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Keywords: metabolic syndrome
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Articles
Clin Sci (Lond) (2022) 136 (5): 345–360.
Published: 09 March 2022
.... Over the past few years, increasing evidence has implicated renal mitochondrial damage in the pathogenesis of common etiologies of CKD, such as diabetes, hypertension, metabolic syndrome (MetS), chronic renal ischemia, and polycystic kidney disease (PKD). However, most compelling evidence is based...
Articles
Clin Sci (Lond) (2021) 135 (19): 2265–2283.
Published: 13 October 2021
... HFpEF and the metabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid...
Articles
Clin Sci (Lond) (2020) 134 (16): 2117–2135.
Published: 21 August 2020
... provided the maximum sensitivity and specificity for the diagnostic test of a metabolic syndrome in young adults [ 16 ] and acted as an indicator of cardiometabolic risk, as determined by both the International Diabetes Federation (IDF) and the Adult Treatment Panel III (ATP III) criteria [ 17...
Articles
Clin Sci (Lond) (2019) 133 (21): 2189–2202.
Published: 08 November 2019
...Jian Wang; Ying Wang; Limei Liu; Kabirullah Lutfy; Theodore C. Friedman; Ya Liu; Meisheng Jiang; Yanjun Liu Excessive glucocorticoid (GC) production in adipose tissue promotes the development of visceral obesity and metabolic syndrome (MS). 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1...
Articles
Clin Sci (Lond) (2018) 132 (7): 791–811.
Published: 16 April 2018
... of the host towards a low-grade chronic inflammation, a hallmark of metabolic syndrome. The primary objective of this review is to examine and discuss some very current research that has been done to study the effect of bacterial metabolites on host metabolism, sometimes referred to as microbiota-host co...
Articles
Clin Sci (Lond) (2017) 131 (7): 595–607.
Published: 17 March 2017
.... 12 1 2017 24 1 2017 27 1 2017 27 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 benign prostatic hyperplasia ERK pathway metabolic syndrome oxytocin • Benign prostatic hyperplasia (BPH) is caused...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (4): 327–328.
Published: 30 January 2017
... on behalf of the Biochemical Society 2017 brown adipose tissue nonshivering thermogenesis metabolic syndrome Visceral obesity, i.e. the excessive fat accumulation in the adipose depots located inside the peritoneal cavity, is associated with the development of several chronic metabolic...
Articles
Clin Sci (Lond) (2017) 131 (4): 285–296.
Published: 20 January 2017
...Laurence Poekes; Vanessa Legry; Olivier Schakman; Christine Detrembleur; Anne Bol; Yves Horsmans; Geoffrey C. Farrell; Isabelle A. Leclercq Fatty liver diseases are complications of the metabolic syndrome associated with obesity, insulin resistance and low grade inflammation. Our aim was to uncover...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (1): 27–36.
Published: 09 December 2016
... antineoplastic properties. For metabolic syndrome patients with hepatocellular carcinoma (HCC), metformin may provide antitumoral effects. We evaluated the impact of metformin on tumour growth and visceral fat composition using relevant preclinical models of metabolic syndrome. Studies were performed in three...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 449–461.
Published: 17 June 2014
...) of subjects with and without the metabolic syndrome (MS), by immunoprecipitation (IP) of the ribonucleoprotein (RNP) complex. We found that SIRT1 overexpression prevented TNF-α- and high-glucose-dependent nuclear factor-κB (NF-κB)-p65 acetylation, E-selectin promoter activity, E-selectin release and adhesion...
Articles
Clin Sci (Lond) (2014) 127 (1): 1–13.
Published: 10 March 2014
... biomarker in patients affected by cardiovascular diseases. atrial fibrillation atrial natriuretic peptide cardiac hypertrophy gene variant heart failure NT-proANP levels hypertension metabolic syndrome vascular damage Correspondence: Professor Massimo Volpe (email massimo.volpe...
Articles
Clin Sci (Lond) (2013) 125 (4): 211–222.
Published: 01 May 2013
... The relationship between MetS (metabolic syndrome), levels of circulating progenitor/immune cells and the risk of VTE (venous thromboembolism) has not yet been investigated. We studied 240 patients with previous VTE and 240 controls. The presence of MetS was identified according to NCEP ATP III guidelines and flow...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2013) 125 (2): 87–97.
Published: 26 March 2013
...-induced AAT dysfunctions in normal rats strongly suggests that OS plays an important role in the FRD-induced MS (metabolic syndrome) phenotype. Small pieces (8–10 per tube, 100–200 mg) of AAT pads from animals of each group were incubated in 1 ml of KRB (Krebs–Ringer–Bicarbonate) buffer (118 mM NaCl...
