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Keywords: liver
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Clin Sci (Lond) (2022) 136 (22): 1711–1730.
Published: 30 November 2022
... evidenced that during HFD-induced obesity, there was elevation of nucleus protein acetylation. Analysis of liver tissue showed that among all SIRT members, SIRT6 expression was significantly down-regulated during HFD feeding, which was sustained to regular level with metformin administration. Our result...
Includes: Supplementary data
Clin Sci (Lond) (2022) 136 (15): 1111–1115.
Published: 01 August 2022
...Federico F. De Ponti; Charlotte L. Scott Non-alcoholic steatohepatitis (NASH) and associated end-stage liver disease is a growing cause of concern throughout the Western world. It constitutes a significant clinical burden for which therapeutic approaches are very limited. Over the last years...
Clin Sci (Lond) (2020) 134 (17): 2279–2294.
Published: 03 September 2020
...Tao Qiu; Tianyu Wang; Jiangqiao Zhou; Zhongbao Chen; Jilin Zou; Long Zhang; Xiaoxiong Ma Hepatic ischemia–reperfusion (I/R) injury is an important risk factor resulting in liver failure during liver surgery. However, there is still lack of effective therapeutic methods to treat hepatic I/R injury...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (20): 2069–2084.
Published: 22 October 2019
... in liver regeneration is unclear. Here, we investigated the pathophysiologic role of GDF11, as well as its plausible signaling mechanisms in a mouse model of partial hepatectomy (PH). We demonstrated that both serum and hepatic GDF11 protein expression increased following PH. Treatment with adeno...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (2): 335–349.
Published: 30 January 2019
... results indicated that USP4 was significantly up-regulated in liver of mice subjected to hepatic I/R injury. USP4 knockout mice exhibited exacerbated hepatic I/R injury, as evidenced by enhanced liver inflammation via the nuclear factor κB (NF-κB) signalling pathway and increased hepatocyte apoptosis...
Clin Sci (Lond) (2015) 129 (10): 839–850.
Published: 19 August 2015
... and G6Pase expression in the liver. Irisin improves glucose homoeostasis by reducing gluconeogenesis via PI3K/Akt/FOXO1-mediated PEPCK and G6Pase down-regulation and increasing glycogenesis via PI3K/Akt/GSK3-mediated GS activation. Irisin may be regarded as a novel therapeutic strategy for insulin resistance...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (1): 29–37.
Published: 27 August 2014
... patients with advanced HCC treated with sorafenib were included. RNA was extracted from formalin-fixed paraffin-embedded (FFPE) liver biopsies. miRNA expression profiling of 818 mature miRNAs was performed using GeneChip® miRNA Array 2.0 (Affymetrix). Global miRNA patterns were assessed using unsupervised...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (6): 405–413.
Published: 29 May 2014
.... The aim of the present study was to analyse the role of B 1 R and B 2 R in liver cell death induced by IRI. Livers from Wistar rats were submitted to ischaemia (4°C) for 4 or 24 h. After this period, livers were reperfused ex vivo with Krebs–Henseleit solution (37°C). BK or DABK was then injected...
Clin Sci (Lond) (2014) 126 (3): 243–252.
Published: 09 October 2013
... inhibitor sorafenib prolongs survival in advanced HCC. We examined the effects of RFA alone and in combination with sorafenib on a bystanding tumour in a two-tumour rat model of HCC. A total of 80 rats were implanted with two liver tumours and randomized to four treatment groups: vehicle and sham operation...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (2): 93–98.
Published: 23 March 2012
... (ischaemia/reperfusion) injury in the liver. I/R is the main cause of primary liver failure and, consequently, minimizing the detrimental effects of this process could increase the number of suitable transplantation grafts and also enhance the survival rate of patients after liver transplantation...
Clin Sci (Lond) (2012) 122 (8): 385–400.
Published: 14 December 2011
... Arnold von Eckardstein (email arnold.voneckardstein@usz.ch ). 16 9 2011 19 10 2011 20 10 2011 20 10 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 bile acid (BA) high-density lipoprotein liver plasma reverse cholesterol transport RCT...
Includes: Supplementary data
Clin Sci (Lond) (2011) 121 (10): 415–426.
Published: 25 July 2011
... between innate and adaptive immunity. In the liver, TLRs play an important role in the wound healing and regeneration processes, but they are also involved in the pathogenesis and progression of various inflammatory liver diseases, including autoimmune liver disease, alcoholic liver disease, non-alcoholic...
Clin Sci (Lond) (2011) 121 (6): 253–255.
Published: 27 May 2011
...Narci C. Teoh Hepatic IR (ischaemia/reperfusion) injury is an important clinical problem complicating liver surgery and transplantation. IPC (ischaemic preconditioning) is a strategy whereby brief episodes of IR in an organ can induce an adaptive response to protect against subsequent prolonged IR...
