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Keywords: liver fibrosis
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Clin Sci (Lond) (2022) 136 (9): 643–656.
Published: 04 May 2022
... share the senior authorship. 30 11 2021 07 04 2022 19 04 2022 19 04 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 Chronic inflammation Galectin-3 Liver fibrosis Macrophages Nonalcoholic fatty liver disease...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (7): 925–941.
Published: 14 April 2021
..., accompanied with reduced liver fibrosis. The anti-fibrotic mechanism involved inhibition of profibrotic genes and blocking of hepatic stellate cell (HSC) activation. Our data show that roscovitine administration protects against liver diseases through inhibition of macrophage inflammatory actions and HSC...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (24): 2565–2582.
Published: 13 December 2018
... in liver fibrosis. By flow cytometry, we documented increased frequencies of peripheral ILC3 (Lin − CD127 + CD117 + CD294 − lymphocytes) in patients, especially at the advanced stage of hepatitis B virus (HBV)-related chronic liver diseases, and demonstrated their correlations with disease progression...
Clin Sci (Lond) (2018) 132 (15): 1645–1667.
Published: 14 August 2018
... of HMGB1-induced HSCs autophagy in liver fibrosis has not been elucidated. Here, we first documented an enrichment of peripheral and intrahepatic HMGB1 signal in hepatitis B virus (HBV)-related liver fibrosis progression, and presented a direct evidence of anatomic proximity of HMGB1 with a-SMA (a marker...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (7): 813–824.
Published: 16 April 2018
... of hepatic perfusion and hepatocyte function is feasible with free breathing dynamic gadoxetic acid-enhanced MRI. Hepatocyte function parameters may be relevant to assess liver fibrosis severity. Correspondence: Benjamin Leporq ( benjamin.leporq2@gmail.com ) 13 06 2017 05 02 2018 09 02...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (15): 2059–2062.
Published: 20 July 2017
... A. , Ramachandran P. , Iredale J.P. and Fallowfield J.A. ( 2014 ) Liver fibrosis and repair: immune regulation of wound healing in a solid organ . Nat. Rev. Immunol. 14 , 181 – 194 10 Setiawan V.W. , Stram D.O. , Porcel J. , Lu S.C. , Le Marchand L...
Clin Sci (Lond) (2017) 131 (15): 1971–1987.
Published: 13 July 2017
... in these models. Results: miR-223 expression was significantly dysregulated in livers from mice after induction of acute liver injury and liver fibrosis as well as in liver samples from patients with ALF or liver cirrhosis. In acute and chronic models, hepatic miR-223 up-regulation was restricted to hepatocytes...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (1): 69–86.
Published: 09 December 2016
.... In conclusion, homocysteine is harmful to vascular derangements and liver fibrosis in cirrhosis. Correspondence: Dr Hui-Chun Huang (email hchuang2@vghtpe.gov.tw ; hchuang2@gmail.com ) or Dr Fa-Yauh Lee (email fylee@vghtpe.gov.tw ) 1 Hung-Chun Tung and Shao-Jung Hsu contributed equally...
Clin Sci (Lond) (2015) 129 (9): 797–808.
Published: 07 August 2015
...-alcoholic steatohepatitis). chronic inflammation CX 3 CR1 dendritic cells liver fibrosis macrophages non-alcoholic fatty liver disease • In healthy livers, DCs (dendritic cells) represent a small fraction of non-parenchymal cells and have a predominantly to-lerogenic phenotype. Recent...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (8): 699–710.
Published: 22 July 2015
...Zhaoyong Yan; Kai Qu; Jing Zhang; Qichao Huang; Ping Qu; Xinsen Xu; Peng Yuan; Xiaojun Huang; Yongping Shao; Chang Liu; Hongxin Zhang; Jinliang Xing Although previous evidence indicates close involvement of CD147 in the pathogenesis of liver fibrosis, the underlying molecular mechanisms and its...
Includes: Supplementary data
Clin Sci (Lond) (2013) 124 (4): 279–287.
Published: 05 November 2012
... 7 2012 12 9 2012 12 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 liver fibrosis liver inflammation natural killer T-cell (NKT cell) non-alcoholic fatty liver disease • NF-κB activation is involved in the pathogenesis of NASH. Among...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (7): 459–471.
Published: 07 June 2012
... unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. CC chemokine ligand 2 chemokine cytokine liver fibrosis non-alcoholic steatohepatitis NAFLD (non-alcoholic fatty liver disease) is the most common cause of chronic liver...
Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
...Josephine A. Grace; Chandana B. Herath; Kai Yan Mak; Louise M. Burrell; Peter W. Angus The RAS (renin–angiotensin system) is now recognized as an important regulator of liver fibrosis and portal pressure. Liver injury stimulates the hepatic expression of components of the RAS, such as ACE...
Clin Sci (Lond) (2011) 121 (4): 159–168.
Published: 28 April 2011
... g.giannelli@intmed.uniba.it ). 7 1 2011 11 3 2011 18 3 2011 18 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell motility extracellular matrix protein laminin liver fibrosis tumour–host interaction In Western industrialized countries...
Clin Sci (Lond) (2002) 103 (2): 213–216.
Published: 19 July 2002
... time–density curves were fitted with a dual-input one-compartmental model to calculate the hepatic mean transit time and distribution volume of the contrast agents. In the rabbits with liver fibrosis, the mean transit time of the high-molecular-mass agent was shorter than that of the low-molecular-mass...
Clin Sci (Lond) (1997) 92 (2): 103–112.
Published: 01 February 1997
...R. Alcolado; M. J. P. Arthur; J. P. Iredale 1. Liver fibrosis is a common sequel to diverse liver injuries. It is characterized by an accumulation of interstitial collagens and other matrix components. The hepatic stellate cell is pivotal to the pathogenic process. Fibrotic liver injury results...
Clin Sci (Lond) (1995) 89 (1): 75–81.
Published: 01 July 1995
...J. P. Iredale; S. Goddard; G. Murphy; R. C. Benyon; M. J. P. Arthur 1. Activated hepatic lipocytes are central to the pathogenesis of liver fibrosis as the principal source of both interstitial collagens and matrix-degrading metalloproteinases. In progressive fibrosis there is a failure to degrade...