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Articles

Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Maria V. Irazabal, Alejandro R. Chade, Alfonso Eirin

Clin Sci (Lond) (2022) 136 (5): 345–360.

https://doi.org/10.1042/CS20210512

Published: 09 March 2022

.... Over the past few years, increasing evidence has implicated renal mitochondrial damage in the pathogenesis of common etiologies of CKD, such as diabetes, hypertension, metabolic syndrome (MetS), chronic renal ischemia, and polycystic kidney disease (PKD). However, most compelling evidence is based...

View article titled, Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Articles

Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Jennifer Leggat, Guillaume Bidault, Antonio Vidal-Puig

Clin Sci (Lond) (2021) 135 (19): 2265–2283.

https://doi.org/10.1042/CS20210127

Published: 13 October 2021

... HFpEF and the metabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid...

View article titled, Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Articles

Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments

Frédéric Clarembeau, Georgia Bale, Nicolas Lanthier

Clin Sci (Lond) (2020) 134 (16): 2117–2135.

https://doi.org/10.1042/CS20200022

Published: 21 August 2020

... ( nicolas.lanthier@uclouvain.be ) 02 04 2020 17 07 2020 31 07 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cirrhosis diabetes insulin resistance metabolic syndrome microbiota sarcopenia Cirrhosis is a liver disease...

View article titled, Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments

Articles

Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice

Jian Wang, Ying Wang, Limei Liu, Kabirullah Lutfy, Theodore C. Friedman, Ya Liu, Meisheng Jiang, Yanjun Liu

Clin Sci (Lond) (2019) 133 (21): 2189–2202.

https://doi.org/10.1042/CS20190679

Published: 08 November 2019

...Jian Wang; Ying Wang; Limei Liu; Kabirullah Lutfy; Theodore C. Friedman; Ya Liu; Meisheng Jiang; Yanjun Liu Excessive glucocorticoid (GC) production in adipose tissue promotes the development of visceral obesity and metabolic syndrome (MS). 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1...

View article titled, Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice

Articles

Disruptions in gut microbial-host co-metabolism and the development of metabolic disorders

Cynthia Rajani, Wei Jia

Clin Sci (Lond) (2018) 132 (7): 791–811.

https://doi.org/10.1042/CS20171328

Published: 16 April 2018

... of the host towards a low-grade chronic inflammation, a hallmark of metabolic syndrome. The primary objective of this review is to examine and discuss some very current research that has been done to study the effect of bacterial metabolites on host metabolism, sometimes referred to as microbiota-host co...

View article titled, Disruptions in gut microbial-host co-metabolism and the development of metabolic disorders

Articles

Oxytocin: its role in benign prostatic hyperplasia via the ERK pathway

Huan Xu, Shi Fu, Yanbo Chen, Qi Chen, Meng Gu, Chong Liu, Zhiguang Qiao, Juan Zhou, Zhong Wang

Clin Sci (Lond) (2017) 131 (7): 595–607.

https://doi.org/10.1042/CS20170030

Published: 17 March 2017

.... 12 1 2017 24 1 2017 27 1 2017 27 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 benign prostatic hyperplasia ERK pathway metabolic syndrome oxytocin • Benign prostatic hyperplasia (BPH) is caused...

View article titled, Oxytocin: its role in benign prostatic hyperplasia via the ERK pathway

Includes: Supplementary data

Articles

Turning up the heat against metabolic syndrome and non-alcoholic fatty liver disease

William T. Festuccia

Clin Sci (Lond) (2017) 131 (4): 327–328.

https://doi.org/10.1042/CS20160855

Published: 30 January 2017

... on behalf of the Biochemical Society 2017 brown adipose tissue nonshivering thermogenesis metabolic syndrome Visceral obesity, i.e. the excessive fat accumulation in the adipose depots located inside the peritoneal cavity, is associated with the development of several chronic metabolic...

View article titled, Turning up the heat against metabolic syndrome and non-alcoholic fatty liver disease

Articles

Defective adaptive thermogenesis contributes to metabolic syndrome and liver steatosis in obese mice

Laurence Poekes, Vanessa Legry, Olivier Schakman, Christine Detrembleur, Anne Bol, Yves Horsmans, Geoffrey C. Farrell, Isabelle A. Leclercq

Clin Sci (Lond) (2017) 131 (4): 285–296.

https://doi.org/10.1042/CS20160469

Published: 20 January 2017

...Laurence Poekes; Vanessa Legry; Olivier Schakman; Christine Detrembleur; Anne Bol; Yves Horsmans; Geoffrey C. Farrell; Isabelle A. Leclercq Fatty liver diseases are complications of the metabolic syndrome associated with obesity, insulin resistance and low grade inflammation. Our aim was to uncover...

