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Keywords: metabolic syndrome
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Articles
Clin Sci (Lond) (2022) 136 (5): 345–360.
Published: 09 March 2022
.... Over the past few years, increasing evidence has implicated renal mitochondrial damage in the pathogenesis of common etiologies of CKD, such as diabetes, hypertension, metabolic syndrome (MetS), chronic renal ischemia, and polycystic kidney disease (PKD). However, most compelling evidence is based...
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Clin Sci (Lond) (2021) 135 (19): 2265–2283.
Published: 13 October 2021
... HFpEF and the metabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid...
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Clin Sci (Lond) (2020) 134 (16): 2117–2135.
Published: 21 August 2020
... of the Biochemical Society 2020 cirrhosis diabetes insulin resistance metabolic syndrome microbiota sarcopenia Cirrhosis is a liver disease characterized by dissection of the hepatic lobules by fibrous septa. The original lobular architecture of the liver parenchyma is progressively transformed...
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Clin Sci (Lond) (2018) 132 (7): 791–811.
Published: 16 April 2018
... of the host towards a low-grade chronic inflammation, a hallmark of metabolic syndrome. The primary objective of this review is to examine and discuss some very current research that has been done to study the effect of bacterial metabolites on host metabolism, sometimes referred to as microbiota-host co...
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Clin Sci (Lond) (2017) 131 (7): 595–607.
Published: 17 March 2017
.... 12 1 2017 24 1 2017 27 1 2017 27 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 benign prostatic hyperplasia ERK pathway metabolic syndrome oxytocin • Benign prostatic hyperplasia (BPH) is caused...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (4): 327–328.
Published: 30 January 2017
... on behalf of the Biochemical Society 2017 brown adipose tissue nonshivering thermogenesis metabolic syndrome Visceral obesity, i.e. the excessive fat accumulation in the adipose depots located inside the peritoneal cavity, is associated with the development of several chronic metabolic...
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Clin Sci (Lond) (2017) 131 (1): 27–36.
Published: 09 December 2016
... antineoplastic properties. For metabolic syndrome patients with hepatocellular carcinoma (HCC), metformin may provide antitumoral effects. We evaluated the impact of metformin on tumour growth and visceral fat composition using relevant preclinical models of metabolic syndrome. Studies were performed in three...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 127 (1): 1–13.
Published: 10 March 2014
... peptide cardiac hypertrophy gene variant heart failure NT-proANP levels hypertension metabolic syndrome vascular damage Studies performed in the SHRsp (stroke-prone spontaneously hypertensive rat) animal model, a spontaneous model of hypertension with a higher predisposition to vascular...
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Clin Sci (Lond) (2013) 125 (1): 19–25.
Published: 13 March 2013
...Jennifer A. Thompson; R. Clinton Webb The developmental origins of the metabolic syndrome have been established through the consistent observation that small-for-gestational age and large-for-gestational age fetuses have an increased risk for hypertension and related metabolic disorders later...
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Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
... Richard.Coward@bristol.ac.uk ). 13 7 2012 14 9 2012 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 diabetes diabetic nephropathy insulin intracellular signalling kidney metabolic syndrome The role of insulin in the human body has been...
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Clin Sci (Lond) (2010) 119 (10): 431–436.
Published: 05 August 2010
... chronic liver disease cirrhosis hepatic fibrosis metabolic syndrome non-alcoholic fatty liver disease (NAFLD) Adiponectin is a 244-amino-acid adipocytokine that plays a pivotal role in metabolic liver diseases. Adiponectin is produced by adipocytes [ 1 , 2 ] and circulates at high...
Includes: Supplementary data
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Clin Sci (Lond) (2010) 118 (1): 47–59.
Published: 02 October 2009
... lipid. © The Authors Journal compilation © 2010 Biochemical Society 2010 birth Caesarean section liver metabolic syndrome steatosis total parenteral nutrition (TPN) The number of babies born by elective CS (Caesarean section) has increased dramatically in the past 25 years...
Includes: Supplementary data
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Clin Sci (Lond) (2009) 117 (5): 173–190.
Published: 03 August 2009
...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...
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Clin Sci (Lond) (2008) 115 (1): 13–23.
Published: 02 June 2008
... of adipocytes are found in this disorder [ 1 ]. Adipose tissue has been shown to secrete various proteins, so-called adipokines. Over the last few years, it has become obvious that obesity and various components of the metabolic syndrome, such as insulin resistance and hypertension, are strongly linked due...
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Clin Sci (Lond) (2008) 115 (1): 1–12.
