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Keywords: lung
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Clin Sci (Lond) (2023) 137 (11): 895–912.
Published: 14 June 2023
... outcome measures in future interventional human trials that target circadian mechanisms. Figure 3 Cell types involved in pulmonary circadian pathology In the lung, circadian effects can be mediated through different cell types, dependent upon the underlying disease. For instance, the peripheral...
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Clin Sci (Lond) (2022) 136 (10): 747–769.
Published: 27 May 2022
...Matthew E. Long; Rama K. Mallampalli; Jeffrey C. Horowitz Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary and critical care healthcare professionals, and these challenges have recently garnered global attention due to the ongoing Sars-CoV-2 pandemic. One...
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Clin Sci (Lond) (2020) 134 (13): 1697–1714.
Published: 10 July 2020
... to the lung architecture, in the form of fibrotic sequelae. Here, we review influenza associated bacterial super-infection, the formation of T-cell memory, and persistent lung injury resulting from influenza infection. * These authors contributed equally to this work. 08 05 2020 25 06 2020...
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Clin Sci (Lond) (2015) 128 (6): 337–347.
Published: 28 November 2014
... integrity, with individual isoforms mediating co-operative, but surprisingly also opposing, functions. Although in vivo studies in mice are in line with some of these observations, a complete understanding of the specific functions of epithelial NOX/DUOX awaits lung epithelial-specific conditional knockout...
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Clin Sci (Lond) (2008) 114 (8): 533–541.
Published: 13 March 2008
... and morbidity worldwide, with the WHO (World Health Organization) projecting that total deaths attributed to COPD will increase by more than 30% in the next 10 years. The pathological hallmarks of COPD are destruction of the lung parenchyma (pulmonary emphysema), inflammation of the central airways (chronic...
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Clin Sci (Lond) (2002) 103 (6): 613–621.
Published: 19 November 2002
...Yuichiro KIMURA; Takashi SUZUKI; Chika KANEKO; Andrew D. DARNEL; Takuya MORIYA; Satoshi SUZUKI; Masashi HANDA; Masahito EBINA; Toshihiro NUKIWA; Hironobu SASANO Nuclear receptors and their ligands are known to play very important roles in lung development. Among these receptors, retinoid receptors...
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Clin Sci (Lond) (1998) 95 (3): 287–294.
Published: 01 September 1998
... of oxygen desaturation and vasodilatation. Correspondence : Dr E. Casiglia. 29 1 1998 11 3 1998 24 3 1998 The Biochemical Society and the Medical Research Society © 1998 1998 haemodynamics lung peripheral flow 287Clinical Science (1998) 95, 287 294 (Printed in Great...
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Clin Sci (Lond) (1993) 85 (4): 385–388.
Published: 01 October 1993
..., with extremely high levels of expression in the lung, where it is associated with the blood vessels. 2. This rat sequence may represent the receptor for calcitonin-gene-related peptide or islet amyloid polypeptide. Both have binding activity in the lung and are potent vasodilators. The gene represented...
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Clin Sci (Lond) (1991) 81 (5): 603–609.
Published: 01 November 1991
...M. Salleh M. Ardawi 1. The metabolism of glutamine and alanine in the lung was studied in rats made septic by a caecal ligation and puncture technique. 2. The blood glucose concentration was not significantly different in septic rats, but blood pyruvate, lactate, glutamine and alanine...
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Clin Sci (Lond) (1991) 81 (3): 379–385.
Published: 01 September 1991
... resulted in an extension of vascular smooth muscle towards the periphery of the lung with the development of muscle in normally non-muscularized vessels (remodelling). Quantitative assessment of the small pulmonary vessels (external diameter 25–55 μm) showed that atrial natriuretic peptide treatment...
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Clin Sci (Lond) (1991) 81 (1): 37–42.
