CKD patients, but underlying mechanisms remain incompletely understood. Here we show that bicarbonate supplementation protected renal function...

View article titled, Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Includes: Supplementary data

Articles

Cholesterol metabolism: a new molecular switch to control inflammation

Diana Cardoso, Esperanza Perucha

Clin Sci (Lond) (2021) 135 (11): 1389–1408.

DOI: https://doi.org/10.1042/CS20201394

Published: 04 June 2021

...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...

View article titled, Cholesterol metabolism: a new molecular switch to control inflammation

Articles

Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells

Ran You, Wei Zhou, Yanwei Li, Yue Zhang, Songming Huang, Zhanjun Jia, Aihua Zhang

Clin Sci (Lond) (2020) 134 (12): 1357–1376.

DOI: https://doi.org/10.1042/CS20200030

Published: 18 June 2020

... proximal tubular epithelial cells (mPTCs). Moreover, impaired cellular metabolism was reported as a crucial pathogenic factor in CKD. By metabolomics analysis, we found that KD025 restored the metabolic disturbance, including the impaired glutathione metabolism in TGF-β1-stimulated tubular epithelial cells...

View article titled, Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells

Articles

Processes exacerbating apoptosis in non-alcoholic steatohepatitis

Marta B. Afonso, Rui E. Castro, Cecília M. P. Rodrigues

Clin Sci (Lond) (2019) 133 (22): 2245–2264.

DOI: https://doi.org/10.1042/CS20190068

Published: 19 November 2019

.... We focus on processes triggering and exacerbating apoptotic signalling in the liver of NAFLD patients and their metabolic and pathological implications. Indeed, liver injury and inflammation are cardinal histopathological features of NASH, a duo in which derailment of apoptosis is of paramount...

View article titled, Processes exacerbating apoptosis in non-alcoholic steatohepatitis

Articles

Adipocyte dedifferentiation in health and diseases

Tongxing Song, Shihuan Kuang

Clin Sci (Lond) (2019) 133 (20): 2107–2119.

DOI: https://doi.org/10.1042/CS20190128

Published: 25 October 2019

...Tongxing Song; Shihuan Kuang Adipose tissues collectively as an endocrine organ and energy storage are crucial for systemic metabolic homeostasis. The major cell type in the adipose tissue, the adipocytes or fat cells, are remarkably plastic and can increase or decrease their size and number...

View article titled, Adipocyte dedifferentiation in health and diseases

Articles

NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy

Xue-liang Zhou, Zhi-bo Liu, Rong-rong Zhu, Huang Huang, Qi-rong Xu, Hua Xu, Liang Zeng, Yun-yun Li, Cha-hua Huang, Qi-cai Wu, Ji-chun Liu

Clin Sci (Lond) (2019) 133 (9): 1085–1096.

DOI: https://doi.org/10.1042/CS20190142

Published: 09 May 2019

...Xue-liang Zhou; Zhi-bo Liu; Rong-rong Zhu; Huang Huang; Qi-rong Xu; Hua Xu; Liang Zeng; Yun-yun Li; Cha-hua Huang; Qi-cai Wu; Ji-chun Liu Nuclear receptor binding SET domain 2 (NSD2)-mediated metabolic reprogramming has been demonstrated to regulate oncogenesis via catalyzing the methylation...

View article titled, NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy

Articles

MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S -adenosylmethionine and de novo purine synthesis

Yi-Cheng Wang, Ming-Tsung Wu, Feng-Yao Tang, Der-Yuan Chen, Hsin-An Ko, Barry Shane, Wen-Nan Huang, En-Pei Isabel Chiang

Clin Sci (Lond) (2019) 133 (2): 253–267.

DOI: https://doi.org/10.1042/CS20180932

Published: 25 January 2019

...Yi-Cheng Wang; Ming-Tsung Wu; Feng-Yao Tang; Der-Yuan Chen; Hsin-An Ko; Barry Shane; Wen-Nan Huang; En-Pei Isabel Chiang Objective: Currently, no guidelines are established for pharmacogenomic testing involving folate metabolic genes in long-term disease-modifying antirheumatic drugs’ (DMARD...

