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Keywords: lysosomes
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Clin Sci (Lond) (1983) 64 (3): 341–347.
Published: 01 March 1983
... border carbonic anhydrase cytosol duodenal ulcer lysosomes mitochondria plasma membrane Clinical Science (1983) 64.341-347 34 1 Mucosal enzyme activities, with special reference to enzymes implicated in bicarbonate secretion, in the duodenum of rats with cysteamine-induced ulcers D A N N Y S T I...
Clin Sci (Lond) (1981) 60 (2): 207–212.
Published: 01 February 1981
...J. Scott; W. Jenkins; G. P. Smith; T. J. Peters 1. Analytical subcellular fractionation in combination with enzymic microanalysis has been used to investigate the hepatic organelle pathology of primary biliary cirrhosis. Activities of plasma membrane and lysosomal enzymes in hepatic needle biopsies...
Clin Sci (Lond) (1980) 59 (6): 457–462.
Published: 01 December 1980
... a major peak (modal density, 1.17) with a small subsidiary peak (modal density 1.24). 3. The following organelles, characterized by their marker enzymes, were located in the density gradients; plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes (β- N...
Clin Sci (Lond) (1980) 59 (1): 7–12.
Published: 01 July 1980
...T. J. Peters; W. Jenkins; V. Dubowitz 1. An homogenate of liver biopsy taken from a patient with Pompe's disease (type II glycogen-storage disease) was analysed by enzyme microassay and subcellular fractionation by sucrose-density-gradient centrifugation. 2. A strikingly low activity of lysosomal...
Clin Sci (Lond) (1980) 59 (1): 1–6.
Published: 01 July 1980
... density 1.18) and a substantial shoulder extending into the denser regions of the gradient. 3. The following organelles, characterized by their marker enzymes, were located in the density gradients: plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes...
Clin Sci (Lond) (1980) 58 (2): 165–168.
Published: 01 February 1980
...P. Maury; J. Palo 1. Aspartylglycosaminuria is a neurovisceral storage disease characterized by reduced or absent activity of the lysosomal enzyme N -aspartyl-β-glucosaminidase. Although vacuolization of peripheral lymphocytes is a well-documented feature of aspartylglucosaminuria, the chemical...
Clin Sci (Lond) (1979) 57 (6): 491–497.
Published: 01 December 1979
... showed normal endoplasmic reticulum density distribution with a peak at 1·20 g/ml, and had normal appearance of the endoplasmic reticulum on electron microscopy. 3. All patients showed increased activity of three lysosomal marker enzymes: N -acetyl-β-glucosaminidase, acid phosphatase and β-glucuronidase...
Clin Sci (Lond) (1979) 56 (5): 479–486.
Published: 01 May 1979
... of the organelle was normal. Homogenization studies revealed that the brush border was unusually fragile. 4. Apart from reduced activities of the basal—lateral marker enzyme 5′-nucleotidase and enhanced lysosomal fragility, other organelles showed normal properties. There were no significant differences in any...
Clin Sci Mol Med (1978) 55 (6): 549–553.
Published: 01 December 1978
... their stay in the coronary care unit. The activities of creatine kinase and its MB-isoenzyme (CK-MB) were assayed in the plasma. A lysosomal enzyme, β- N -acetylglucosaminidase, was also assayed. 2. In the 35 untreated patients it was found that creatine kinase activity was maximal at a mean time of 21.3...
Clin Sci Mol Med (1978) 55 (4): 383–389.
Published: 01 October 1978
...Carol A. Seymour; T. J. Peters 1. Liver biopsy specimens obtained from patients with alcoholic liver disease of varying severity were assayed for lysosomal and microsomal enzyme activities, the results being compared with values previously obtained in control subjects. 2. Analytical subcellular...
Clin Sci Mol Med (1978) 55 (3): 285–292.
Published: 01 September 1978
... of control values. On sucrose density gradients the distinct brush-border peak at density 1.21 was replaced by a broad peak at density 1.16. 4. Two out of three lysosomal enzymes showed increased activities and there was evidence of enhanced fragility of both lysosomes and peroxisomes. 5. There were reduced...
Clin Sci Mol Med (1978) 54 (6): 667–672.
Published: 01 June 1978
...E. Sanders; G. A. Coles; M. Davies 1. Lysosomal proteinase activity was assayed in human cadaver kidney, urine, granules from polymorphonuclear leucocytes of normal persons, and urine samples from 154 patients with renal disease. 2. Granules from polymorphonuclear leucocytes showed proteinase...
Clin Sci Mol Med (1978) 54 (5): 549–553.
Published: 01 May 1978
... hyperbilirubinaemia liver disease lysosomes melanin mitochondria superoxide dismutase Clinical Science and Molecular Medicine (1978) 54,549-553 The organelle pathology and demonstration of mitochondrial Superoxide dismutase deficiency in two patients with Dubin-Johnson-Sprinz syndrome T. J. PETERS AND CAROL...
Clin Sci Mol Med (1977) 53 (6): 551–562.
