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Keywords: lung
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Clin Sci (Lond) (2022) 136 (10): 747–769.
Published: 27 May 2022
...Matthew E. Long; Rama K. Mallampalli; Jeffrey C. Horowitz Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary and critical care healthcare professionals, and these challenges have recently garnered global attention due to the ongoing Sars-CoV-2 pandemic. One...
Clin Sci (Lond) (2020) 134 (13): 1697–1714.
Published: 10 July 2020
... to the lung architecture, in the form of fibrotic sequelae. Here, we review influenza associated bacterial super-infection, the formation of T-cell memory, and persistent lung injury resulting from influenza infection. Correspondence: John F. Alcorn ( john.alcorn@chp.edu ) * These authors...
Clin Sci (Lond) (2018) 132 (21): 2357–2368.
Published: 13 November 2018
...Reiko Sakurai; Jie Liu; Ying Wang; John S. Torday; Virender K. Rehan Perinatal nicotine exposure drives the differentiation of alveolar lipofibroblasts (LIFs), which are critical for lung injury repair, to myofibroblasts (MYFs), which are the hallmark of chronic lung disease. Bone marrow-derived...
Clin Sci (Lond) (2016) 130 (21): 1939–1954.
Published: 22 September 2016
... neurotoxicity. GLA shares structural analogy with glutamate. It is a powerful inhibitor of glutamine synthetase (GS) and may bind to glutamate receptors. Since these potentials targets of GLA are present in lung and immune cells, we asked whether airway exposure to GLA may cause lung inflammation in mice...
Clin Sci (Lond) (2015) 128 (6): 337–347.
Published: 28 November 2014
... integrity, with individual isoforms mediating co-operative, but surprisingly also opposing, functions. Although in vivo studies in mice are in line with some of these observations, a complete understanding of the specific functions of epithelial NOX/DUOX awaits lung epithelial-specific conditional knockout...
Clin Sci (Lond) (2013) 125 (12): 555–564.
Published: 02 August 2013
...Kumar Changani; Catherine Pereira; Simon Young; Robert Shaw; Simon P. Campbell; Kashmira Pindoria; Steve Jordan; Katherine Wiley; Sarah Bolton; Tony Nials; Michael Haase; Mike Pedrick; Richard Knowles The present study investigated the role that imaging could have for assessing lung inflammation...
Includes: Supplementary data
Clin Sci (Lond) (2011) 120 (12): 505–514.
Published: 07 March 2011
... Biochemical Society 2011 apnoea/hypopnoae index (AHI) lung sedative medication sleep-disordered breathing therapeutic target upper-airway physiology OSA (obstructive sleep apnoea) is a serious condition with major cardiovascular and neurocognitive morbidity [ 1 – 3 ]. Existing treatments...
Clin Sci (Lond) (2010) 118 (8): 519–526.
Published: 26 January 2010
...Rafal Fudala; Agnieszka Krupa; Dorota Stankowska; Timothy C. Allen; Anna K. Kurdowska ALI (acute lung injury) and its more severe form ARDS (acute respiratory distress syndrome) are inflammatory diseases of the lung characterized by hypoxaemia and diffuse bilateral infiltrates. Disruption...
Clin Sci (Lond) (2008) 115 (8): 245–253.
Published: 12 September 2008
.... The aim of the present study was determine the expression of cholinergic system components in bronchial aspirates from control subjects and patients with lung cancer. We conducted an analysis of cholinergic components in the stored soluble and cellular fraction of bronchial aspirates from non-cancerous...
Clin Sci (Lond) (2008) 114 (8): 533–541.
Published: 13 March 2008
... and morbidity worldwide, with the WHO (World Health Organization) projecting that total deaths attributed to COPD will increase by more than 30% in the next 10 years. The pathological hallmarks of COPD are destruction of the lung parenchyma (pulmonary emphysema), inflammation of the central airways (chronic...
Clin Sci (Lond) (2008) 114 (6): 403–412.
Published: 12 February 2008
...Rafal Fudala; Agnieszka Krupa; Dorota Stankowska; Timothy C. Allen; Anna K. Kurdowska ALI/ARDS (acute lung injury/acute respiratory distress syndrome) is a severe inflammatory lung disease associated with very high mortality. Importantly, no effective therapy has been developed to date for ALI/ARDS...
Clin Sci (Lond) (2002) 103 (6): 613–621.