View article titled, MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S -adenosylmethionine and de novo purine synthesis

Articles

MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets

Silvia Lorente-Cebrián, Pedro González-Muniesa, Fermín I. Milagro, J. Alfredo Martínez

Clin Sci (Lond) (2019) 133 (1): 23–40.

DOI: https://doi.org/10.1042/CS20180890

Published: 03 January 2019

...Silvia Lorente-Cebrián; Pedro González-Muniesa; Fermín I. Milagro; J. Alfredo Martínez Obesity is a metabolic condition usually accompanied by insulin resistance (IR), type 2 diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation and related to white adipose tissue...

View article titled, MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets

Articles

The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right

Matthew Kerr, Michael S. Dodd, Lisa C. Heather

Clin Sci (Lond) (2017) 131 (16): 2079–2094.

DOI: https://doi.org/10.1042/CS20160671

Published: 24 July 2017

... but less oxygen efficient fuel compared with glucose. The pathways involved in myocardial FA metabolism are regulated at various subcellular levels, and can be divided into sarcolemmal FA uptake, cytosolic activation and storage, mitochondrial uptake and β-oxidation. An understanding of the critical...

View article titled, The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right

Articles

Lamins and metabolism

Chayki Charar, Yosef Gruenbaum

Clin Sci (Lond) (2017) 131 (2): 105–111.

DOI: https://doi.org/10.1042/CS20160488

Published: 14 December 2016

... are autosomal dominant and can be roughly divided into four major groups: muscle diseases, peripheral neuronal diseases, accelerated aging disorders and metabolic diseases including Dunnigan type familial partial lipodystrophy (FLPD), acquired partial lipodystrophy (APL) and autosomal dominant leucodystrophy...

View article titled, Lamins and metabolism

Articles

GPER–novel membrane oestrogen receptor

Margaret A. Zimmerman, Rebecca A. Budish, Shreya Kashyap, Sarah H. Lindsey

Clin Sci (Lond) (2016) 130 (12): 1005–1016.

DOI: https://doi.org/10.1042/CS20160114

Published: 06 May 2016

... on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target. Correspondence: Dr...

View article titled, GPER–novel membrane oestrogen receptor

Articles

Impaired glucose tolerance after brief heat exposure: a randomized crossover study in healthy young men

Cécile Faure, Keyne Charlot, Stéphane Henri, Marie-dominique Hardy-Dessources, Olivier Hue, Sophie Antoine-Jonville

Clin Sci (Lond) (2016) 130 (12): 1017–1025.

DOI: https://doi.org/10.1042/CS20150461

Published: 06 May 2016

... of humans. The objective of this project was to examine the isolated and combined effects of experimental short-term mild heat exposure and metabolic level on glucoregulation. Two experimental randomized crossover studies were conducted. Ten healthy young men participated in study A, which comprises four...

View article titled, Impaired glucose tolerance after brief heat exposure: a randomized crossover study in healthy young men

Articles

Metabolic dysfunction in lymphocytes promotes postoperative morbidity

Mark R. Edwards, Pervez Sultan, Ana Gutierrez del Arroyo, John Whittle, Shamir N. Karmali, S. Ramani Moonesinghe, Fares S. Haddad, Michael G. Mythen, Mervyn Singer, Gareth L. Ackland

Clin Sci (Lond) (2015) 129 (5): 423–437.

DOI: https://doi.org/10.1042/CS20150024

Published: 11 June 2015

... the circulation to lymphoid tissue and sites of inflammation, and from loss of lymphocytes through apoptosis [ 5 , 7 ]. apoptosis inflammasome lymphocyte metabolism mitochondria sepsis Activation of lymphocytes is critically dependent upon rapid increases in energy generation from both...

View article titled, Metabolic dysfunction in lymphocytes promotes postoperative morbidity

Includes: Supplementary data

Articles

NUCKS: a potential biomarker in cancer and metabolic disease

Beiying Qiu, Weiping Han, Vinay Tergaonkar

Clin Sci (Lond) (2015) 128 (10): 715–721.