Published: 01 December 1977
... in the duodenal mucosa. © 1977 The Biochemical Society and the Medical Research Society 1977 brush borders cytosol duodenum enterokinase lysosomes microvillous membranes mitochondria subcellular fractionation Clinical Science and Molecular Medicine (1977) 53,551-562. Subcellular localization...
Clin Sci Mol Med (1977) 53 (1): 63–74.
Published: 01 July 1977
... content, were resolved by density gradient centrifugation in a small-volume zonal rotor. The equilibrium densities ( p ) of the principal organelles are (with marker enzymes in parentheses): sarcolemma, 1·12 (5′-nucleotidase); lysosomes, 1·16 ( N -acetyl-β-glucosaminidase); mitochondria, 1·17 (cytochrome...
Clin Sci Mol Med (1977) 52 (4): 429–442.
Published: 01 April 1977
... a primary bactericidal role. The cytosol contains mechan- isms which detoxify hydrogen peroxide, super- oxide and free radicals and protect the gran- ulocyte from these compounds. Key words : azurophil granules, catalase, cyto- sol, endoplasmic reticulum, free radicals, glutathione, granulocytes, lysosomes...
Clin Sci Mol Med (1977) 52 (3): 241–248.
Published: 01 March 1977
... fractionation experiments demonstrate that the lysosomes, which have strikingly reduced equilibrium densities, accumulate melanin. Morphological studies confirm the presence of pigments within lysosomes. 3. Although there are increased activities of lysosomal acid hydrolases in the liver tissue from patients...
Clin Sci Mol Med (1977) 52 (3): 229–239.
Published: 01 March 1977
... activities in samples of human liver, obtained by closed needle biopsy, and in sera have been determined. 2 1 1976 27 9 1976 © 1977 The Biochemical Society and the Medical Research Society 1977 biliary tract enzymes liver lysosomes microsomes needle biopsy Clinical Science...
Clin Sci Mol Med (1976) 51 (6): 557–574.
Published: 01 December 1976
... densities in sucrose density gradients: brush borders (1·21), peroxisomes (1·18), mitochondria (1·16), endoplasmic reticulum (1·16), basal—lateral membranes (1·12). At least three distinct populations of lysosomes with different modal densities and enzyme content were demonstrated. 5. This analytical...
Clin Sci Mol Med (1976) 51 (1): 19–25.
Published: 01 July 1976
... subcellular organelles were performed on isolated jejunal and ileal enterocytes. In the ileum there was a striking decrease in lysosomal enzyme activities and a smaller but significant decrease of lactate dehydrogenase, catalase and malate dehydrogenase activities. In the jejunum there was no significant...
Clin Sci Mol Med (1976) 50 (5): 355–366.
Published: 01 May 1976
...T. J. Peters; H. Shio 1. Enterocytes were isolated from rat jejunum and characterized morphologically. 2. Attempts to separate the enterocyte subcellular organelles, characterized by their marker enzymes, with isopycnic centrifugation were unsuccessful but good separation of peroxisomes, lysosomes...
Clin Sci Mol Med (1976) 50 (1): 75–78.
Published: 01 January 1976
...T. J. Peters; Carol A. Seymour 1. Iron, acid phosphatase and N -acetyl-β-glucosaminidase were assayed in liver biopsies from control subjects and patients with primary and secondary haemochromatosis. 2. The activities of the lysosomal enzymes were significantly higher in liver biopsies from...
Clin Sci Mol Med (1975) 49 (2): 171–182.
Published: 01 August 1975
... The Biochemical Society and the Medical Research Society 1975 granulocytes leucocytes lysosomes microsomes mitochondria plasma membranes subcellular fractionation vitamin B 12 vitamin B 12 -binding proteins Clinical Science and Molecular Medicine (1975) 49, 171-1 82 Analytical subcellular...
Clin Sci Mol Med (1975) 48 (4): 307–313.
Published: 01 April 1975
... in activity after bile-duct ligation. 4. No changes in mitochondrial enzyme activities were noted after 1 day but there was a 50% reduction 8 days after ligation. Lysosomal enzyme activities did not change in the liver tissue. 5. Liver catalase and d-amino acid oxidase activities showed a slight increase at 1...
Clin Sci Mol Med (1975) 48 (4): 259–267.
Published: 01 April 1975
.... Increased activities of six acid hydrolases (lysosomal enzymes) were found in biopsies from untreated coeliac patients. Normal values were obtained for biopsies from treated patients. 4. Assessment of lysosomal integrity by assay of latent N -acetyl-β-glucosaminidase and of sedimentable activity of four...
Clin Sci (1972) 42 (4): 405–414.
Published: 01 April 1972
... acid (pteroylglutamic acid) pteroylpolyglutamates folate conjugase (pteroylpolyglutamate hydrolase) oral contraceptives lysosomes Clinical Science (1972) 42,405-414. ORAL CONTRACEPTIVES A N D FOLATE METABOLISM M. E. M. STEPHENS, I. CRAFT, T. J . PETERS A N D A . V. H O F F B R A N D Department...