View article titled, Defective adaptive thermogenesis contributes to metabolic syndrome and liver steatosis in obese mice

Includes: Supplementary data

Articles

Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis

François Cauchy, Mouniya Mebarki, Benjamin Leporq, Samira Laouirem, Miguel Albuquerque, Simon Lambert, Pierre Bourgoin, Olivier Soubrane, Bernard E. Van Beers, Sandrine Faivre, Pierre Bedossa, Valérie Paradis

Clin Sci (Lond) (2017) 131 (1): 27–36.

https://doi.org/10.1042/CS20160438

Published: 09 December 2016

... antineoplastic properties. For metabolic syndrome patients with hepatocellular carcinoma (HCC), metformin may provide antitumoral effects. We evaluated the impact of metformin on tumour growth and visceral fat composition using relevant preclinical models of metabolic syndrome. Studies were performed in three...

View article titled, Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis

Includes: Supplementary data

Articles

Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro : relevance to human metabolic syndrome

Giulio Ceolotto, Saula Vigili De Kreutzenberg, Arianna Cattelan, Aline S. C. Fabricio, Elisa Squarcina, Massimo Gion, Andrea Semplicini, Gian Paolo Fadini, Angelo Avogaro

Clin Sci (Lond) (2014) 127 (7): 449–461.

https://doi.org/10.1042/CS20130439

Published: 17 June 2014

...) of subjects with and without the metabolic syndrome (MS), by immunoprecipitation (IP) of the ribonucleoprotein (RNP) complex. We found that SIRT1 overexpression prevented TNF-α- and high-glucose-dependent nuclear factor-κB (NF-κB)-p65 acetylation, E-selectin promoter activity, E-selectin release and adhesion...

View article titled, Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro : relevance to human metabolic syndrome

Articles

Atrial natriuretic peptide gene variants and circulating levels: implications in cardiovascular diseases

Speranza Rubattu, Sebastiano Sciarretta, Massimo Volpe

Clin Sci (Lond) (2014) 127 (1): 1–13.

https://doi.org/10.1042/CS20130427

Published: 10 March 2014

... peptide cardiac hypertrophy gene variant heart failure NT-proANP levels hypertension metabolic syndrome vascular damage Studies performed in the SHRsp (stroke-prone spontaneously hypertensive rat) animal model, a spontaneous model of hypertension with a higher predisposition to vascular...

View article titled, Atrial natriuretic peptide gene variants and circulating levels: implications in cardiovascular diseases

Articles

Low CD34 + cells, high neutrophils and the metabolic syndrome are associated with an increased risk of venous thromboembolism

Marcello Rattazzi, Sabina Villalta, Silvia Galliazzo, Laura Del Pup, Alessandra Sponchiado, Elisabetta Faggin, Elisa Bertacco, Roberta Buso, Elena Seganfreddo, Valeria Pagliara, Elena Callegari, Massimo Puato, Livio Caberlotto, Gianluigi Scannapieco, Gian Paolo Fadini, Paolo Pauletto

Clin Sci (Lond) (2013) 125 (4): 211–222.

https://doi.org/10.1042/CS20120698

Published: 01 May 2013

... The relationship between MetS (metabolic syndrome), levels of circulating progenitor/immune cells and the risk of VTE (venous thromboembolism) has not yet been investigated. We studied 240 patients with previous VTE and 240 controls. The presence of MetS was identified according to NCEP ATP III guidelines and flow...

View article titled, Low CD34 + cells, high neutrophils and the metabolic syndrome are associated with an increased risk of venous thromboembolism

Includes: Supplementary data

Articles

Antioxidant treatment prevents the development of fructose-induced abdominal adipose tissue dysfunction

Juan Pablo Fariña, María Elisa García, Ana Alzamendi, Andrés Giovambattista, Carlos Alberto Marra, Eduardo Spinedi, Juan José Gagliardino

Clin Sci (Lond) (2013) 125 (2): 87–97.

https://doi.org/10.1042/CS20120470

Published: 26 March 2013

...-induced AAT dysfunctions in normal rats strongly suggests that OS plays an important role in the FRD-induced MS (metabolic syndrome) phenotype. 30 8 2012 29 11 2012 6 2 2013 6 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Isolated adipocytes were...

