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Keywords: mTOR
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Low CEACAM5 expression in HNSCC is associated with lymph node (N) stage  ( ...
Published: 25 November 2022
Figure 1 Low CEACAM5 expression in HNSCC is associated with lymph node (N) stage ( A,C ) Transcriptome sequencing was performed on HNSCC tissues and the results were visualized in a heatmap and volcano plot. CEACAM5 was identified as a DEG in HNSCC. L: HNSCC tissue with LN metastasis. NL: HNSCC t... More
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CEACAM5 expression is down-regulated in HNSCC tissue samples and is correla...
Published: 25 November 2022
Figure 2 CEACAM5 expression is down-regulated in HNSCC tissue samples and is correlated with prognosis ( A ) CEACAM5 expression was analyzed based on data from TCGA. ( B ) The protein expression of CEACAM5 in HNSCC tissues and adjacent normal tissues was analyzed by WB. NAT represents normal adja... More
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CEACAM5 inhibits the proliferative ability of HNSCC cells  ( A,B ) The effi...
Published: 25 November 2022
Figure 3 CEACAM5 inhibits the proliferative ability of HNSCC cells ( A,B ) The efficiencies of the different siRNAs in silencing CEACAM5 expression in FaDu cells were screened by qRT-PCR and WB. CEACAM5 knockdown and overexpression efficiencies in stably transduced FaDu and SCC15 cells were detec... More
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CEACAM5 inhibits proliferation, migration, and invasion and promotes apopto...
Published: 25 November 2022
Figure 4 CEACAM5 inhibits proliferation, migration, and invasion and promotes apoptosis in HNSCC cells in vitro ( A ) A colony formation assay was used to assess the tumorigenicity of HNSCC cells. ( B ) The migratory and invasive abilities of FaDu and SCC15 cells were assessed by Transwell assa... More
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CEACAM5 overexpression inhibits lymphatic metastasis  in vivo   ( A ) Proce...
Published: 25 November 2022
Figure 5 CEACAM5 overexpression inhibits lymphatic metastasis in vivo ( A ) Procedure and animal grouping in the in vivo experiment. ( B ) Representative images of inguinal LN metastasis in nude mice. ( C,G ) Foot pad tumors and inguinal LNs collected from nude mice. ( D,E ) Foot pad tumor vo... More
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CEACAM5 inhibits EMT in HNSCC cells  ( A ) Spearman’s correlation between t...
Published: 25 November 2022
Figure 6 CEACAM5 inhibits EMT in HNSCC cells ( A ) Spearman’s correlation between the expression of EMT-related transcription factors and that of CEACAM5 was analyzed based on data from TCGA. ( B,C ) The mRNA expression levels of EMT-associated transcription factors and markers in stably transfec... More
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CEACAM5 inhibits the expression of MDM2  ( A,B ) Gene ontology (GO) terms r...
Published: 25 November 2022
Figure 7 CEACAM5 inhibits the expression of MDM2 ( A,B ) Gene ontology (GO) terms related to the biological process (BP) category were assigned to genes associated with CEACAM5 and MDM2 based on HNSCC transcriptome-sequencing data. ( C,E ) The expression of CEACAM5 and MDM2 in normal and HNSCC ti... More
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MDM2 knockdown reversed the effect of CEACAM5 silencing on the EMT  sh-MDM2...
Published: 25 November 2022
Figure 8 MDM2 knockdown reversed the effect of CEACAM5 silencing on the EMT sh-MDM2-NC or sh-MDM2 was transfected into HNSCC cells after stable lentivirus-mediated transduction. ( A ) The mRNA levels of EMT-related transcription factors and biomarkers were measured by qRT-PCR. ( B ) The protein e... More
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Microbiome modifiers  Representative overview of the diverse overlapping an...
Published: 23 November 2022
Figure 1 Microbiome modifiers Representative overview of the diverse overlapping and interactive influences on the human gut microbiome composition and function. More
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Male mice with tamoxifen-inducible cardiomyocyte-specific BRAF knockout  BR...