DOI: https://doi.org/10.1042/CS20140656

Published: 10 March 2015

... and the metabolic syndrome, and how its sundry modifications can affect its function. Such studies could reveal how NUCKS could be a link between physiological cues and human ailments. The HMG protein family is one of the most abundant non-histone proteins that control chromatin remodelling and regulate gene...

View article titled, NUCKS: a potential biomarker in cancer and metabolic disease

Articles

Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability

Yvette C. Luiking, Martijn Poeze, Nicolaas E. Deutz

Clin Sci (Lond) (2015) 128 (1): 57–67.

DOI: https://doi.org/10.1042/CS20140343

Published: 29 August 2014

... study was to investigate the dose–response effect of intravenous arginine supplementation in post-absorptive patients with septic shock on arginine-NO and protein metabolism and on global and regional haemodynamics. Eight critically ill patients with a diagnosis of septic shock participated...

View article titled, Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability

Includes: Supplementary data

Articles

Magnesium and its transporters in cancer: a novel paradigm in tumour development

Federica I. Wolf, Valentina Trapani

Clin Sci (Lond) (2012) 123 (7): 417–427.

DOI: https://doi.org/10.1042/CS20120086

Published: 07 June 2012

... effects. In the present review, we briefly outline the new findings on the role of magnesium in angiogenesis and metastatization, and focus on the relationship between tumour cell proliferation and metabolic reprogramming, discussing how magnesium and its transporters are involved in these processes...

View article titled, Magnesium and its transporters in cancer: a novel paradigm in tumour development

Articles

Cellular and molecular mechanisms of metformin: an overview

Benoit Viollet, Bruno Guigas, Nieves Sanz Garcia, Jocelyne Leclerc, Marc Foretz, Fabrizio Andreelli

Clin Sci (Lond) (2012) 122 (6): 253–270.

DOI: https://doi.org/10.1042/CS20110386

Published: 11 November 2011

... status activates AMPK (AMP-activated protein kinase), a cellular metabolic sensor, providing a generally accepted mechanism for the action of metformin on hepatic gluconeogenesis. The demonstration that respiratory chain complex I, but not AMPK, is the primary target of metformin was recently...

View article titled, Cellular and molecular mechanisms of metformin: an overview

Articles

Cellular and molecular effects of sirtuins in health and disease

Yoshiyuki Horio, Takashi Hayashi, Atsushi Kuno, Risa Kunimoto

Clin Sci (Lond) (2011) 121 (5): 191–203.

DOI: https://doi.org/10.1042/CS20100587

Published: 20 May 2011

... as potential treatments. In the present review, we describe the functions of sirtuins in cell survival, inflammation, energy metabolism, cancer and differentiation, and their impact on diseases. We also discuss the organ-specific functions of sirtuins, focusing on the brain and blood vessels...

View article titled, Cellular and molecular effects of sirtuins in health and disease

Articles

The circadian clock and metabolism

Oren Froy

Clin Sci (Lond) (2011) 120 (2): 65–72.

DOI: https://doi.org/10.1042/CS20100327

Published: 08 October 2010

... in metabolism. In turn, key metabolic enzymes and transcription activators interact with and affect the core clock mechanism. Animals with mutations in clock genes that disrupt cellular rhythmicity have provided evidence to the relationship between the circadian clock and metabolic homoeostasis. The present...

View article titled, The circadian clock and metabolism

Articles

Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice

Yvonne L. J. Vissers, Maarten F. von Meyenfeldt, Yvette C. Luiking, Cornelis H. C. Dejong, Wim A. Buurman, Nicolaas E. P. Deutz

Clin Sci (Lond) (2007) 112 (10): 527–532.

DOI: https://doi.org/10.1042/CS20060340

Published: 12 April 2007

... availability may be a specific feature of the presence of tumour. As arginine is important in post-operative repair, we hypothesized that abnormalities in arginine metabolism in cancer lead to an aberrant post-operative response in arginine and NO metabolism. To investigate this, we studied post-operative...