View article titled, Antioxidant treatment prevents the development of fructose-induced abdominal adipose tissue dysfunction

Articles

Potential role of Toll-like receptors in programming of vascular dysfunction

Jennifer A. Thompson, R. Clinton Webb

Clin Sci (Lond) (2013) 125 (1): 19–25.

https://doi.org/10.1042/CS20120673

Published: 13 March 2013

...Jennifer A. Thompson; R. Clinton Webb The developmental origins of the metabolic syndrome have been established through the consistent observation that small-for-gestational age and large-for-gestational age fetuses have an increased risk for hypertension and related metabolic disorders later...

View article titled, Potential role of Toll-like receptors in programming of vascular dysfunction

Articles

Insulin signalling to the kidney in health and disease

Lorna J. Hale, Richard J. M. Coward

Clin Sci (Lond) (2013) 124 (6): 351–370.

https://doi.org/10.1042/CS20120378

Published: 27 November 2012

... Richard.Coward@bristol.ac.uk ). 13 7 2012 14 9 2012 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 diabetes diabetic nephropathy insulin intracellular signalling kidney metabolic syndrome The role of insulin in the human body has been...

View article titled, Insulin signalling to the kidney in health and disease

Articles

Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1α in a rat model

Adriana L. Burgueño, Tomas F. Gianotti, Noelia G. Mansilla, Carlos J. Pirola, Silvia Sookoian

Clin Sci (Lond) (2013) 124 (1): 53–63.

https://doi.org/10.1042/CS20120151

Published: 07 September 2012

... rats, after exposure to long-term HFD. Overall, compared with the control strain, SHRs clustered some features of the metabolic syndrome, including elevated blood pressure and IR ( Figure 1 ). Figure 1 Phenotypic characteristics and biometric variables in the disease model (SHR...

View article titled, Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1α in a rat model

Includes: Supplementary data

Articles

Enhanced phosphorylation of Na + –Cl − co-transporter in experimental metabolic syndrome: role of insulin

Radko Komers, Shaunessy Rogers, Terry T. Oyama, Bei Xu, Chao-Ling Yang, James McCormick, David H. Ellison

Clin Sci (Lond) (2012) 123 (11): 635–647.

https://doi.org/10.1042/CS20120003

Published: 01 August 2012

...Radko Komers; Shaunessy Rogers; Terry T. Oyama; Bei Xu; Chao-Ling Yang; James McCormick; David H. Ellison In the present study, we investigated the activity of the thiazide-sensitive NCC (Na + –Cl − co-transporter) in experimental metabolic syndrome and the role of insulin in NCC activation. Renal...

View article titled, Enhanced phosphorylation of Na + –Cl − co-transporter in experimental metabolic syndrome: role of insulin

Articles

Thymic stromal lymphopoietin: an immune cytokine gene associated with the metabolic syndrome and blood pressure in severe obesity

Valérie Turcot, Luigi Bouchard, Geneviève Faucher, Véronique Garneau, André Tchernof, Yves Deshaies, Louis Pérusse, Simon Marceau, Simon Biron, Odette Lescelleur, Laurent Biertho, Marie-Claude Vohl

Clin Sci (Lond) (2012) 123 (2): 99–109.

https://doi.org/10.1042/CS20110584

Published: 27 March 2012

... stromal lymphopoietin) gene was less expressed in severely obese men with ( n =7) compared with without ( n =7) the MetS (metabolic syndrome). We hypothesized that TSLP SNPs (single nucleotide polymorphisms) are associated with TSLP gene expression in VAT and with MetS phenotypes. Following validation...

View article titled, Thymic stromal lymphopoietin: an immune cytokine gene associated with the metabolic syndrome and blood pressure in severe obesity

Includes: Supplementary data

Articles

Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome

Yi Tan, Mohammad A. Kamal, Zheng-Zhong Wang, Wei Xiao, John P. Seale, Xianqin Qu

Clin Sci (Lond) (2011) 120 (7): 297–305.

https://doi.org/10.1042/CS20100441

Published: 13 December 2010

...Yi Tan; Mohammad A. Kamal; Zheng-Zhong Wang; Wei Xiao; John P. Seale; Xianqin Qu The metabolic syndrome has reached epidemic proportions worldwide, but currently there is a lack of effective therapies for this multifactorial endocrine disease. TCM (traditional Chinese medicine) has been utilized...