Published: 19 November 2002
...Yuichiro KIMURA; Takashi SUZUKI; Chika KANEKO; Andrew D. DARNEL; Takuya MORIYA; Satoshi SUZUKI; Masashi HANDA; Masahito EBINA; Toshihiro NUKIWA; Hironobu SASANO Nuclear receptors and their ligands are known to play very important roles in lung development. Among these receptors, retinoid receptors...
Clin Sci (Lond) (2002) 103 (s2002): 357S–362S.
Published: 01 September 2002
... as a therapeutic strategy. The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr A. Davenport (e-mail apd10@medschl.cam.ac.uk ). © 2002 The Biochemical Society and the Medical Research Society 2002 adenovirus aorta heart lung...
Clin Sci (Lond) (2002) 103 (s2002): 128S–131S.
Published: 01 September 2002
...), compared with ET-1, on the release of eicosanoids in the isolated and perfused guinea pig lung. We also clarified the implication of ET receptors in these effects using selective ET A or ET B receptor antagonists, BQ-123 and BQ-788 respectively. Finally, using the neutral endopeptidase 24.11 (NEP 24.11...
Clin Sci (Lond) (1998) 95 (3): 287–294.
Published: 01 September 1998
... of oxygen desaturation and vasodilatation. Correspondence : Dr E. Casiglia. 29 1 1998 11 3 1998 24 3 1998 The Biochemical Society and the Medical Research Society © 1998 1998 haemodynamics lung peripheral flow 287Clinical Science (1998) 95, 287 294 (Printed in Great...
Clin Sci (Lond) (1996) 91 (3): 319–327.
Published: 01 September 1996
...Annick Buvry; Monique Garbarg; Violetta Dimitriadou; Agnès Rouleau; George F. J. Newlands; Reza Tavakoli; Virginie Poaty; Alain Lockhart; Jean-Charles Schwartz; Nelly Frossard 1. Lung transplantation causes a total interruption of the innervation and vascularization within the transplanted organ...
Clin Sci (Lond) (1993) 85 (4): 385–388.
Published: 01 October 1993
..., with extremely high levels of expression in the lung, where it is associated with the blood vessels. 2. This rat sequence may represent the receptor for calcitonin-gene-related peptide or islet amyloid polypeptide. Both have binding activity in the lung and are potent vasodilators. The gene represented...
Clin Sci (Lond) (1991) 81 (5): 603–609.
Published: 01 November 1991
...M. Salleh M. Ardawi 1. The metabolism of glutamine and alanine in the lung was studied in rats made septic by a caecal ligation and puncture technique. 2. The blood glucose concentration was not significantly different in septic rats, but blood pyruvate, lactate, glutamine and alanine...
Clin Sci (Lond) (1991) 81 (3): 379–385.
Published: 01 September 1991
... resulted in an extension of vascular smooth muscle towards the periphery of the lung with the development of muscle in normally non-muscularized vessels (remodelling). Quantitative assessment of the small pulmonary vessels (external diameter 25–55 μm) showed that atrial natriuretic peptide treatment...
Clin Sci (Lond) (1991) 81 (1): 37–42.
Published: 01 July 1991
...M. Salleh; M. Ardawi 1. The effect of dexamethasone (30 μg day −1 100 g −1 body weight) on the regulation of glutamine metabolism was studied in the lungs of rats after 9 days of treatment. 2. Dexamethasone resulted in a negative nitrogen balance, and produced decreases in the blood concentrations...
Clin Sci (Lond) (1990) 78 (4): 409–417.
Published: 01 April 1990
...Rajiev K. Sharma; Peter K. Jeffery 1. Maximal binding capacity ( B max. ) and the dissociation constant ( K D ) for the β-adrenoceptor antagonist 125 I-cyanopindol were estimated in membrane preparations of hilar, lobar/main bronchi (level 1) and peripheral lung (level 11) of grossly normal lungs...
Clin Sci (Lond) (1987) 73 (3): 319–327.
Published: 01 September 1987
...B. A. Briggs; T. M. Bradley; P. Vernon; N. T. Cooke; C. Drinkwater; M. K. Gillett; P. D. Snashall 1. We have developed a method for non-invasive measurement of lung tissue mass, thoracic blood and interstitial volumes by a combination of transmission and emission scanning with technetium isotope...
Clin Sci (Lond) (1986) 70 (1): 39–45.
