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Clin Sci (Lond) (2024) 137 (S1): A1–A42.
Published: 01 March 2024
... or operation of any methods, products, instruments, or ideas contained in the content. A4 Clinical Science (2023) 137 Suppl 1 A5-A42 httpsdoi.org/10.1042/CS2023ECCR001 5 Phosphoproteomics analysis reveals that angiotensin(1-5) inhibits mTOR signalling and cell senescence in human endothelial cells Igor Maciel...
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Clin Sci (Lond) (2024) 138 (5): 269–288.
Published: 27 February 2024
... 1.04 2.24E-06 0.74 0.000713 MAP2K1 1.96 0.0433 Activated 2.16 0.00658 MAP2K4 Activated 2.19 0.00573 1.64 0.0456 MAPK8 1.98 0.000343 MTOR -0.21 0.0152 PLCG1 -0.28 9.89E-05 -1.18 0.00319 -0.16 0.0408 SRC 0.25 1.06...
Includes: Supplementary data
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Expression of XDH in the kidney throughout postnatal development  ( A ) Rep...
Published: 27 February 2024
Figure 1 Expression of XDH in the kidney throughout postnatal development ( A ) Representative images (dark brown: XDH) and ( B ) quantification of the immunohistochemical staining of XDH in the kidney cortices of SS Xdh+/+ (WT), SS Xdh+/− (Het), and SS Xdh-/- (Homo) rats collected at postnata... More about this image found in Expression of XDH in the kidney throughout postnatal development ( A ) Rep...
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Structural differences throughout the postnatal development in the rat kidn...
Published: 27 February 2024
Figure 2 Structural differences throughout the postnatal development in the rat kidney ( A ) Representative images of full kidney slices stained with Masson’s Trichrome of the SS Xdh+/+ (WT) and SS Xdh-/− (Homo) rats at postnatal day (PND) 0, 5, 15, and 21. ( B ) Representative images of the ki... More about this image found in Structural differences throughout the postnatal development in the rat kidn...
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Gene expression patterns in the kidney tissue  ( A ) Principal Component An...
Published: 27 February 2024
Figure 3 Gene expression patterns in the kidney tissue ( A ) Principal Component Analysis (PCA) plot and ( B ) heatmap with hierarchical clustering of the gene expression of SS Xdh+/+ (WT), SS Xdh+/− (Het), and SS Xdh-/- (Homo) rats collected at Postnatal day (PND) 0, 5, 15, and 21; N = 3–4 ... More about this image found in Gene expression patterns in the kidney tissue ( A ) Principal Component An...
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Comparative analyses related to differentially expressed genes in homozygot...
Published: 27 February 2024
Figure 4 Comparative analyses related to differentially expressed genes in homozygotes compared with wild-type in each of the timepoint ( A ) Top Canonical Pathways (only the top 30 are shown) and ( B ) Tox Functions that are related to the kidney. Orange: predicted to be up-regulated/activated, ... More about this image found in Comparative analyses related to differentially expressed genes in homozygot...
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Heatmaps of the diseases and biological functions associated with temporal ...
Published: 27 February 2024
Figure 5 Heatmaps of the diseases and biological functions associated with temporal comparisons in SS Xdh+/+ (WT), SS Xdh+/− (Het), and SS Xdh-/- (Homo) transcriptomes Analyses ‘a’, ‘b’, and ‘c’ (See Tables 1 and 2 for details) are used. The top 15 annotations that are predicted by a compa... More about this image found in Heatmaps of the diseases and biological functions associated with temporal ...
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Differentially expressed (DE) genes related to kidney formation in homozygo...
Published: 27 February 2024
Figure 6 Differentially expressed (DE) genes related to kidney formation in homozygotes compared with the wild-types ( A ) Fold change of the DE genes related to kidney formation. Red arrows: genes of interest. ( B ) Fold change of the DE genes in the EGF signaling pathway. Orange: up-regulated, ... More about this image found in Differentially expressed (DE) genes related to kidney formation in homozygo...