View article titled, Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome

Articles

Significance of serum adiponectin levels in patients with chronic liver disease

Maria Luisa Balmer, Jeannine Joneli, Alain Schoepfer, Felix Stickel, Wolfgang Thormann, Jean-François Dufour

Clin Sci (Lond) (2010) 119 (10): 431–436.

https://doi.org/10.1042/CS20100008

Published: 05 August 2010

... chronic liver disease cirrhosis hepatic fibrosis metabolic syndrome non-alcoholic fatty liver disease (NAFLD) Adiponectin is a 244-amino-acid adipocytokine that plays a pivotal role in metabolic liver diseases. Adiponectin is produced by adipocytes [ 1 , 2 ] and circulates at high...

View article titled, Significance of serum adiponectin levels in patients with chronic liver disease

Includes: Supplementary data

Articles

Postprandial oxidative stress is modified by dietary fat: evidence from a human intervention study

Pablo Perez-Martinez, Jose Maria Garcia-Quintana, Elena M. Yubero-Serrano, Inmaculada Tasset-Cuevas, Isaac Tunez, Antonio Garcia-Rios, Javier Delgado-Lista, Carmen Marin, Francisco Perez-Jimenez, Helen M. Roche, Jose Lopez-Miranda

Clin Sci (Lond) (2010) 119 (6): 251–261.

https://doi.org/10.1042/CS20100015

Published: 15 June 2010

... stress may play an important role in MetS (metabolic syndrome)-related manifestations. Dietary fat quality has been proposed to be critical in oxidative stress and the pathogenesis of the MetS. In the present study, we investigated whether oxidative stress parameters are affected by diets with different...

View article titled, Postprandial oxidative stress is modified by dietary fat: evidence from a human intervention study

Articles

Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet

Vanessa Souza-Mello, Bianca M. Gregório, Fernando S. Cardoso-de-Lemos, Laís de Carvalho, Márcia B. Aguila, Carlos A. Mandarim-de-Lacerda

Clin Sci (Lond) (2010) 119 (6): 239–250.

https://doi.org/10.1042/CS20100061

Published: 08 June 2010

...) in the drug-treated groups. In conclusion, all of the drug treatments were effective in controlling the metabolic syndrome. The best results were achieved using telmisartan and sitagliptin as monotherapies or as a dual treatment, combining partial PPAR-γ agonism and PPAR-α activation in the liver...

View article titled, Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet

Articles

Natriuretic peptides and cardiovascular damage in the metabolic syndrome: molecular mechanisms and clinical implications

Carmine Savoia, Massimo Volpe, Alessandro Alonzo, Chiara Rossi, Speranza Rubattu

Clin Sci (Lond) (2010) 118 (4): 231–240.

https://doi.org/10.1042/CS20090204

Published: 09 November 2009

..., diuretic and natriuretic properties. In addition, natriuretic peptides may play a role in the modulation of the molecular mechanisms involved in metabolic regulation and cardiovascular remodelling. The metabolic syndrome is characterized by visceral obesity, hyperlipidaemia, vascular inflammation...

View article titled, Natriuretic peptides and cardiovascular damage in the metabolic syndrome: molecular mechanisms and clinical implications

Articles

Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets

Matthew J. Hyde, Julian L. Griffin, Emilio Herrera, Christopher D. Byrne, Lynne Clarke, Paul R. Kemp

Clin Sci (Lond) (2010) 118 (1): 47–59.

https://doi.org/10.1042/CS20090169

Published: 02 October 2009

... lipid. © The Authors Journal compilation © 2010 Biochemical Society 2010 birth Caesarean section liver metabolic syndrome steatosis total parenteral nutrition (TPN) The number of babies born by elective CS (Caesarean section) has increased dramatically in the past 25 years...

View article titled, Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets

Includes: Supplementary data

Articles

Effects of insulin resistance on endothelial progenitor cells and vascular repair

Richard M. Cubbon, Matthew B. Kahn, Stephen B. Wheatcroft

Clin Sci (Lond) (2009) 117 (5): 173–190.

https://doi.org/10.1042/CS20080263

Published: 03 August 2009

...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...

View article titled, Effects of insulin resistance on endothelial progenitor cells and vascular repair

Articles

IGF-I/IGFBP-3 ratio: a mechanistic insight into the metabolic syndrome

Justo Sierra-Johnson, Abel Romero-Corral, Virend K. Somers, Francisco Lopez-Jimenez, Anders Mälarstig, Kerstin Brismar, Anders Hamsten, Rachel M. Fisher, Mai-Lis Hellénius

Clin Sci (Lond) (2009) 116 (6): 507–512.

https://doi.org/10.1042/CS20080382

Published: 12 February 2009

... and opposing mechanistic effects on insulin. The aim of the present study was to assess the relationship between the IGF-I/IGFBP-3 ratio and the metabolic syndrome. We examined 3281 subjects (1463 men and 1818 women, aged 20–49 years), otherwise healthy adults, who participated in NHANES III (Third National...

View article titled, IGF-I/IGFBP-3 ratio: a mechanistic insight into the metabolic syndrome

Articles

Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine

Grit Sommer, Antje Garten, Stefanie Petzold, Annette G. Beck-Sickinger, Matthias Blüher, Michael Stumvoll, Mathias Fasshauer

Clin Sci (Lond) (2008) 115 (1): 13–23.

https://doi.org/10.1042/CS20070226

Published: 02 June 2008

... of adipocytes are found in this disorder [ 1 ]. Adipose tissue has been shown to secrete various proteins, so-called adipokines. Over the last few years, it has become obvious that obesity and various components of the metabolic syndrome, such as insulin resistance and hypertension, are strongly linked due...

View article titled, Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine

Articles

Is liver fat detrimental to vessels?: intersections in the pathogenesis of NAFLD and atherosclerosis

Paola Loria, Amedeo Lonardo, Giovanni Targher

Clin Sci (Lond) (2008) 115 (1): 1–12.

https://doi.org/10.1042/CS20070311

Published: 02 June 2008

.... Correspondence: Dr Paola Loria (email loria.paola@unimore.it ). 4 9 2007 13 11 2007 21 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 atherosclerosis cardiovascular disease energy homoeostasis fatty acid metabolic syndrome non-alcoholic fatty liver...

View article titled, Is liver fat detrimental to vessels?: intersections in the pathogenesis of NAFLD and atherosclerosis

Articles

Apolipoprotein C-III: understanding an emerging cardiovascular risk factor

Esther M. M. Ooi, P. Hugh R. Barrett, Dick C. Chan, Gerald F. Watts

Clin Sci (Lond) (2008) 114 (10): 611–624.

https://doi.org/10.1042/CS20070308

Published: 14 April 2008

...Esther M. M. Ooi; P. Hugh R. Barrett; Dick C. Chan; Gerald F. Watts The concurrence of visceral obesity, insulin resistance and dyslipidaemia comprises the concept of the metabolic syndrome. The metabolic syndrome is an escalating problem in developed and developing societies that tracks...

View article titled, Apolipoprotein C-III: understanding an emerging cardiovascular risk factor

Articles

Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome

Heiko Bugger, E. Dale Abel

Clin Sci (Lond) (2008) 114 (3): 195–210.

https://doi.org/10.1042/CS20070166

Published: 08 January 2008

...Heiko Bugger; E. Dale Abel The metabolic syndrome represents a cluster of abnormalities, including obesity, insulin resistance, dyslipidaemia and Type 2 diabetes, that increases the risk of developing cardiovascular diseases, such as coronary artery disease and heart failure. The heart failure risk...

View article titled, Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome

Articles

Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome

Concepción M. Aguilera, Mercedes Gil-Campos, Ramón Cañete, Ángel Gil

Clin Sci (Lond) (2008) 114 (3): 183–193.

https://doi.org/10.1042/CS20070115

Published: 08 January 2008

...Concepción M. Aguilera; Mercedes Gil-Campos; Ramón Cañete; Ángel Gil The MS (metabolic syndrome) is a cluster of clinical and biochemical abnormalities characterized by central obesity, dyslipidaemia [hypertriglyceridaemia and decreased HDL-C (high-density lipoprotein cholesterol)], glucose...