Articles
Clin Sci (Lond) (2013) 125 (1): 19–25.
Published: 13 March 2013
...Jennifer A. Thompson; R. Clinton Webb The developmental origins of the metabolic syndrome have been established through the consistent observation that small-for-gestational age and large-for-gestational age fetuses have an increased risk for hypertension and related metabolic disorders later...
Articles
Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
... Richard.Coward@bristol.ac.uk ). 13 7 2012 14 9 2012 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 diabetes diabetic nephropathy insulin intracellular signalling kidney metabolic syndrome The role of insulin in the human body has been...
Articles
Clin Sci (Lond) (2013) 124 (1): 53–63.
Published: 07 September 2012
... 2013 arterial hypertension fatty liver hypoxia hypoxia inducible factor 1α liver damage metabolic syndrome non-alcoholic fatty liver disease • Liver damage and CVD are clinically related and often co-existing entities, but the mechanisms behind this association are still unclear...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (11): 635–647.
Published: 01 August 2012
...Radko Komers; Shaunessy Rogers; Terry T. Oyama; Bei Xu; Chao-Ling Yang; James McCormick; David H. Ellison In the present study, we investigated the activity of the thiazide-sensitive NCC (Na + –Cl − co-transporter) in experimental metabolic syndrome and the role of insulin in NCC activation. Renal...
Articles
Clin Sci (Lond) (2012) 123 (2): 99–109.
Published: 27 March 2012
... stromal lymphopoietin) gene was less expressed in severely obese men with ( n =7) compared with without ( n =7) the MetS (metabolic syndrome). We hypothesized that TSLP SNPs (single nucleotide polymorphisms) are associated with TSLP gene expression in VAT and with MetS phenotypes. Following validation...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 120 (7): 297–305.
Published: 13 December 2010
...Yi Tan; Mohammad A. Kamal; Zheng-Zhong Wang; Wei Xiao; John P. Seale; Xianqin Qu The metabolic syndrome has reached epidemic proportions worldwide, but currently there is a lack of effective therapies for this multifactorial endocrine disease. TCM (traditional Chinese medicine) has been utilized...
Articles
Clin Sci (Lond) (2010) 119 (10): 431–436.
Published: 05 August 2010
.../by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. adiponectin chronic liver disease cirrhosis hepatic fibrosis metabolic syndrome non-alcoholic fatty liver disease (NAFLD) Adiponectin...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 119 (6): 251–261.
Published: 15 June 2010
... stress may play an important role in MetS (metabolic syndrome)-related manifestations. Dietary fat quality has been proposed to be critical in oxidative stress and the pathogenesis of the MetS. In the present study, we investigated whether oxidative stress parameters are affected by diets with different...
Articles
Clin Sci (Lond) (2010) 119 (6): 239–250.
Published: 08 June 2010
...) in the drug-treated groups. In conclusion, all of the drug treatments were effective in controlling the metabolic syndrome. The best results were achieved using telmisartan and sitagliptin as monotherapies or as a dual treatment, combining partial PPAR-γ agonism and PPAR-α activation in the liver...
Articles
Clin Sci (Lond) (2010) 118 (4): 231–240.
Published: 09 November 2009
..., diuretic and natriuretic properties. In addition, natriuretic peptides may play a role in the modulation of the molecular mechanisms involved in metabolic regulation and cardiovascular remodelling. The metabolic syndrome is characterized by visceral obesity, hyperlipidaemia, vascular inflammation...
Articles
Clin Sci (Lond) (2010) 118 (1): 47–59.
Published: 02 October 2009
... lipid. Correspondence: Dr Paul R. Kemp (email p.kemp@imperial.ac.uk ). 20 3 2009 14 5 2009 15 5 2009 15 5 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 birth Caesarean section liver metabolic syndrome steatosis total parenteral...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2009) 117 (5): 173–190.
Published: 03 August 2009
...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...
Articles
Clin Sci (Lond) (2009) 116 (6): 507–512.
Published: 12 February 2009
... and opposing mechanistic effects on insulin. The aim of the present study was to assess the relationship between the IGF-I/IGFBP-3 ratio and the metabolic syndrome. We examined 3281 subjects (1463 men and 1818 women, aged 20–49 years), otherwise healthy adults, who participated in NHANES III (Third National...
Articles
Clin Sci (Lond) (2008) 115 (1): 13–23.