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Overlap of genes that are differentially expressed in postnatal day (PND) 1...
Published: 27 February 2024
Figure 7 Overlap of genes that are differentially expressed in postnatal day (PND) 15 versus 5 in SS Xdh+/+ (WT) and SS Xdh-/- (Homo) transcriptomes ( A ) A chord diagram of the DE genes in the PND15 compared with PND5 in WT and Homo rats. Analysis ‘e’ was used (see Tables 1 and 2 for detai... More about this image found in Overlap of genes that are differentially expressed in postnatal day (PND) 1...
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Protein expression related to the genes of interest in postnatal day (PND) ...
Published: 27 February 2024
Figure 8 Protein expression related to the genes of interest in postnatal day (PND) 5, 15, and 21 in SS Xdh+/+ (WT) and SS Xdh-/- (Homo) rat kidneys ( A ) Western blots, ( B ) relative quantification of EGFR, STAT3, phosphorylated STAT3, cleaved caspase 3, catalase, TIMP-1 and COX-2 proteins. (... More about this image found in Protein expression related to the genes of interest in postnatal day (PND) ...
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TMP alleviated kidney injury and ferroptosis in rats with CIN  ( A ) Flowch...
Published: 27 February 2024
Figure 1 TMP alleviated kidney injury and ferroptosis in rats with CIN ( A ) Flowchart of CIN rat model construction. ( B ) Hematoxylin-eosin staining of renal tissue. ( C ) Scr, BUN, UNAG, and UGGT levels of rats with CIN ( n =8). ( D ) Representative images of ferroptosis in kidney tissue based... More about this image found in TMP alleviated kidney injury and ferroptosis in rats with CIN ( A ) Flowch...
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TMP alleviated intracellular Fe 2+  accumulation and ferroptosis in CIN HK-...
Published: 27 February 2024
Figure 2 TMP alleviated intracellular Fe 2+ accumulation and ferroptosis in CIN HK-2 cells ( A ) Morphology was examined using phase-contrast microscopy at 200× magnification. ( B ) Cell viability was measured at 0, 3, 6, 12, and 24 h using CCK-8 assay ( C,D ) Intracellular Fe 2+ and LDH levels... More about this image found in TMP alleviated intracellular Fe 2+ accumulation and ferroptosis in CIN HK-...
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Ferroptosis inhibitors alleviated iohexol-induced cell death and intracellu...
Published: 27 February 2024
Figure 3 Ferroptosis inhibitors alleviated iohexol-induced cell death and intracellular ROS production in vitro ( A–C ) HK-2 cell viability was tested by the CCK-8 assay after Fer-1 and DFO treatment. ( D ) Intracellular ROS measured using flow cytometry. ( E ) Detection of GSH level. ( F ) Wes... More about this image found in Ferroptosis inhibitors alleviated iohexol-induced cell death and intracellu...
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TMP alleviates ferroptosis in CIN by inhibiting TFRC  ( A,B ) The knockdown...
Published: 27 February 2024
Figure 4 TMP alleviates ferroptosis in CIN by inhibiting TFRC ( A,B ) The knockdown efficiency of TFRC in HK-2 cells was evaluated using qRT-PCR and Western blotting. ( C ) Western blotting results of TFRC protein in CIN HK-2 cells. ( D ) Cell viability was measured at 0, 3, 6, 12, and 24 h using... More about this image found in TMP alleviates ferroptosis in CIN by inhibiting TFRC ( A,B ) The knockdown...
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TFRC overexpression abolished the effects of TMP on ferroptosis and intrace...
Published: 27 February 2024
Figure 5 TFRC overexpression abolished the effects of TMP on ferroptosis and intracellular ROS production in CIN HK-2 cells ( A,B ) The overexpression efficiency of TFRC in HK-2 cells was evaluated using qRT-PCR and Western blotting. ( C ) Western blotting results of TFRC protein. ( D ) Cell viab... More about this image found in TFRC overexpression abolished the effects of TMP on ferroptosis and intrace...