View article titled, Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice

Articles

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis

Grainne A. Cunningham, Neville H. Mcclenaghan, Peter R. Flatt, Philip Newsholme

Clin Sci (Lond) (2005) 109 (5): 447–455.

DOI: https://doi.org/10.1042/CS20050149

Published: 24 October 2005

... changes in gene expression of BRIN-BD11 cells. Sixty-six genes were up-regulated >1.8-fold, including many involved in cellular signalling, metabolism, gene regulation, protein synthesis, apoptosis and the cellular stress response. Subsequent functional experiments confirmed that L -alanine provided...

View article titled, L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis

Includes: Supplementary data

Articles

New insights into amino acid metabolism, β-cell function and diabetes

Philip NEWSHOLME, Lorraine BRENNAN, Blanca RUBI, Pierre MAECHLER

Clin Sci (Lond) (2005) 108 (3): 185–194.

DOI: https://doi.org/10.1042/CS20040290

Published: 18 February 2005

... identify novel targets for future diabetes therapies. Mitochondrial metabolism is crucial for the coupling of amino acid and glucose recognition to the exocytosis of the insulin granules. This is illustrated by in vitro and in vivo observations discussed in the present review. Mitochondria generate ATP...

View article titled, New insights into amino acid metabolism, β-cell function and diabetes

Articles

Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans

Luc J.C. van LOON, Audrey M. OOSTERLAAR, Fred HARTGENS, Matthijs K.C. HESSELINK, Rodney J. SNOW, Anton J.M. WAGENMAKERS

Clin Sci (Lond) (2003) 104 (2): 153–162.

DOI: https://doi.org/10.1042/cs1040153

Published: 17 January 2003

...-mail L.vanLoon@HB.Unimaas.nl ). 18 6 2002 13 9 2002 14 11 2002 The Biochemical Society and the Medical Research Society © 2003 2003 creatine phosphate ergogenic aids functional foods metabolism oxidative capacity skeletal muscle substrate utilization 153Clinical Science...

View article titled, Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans

Articles

Determinants of the acetate recovery factor: implications for estimation of [ 13 C]substrate oxidation

Patrick SCHRAUWEN, Ellen E. BLAAK, Dorien P. C. van AGGEL-LEIJSSEN, Lars B. BORGHOUTS, Anton J. M. WAGENMAKERS

Clin Sci (Lond) (2000) 98 (5): 587–592.

DOI: https://doi.org/10.1042/cs0980587

Published: 11 April 2000

...Patrick SCHRAUWEN; Ellen E. BLAAK; Dorien P. C. van AGGEL-LEIJSSEN; Lars B. BORGHOUTS; Anton J. M. WAGENMAKERS When using 13 C or 14 C tracers to study substrate metabolism, an acetate correction factor should be applied to correct for loss of label in the exchange pathways of the tricarboxylic...

View article titled, Determinants of the acetate recovery factor: implications for estimation of [ 13 C]substrate oxidation

Articles

Metabolic and Myoelectrical Effects of Acute Hypoxaemia during Isometric Contraction of Forearm Muscles in Humans: A Combined 31 P-Magnetic Resonance Spectroscopy-Surface Electromyogram (MRS—SEMG) Study

D. Bendahan, M. Badier, Y. Jammes, S. Confort-Gouny, A. M. Salvan, C. Guillot, P. J. Cozzone

Clin Sci (Lond) (1998) 94 (3): 279–286.

DOI: https://doi.org/10.1042/cs0940279

Published: 01 March 1998

...D. Bendahan; M. Badier; Y. Jammes; S. Confort-Gouny; A. M. Salvan; C. Guillot; P. J. Cozzone 1. Failure of muscle force during sustained fatiguing contraction is associated with myoelectrical and metabolic alterations. However, the inter-relationships between these two types of events remain...

View article titled, Metabolic and Myoelectrical Effects of Acute Hypoxaemia during Isometric Contraction of Forearm Muscles in Humans: A Combined 31 P-Magnetic Resonance Spectroscopy-Surface Electromyogram (MRS—SEMG) Study

Articles

α-Adrenoceptor Mechanisms of Thermoregulation during Cold Challenge in Humans

Steven M. Frank, Nader El-Gamal, Srinivasa N. Raja, Peter K. Wu

Clin Sci (Lond) (1996) 91 (5): 627–631.