Published: 02 June 2008
... 13 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 adipokine inflammation metabolic syndrome nicotinamide phosphoribosyltransferase (Nampt) obesity pre-B-cell colony-enhancing factor (PBEF) Obesity is a rapidly growing disease in industrialized...
Articles
Clin Sci (Lond) (2008) 115 (1): 1–12.
Published: 02 June 2008
... Society 2008 atherosclerosis cardiovascular disease energy homoeostasis fatty acid metabolic syndrome non-alcoholic fatty liver disease (NAFLD) NAFLD (non-alcoholic fatty liver disease) encompasses the spectrum of fatty liver diseases seen in individuals with the MS (metabolic syndrome...
Articles
Clin Sci (Lond) (2008) 114 (10): 611–624.
Published: 14 April 2008
...Esther M. M. Ooi; P. Hugh R. Barrett; Dick C. Chan; Gerald F. Watts The concurrence of visceral obesity, insulin resistance and dyslipidaemia comprises the concept of the metabolic syndrome. The metabolic syndrome is an escalating problem in developed and developing societies that tracks...
Articles
Clin Sci (Lond) (2008) 114 (3): 195–210.
Published: 08 January 2008
...Heiko Bugger; E. Dale Abel The metabolic syndrome represents a cluster of abnormalities, including obesity, insulin resistance, dyslipidaemia and Type 2 diabetes, that increases the risk of developing cardiovascular diseases, such as coronary artery disease and heart failure. The heart failure risk...
Articles
Clin Sci (Lond) (2008) 114 (3): 183–193.
Published: 08 January 2008
...Concepción M. Aguilera; Mercedes Gil-Campos; Ramón Cañete; Ángel Gil The MS (metabolic syndrome) is a cluster of clinical and biochemical abnormalities characterized by central obesity, dyslipidaemia [hypertriglyceridaemia and decreased HDL-C (high-density lipoprotein cholesterol)], glucose...
Articles
Clin Sci (Lond) (2007) 113 (10): 417–425.
Published: 12 October 2007
...Natalia Sinitskaya; Sylviane Gourmelen; Carole Schuster-Klein; Béatrice Guardiola-Lemaitre; Paul Pévet; Etienne Challet Metabolic disorders induced by high-fat feeding in rodents evoke some, if not all, of the features of human metabolic syndrome. The occurrence and severity of metabolic disorders...
Articles
Clin Sci (Lond) (2007) 113 (10): 397–399.
Published: 12 October 2007
...: Dr Marie C. Guldstrand (email marie.guldstrand@ds.se ). 30 7 2007 22 8 2007 23 8 2007 23 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 adiponectin high-fat diet insulin resistance leptin metabolic syndrome obesity Type 2 diabetes...
Articles
Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
... receptor signalling in the development of Type 2 diabetic metabolic syndromes and end-organ injury has received little attention. The aim of this review is to examine the evidence as to whether glucagon and its receptor signalling play any role(s) in the pathogenesis of Type 2 diabetic renal injury...
Articles
Clin Sci (Lond) (2006) 111 (3): 185–187.
Published: 15 August 2006
... of Clinical Science . Correspondence: Dr Gary F. Lewis (email gary.lewis@uhn.on.ca ). apolipoprotein B-100 (apoB) cholesteryl ester transfer protein (CETP) fenofibrate fractional catabolic rate metabolic syndrome peroxisome-proliferator-activated receptor-α (PPAR-α) plasma phospholipid...
Articles
Clin Sci (Lond) (2006) 111 (3): 193–199.
Published: 15 August 2006
... (cholesteryl ester transfer protein) activities in men with MetS (the metabolic syndrome) treated with fenofibrate. Eleven men with MetS underwent a double-blind cross-over treatment with fenofibrate (200 mg/day) or placebo for 5 weeks. Compared with placebo, fenofibrate significantly increased the FCRs...
Articles
Clin Sci (Lond) (2006) 111 (1): 21–34.
Published: 14 June 2006
... in pathophysiological conditions such as hypertension, diabetes, metabolic syndrome and acute renal failure. Experimental evidence supports the concept that altered eicosanoid metabolism contributes to renal haemodynamic alterations and the development and progression of nephropathy. The possible beneficial renal...
Articles
Clin Sci (Lond) (2006) 110 (6): 665–671.
Published: 15 May 2006
...Troels Thim; Jacob F. Bentzon; Steen B. Kristiansen; Ulf Simonsen; Heidi L. Andersen; Karsten Wassermann; Erling Falk Obesity is associated with metabolic syndrome and increased incidence of and mortality from myocardial infarction. The aim of the present study was to develop an animal model...