Clin Sci (Lond) (2011) 121 (6): 257–266.
Published: 27 May 2011
...Mahmoud Abu-Amara; Shi Yu Yang; Alberto Quaglia; Peter Rowley; Achala De Mel; Niteen Tapuria; Alexander Seifalian; Brian Davidson; Barry Fuller NO (nitric oxide) may protect the liver from IR (ischaemia/reperfusion) injury. RIPC (remote ischaemic preconditioning) also protects against liver IR...
Clin Sci (Lond) (2010) 118 (1): 47–59.
Published: 02 October 2009
... with metabolomic and genomic approaches. Hepatic lipid in the CS piglets at 7 days post-partum was in excess of 5 mg/g of liver consistent with hepatic steatosis, whereas in the VD piglets the amount of lipid was markedly lower (3 mg/g of liver) and below the threshold for a diagnosis of steatosis. Metabolomic...
Includes: Supplementary data
Clin Sci (Lond) (2008) 115 (5): 141–150.
Published: 01 August 2008
...David Preiss; Naveed Sattar The global increase in the prevalence of obesity has heralded a rise in associated liver injury namely NAFLD (non-alcoholic fatty liver disease). It is estimated that 20–30% of adult populations in developed countries have NAFLD and, although high quality data...
Clin Sci (Lond) (2008) 114 (8): 553–560.
Published: 13 March 2008
... preconditioning. The extent and source of oxidative stress and its effect on antioxidant status in the human liver during intermittent ischaemia and reperfusion remains ill-defined. Therefore the aim of the present study was to investigate the occurrence of oxidative stress in humans undergoing liver resection...
Clin Sci (Lond) (2008) 114 (7): 467–477.
Published: 29 February 2008
... ]. HCC accounts for more than 80% of primary liver cancers. A total of 80% of HCC cases occur in Africa and Asia, and China alone accounts for more than 50% of the cases worldwide [ 22 ]. Over the last few years, evidence indicates that the incidence of HCC is rising worldwide because of the increased...
Clin Sci (Lond) (2008) 114 (1): 73–83.
Published: 30 November 2007
... ). 2 5 2007 5 7 2007 3 8 2007 3 8 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 cell cycle S -farnesylthiosalicylic acid (FTS) hepatocellular carcinoma liver mitogen-activated protein kinase (MAPK) partial hepatectomy Ras All operations...
Clin Sci (Lond) (2007) 113 (9): 365–367.
Published: 01 October 2007
... to the central role of the liver in defining the FCHL phenotypes and demonstrates how they vary over time in relation to energy excess. On the basis of their work and that of others, we propose that FCHL is a multiple gene/multiple pathway/multiple phenotype disease. The key feature of this model of common...
Clin Sci (Lond) (2007) 113 (9): 375–381.
Published: 01 October 2007
.... Additionally, the association of ALT with the switch in triacylglycerol phenotype suggests a central role of the liver in the pathogenesis of FCHL. The hypertriglyceridaemic phenotype in FCHL is the consequence of both an excessive production of VLDL (very-low-density lipoprotein) particles and an impaired...
Clin Sci (Lond) (2007) 113 (3): 109–118.
Published: 02 July 2007
...Fiona J. Warner; John S. Lubel; Geoffrey W. McCaughan; Peter W. Angus There is an increasing body of evidence to suggest that the RAS (renin–angiotensin system) contributes to tissue injury and fibrosis in chronic liver disease. A number of studies have shown that components of a local hepatic RAS...
Clin Sci (Lond) (2007) 112 (5): 265–280.
Published: 01 February 2007
...Neil C. Henderson; John P. Iredale Liver fibrosis represents a major worldwide health care burden. The last 15 years have seen a rapid growth in our understanding of the pathogenesis of this clinically relevant model of inflammation and repair. This work is likely to inform the design of effective...
Clin Sci (Lond) (2005) 109 (2): 199–207.
Published: 25 July 2005
...Maria J. Monte; Maria Fernandez-Tagarro; Rocio I. R. Macias; Felipe Jimenez; Francisco Gonzalez-San Martin; Jose J. G. Marin The relationship between BA (bile acid) secretion (measured by GC–MS) and the expression of genes (measured by reverse transcription real-time PCR) involved in liver BA...
Clin Sci (Lond) (2005) 108 (4): 309–321.
Published: 22 March 2005
... to a neoplastic state. Secondly, metaplasia (or transdifferentiation) provides an alternative method for the development of cell-based therapies. The latter will be discussed in more detail later in relation to the treatment of conditions such as diabetes and liver dysfunction. