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Keywords: lymphocytes
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Clin Sci (Lond) (2021) 135 (9): 1065–1082.
Published: 07 May 2021
... (EAE). MSC-treated animals had milder disease, with a significant reduction in Th1 and Th17 lymphocytes in the lymph nodes and in the central nervous system (CNS). This was associated with increased Il27 and Cyp1a1 expression, and presence of IL-10-secreting T CD4 + cells. At EAE peak, animals had...
Clin Sci (Lond) (2006) 110 (6): 627–639.
Published: 15 May 2006
... spontaneously develop a form of diabetes that closely resembles the human counterpart. Early studies of these animals quickly led to the realization that T1DM is caused by autoreactive T-lymphocytes and revealed that the development of T1DM is controlled by numerous polymorphic genetic elements...
Clin Sci (Lond) (1999) 97 (4): 475–483.
Published: 01 September 1999
... to parity. There were no differences in a number of other biochemical markers of pre-eclampsia, including plasma albumin, uric acid, triacylglycerol, and total, low-density lipoprotein and high-density lipoprotein cholesterol. Basophil, monocyte and lymphocyte counts were elevated before delivery...
Clin Sci (Lond) (1998) 94 (4): 447–452.
Published: 01 April 1998
...E. García-Arumí; A. L. Andreu; J. López-Hellín; S. Schwartz 1. Oxidative damage has been associated with ageing, but there is no agreement as to whether or not it is produced by a decrease in antioxidant defences with the ageing process. In purified lymphocytes from 47 healthy elderly (75.27 ± 0.91...
Clin Sci (Lond) (1996) 91 (5): 621–626.
Published: 01 November 1996
...J. H. Knudsen; F. Gustafsson; J. Toft; N. J. Christensen 1. We studied 37 healthy men at rest in the supine position to examine the effect of ageing, smoking and physical training on β 2 -adrenoceptor function, plasma catecholamines and the proportions of various lymphocyte subsets. 2. In 14 young...
Clin Sci (Lond) (1996) 91 (1): 99–106.
Published: 01 July 1996
...Pia Essén; Margaret A. McNurlan; Anders Thorell; Inga Tjäder; Giuseppe Caso; Susan E. Anderson; Jan Wernerman; Peter J. Garlick 1. The stimulation and depression of peripheral blood lymphocytes has previously been studied in vitro , showing an immune depression postoperatively; however...
Clin Sci (Lond) (1995) 88 (6): 695–700.
Published: 01 June 1995
... was measured in human lymphocytes by determining ouabain-sensitive 86 Rb + influx at several concentrations of K + . The Na + -K + pump rate increased within the physiological range of extracellular free [K + ] (K 1/2 = 1.5 mmol/l). 3. To test the hypothesis that elevation of extracellular free [K + ] reduces...
Clin Sci (Lond) (1994) 86 (5): 505–510.
Published: 01 May 1994
... known to affect leucocyte formation, mobilization and activity are involved in this leucocytosis. cytokines granulocytes lymphocytes monocytes splenectomy Clinical Science (1994) 86, 505-510 (Printed in Great Britain) 505 No mandatory role for the spleen in the exerciseinduced leucocytosis...
Clin Sci (Lond) (1991) 80 (6): 539–547.
Published: 01 June 1991
...L. L. Ng; J. E. Davies; M. C. Garrido 1. Intracellular free [Mg 2+ ] was measured in human peripheral blood lymphocytes using a fluorimetric method based on the dye furaptra. It was necessary to correct for the extracellular leakage of the dye by using either 10 mmol/l EDTA or 0.05 mmol/l Mn 2+ . 2...
Clin Sci (Lond) (1990) 78 (5): 509–514.
Published: 01 May 1990
... to the membranous compartment in human circulating lymphocytes has been studied. 2. Pretreatment of lymphocytes with pertussis toxin inhibited significantly the low-density-lipoprotein-induced formation of inositol trisphosphate. 3. The calcium-channel blockers verapamil, nifedipine and diltiazem, each...
Clin Sci (Lond) (1987) 73 (5): 501–505.
Published: 01 November 1987
...M. Gleeson; J. D. Robertson; R. J. Maughan 1. The response of circulating leucocytes with regard to changes in number, proportion of granulocytes and lymphocytes, as well as changes in the ascorbic acid (AA) concentration of plasma and isolated lymphocytes, were studied in nine men who ran a 21 km...
Clin Sci (Lond) (1987) 72 (1): 47–54.
Published: 01 January 1987
... pressure, heart rate, plasma noradrenaline and plasma cyclic AMP responses to isoprenaline (0.01, 0.02 and 0.05 μg min −1 kg −1 intravenously) were related to the plasma concentrations of isoprenaline. For comparison, β 2 -adrenoceptor function was evaluated in lymphocytes in vitro by studies...
Clin Sci (Lond) (1987) 72 (1): 71–79.
Published: 01 January 1987
...V. M. S. Oh; E. A. Taylor; J. L. Ding; N. A. Boon; J. K. Aronson; D. G. Grahame-Smith 1. We have measured specific [ 3 H]ouabain binding and ouabain sensitive 86 rubidium influx in intact human lymphocytes incubated for up to 7 days in media containing different concentrations of fetal calf serum...
Clin Sci (Lond) (1985) 69 (6): 681–686.
Published: 01 December 1985
... by measuring calmodulin in another unrelated tissue. Calmodulin activity in circulating peripheral blood lymphocytes of seven patients with psoriasis was similar to that found in the lymphocytes of ten normal volunteers. 4. The relationship between calmodulin and the hyperproliferative state of the psoriatic...
Clin Sci (Lond) (1984) 67 (2): 249–258.
Published: 01 August 1984
... the expected acceleration of purine synthesis de novo in vitro. 5. The accelerated purine synthesis de novo in vitro associated with phytohaemagglutinin-induced lymphocyte transformation was detectable by the method used. 6. We conclude that familial hyperuricaemic nephropathy is not due to a metabolic lesion...
Clin Sci (Lond) (1984) 66 (3): 323–328.
Published: 01 March 1984
... for future studies of β-adrenoceptors in asthmatic patients. 19 8 1983 19 9 1983 © 1984 The Biochemical Society and the Medical Research Society 1984 β-adrenoceptors circadian variation extrinsic asthma lymphocytes Clinical Science (1984) 66,323-328 323 Circadian variation...
Clin Sci (Lond) (1983) 65 (1): 95–98.
Published: 01 July 1983
...C. Cortese; P. R. Turner; C. B. Marenah; U. Sule; S. Price; N. E. Miller; B. Lewis 1. Measurements were made of the maximal low-density lipoprotein (LDL) receptor activities of blood lymphocytes from 81 healthy men with a wide range of plasma LDL cholesterol concentrations (1.45-7.55 mmol/l). 2...
Clin Sci (Lond) (1982) 63 (5): 429–435.
Published: 01 November 1982
...R. B. Gordon; A. C. Counsilman; S. M. C. Cross; B. T. Emmerson 1. Variables that affect the measurement of purine synthesis de novo in human lymphocytes were studied and a reliable method of measurement of purine synthetic activity in these cells was established. 2. Purine synthesis de novo...
Clin Sci (Lond) (1982) 63 (s8): 53s–55s.
Published: 01 October 1982
...F. V. Costa; L. Montebugnoli; M. F. Giordani; L. Vasconi; E. Ambrosioni 1. Lymphocytes from normotensive subjects with normal intralymphocytic sodium content were incubated for 1 h in plasma from subjects with essential hypertension, secondary hypertension or borderline hypertension, and from...
Clin Sci (Lond) (1982) 63 (s8): 231s–234s.
Published: 01 October 1982
... lymphocytes potassium sodium Clinical Science (1982) 63.23 1 s-234s 231s Effects of moderate salt restriction and high potassium intake on intralymphocytic sodium content and pressor response to stress in borderline hypertension E. A M B R O S I O N I , F. V. C O S T A , C . B O R G H I , L. M O N T E B...
Clin Sci (Lond) (1981) 61 (s7): 21s–23s.
Published: 01 December 1981
... it was initially normal. © 1981 The Biochemical Society and the Medical Research Society 1981 borderline hypertension lymphocytes sodium ClinicalScience (1981) 61, 21s-23s 21s Effects of a low-salt diet and of acute salt loading on blood pressure and intralymphocytic sodium concentration in young...
Clin Sci (Lond) (1981) 61 (s7): 25s–27s.
Published: 01 December 1981
...; P < 0.005) was detected between baseline systolic blood pressure and intra- lymphocytic sodium in the group of patients with sustained hypertension. Heart rate No significant difference in the increase of heart rate was found in any of the groups of subjects during the test and no significant...
Clin Sci (Lond) (1981) 61 (2): 181–186.
Published: 01 August 1981
...E. Ambrosioni; F. V. Costa; L. Montebugnoli; F. Tartagni; B. Magnani 1. The sodium concentration in lymphocytes was measured in a group of 66 normotensive subjects (40 without familial hypertension and 26 with familial hypertension), in a group of 81 patients with essential hypertension...
Clin Sci (Lond) (1981) 60 (5): 587–589.
Published: 01 May 1981
...C. A. Kraft; C. M. Castleden 1. Responsiveness of the β-adrenoceptor adenylate cyclase system was measured in lymphocytes from healthy young and old subjects by incubating the cells with isoprenaline in the presence of a phosphodiesterase inhibitor and by measuring production of adenosine 3′:5...
Clin Sci (Lond) (1980) 58 (2): 165–168.
Published: 01 February 1980
...P. Maury; J. Palo 1. Aspartylglycosaminuria is a neurovisceral storage disease characterized by reduced or absent activity of the lysosomal enzyme N -aspartyl-β-glucosaminidase. Although vacuolization of peripheral lymphocytes is a well-documented feature of aspartylglucosaminuria, the chemical...
Clin Sci (Lond) (1979) 57 (s5): 325s–327s.
Published: 01 December 1979
... and the Medical Research Society 1979 hypertension lymphocytes sodium Clinical Science (1979) 51,325s-327s Intralymphocytic sodium in hypertensive patients: a significant correlation E. AMBROSIONI, F. T A R T A G N I , L. MONTEBUGNOLI AND B. M A G N A N I Istiluto di Cardiologia de" Universitd, Bologna...
Clin Sci Mol Med (1978) 54 (6): 595–601.
Published: 01 June 1978
...P. Kamoun; J. Chanard; M. Brami; J. L. Funck-Brentano 1. A method of measurement in vitro of purine biosynthesis de novo in human circulating blood lymphocytes is proposed. The rate of early reactions of purine biosynthesis de novo was determined by the incorporation of [ 14 C]formate into N...
Clin Sci Mol Med (1976) 51 (5): 463–465.
Published: 01 November 1976
.... The rates of turnover of the apoprotein of the two types of LDL in a normal subject, and their uptake and catabolism by normal lymphocytes in vitro , were similar. 3. It is concluded that the abnormal behaviour of the patient's LDL may not be due to an abnormality in the apoprotein component. 13 2...
Clin Sci Mol Med (1976) 50 (1): 61–68.
Published: 01 January 1976
...A. V. Hoffbrand; E. Tripp; A. Lavoie 1. Synthesis of polyglutamate derivatives from radioactively labelled folic acid, folinic acid and methotrexate has been studied in human phytohaemagglutinin-transformed lymphocytes. 2. With labelled folic acid as the precursor, approximately 20% of the labelled...