Published: 01 January 1986
...Jacqueline M. E. Kirk; P. E. Da Costa; Margaret Turner-Warwick; R. J. Littleton; G. J. Laurent 1. To assess the role of changes in lung collagen in pulmonary fibrosis, the content of this protein was measured in biopsy and autopsy lung from patients with cryptogenic fibrosing alveolitis (CFA...
Clin Sci (Lond) (1984) 66 (5): 585–590.
Published: 01 May 1984
...J. A. M. Raaijmakers; G. K. Terpstra; A. J. Van Rozen; A. Witter; J. Kreukniet 1. Muscarinic cholinergic receptors have been identified and characterized by radioligand binding studies in human peripheral lung tissue. The tissue was obtained at thoracotomy of 12 patients, of whom four had chronic...
Clin Sci (Lond) (1981) 61 (s7): 253s–256s.
Published: 01 December 1981
...Yasuharu Takada; Masazumi Unno; Kunio Hiwada; Tatsuo Kokubu 1. Human angiotensin-converting enzyme from kidney, lung, small intestine, plasma and urine was found to be immunologically indistinguishable by double immunodiffusion and inhibition of enzyme activity with specific anti-(human kidney...
Clin Sci (Lond) (1980) 59 (2): 105–113.
Published: 01 August 1980
...J. S. Prichard; B. Rajagopalan; G. de J. Lee 1. External counting of radioactivity over the lung has been used to measure the size of the interstitial compartment and transvascular albumin fluxes under normal and pathological conditions in the lungs of open-chested ventilated dogs. 2. When...
Clin Sci (Lond) (1980) 58 (6): 457–461.
Published: 01 June 1980
...P. J. Barnes; J. S. Karliner; C. T. Dollery 1. Direct radioligand—binding techniques have been used to characterize and quantify adrenoreceptors in human peripheral lung tissue removed at thoracotomy from ten patients, nine of whom had evidence of obstructive airways disease. 2. [ 3 H...
Clin Sci (Lond) (1980) 58 (1): 45–51.
Published: 01 January 1980
...F. Al-Ubaidi; Y. S. Bakhle 1. The metabolism of some vasoactive hormones perfused through pulmonary vessels was studied in samples of human lung obtained at operations. 2. 5-Hydroxytryptamine was inactivated and this inactivation was inhibited by desmethylimipramine and mebanazine. 3. β[ 14 C...
Clin Sci Mol Med (1978) 55 (5): 477–484.
Published: 01 November 1978
...J. Banks; F. V. McL. Booth; E. H. MacKay; B. Rajagopalan; G. De J. Lee 1. We have studied the extensibility of circumferential strips of main pulmonary artery and large pulmonary veins obtained at post mortem from patients of all ages, dying from conditions other than heart and lung disease. 2...
Clin Sci Mol Med (1978) 54 (6): 627–631.
Published: 01 June 1978
...Elizabeth H. Clark; R. L. Woods; J. M. B. Hughes 1. Ten studies were performed on nine patients with haematological disorders but with normal lungs, who required intermittent blood transfusions. The transfer factor for carbon monoxide and uptake of carbon monoxide per unit lung volume ( K CO ) were...
Clin Sci Mol Med (1978) 54 (3): 295–304.
Published: 01 March 1978
...J. Šorli; A. Grassino; G. Lorange; J. Milic-Emili 1. Using the mouth occlusion pressure technique, we have studied the control of breathing in seven hypercapnic and eight non-hypercapnic patients with chronic obstructive lung disease. 2. When breathing room air, pulmonary ventilation, mean...
Clin Sci (1972) 42 (3): 277–287.
Published: 01 March 1972
... during hypoxia to a small extent. 4 9 1971 © 1972 The Biochemical Society and the Medical Research Society 1972 hypoxia acidosis alkalosis pulmonary vascular resistance lung Clinical Science (1912) 42,217-281. EFFECTS OF ACUTELY INDUCED CHANGES I N ARTERIAL pH O N PULMONARY...
Clin Sci (1972) 42 (3): 325–335.
Published: 01 March 1972
... in haemoglobin concentration in the range 8–15 g/100 ml. For transfer factor a correction should be made by using a variant of the relationship of Roughton & Forster (1957). 22 7 1971 © 1972 The Biochemical Society and the Medical Research Society 1972 anaemia exercise lung cardiac...