View article titled, Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome

Articles

Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats

Natalia Sinitskaya, Sylviane Gourmelen, Carole Schuster-Klein, Béatrice Guardiola-Lemaitre, Paul Pévet, Etienne Challet

Clin Sci (Lond) (2007) 113 (10): 417–425.

https://doi.org/10.1042/CS20070182

Published: 12 October 2007

...Natalia Sinitskaya; Sylviane Gourmelen; Carole Schuster-Klein; Béatrice Guardiola-Lemaitre; Paul Pévet; Etienne Challet Metabolic disorders induced by high-fat feeding in rodents evoke some, if not all, of the features of human metabolic syndrome. The occurrence and severity of metabolic disorders...

View article titled, Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats

Articles

High-fat diets: healthy or unhealthy?

Marie C. Guldstrand, Caroline L. Simberg

Clin Sci (Lond) (2007) 113 (10): 397–399.

https://doi.org/10.1042/CS20070263

Published: 12 October 2007

...: Dr Marie C. Guldstrand (email marie.guldstrand@ds.se ). 30 7 2007 22 8 2007 23 8 2007 23 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 adiponectin high-fat diet insulin resistance leptin metabolic syndrome obesity Type 2 diabetes...

View article titled, High-fat diets: healthy or unhealthy?

Articles

Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise

Xiao C. Li, Jia L. Zhuo

Clin Sci (Lond) (2007) 113 (4): 183–193.

https://doi.org/10.1042/CS20070040

Published: 13 July 2007

... receptor signalling in the development of Type 2 diabetic metabolic syndromes and end-organ injury has received little attention. The aim of this review is to examine the evidence as to whether glucagon and its receptor signalling play any role(s) in the pathogenesis of Type 2 diabetic renal injury...

View article titled, Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise

Articles

Are the lipid-modifying effects of fibrates mediated by alterations in plasma lipid transfer activity?

Gary F. Lewis

Clin Sci (Lond) (2006) 111 (3): 185–187.

https://doi.org/10.1042/CS20060140

Published: 15 August 2006

... atherosclerosis. Correspondence: Dr Gary F. Lewis (email gary.lewis@uhn.on.ca ). 7 6 2006 9 6 2006 9 6 2006 The Biochemical Society 2006 apolipoprotein B-100 (apoB) cholesteryl ester transfer protein (CETP) fenofibrate fractional catabolic rate metabolic syndrome...

View article titled, Are the lipid-modifying effects of fibrates mediated by alterations in plasma lipid transfer activity?

Articles

Relationships between changes in plasma lipid transfer proteins and apolipoprotein B-100 kinetics during fenofibrate treatment in the metabolic syndrome

Gerald F. Watts, Juying Ji, Dick C. Chan, Esther M. M. Ooi, Anthony G. Johnson, Kerry-Anne Rye, P. Hugh R. Barrett

Clin Sci (Lond) (2006) 111 (3): 193–199.

https://doi.org/10.1042/CS20060072

Published: 15 August 2006

... (cholesteryl ester transfer protein) activities in men with MetS (the metabolic syndrome) treated with fenofibrate. Eleven men with MetS underwent a double-blind cross-over treatment with fenofibrate (200 mg/day) or placebo for 5 weeks. Compared with placebo, fenofibrate significantly increased the FCRs...

View article titled, Relationships between changes in plasma lipid transfer proteins and apolipoprotein B-100 kinetics during fenofibrate treatment in the metabolic syndrome

Articles

Eicosanoids and renal vascular function in diseases

John D. Imig

Clin Sci (Lond) (2006) 111 (1): 21–34.

https://doi.org/10.1042/CS20050251

Published: 14 June 2006

... in pathophysiological conditions such as hypertension, diabetes, metabolic syndrome and acute renal failure. Experimental evidence supports the concept that altered eicosanoid metabolism contributes to renal haemodynamic alterations and the development and progression of nephropathy. The possible beneficial renal...

View article titled, Eicosanoids and renal vascular function in diseases

Articles

Size of myocardial infarction induced by ischaemia/reperfusion is unaltered in rats with metabolic syndrome

Troels Thim, Jacob F. Bentzon, Steen B. Kristiansen, Ulf Simonsen, Heidi L. Andersen, Karsten Wassermann, Erling Falk

Clin Sci (Lond) (2006) 110 (6): 665–671.

https://doi.org/10.1042/CS20050326

Published: 15 May 2006

...Troels Thim; Jacob F. Bentzon; Steen B. Kristiansen; Ulf Simonsen; Heidi L. Andersen; Karsten Wassermann; Erling Falk Obesity is associated with metabolic syndrome and increased incidence of and mortality from myocardial infarction. The aim of the present study was to develop an animal model...