DOI: https://doi.org/10.1042/cs0910627

Published: 01 November 1996

... vasoconstriction and metabolic heat production were measured. 3. The α-adrenoceptor antagonist caused a dose-dependent inhibition of vasoconstriction in the elderly but did not impair vasoconstriction in the young subjects at the doses that were given. Shivering and metabolic heat production were unaffected by α...

View article titled, α-Adrenoceptor Mechanisms of Thermoregulation during Cold Challenge in Humans

Articles

Effect of Methionine Loading on 5-Methyltetrahydrofolate, S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma of Healthy Humans

Franziska M. T. Loehrer, Walter E. Haefeli, Christian P. Angst, Garry Browne, Greta Frick, Brian Fowler

Clin Sci (Lond) (1996) 91 (1): 79–86.

DOI: https://doi.org/10.1042/cs0910079

Published: 01 July 1996

... to investigate impaired methionine metabolism, especially of the trans-sulphuration pathway, but most studies have focused on changes in homocysteine. 2. We investigated the effect of methionine excess on total plasma homocysteine, 5-methyltetrahydrofolate (which is the active form of folate in the remethylation...

View article titled, Effect of Methionine Loading on 5-Methyltetrahydrofolate, S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma of Healthy Humans

Articles

Relationship between Serum Tryptophan and Tryptophan Metabolite Levels after Tryptophan Ingestion in Normal Subjects and Age-Related Cataract Patients

Roger J. W. Truscott, Anthony J. Elderfield

Clin Sci (Lond) (1995) 89 (6): 591–599.

DOI: https://doi.org/10.1042/cs0890591

Published: 01 December 1995

... in tryptophan metabolism in the two groups. 3. Tryptophan, kynurenine, kynurenic acid, xanthurenic acid, 3-hydroxyanthranilic acid, 5-hydroxyanthranilic acid, 5-hydroxytryptophan and anthranilic acid were measured by HPLC with dual electrochemical and programmable wavelength fluorescence detection. Fasting...

View article titled, Relationship between Serum Tryptophan and Tryptophan Metabolite Levels after Tryptophan Ingestion in Normal Subjects and Age-Related Cataract Patients

Articles

Role of α-Adrenoceptors in the Maintenance of Core Temperature in Humans

Steven M. Frank, Nader El-Gamal, Srinivasa N. Raja, Peter K. Wu, Osama Afifi

Clin Sci (Lond) (1995) 89 (3): 219–225.

DOI: https://doi.org/10.1042/cs0890219

Published: 01 September 1995

..., mean skin-surface temperature, fingertip capillary blood flow and metabolic heat production were measured. Dose—response curves were plotted for all measured variables, and males and females were compared to identify potential gender differences. 3. Core temperature decreased with all doses...

View article titled, Role of α-Adrenoceptors in the Maintenance of Core Temperature in Humans

Articles

Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats

Sylvia Heeneman, Nicolaas E. P. Deutz

Clin Sci (Lond) (1993) 85 (4): 437–444.

DOI: https://doi.org/10.1042/cs0850437

Published: 01 October 1993

... were reduced by 50% at day 4, no changes in intestinal amino acid and ammonia metabolism were observed. 3. In the liver, glutamine consumption was reduced and ammonia uptake was increased, but urea synthesis was not changed. The decreased intracellular glutamine, glutamate, aspartate and ammonia...

View article titled, Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats

Articles

Tumour necrosis factor- α : Its role in the metabolic response to sepsis

Tom van der Poll, Hans P. Sauerwein

Clin Sci (Lond) (1993) 84 (3): 247–256.

DOI: https://doi.org/10.1042/cs0840247

Published: 01 March 1993

...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...

View article titled, Tumour necrosis factor- α : Its role in the metabolic response to sepsis

Articles

Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique

David L. Chinkes, Judah Rosenblatt, Robert R. Wolfe

Clin Sci (Lond) (1993) 84 (2): 177–183.