Articles
Clin Sci (Lond) (2006) 110 (3): 267–278.
Published: 10 February 2006
...Yoshihisa Okamoto; Shinji Kihara; Tohru Funahashi; Yuji Matsuzawa; Peter Libby The metabolic syndrome, a cluster of metabolic disorders often associated with visceral obesity, increases cardiovascular mortality and morbidity. As the body's largest endocrine organ, adipose tissue not only stores...
Articles
Clin Sci (Lond) (2005) 109 (4): 413–420.
Published: 23 September 2005
...Leanne Bellinger; Simon C. Langley-Evans Undernutrition in fetal life programmes risk of obesity and the metabolic syndrome in adult life. Rat studies indicate that exposure to a maternal low-protein diet throughout fetal life establishes a preference for high-fat foods. The present study aimed...
Articles
Clin Sci (Lond) (2005) 109 (2): 143–159.
Published: 25 July 2005
... in other cells. Finally, the components of the metabolic syndrome can impair endothelial function. Correspondence: Dr Casper G. Schalkwijk, Department of Internal Medicine, Maastricht University, Debeyelaan 25, 6202 AZ Maastricht, The Netherlands (email C.Schalkwijk@intmed.unimaas.nl ). 19 1...
Articles
Clin Sci (Lond) (2005) 109 (1): 1–11.
Published: 23 June 2005
... to many adult diseases in humans, such as Type II diabetes, cardiovascular disease, hypertension and the metabolic syndrome. Obesity is a causal factor in all these conditions. There are epidemiological studies linking low birth weight to increased adiposity, but the timing of the insult during gestation...
Articles
Clin Sci (Lond) (2005) 108 (6): 553–559.
Published: 24 May 2005
...Seung-Ha PARK; Won-Young LEE; Eun-Jung RHEE; Woo-Kyu JEON; Byung-Ik KIM; Seung-Ho RYU; Sun-Woo KIM A new simple criterion for diagnosing metabolic syndrome was proposed in the third report of the NCEP (National Cholesterol Education Program). In the present study, we analysed the association...
Articles
Clin Sci (Lond) (2004) 107 (3): 233–249.
Published: 24 August 2004
... on our understanding of the dysregulation and therapeutic regulation of lipoprotein transport in the metabolic syndrome based on the application of stable isotope and modelling methods. Dysregulation of lipoprotein metabolism in metabolic syndrome may be due to a combination of overproduction of VLDL...
Articles
Clin Sci (Lond) (2004) 107 (3): 221–232.
Published: 24 August 2004
...Dick C. CHAN; P. Hugh R. BARRETT; Gerald F. WATTS The metabolic syndrome encapsulates visceral obesity, insulin resistance, diabetes, hypertension and dyslipidaemia. Dyslipidaemia is a cardinal feature of the metabolic syndrome that accelerates the risk of cardiovascular disease. It is usually...
Articles
Clin Sci (Lond) (2002) 103 (4): 397–402.
Published: 05 September 2002
...Maria G. MELIS; Giannina SECCHI; Patrizia BRIZZI; Cristiana SEVERINO; Mario MAIOLI; Giancarlo TONOLO The β 3 -adrenergic receptor (β 3 AR) plays a critical role in lipid metabolism, and thus alterations in its function may be involved in the metabolic syndrome. Indeed, we have found previously...
Articles
Clin Sci (Lond) (2002) 102 (3): 345–352.
Published: 14 February 2002
...Daniel GOUDE; Björn FAGERBERG; Johannes HULTHE It has been shown that a light-to-moderate intake of alcohol may enhance insulin sensitivity; a decrease in insulin sensitivity is a component of the clustering of risk factors known as the metabolic syndrome. However, previous studies have been...
Articles
Clin Sci (Lond) (2001) 100 (4): 443–449.
Published: 20 March 2001
...Hans HERLITZ; Lena BOKEMARK; Eva-Lena ALENHAG; John WIKSTRAND; Björn FAGERBERG The activity of the erythrocyte transport system, sodium/lithium countertransport (SLC), has been linked to the metabolic syndrome characterized by insulin resistance and compensatory hyperinsulinaemia. We measured SLC...
Articles
Clin Sci (Lond) (2000) 99 (6): 511–516.
Published: 07 November 2000
... CLA supplementation are unknown. abdominal obesity CLA human isoprostanes lipid peroxidation metabolic syndrome prostaglandins The Biochemical Society and the Medical Research Society © 2000 2000 27 4 2000 16 6 2000 7 8 2000 Correspondence : Dr S. Basu (e...