View article titled, Size of myocardial infarction induced by ischaemia/reperfusion is unaltered in rats with metabolic syndrome

Articles

Adiponectin: a key adipocytokine in metabolic syndrome

Yoshihisa Okamoto, Shinji Kihara, Tohru Funahashi, Yuji Matsuzawa, Peter Libby

Clin Sci (Lond) (2006) 110 (3): 267–278.

https://doi.org/10.1042/CS20050182

Published: 10 February 2006

...Yoshihisa Okamoto; Shinji Kihara; Tohru Funahashi; Yuji Matsuzawa; Peter Libby The metabolic syndrome, a cluster of metabolic disorders often associated with visceral obesity, increases cardiovascular mortality and morbidity. As the body's largest endocrine organ, adipose tissue not only stores...

View article titled, Adiponectin: a key adipocytokine in metabolic syndrome

Articles

Fetal programming of appetite by exposure to a maternal low-protein diet in the rat

Leanne Bellinger, Simon C. Langley-Evans

Clin Sci (Lond) (2005) 109 (4): 413–420.

https://doi.org/10.1042/CS20050127

Published: 23 September 2005

...Leanne Bellinger; Simon C. Langley-Evans Undernutrition in fetal life programmes risk of obesity and the metabolic syndrome in adult life. Rat studies indicate that exposure to a maternal low-protein diet throughout fetal life establishes a preference for high-fat foods. The present study aimed...

View article titled, Fetal programming of appetite by exposure to a maternal low-protein diet in the rat

Articles

Vascular complications in diabetes mellitus: the role of endothelial dysfunction

Casper G. Schalkwijk, Coen D. A. Stehouwer

Clin Sci (Lond) (2005) 109 (2): 143–159.

https://doi.org/10.1042/CS20050025

Published: 25 July 2005

... in other cells. Finally, the components of the metabolic syndrome can impair endothelial function. Correspondence: Dr Casper G. Schalkwijk, Department of Internal Medicine, Maastricht University, Debeyelaan 25, 6202 AZ Maastricht, The Netherlands (email C.Schalkwijk@intmed.unimaas.nl ). 19 1...

View article titled, Vascular complications in diabetes mellitus: the role of endothelial dysfunction

Articles

Fetal and perinatal programming of appetite

Roselle L. CRIPPS, Malgorzata S. MARTIN-GRONERT, Susan E. OZANNE

Clin Sci (Lond) (2005) 109 (1): 1–11.

https://doi.org/10.1042/CS20040367

Published: 23 June 2005

... to many adult diseases in humans, such as Type II diabetes, cardiovascular disease, hypertension and the metabolic syndrome. Obesity is a causal factor in all these conditions. There are epidemiological studies linking low birth weight to increased adiposity, but the timing of the insult during gestation...

View article titled, Fetal and perinatal programming of appetite

Articles

Relative risks of the metabolic syndrome according to the degree of insulin resistance in apparently healthy Korean adults

Seung-Ha PARK, Won-Young LEE, Eun-Jung RHEE, Woo-Kyu JEON, Byung-Ik KIM, Seung-Ho RYU, Sun-Woo KIM

Clin Sci (Lond) (2005) 108 (6): 553–559.

https://doi.org/10.1042/CS20040331

Published: 24 May 2005

...Seung-Ha PARK; Won-Young LEE; Eun-Jung RHEE; Woo-Kyu JEON; Byung-Ik KIM; Seung-Ho RYU; Sun-Woo KIM A new simple criterion for diagnosing metabolic syndrome was proposed in the third report of the NCEP (National Cholesterol Education Program). In the present study, we analysed the association...

View article titled, Relative risks of the metabolic syndrome according to the degree of insulin resistance in apparently healthy Korean adults

Articles

Lipoprotein transport in the metabolic syndrome: pathophysiological and interventional studies employing stable isotopy and modelling methods

Dick C. CHAN, P. Hugh R. BARRETT, Gerald F. WATTS

Clin Sci (Lond) (2004) 107 (3): 233–249.

https://doi.org/10.1042/CS20040109

Published: 24 August 2004

... on our understanding of the dysregulation and therapeutic regulation of lipoprotein transport in the metabolic syndrome based on the application of stable isotope and modelling methods. Dysregulation of lipoprotein metabolism in metabolic syndrome may be due to a combination of overproduction of VLDL...