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Mechanisms by which TMP modulates ferroptosis in CIN  After co-incubation w...
Published: 27 February 2024
Figure 6 Mechanisms by which TMP modulates ferroptosis in CIN After co-incubation with iohexol, various proteins associated with iron ion transport significantly changed, along with an upregulation of intracellular iron overload and lipid peroxidation (black arrows). After TMP pretreatment, only ... More about this image found in Mechanisms by which TMP modulates ferroptosis in CIN After co-incubation w...
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GSK126 decreases methylation and increases acetylation of H3K27  in vivo  a...
Published: 27 February 2024
Figure 1 GSK126 decreases methylation and increases acetylation of H3K27 in vivo and in vitro H3K27 modifications were quantified in lysates from aortas of young (3-month-old) mice treated with GSK126 or vehicle for 4 weeks and 8 weeks and primary human aortic smooth muscle cells (HASMCs) tre... More about this image found in GSK126 decreases methylation and increases acetylation of H3K27 in vivo a...
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EZH2 inhibition with GSK126 increases vascular stiffness in young and middl...
Published: 27 February 2024
Figure 2 EZH2 inhibition with GSK126 increases vascular stiffness in young and middle-aged mice ( A,B ) Young (3-month-old) and ( C,D) middle-aged (12-month-old) mice were randomized to vehicle or GSK126 treatment and aortic stiffness was measured by abdominal aortic pulse wave velocity (PWV) us... More about this image found in EZH2 inhibition with GSK126 increases vascular stiffness in young and middl...
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GSK126 induces the synthetic smooth muscle cell phenotype, cellular stiffne...
Published: 27 February 2024
Figure 3 GSK126 induces the synthetic smooth muscle cell phenotype, cellular stiffness and cytoskeletal rearrangement in primary human aortic smooth cells HASMCs from donors under 30 years of age were treated with vehicle (Veh) or GSK126 for 48 h: ( A ) Quantification of mRNA expression of contra... More about this image found in GSK126 induces the synthetic smooth muscle cell phenotype, cellular stiffne...
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EZH2 inhibition does not impact fibrosis in mice and in human SMCs  Young m...
Published: 27 February 2024
Figure 4 EZH2 inhibition does not impact fibrosis in mice and in human SMCs Young mice were treated for 8 weeks with GSK126 or vehicle and aortic tissue was isolated. ( A ) Representative images of aortic sections stained with Masson’s trichrome. Scale bar = 100 µM. Quantification of ( B ) vascul... More about this image found in EZH2 inhibition does not impact fibrosis in mice and in human SMCs Young m...
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EZH2 inhibition increase vascular mmp2 expression and elastin degradation  ...
Published: 27 February 2024
Figure 5 EZH2 inhibition increase vascular mmp2 expression and elastin degradation Young and middle-aged mice were treated with GSK126 or vehicle. ( A ) Elastin fiber integrity was quantified in aortic sections stained with Verhoeff's Van Gieson Stain. Representative images are displayed. Scale b... More about this image found in EZH2 inhibition increase vascular mmp2 expression and elastin degradation ...
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GSK126 increases MMP2 promoter acetylation, mRNA and protein expression, an...
Published: 27 February 2024
Figure 6 GSK126 increases MMP2 promoter acetylation, mRNA and protein expression, and enzyme activity HASMCs from young donors were treated with vehicle or GSK126 for 24 and 48 h. ( A ) Quantification of MMP2 mRNA expression. ( B ) Representative immunoblots and quantification of MMP2 protein exp... More about this image found in GSK126 increases MMP2 promoter acetylation, mRNA and protein expression, an...
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EZH2 inhibition with GSK126 induces aortic stiffening  in vivo  in mice and...
