.... Macrophage polarization is involved in tissue injury and repair, and is regulated by Notch signaling during certain inflammatory diseases. The present study explores the relationship among hyperglycemia, macrophage polarization, and Notch signaling during AP and the related mechanisms. A cerulein-induced AP...

... of mucin-secreting goblet cells in the colon crypt in a macrophage-dependent manner by using clodronate liposomes. Furthermore, in vivo and in vitro studies were conducted, validating that butyrate facilitates M2 macrophage polarization with the elevated expressions of CD206 and arginase-1 (Arg1...

... ) or Jian Kong ( jian_kong2019@tom.com ) 11 01 2020 13 08 2020 28 08 2020 28 08 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 acute coronary syndrome CREB signaling foam cell macrophage polarization Phactr1...

...Yan Tang; Yao Shi; Yifei Gao; Xiaomeng Xu; Ting Han; Jingxin Li; Chuanyong Liu Inflammatory bowel disease (IBD) is a chronic intestinal inflammation, but the accurate etiology remains to be elucidated. Increasing evidence has shown that macrophages polarize to different phenotypes depending...

...Yujia Yuan; Younan Chen; Tianqing Peng; Lan Li; Wuzheng Zhu; Fei Liu; Shuyun Liu; Xingxing An; Ruixi Luo; Jingqiu Cheng; Jingping Liu; Yanrong Lu Macrophage polarization toward the M1 phenotype and its subsequent inflammatory response have been implicated in the progression of diabetic...

... from treated adipocytes. The targeted inhibition of macrophage CD74 prevented M1 macrophage polarization in the above co-culture model. The COX-2-dependent increases in CD74 gene expression and MIF release in M1-polarized macrophages facilitated the expression of COX-2 and MIF in co-cultured SGBS...