View article titled, Lipoprotein transport in the metabolic syndrome: pathophysiological and interventional studies employing stable isotopy and modelling methods

Articles

Lipoprotein transport in the metabolic syndrome: methodological aspects of stable isotope kinetic studies

Dick C. CHAN, P. Hugh R. BARRETT, Gerald F. WATTS

Clin Sci (Lond) (2004) 107 (3): 221–232.

https://doi.org/10.1042/CS20040108

Published: 24 August 2004

...Dick C. CHAN; P. Hugh R. BARRETT; Gerald F. WATTS The metabolic syndrome encapsulates visceral obesity, insulin resistance, diabetes, hypertension and dyslipidaemia. Dyslipidaemia is a cardinal feature of the metabolic syndrome that accelerates the risk of cardiovascular disease. It is usually...

View article titled, Lipoprotein transport in the metabolic syndrome: methodological aspects of stable isotope kinetic studies

Articles

The Trp64Arg β3-adrenergic receptor amino acid variant confers increased sensitivity to the pressor effects of noradrenaline in Sardinian subjects

Maria G. MELIS, Giannina SECCHI, Patrizia BRIZZI, Cristiana SEVERINO, Mario MAIOLI, Giancarlo TONOLO

Clin Sci (Lond) (2002) 103 (4): 397–402.

https://doi.org/10.1042/cs1030397

Published: 05 September 2002

...Maria G. MELIS; Giannina SECCHI; Patrizia BRIZZI; Cristiana SEVERINO; Mario MAIOLI; Giancarlo TONOLO The β 3 -adrenergic receptor (β 3 AR) plays a critical role in lipid metabolism, and thus alterations in its function may be involved in the metabolic syndrome. Indeed, we have found previously...

View article titled, The Trp64Arg β3-adrenergic receptor amino acid variant confers increased sensitivity to the pressor effects of noradrenaline in Sardinian subjects

Articles

Alcohol consumption, the metabolic syndrome and insulin resistance in 58-year-old clinically healthy men (AIR study)

Daniel GOUDE, Björn FAGERBERG, Johannes HULTHE

Clin Sci (Lond) (2002) 102 (3): 345–352.

https://doi.org/10.1042/cs1020345

Published: 14 February 2002

...Daniel GOUDE; Björn FAGERBERG; Johannes HULTHE It has been shown that a light-to-moderate intake of alcohol may enhance insulin sensitivity; a decrease in insulin sensitivity is a component of the clustering of risk factors known as the metabolic syndrome. However, previous studies have been...

View article titled, Alcohol consumption, the metabolic syndrome and insulin resistance in 58-year-old clinically healthy men (AIR study)

Articles

Sodium/lithium countertransport, insulin resistance, insulin peptides and microalbuminuria in clinically healthy 58-year-old men

Hans HERLITZ, Lena BOKEMARK, Eva-Lena ALENHAG, John WIKSTRAND, Björn FAGERBERG

Clin Sci (Lond) (2001) 100 (4): 443–449.

https://doi.org/10.1042/cs1000443

Published: 20 March 2001

...Hans HERLITZ; Lena BOKEMARK; Eva-Lena ALENHAG; John WIKSTRAND; Björn FAGERBERG The activity of the erythrocyte transport system, sodium/lithium countertransport (SLC), has been linked to the metabolic syndrome characterized by insulin resistance and compensatory hyperinsulinaemia. We measured SLC...

View article titled, Sodium/lithium countertransport, insulin resistance, insulin peptides and microalbuminuria in clinically healthy 58-year-old men

Articles

Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity

S. BASU, U. RISÉRUS, A. TURPEINEN, B. VESSBY

Clin Sci (Lond) (2000) 99 (6): 511–516.

https://doi.org/10.1042/cs0990511

Published: 07 November 2000

... metabolic syndrome prostaglandins 511Clinical Science (2000) 99, 511 516 (Printed in Great Britain) Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity S. BASU*, U. RISE! RUS*, A. TURPEINEN and B. VESSBY* *Sections of Geriatrics and Clinical Nutrition Research, Faculty...

View article titled, Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity

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