DOI: https://doi.org/10.1042/cs0840177

Published: 01 February 1993

... rate. 20 7 1992 19 10 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 amino acids constant infusion flooding dose fractional synthesis rate leucine metabolism modelling muscle protein degradation protein synthesis tracer Clinical Science...

View article titled, Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique

Articles

Weight loss normalizes the inhibitory effect of N 6 -(phenylisopropyl)adenosine on lipolysis in fat cells of massively obese human subjects

Jorma J. Ohisalo, Johanna M. Kaartinen, Susanna Ranta, Pertti Mustajoki, Stanely P. Hreniuk, Kathryn F. LaNoue, Louis F. Martin

Clin Sci (Lond) (1992) 83 (5): 589–592.

DOI: https://doi.org/10.1042/cs0830589

Published: 01 November 1992

... observed in the inhibitory regulation of lipolysis in obesity are secondary. 26 5 1992 11 6 1992 © 1992 The Biochemical Society and the Medical Research Society 1992 adenosine adenylate cyclase cell size gastric bypass hormone regulation metabolism obesity Clinical Science...

View article titled, Weight loss normalizes the inhibitory effect of N 6 -(phenylisopropyl)adenosine on lipolysis in fat cells of massively obese human subjects

Articles

Effects of lysine infusion on the renal metabolism of aprotinin (Trasylol) in man

R. Rustom, P. Maltby, J. S. Grime, H. R. Stockdale, M. Critchley, J. M. Bone

Clin Sci (Lond) (1992) 83 (3): 295–299.

DOI: https://doi.org/10.1042/cs0830295

Published: 01 September 1992

.... Lysine potently inhibits tubular peptide uptake, and may thus depress the uptake and metabolism of aprotinin. This was investigated in 14 glomerulonephritic patients with normal renal function and variable proteinuria and in one healthy subject. 2. 99m Tc-labelled aprotinin was given intravenously alone...

View article titled, Effects of lysine infusion on the renal metabolism of aprotinin (Trasylol) in man

Articles

Hepatic glutamine metabolism in the septic rat

M. Salleh, M. Ardawi

Clin Sci (Lond) (1992) 82 (6): 709–716.

DOI: https://doi.org/10.1042/cs0820709

Published: 01 June 1992

...M. Salleh; M. Ardawi 1. The hepatic metabolism of glutamine, alanine, ammonia, urea, glutathione and glucose was studied in rats made septic by caecal ligation and puncture and was compared with that in rats that had undergone sham operation (laparotomy). 2. Sepsis resulted in increases...

View article titled, Hepatic glutamine metabolism in the septic rat

Articles

Effects of epidermal growth factor and glutamine-supplemented parenteral nutrition on the small bowel of septic rats

M. Salleh, M. Ardawi

Clin Sci (Lond) (1992) 82 (5): 573–580.

DOI: https://doi.org/10.1042/cs0820573

Published: 01 May 1992

... glutamine metabolism nitrogen balance parenteral nutrition sepsis small bowel Clinical Science (1992) 82, 573-580 (Printed in Great Britain) 573 Effects of epidermal growth factor and glutamine- supplemented parenteral nutrition on the small bowel of septic rats M. Salleh M. ARDAWI Department...

View article titled, Effects of epidermal growth factor and glutamine-supplemented parenteral nutrition on the small bowel of septic rats

Articles

Metabolic balance studies of mineral supplementation in osteoporosis

Trevor Stamp, Monica Katakity, A. J. Goldstein, M. V. Jenkins, C. R. Kelsey, G. A. Rose

Clin Sci (Lond) (1991) 81 (6): 799–802.

DOI: https://doi.org/10.1042/cs0810799

Published: 01 December 1991

... © 1991 The Biochemical Society and the Medical Research Society 1991 calcium metabolic balance metabolism osteoporosis phosphorus Clinical Science (1991) 81,799-802 799 Metabolic balance studies of mineral supplementation in osteoporosis TREVOR STAMP, MONICA KATAKITY, A. J. GOLDSTEIN, M...