Published: 21 November 2022
Figure 1 Male mice with tamoxifen-inducible cardiomyocyte-specific BRAF knockout BRAF fl/fl /Cre +/− (homozygous for floxed BRAF; hemizygous for Cre) male mice were treated with corn-oil (CO) or tamoxifen in CO (Tx) for 24 h or 11 d as indicated. ( A ) Confirmation of BRAF knockout using cDNA pr... More
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Cardiomyocyte BRAF knockout inhibits the hypertrophic response induced by A...
Published: 21 November 2022
Figure 2 Cardiomyocyte BRAF knockout inhibits the hypertrophic response induced by AngII in male mouse hearts Male BRAF fl/fl /Cre +/− (BRAF) or wild-type (WT) mice were treated with corn-oil vehicle (CO) or tamoxifen in CO (Tx) 4 days before minipumps (MP) were implanted to deliver acidified PB... More
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Cardiomyocyte BRAF knockout inhibits interstitial but not perivascular fibr...
Published: 21 November 2022
Figure 3 Cardiomyocyte BRAF knockout inhibits interstitial but not perivascular fibrosis induced by AngII in male mouse hearts Male BRAF fl/fl /Cre +/− (BRAF) or wild-type (WT) mice were treated with CO or tamoxifen in CO (Tx) 4 days before minipumps were implanted to deliver acidified PBS (AcPB... More
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Effects of cardiomyocyte BRAF knockout on changes in mRNA expression induce...
Published: 21 November 2022
Figure 4 Effects of cardiomyocyte BRAF knockout on changes in mRNA expression induced by AngII in male mouse hearts Male BRAF fl/fl /Cre +/− (BRAF) mice were treated with corn-oil (CO) or tamoxifen in CO (Tx) 4 days before minipumps were implanted to deliver acidified PBS (AcPBS) or 0.8 mg/kg/d ... More
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Cardiomyocyte BRAF knockout does not inhibit cardiomyocyte hypertrophy indu...
Published: 21 November 2022
Figure 5 Cardiomyocyte BRAF knockout does not inhibit cardiomyocyte hypertrophy induced by phenylephrine in male mouse hearts but increases cardiac fibrosis Male BRAF fl/fl /Cre +/− mice were treated with corn-oil (CO) or tamoxifen in CO (Tx) 4 days before minipumps were implanted to deliver PBS... More
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Comparison of cardiac function/dimensions and confirmation of recombination...
Published: 21 November 2022
Figure 6 Comparison of cardiac function/dimensions and confirmation of recombination in female BRAF fl/fl /Cre +/− mice compared with male littermates ( A–D ) Data were gathered from mice at the time of the first baseline echocardiogram taken from male and female BRAF fl/fl /Cre +/− littermates... More
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Assessment of the effects of cardiomyocyte BRAF knockout on the response of...
Published: 21 November 2022
Figure 7 Assessment of the effects of cardiomyocyte BRAF knockout on the response of female mouse hearts to phenylephrine Female BRAF fl/fl /Cre +/− mice were treated with corn-oil (CO) or tamoxifen in CO (Tx) 4 days before minipumps were implanted to deliver PBS or 40 mg/kg/d phenylephrine in P... More
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Comparison of effects of cardiomyocyte BRAF knockout on cardiac function in...
Published: 21 November 2022
Figure 8 Comparison of effects of cardiomyocyte BRAF knockout on cardiac function in male and female hearts Male and female BRAF fl/fl /Cre +/− mice were treated with CO or tamoxifen in CO (Tx) 4 days before minipumps were implanted to deliver PBS (PBS) or 40 mg/kg/d phenylephrine in PBS (PE) fo... More
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Schematic representations of the conclusions from this study  ( A ) AngII c...
Published: 21 November 2022
Figure 9 Schematic representations of the conclusions from this study ( A ) AngII causes hypertension and directly stimulates cells in the walls of cardiac arterioles (e.g. endothelial cells or smooth muscle cells). Acutely (over 7 d), this resulted in perivascular fibrosis around arterioles, alo... More
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Regional distribution of cardiac output during various intensities of exerc...
