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Keywords: metabolic programming
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Articles

Maternal high-fat diet induces long-term obesity with sex-dependent metabolic programming of adipocyte differentiation, hypertrophy and dysfunction in the offspring

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Adipose biology, cardiovascular and cardiometabolic disease , Clinical and translational research highlights
Thorsten Litzenburger, Eva-Kristina Huber, Katharina Dinger, Rebecca Wilke, Christina Vohlen, Jaco Selle, Mazlum Kadah, Thorsten Persigehl, Carola Heneweer, Jörg Dötsch, Miguel A. Alejandre Alcazar
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 921–939.
https://doi.org/10.1042/CS20191229
Published: 17 April 2020
... (WAT) orchestrates metabolic pathways, and its dysfunction contributes to metabolic disorders in a sex-dependent manner. Here, we tested if sex differences influence the molecular mechanisms of metabolic programming of WAT in offspring of obese dams. To this end, maternal obesity was induced with high...
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Articles

Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring

Eleanor Jarvie, Sylvie Hauguel-de-Mouzon, Scott M. Nelson, Naveed Sattar, Patrick M. Catalano, Dilys J. Freeman
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (3): 123–129.
https://doi.org/10.1042/CS20090640
Published: 28 April 2010
... ], and this could be interpreted as ‘pear-shaped’ women being efficient at storing fat in lower-body depots that provide protection against metabolic risk and endothelial dysfunction. body fat lipotoxicity metabolic programming non-esterified fatty acid (NEFA) obesity pregnancy The 70–100...
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Articles

Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine

Alan A. JACKSON, Rebecca L. DUNN, Michael C. MARCHAND, Simon C. LANGLEY-EVANS
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (6): 633–639.
https://doi.org/10.1042/cs1030633
Published: 19 November 2002
.... Correspondence : Professor Alan A. Jackson (e-mail iohn@soton.ac.uk ). 21 3 2002 1 8 2002 21 9 2002 The Biochemical Society and the Medical Research Society © 2002 2002 alanine amino acid fetus glycine growth hypertension metabolic programming methionine pregnancy protein...
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