View article titled, Metabolic balance studies of mineral supplementation in osteoporosis

Articles

Reduced oxygen consumption induced by vasopressin in dogs depends on systemic administration

Jean-Francois Liard

Clin Sci (Lond) (1991) 81 (6): 751–758.

DOI: https://doi.org/10.1042/cs0810751

Published: 01 December 1991

... cannot be primarily a consequence of oxygen delivery limitation. 8 7 1991 15 7 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 antidiuretic hormone cardiac output hypoxia metabolism oxygen consumption regional blood flows ClinicalScience(l991)81...

View article titled, Reduced oxygen consumption induced by vasopressin in dogs depends on systemic administration

Articles

Glutamine and alanine metabolism in lungs of septic rats

M. Salleh M. Ardawi

Clin Sci (Lond) (1991) 81 (5): 603–609.

DOI: https://doi.org/10.1042/cs0810603

Published: 01 November 1991

...M. Salleh M. Ardawi 1. The metabolism of glutamine and alanine in the lung was studied in rats made septic by a caecal ligation and puncture technique. 2. The blood glucose concentration was not significantly different in septic rats, but blood pyruvate, lactate, glutamine and alanine...

View article titled, Glutamine and alanine metabolism in lungs of septic rats

Articles

Measurement of protein synthesis in human skeletal muscle: further investigation of the flooding technique

M. A. McNurlan, P. Essen, S. D. Heys, V. Buchan, P. J. Garlick, J. Wernerman

Clin Sci (Lond) (1991) 81 (s25): 557–564.

DOI: https://doi.org/10.1042/cs0810557

Published: 01 October 1991

...- 13 C]leucine (mean difference 0.16%/day) and l -[1- 13 C]phenylalanine (mean difference 0.2%/day). 15 3 1991 29 5 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 flooding technique leucine mass spectrometry metabolism muscle protein protein...

View article titled, Measurement of protein synthesis in human skeletal muscle: further investigation of the flooding technique

Articles

Effects of hypothyroidism on glucose and glutamine metabolism by the gut of the rat

M. Salleh M. Ardawi, Sawsan M. Jalalah

Clin Sci (Lond) (1991) 81 (3): 347–355.

DOI: https://doi.org/10.1042/cs0810347

Published: 01 September 1991

...M. Salleh M. Ardawi; Sawsan M. Jalalah 1. The metabolism of glucose and glutamine was studied in the small intestine and the colon of rats after 4–5 weeks of hypothyroidism. 2. Hypothyroidism resulted in increases in the plasma concentrations of ketone bodies ( P < 0.05), cholesterol ( P...

View article titled, Effects of hypothyroidism on glucose and glutamine metabolism by the gut of the rat

Articles

Effect of glutamine-enriched total parenteral nutrition on septic rats

M. Salleh M. Ardawi

Clin Sci (Lond) (1991) 81 (2): 215–222.

DOI: https://doi.org/10.1042/cs0810215

Published: 01 August 1991

... of glutamine-enriched total parenteral nutrition is beneficial to septic rats and possibly to septic patients. 7 2 1991 4 3 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 amino acids glutamine metabolism muscle nitrogen balance parenteral nutrition sepsis...

View article titled, Effect of glutamine-enriched total parenteral nutrition on septic rats

Articles

Glutamine metabolism in the lungs of glucocorticoid-treated rats

M. Salleh, M. Ardawi

Clin Sci (Lond) (1991) 81 (1): 37–42.

DOI: https://doi.org/10.1042/cs0810037

Published: 01 July 1991

...M. Salleh; M. Ardawi 1. The effect of dexamethasone (30 μg day −1 100 g −1 body weight) on the regulation of glutamine metabolism was studied in the lungs of rats after 9 days of treatment. 2. Dexamethasone resulted in a negative nitrogen balance, and produced decreases in the blood concentrations...

View article titled, Glutamine metabolism in the lungs of glucocorticoid-treated rats

Articles

Effect of Infused Branched-Chain Amino Acids on Muscle and Whole-Body Amino Acid Metabolism in Man

Rita J. Louard, Eugene J. Barrett, Robert A. Gelfand

Clin Sci (Lond) (1990) 79 (5): 457–466.