Published: 18 November 2022
Figure 1 Regional distribution of cardiac output during various intensities of exercise expressed as percent of maximal oxygen consumption More
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Timeline of NIPD milestones  Timeline showing the major milestones reached ...
Published: 16 November 2022
Figure 1 Timeline of NIPD milestones Timeline showing the major milestones reached for NIPD in the research, clinical, and commercial settings since the discovery of cffDNA in maternal plasma. Abbreviations: AR, autosomal recessive; cfDNA, cell-free DNA; ddPCR, droplet digital PCR; dPCR, digital ... More
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Non-invasive prenatal tests available and in development for diagnosis of m...
Published: 16 November 2022
Figure 2 Non-invasive prenatal tests available and in development for diagnosis of monogenic disease Diagram depicting the different tests that are currently available either in the public health or commercial settings for high- and low-risk pregnancies, as well as those which are in development ... More
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Schematic overview of RHDO and RMD for NIPD of AR and inherited X-linked co...
Published: 16 November 2022
Figure 3 Schematic overview of RHDO and RMD for NIPD of AR and inherited X-linked conditions ( A ) Representative family trees depicting possible familial haplotypes for AR and inherited X-linked conditions. Left hand panel: family tree shows parents that are heterozygous carriers for an AR condi... More
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Effects of sodium-glucose transporter 2 inhibitors (SGLT-2i) and glucagon-l...
Published: 16 November 2022
Figure 1 Effects of sodium-glucose transporter 2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on epicardial adipose tissue (ECAT) Increased ECAT thickness and volume is associated with heart failure (HF), myocardial infarction (MI), atrial fibrillation (AF), and co... More
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Effects of SGLT-2 inhibitors and GLP-1R agonists on PVAT  Dysfunctional PVA...
Published: 16 November 2022
Figure 2 Effects of SGLT-2 inhibitors and GLP-1R agonists on PVAT Dysfunctional PVAT secretome aggravates vascular diseases like atherosclerosis and CAD. Alleviation of PVAT dysfunction via SGLT-2 inhibition and/or GLP-1R activation is associated with improved vascular endothelial and smooth musc... More
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Effect of SGLT-2is on EDAT  SGLT-2 inhibition suppresses proinflammatory pr...
Published: 16 November 2022
Figure 3 Effect of SGLT-2is on EDAT SGLT-2 inhibition suppresses proinflammatory processes in EDAT by inhibiting cytokines release as well as macrophage infiltration. SGLT-2is promote EDAT thermogenesis via uncoupling protein 1 (UCP1). SGLT-2 inhibition in EDAT is associated with lower expression... More
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Effect of GLP-1RAs on EDAT  GLP-1RAs support the healthy expansion of EDAT ...
Published: 16 November 2022
Figure 4 Effect of GLP-1RAs on EDAT GLP-1RAs support the healthy expansion of EDAT by enhancing angiogenesis, a process which reduces hypertrophy-induced hypoxia. Additionally, GLP-1RA are associated with enhanced hyperplasia. Abbreviations: Akt, Protein kinase B; ERK, extracellular signal-regula... More
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A model system establishment to study the p38 role in EMT and inflammation ...
Published: 14 November 2022
Figure 1 A model system establishment to study the p38 role in EMT and inflammation ( A ) A cartoon illustration of a dashed box displaying the fetal membrane location in the human embryo. ( B ) A Representative image showing human fetal membrane structure. An arrow is displaying the orientation ... More
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Reconstructing amnion membrane using p38 KO AEC-RFP and nude membrane  ( A ...
Published: 14 November 2022
Figure 2 Reconstructing amnion membrane using p38 KO AEC-RFP and nude membrane ( A ) CRISPR/Cas9 transfection condition optimization in AEC-RFP cells using TRAC gene deletion. TRAC gene was successfully knocked out two different transfection conditions (x1 and x2, see Methods section) using C... More
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Analysis of p38 KO cellular fate and phenotypes using imaging mass cytometr...
