... of Clinical Science , Giachini and co-workers found that clopidogrel could normalize the increased phenylephrine-induced vascular contraction and the impaired acetylcholine-induced vasodilation in mesenteric arteries from AngII (angiotensin II)-infused Sprague–Dawley rats. This might develop a new area...

... for 14 days. The animals were treated with clopidogrel (10 mg·kg −1 of body weight·day −1 ) or vehicle. Vascular reactivity was evaluated in second-order mesenteric arteries. Clopidogrel treatment did not change systolic blood pressure [(mmHg) control-vehicle, 117±7.1 versus control-clopidogrel, 125±4.2...

...; atrial, ventricular and lung weights were increased. Coronary artery adventitial and medial thickness were increased, but mesenteric arterial wall morphology was unaffected. Coronary artery relaxation to ACH, ISO, FSK and SNP were reduced in banded animals. In contrast, relaxation of mesenteric arteries...

... conductivity pre-eclampsia mesenteric artery microvascular permeability oncotic pressure Pre-eclampsia occurs in 5% of first pregnancies and is characterized by widespread endothelial dysfunction [ 1 ]. Failure of adequate trophoblast invasion results in an underperfused placenta and the release...

... normalized diameters, were not significantly different in SHR and WKY rat femoral (0.41±0.03 and 0.40±0.02 respectively) or mesenteric (0.56±0.02 and 0.63±0.03 respectively) arteries. Arterial mechanical analyses demonstrated that incremental elastic modulus is reduced in SHR mesenteric arteries...

...-related increases in protein kinase C (PKC) activity in the streptozotocin-diabetic rat. PKC activity in the glomeruli, retina and mesenteric artery was increased by 1.5–2-fold after induction of diabetes, and this increase was maintained over 24 weeks. Treatment with insulin at 2 units or 6 units per day...

... of Key words: Mesenteric artery; noradrenaline; pregnancy; vascular reactiviy. Abbreviations: ADRP, rats mating 2 weeks after adriamycin administration; ADRV, virgin rats studied 5 weeks after adriamycin administration; MAP, mean arterial pressure; L-NAME, p-nitrc-L-arginine-methyl ester: NP, normal...

... of octreotide can increase vascular responsiveness in rats with portal hypertension. 2. Portal hypertension was induced by partial portal vein ligation. Octreotide was given for 9 days subcutaneously (100 μg/kg every 12 h) starting 1 day before ligation. The aorta and mesenteric artery were then removed...

...Jane A. Madden; G. A. Smith; J. G. Llaurado 1. Hypertension was induced in rats by substituting 2% (w/v) sodium chloride solution for drinking water. Sodium distribution in isolated mesenteric arterial wall was studied with the aid of 22 Na, which was continuously washed out. Data were analysed...