Published: 27 February 2024
Figure 7 EZH2 inhibition with GSK126 induces aortic stiffening in vivo in mice and in vitro in primary human vascular smooth muscle cells. The data are consistent with a model in which H3K27 methylation (me) is decreased by EZH2 inhibition with GSK126 which leads to: (1) SMC phenotype switchi... More about this image found in EZH2 inhibition with GSK126 induces aortic stiffening in vivo in mice and...
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Lifetime number of TCs, survival, seizure bouts and gaps  ( A ) Kaplan–Meie...
Published: 21 February 2024
Figure 1 Lifetime number of TCs, survival, seizure bouts and gaps ( A ) Kaplan–Meier survival curves (solid lines) for 17 females and 17 males. Log rank test P -value <0.0001. Cumulative number of TCs is shown in dotted lines. ( B ) Pattern of TC frequency by day for a representative female (... More about this image found in Lifetime number of TCs, survival, seizure bouts and gaps ( A ) Kaplan–Meie...
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BBB paracellular permeability to sucrose is increased in male and female D/...
Published: 21 February 2024
Figure 2 BBB paracellular permeability to sucrose is increased in male and female D/+ mice both before and after seizure onset In situ brain perfusion with 14C-sucrose as a vascular permeability marker shows significantly elevated radioactivity represented by brain-to-perfusate radioactivity ra... More about this image found in BBB paracellular permeability to sucrose is increased in male and female D/...
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Genes and pathways identified by analysis of RNAseq data that are shared by...
Published: 21 February 2024
Figure 3 Genes and pathways identified by analysis of RNAseq data that are shared by the sexes or unique to each sex Number of differentially expressed genes (DEGs) identified in ( A ) pre-TC and ( B ) post-TC females and males. Number of significantly enriched canonical pathways identified by IP... More about this image found in Genes and pathways identified by analysis of RNAseq data that are shared by...
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Canonical pathways in (A) pre-TC females and (B) males  Bubble charts showi...
Published: 21 February 2024
Figure 4 Canonical pathways in (A) pre-TC females and (B) males Bubble charts showing significantly enriched pathways (−log [ P -value-] ≥ 1.3) that are color-coded by strength of activation (positive z -score ≥ +2.0) or deactivation (negative z -score ≤ −2.0). Circumference of pie chart repres... More about this image found in Canonical pathways in (A) pre-TC females and (B) males Bubble charts showi...
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Integrative model for sex differences in epileptogenesis  Impaired inactiva...
Published: 21 February 2024
Figure 6 Integrative model for sex differences in epileptogenesis Impaired inactivation gating caused by the N1768D Na V 1.6 variant is shown at the top, resulting in persistent sodium current, (1) glutamate excitotoxicity, and (2) downstream oxidative stress (OS). This process continues througho... More about this image found in Integrative model for sex differences in epileptogenesis Impaired inactiva...
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Possible associations between COVID-19 and menstrual disturbance.  Summary ...
Published: 19 February 2024
Figure 1 Possible associations between COVID-19 and menstrual disturbance. Summary of the symptoms of abnormal uterine bleeding (AUB), as defined by the FIGO AUB System 1 [ 15 ], and the different aspects of COVID-19 which may be associated with reported menstrual changes. More about this image found in Possible associations between COVID-19 and menstrual disturbance. Summary ...
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Classification of abnormal uterine bleeding (AUB) using PALM-COEIN, and the...
Published: 19 February 2024
Figure 2 Classification of abnormal uterine bleeding (AUB) using PALM-COEIN, and the hypothesised mechanisms of menstrual disturbance with COVID-19. ( A ) Structural causes of AUB including Polyp, Adenomyosis, Leiomyoma and Malignancy (PALM). Non-structural causes of AUB including Coagulopathy, O... More about this image found in Classification of abnormal uterine bleeding (AUB) using PALM-COEIN, and the...
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The impact of the menstrual cycle on COVID-19  The potential role of ovaria...