Published: 14 November 2022
Figure 3 Analysis of p38 KO cellular fate and phenotypes using imaging mass cytometry ( A ) Cartoon representing the amnion compartment of the fetal membrane with WT and p38 KO AEC in CTRL vs . OS environment to determine their phenotype and fate using imaging mass cytometry technology. ( B ) Gr... More
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p38 KO AEC show diminished senescence  ( A)  Senescence-associated β-galact...
Published: 14 November 2022
Figure 4 p38 KO AEC show diminished senescence ( A) Senescence-associated β-galactosidase staining performed at 48 h upon OS treatment comparing WT and p38 KO AEC. Arrows showing senescent cells stained in blue; OS, oxidative stress. Senescence positive cells were quantified and displayed in per... More
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In vitro  reconstructed amnion membrane mimics the intact amnion membrane f...
Published: 14 November 2022
Figure 5 In vitro reconstructed amnion membrane mimics the intact amnion membrane for OS-induced EMT ( A ) A representative image of CTRL vs . OS-treated intact amnion membrane explant staining of CK-18 (red) for epithelial cell marker and vimentin (yellow) for mesenchymal cell marker. An inta... More
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EMT and migration of the AEC are mediated by p38 in the human amnion membra...
Published: 14 November 2022
Figure 6 EMT and migration of the AEC are mediated by p38 in the human amnion membrane ( A ) Reconstructed amnion membrane using WT and p38 KO AEC-RFP cells. 120,000 WT and p38 KO AEC-RFP (red) cells were seeded onto Col-F labeled (green) nude membranes in the transwell system. p38 KO AEC-RFP cel... More
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The loss of p38 blocked TGF-β-induced EMT in cell morphology  ( A ) p38 KO ...
Published: 14 November 2022
Figure 7 The loss of p38 blocked TGF-β-induced EMT in cell morphology ( A ) p38 KO AEC-RFP cells lacked TGF-β-induced EMT morphological changes. WT and p38 KO AEC-RFP cells were treated with EMT inducer TGF-β at 5, 15, and 20 ng/ml concentrations for 7 days. Representative bright field images dis... More
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OS-induced inflammation is inhibited in p38 KO cells  ( A ) Cartoon illustr...
Published: 14 November 2022
Figure 8 OS-induced inflammation is inhibited in p38 KO cells ( A ) Cartoon illustration of media collection from reconstructed WT and p38 KO amnion membrane in the transwell system. Media from top side of the transwell represents the cytokines released from epithelial cells, while the media from... More
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p38 cKO in fetal membrane exhibited reduced senescence and inflammation in ...
Published: 14 November 2022
Figure 9 p38 cKO in fetal membrane exhibited reduced senescence and inflammation in mice ( A ) Schematic of conditionally knocking out p38 in fetal membrane using p38α loxP/loxP mice and Cre-recombinase containing exosomes. E13 pregnant mice were exposed to Cre-recombinase intra-amniotically f... More
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Schematic summary of p38 role in amnion membrane homeostasis  The amnion la...
Published: 14 November 2022
Figure 10 Schematic summary of p38 role in amnion membrane homeostasis The amnion layer of the fetal membrane consists of AEC (red) and AMC (brown) in collagen-rich ECM (purple). Upon exposure to oxidative stress-inducing exposomes, the characteristics of AEC change to several different paths inv... More
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Potential entry mechanisms of SARS-CoV-2 in vascular cells and the role of ...
Published: 11 November 2022
Figure 1 Potential entry mechanisms of SARS-CoV-2 in vascular cells and the role of lncRNA ACE2, angiotensin-converting enzyme 2; ADAM17, disintegrin and metalloproteinase domain-containing protein 17; CD209L, C-type lectin membrane protein; ENaC, epithelial sodium channel-α; HSPG, heparan sulfat... More
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