Published: 01 July 1991
...M. Salleh; M. Ardawi 1. The effect of dexamethasone (30 μg day −1 100 g −1 body weight) on the regulation of glutamine metabolism was studied in the lungs of rats after 9 days of treatment. 2. Dexamethasone resulted in a negative nitrogen balance, and produced decreases in the blood concentrations...
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Clin Sci (Lond) (1990) 78 (4): 409–417.
Published: 01 April 1990
...Rajiev K. Sharma; Peter K. Jeffery 1. Maximal binding capacity ( B max. ) and the dissociation constant ( K D ) for the β-adrenoceptor antagonist 125 I-cyanopindol were estimated in membrane preparations of hilar, lobar/main bronchi (level 1) and peripheral lung (level 11) of grossly normal lungs...
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Clin Sci (Lond) (1981) 61 (s7): 253s–256s.
Published: 01 December 1981
...Yasuharu Takada; Masazumi Unno; Kunio Hiwada; Tatsuo Kokubu 1. Human angiotensin-converting enzyme from kidney, lung, small intestine, plasma and urine was found to be immunologically indistinguishable by double immunodiffusion and inhibition of enzyme activity with specific anti-(human kidney...
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Clin Sci (Lond) (1980) 59 (2): 105–113.
Published: 01 August 1980
...J. S. Prichard; B. Rajagopalan; G. de J. Lee 1. External counting of radioactivity over the lung has been used to measure the size of the interstitial compartment and transvascular albumin fluxes under normal and pathological conditions in the lungs of open-chested ventilated dogs. 2. When...
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Clin Sci (Lond) (1980) 58 (6): 457–461.
Published: 01 June 1980
...P. J. Barnes; J. S. Karliner; C. T. Dollery 1. Direct radioligand—binding techniques have been used to characterize and quantify adrenoreceptors in human peripheral lung tissue removed at thoracotomy from ten patients, nine of whom had evidence of obstructive airways disease. 2. [ 3 H...
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Clin Sci (Lond) (1980) 58 (1): 45–51.
Published: 01 January 1980
...F. Al-Ubaidi; Y. S. Bakhle 1. The metabolism of some vasoactive hormones perfused through pulmonary vessels was studied in samples of human lung obtained at operations. 2. 5-Hydroxytryptamine was inactivated and this inactivation was inhibited by desmethylimipramine and mebanazine. 3. β[ 14 C...
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Clin Sci Mol Med (1978) 55 (5): 477–484.
Published: 01 November 1978
...J. Banks; F. V. McL. Booth; E. H. MacKay; B. Rajagopalan; G. De J. Lee 1. We have studied the extensibility of circumferential strips of main pulmonary artery and large pulmonary veins obtained at post mortem from patients of all ages, dying from conditions other than heart and lung disease. 2...
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Clin Sci Mol Med (1978) 54 (6): 627–631.
Published: 01 June 1978
...Elizabeth H. Clark; R. L. Woods; J. M. B. Hughes 1. Ten studies were performed on nine patients with haematological disorders but with normal lungs, who required intermittent blood transfusions. The transfer factor for carbon monoxide and uptake of carbon monoxide per unit lung volume ( K CO ) were...
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Clin Sci Mol Med (1978) 54 (3): 295–304.
Published: 01 March 1978
...J. Šorli; A. Grassino; G. Lorange; J. Milic-Emili 1. Using the mouth occlusion pressure technique, we have studied the control of breathing in seven hypercapnic and eight non-hypercapnic patients with chronic obstructive lung disease. 2. When breathing room air, pulmonary ventilation, mean...
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Clin Sci (1972) 42 (3): 277–287.
Published: 01 March 1972
... during hypoxia to a small extent. 4 9 1971 © 1972 The Biochemical Society and the Medical Research Society 1972 hypoxia acidosis alkalosis pulmonary vascular resistance lung Clinical Science (1912) 42,217-281. EFFECTS OF ACUTELY INDUCED CHANGES I N ARTERIAL pH O N PULMONARY...
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