Published: 19 February 2024
Figure 3 The impact of the menstrual cycle on COVID-19 The potential role of ovarian hormones, estrogen (E 2 ) and progesterone (P 4 ) on the development and symptomatology of acute COVID-19 and long COVID (IL, interleukin; CCL2, chemokine ligand 2; TNF, tumour necrosis factor; Treg: regulatory T... More about this image found in The impact of the menstrual cycle on COVID-19 The potential role of ovaria...
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Semaglutide and BAM15 did not alter total food intake  Chemical structures ...
Published: 19 February 2024
Figure 1 Semaglutide and BAM15 did not alter total food intake Chemical structures of BAM15 and semaglutide ( A ). Letters in circles indicate one-letter amino acid code for peptide section of semaglutide. Aib = aminoisobutyric acid. Daily food intake ( B ), cumulative food intake ( C ), and tota... More about this image found in Semaglutide and BAM15 did not alter total food intake Chemical structures ...
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High-dose semaglutide combined with BAM15 decreased body weight and body fa...
Published: 19 February 2024
Figure 2 High-dose semaglutide combined with BAM15 decreased body weight and body fat composition Schematic diagram of treatment regime ( A ). Weekly body weight during WD conditioning (before dotted line) and treatment period (after dotted line) ( B ). Weekly monitoring of fat mass ( C ) and fat... More about this image found in High-dose semaglutide combined with BAM15 decreased body weight and body fa...
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Tissue wet weights at termination  Wet weights of single gonadal and inguin...
Published: 19 February 2024
Figure 3 Tissue wet weights at termination Wet weights of single gonadal and inguinal fat pads ( A ), fat pad weights normalised to body weight ( B ), wet weights of quadriceps and gastrocnemius muscles ( C ), muscle weights normalised to body weight ( D ). Semag = semaglutide. * indicates P <... More about this image found in Tissue wet weights at termination Wet weights of single gonadal and inguin...
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High-dose semaglutide combined with BAM15 caused the greatest improvement i...
Published: 19 February 2024
Figure 4 High-dose semaglutide combined with BAM15 caused the greatest improvement in glucose homeostasis Glucose tolerance curves ( A ), total area under the curve ( B ), and incremental area under the curve ( C ) after 4 weeks of treatment. Fasting glucose levels ( D ) and fasting insulin level... More about this image found in High-dose semaglutide combined with BAM15 caused the greatest improvement i...
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Liver triglyceride content was decreased by combination treatments of BAM15...
Published: 19 February 2024
Figure 5 Liver triglyceride content was decreased by combination treatments of BAM15 and semaglutide Liver wet weights as raw values ( A ) and normalized to body weight ( B ). Liver triglyceride content in frozen liver tissue ( C ). Semag = semaglutide. * indicates P <0.05 by one-way ANOVA wi... More about this image found in Liver triglyceride content was decreased by combination treatments of BAM15...
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Blood pressure in 2/3 Nx rats treated with NaCl (n=6, closed triangles) or ...
Published: 19 February 2024
Figure 1 Blood pressure in 2/3 Nx rats treated with NaCl (n=6, closed triangles) or NaHCO 3 (n=6, open circles) for 7 weeks. ( A ) Mean arterial pressure in mmHg over 1 week of control (baseline) and 7 weeks of high Na + (0.1 M NaCl, closed triangles or 0.1 M NaHCO 3 , open circles) treatment.... More about this image found in Blood pressure in 2/3 Nx rats treated with NaCl (n=6, closed triangles) or ...
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Blood pressure responses to NaHCO  3  and NaCl in 5/6 Nx and sham control r...
Published: 19 February 2024
Figure 2 Blood pressure responses to NaHCO 3 and NaCl in 5/6 Nx and sham control rats. Y -axis is blood pressure in mmHg. X -axis is time. ( A ) Diastolic blood pressure. ( B ) Mean arterial blood pressure. ( C ) Systolic blood pressure. ( D ) Change (Δ) in diastolic blood pressure from avera... More about this image found in Blood pressure responses to NaHCO 3 and NaCl in 5/6 Nx and sham control r...