DOI: https://doi.org/10.1042/cs0790457

Published: 01 November 1990

... amino acid kinetics branched-chain amino acids leucine metabolism protein proteolysis skeletal muscle Clinical Science (1990) 79,457-466 457 Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man RITA J. LOUARD, EUGENE J. BARRETT AND ROBERT A. GELFAND...

View article titled, Effect of Infused Branched-Chain Amino Acids on Muscle and Whole-Body Amino Acid Metabolism in Man

Articles

Glutamine Metabolism in Skeletal Muscle of Glucocorticoid-Treated Rats

M. Salleh M. Ardawi, Yasir S. Jamal

Clin Sci (Lond) (1990) 79 (2): 139–147.

DOI: https://doi.org/10.1042/cs0790139

Published: 01 August 1990

...M. Salleh M. Ardawi; Yasir S. Jamal 1. The effect of dexamethasone (30 μg day −-1 100 g −-1 body weight) on the regulation of glutamine metabolism was studied in skeletal muscles of rats after 9 days of treatment. 2. Dexamethasone resulted in negative nitrogen balance, and produced increases...

View article titled, Glutamine Metabolism in Skeletal Muscle of Glucocorticoid-Treated Rats

Articles

Regulation of nicotinamide–adenine dinucleotide synthesis in erythrocytes of patients with hypoxanthine–guanine phosphoribosyltransferase deficiency and a patient with phosphoribosylpyrophosphate synthetase superactivity

Vanna Micheli, H. Anne Simmonds, Carlo Ricci

Clin Sci (Lond) (1990) 78 (2): 239–245.

DOI: https://doi.org/10.1042/cs0780239

Published: 01 February 1990

..., but not further metabolism, was impaired in phosphoribosylpyrophosphate synthetase-mutant cells. The Lesch–Nyhan and phosphoribosylpyrophosphate synthetase-mutant cells were unusual in that both showed no further stimulation of nucleotide synthesis at 18 mmol/l P i compared with 1 mmol/l. 3. At the high substrate...

View article titled, Regulation of nicotinamide–adenine dinucleotide synthesis in erythrocytes of patients with hypoxanthine–guanine phosphoribosyltransferase deficiency and a patient with phosphoribosylpyrophosphate synthetase superactivity

Articles

Measurement of the transfer of the nitrogen moiety of intestinal lumen glutamic acid in man after oral ingestion of l -[ 15 N]glutamic acid

A. W. Johnson, J. M. Berrington, I. Walker, A. Manning, M. S. Losowsky

Clin Sci (Lond) (1988) 75 (5): 499–502.

DOI: https://doi.org/10.1042/cs0750499

Published: 01 November 1988

...A. W. Johnson; J. M. Berrington; I. Walker; A. Manning; M. S. Losowsky 1. The measurement of the intestinal metabolism of the nitrogen moiety of glutamic acid has been investigated by oral ingestion of l -[ 15 N]glutamic acid and sampling of arterialized blood. 2. Measurements have been made in six...

View article titled, Measurement of the transfer of the nitrogen moiety of intestinal lumen glutamic acid in man after oral ingestion of l -[ 15 N]glutamic acid

Articles

Effect of glucocorticoid treatment on glucose and glutamine metabolism by the small intestine of the rat

M. Salleh M. Ardawi, May F. Majzoub, Eric A. Newsholme

Clin Sci (Lond) (1988) 75 (1): 93–100.

DOI: https://doi.org/10.1042/cs0750093

Published: 01 July 1988

...M. Salleh M. Ardawi; May F. Majzoub; Eric A. Newsholme 1. The effect of dexamethasone (30 μg day −1 100 g −1 body wt.) on the metabolism of glucose and glutamine was studied in the small intestine of rats after 9 days of treatment. 2. Dexamethasone treatment resulted in negative nitrogen balance...

View article titled, Effect of glucocorticoid treatment on glucose and glutamine metabolism by the small intestine of the rat

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