Published: 02 June 2008
.... Correspondence: Dr Paola Loria (email loria.paola@unimore.it ). 4 9 2007 13 11 2007 21 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 atherosclerosis cardiovascular disease energy homoeostasis fatty acid metabolic syndrome non-alcoholic fatty liver...
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Clin Sci (Lond) (2008) 114 (10): 611–624.
Published: 14 April 2008
...Esther M. M. Ooi; P. Hugh R. Barrett; Dick C. Chan; Gerald F. Watts The concurrence of visceral obesity, insulin resistance and dyslipidaemia comprises the concept of the metabolic syndrome. The metabolic syndrome is an escalating problem in developed and developing societies that tracks...
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Clin Sci (Lond) (2008) 114 (3): 195–210.
Published: 08 January 2008
...Heiko Bugger; E. Dale Abel The metabolic syndrome represents a cluster of abnormalities, including obesity, insulin resistance, dyslipidaemia and Type 2 diabetes, that increases the risk of developing cardiovascular diseases, such as coronary artery disease and heart failure. The heart failure risk...
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Clin Sci (Lond) (2007) 113 (10): 397–399.
Published: 12 October 2007
...: Dr Marie C. Guldstrand (email marie.guldstrand@ds.se ). 30 7 2007 22 8 2007 23 8 2007 23 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 adiponectin high-fat diet insulin resistance leptin metabolic syndrome obesity Type 2 diabetes...
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Clin Sci (Lond) (2006) 111 (3): 185–187.
Published: 15 August 2006
... atherosclerosis. Correspondence: Dr Gary F. Lewis (email gary.lewis@uhn.on.ca ). 7 6 2006 9 6 2006 9 6 2006 The Biochemical Society 2006 apolipoprotein B-100 (apoB) cholesteryl ester transfer protein (CETP) fenofibrate fractional catabolic rate metabolic syndrome...
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Clin Sci (Lond) (2006) 111 (1): 21–34.
Published: 14 June 2006
... in pathophysiological conditions such as hypertension, diabetes, metabolic syndrome and acute renal failure. Experimental evidence supports the concept that altered eicosanoid metabolism contributes to renal haemodynamic alterations and the development and progression of nephropathy. The possible beneficial renal...
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Clin Sci (Lond) (2006) 110 (3): 267–278.
Published: 10 February 2006
...Yoshihisa Okamoto; Shinji Kihara; Tohru Funahashi; Yuji Matsuzawa; Peter Libby The metabolic syndrome, a cluster of metabolic disorders often associated with visceral obesity, increases cardiovascular mortality and morbidity. As the body's largest endocrine organ, adipose tissue not only stores...
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Clin Sci (Lond) (2005) 109 (4): 413–420.
Published: 23 September 2005
...Leanne Bellinger; Simon C. Langley-Evans Undernutrition in fetal life programmes risk of obesity and the metabolic syndrome in adult life. Rat studies indicate that exposure to a maternal low-protein diet throughout fetal life establishes a preference for high-fat foods. The present study aimed...
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Clin Sci (Lond) (2005) 109 (2): 143–159.
Published: 25 July 2005
... in other cells. Finally, the components of the metabolic syndrome can impair endothelial function. Correspondence: Dr Casper G. Schalkwijk, Department of Internal Medicine, Maastricht University, Debeyelaan 25, 6202 AZ Maastricht, The Netherlands (email C.Schalkwijk@intmed.unimaas.nl ). 19 1...
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Clin Sci (Lond) (2005) 109 (1): 1–11.
Published: 23 June 2005
... to many adult diseases in humans, such as Type II diabetes, cardiovascular disease, hypertension and the metabolic syndrome. Obesity is a causal factor in all these conditions. There are epidemiological studies linking low birth weight to increased adiposity, but the timing of the insult during gestation...
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Clin Sci (Lond) (2001) 100 (4): 443–449.
Published: 20 March 2001
...Hans HERLITZ; Lena BOKEMARK; Eva-Lena ALENHAG; John WIKSTRAND; Björn FAGERBERG The activity of the erythrocyte transport system, sodium/lithium countertransport (SLC), has been linked to the metabolic syndrome characterized by insulin resistance and compensatory hyperinsulinaemia. We measured SLC...
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Clin Sci (Lond) (2000) 99 (6): 511–516.
Published: 07 November 2000
... metabolic syndrome prostaglandins 511Clinical Science (2000) 99, 511 516 (Printed in Great Britain) Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity S. BASU*, U. RISE! RUS*, A. TURPEINEN and B. VESSBY* *Sections of Geriatrics and Clinical Nutrition Research, Faculty...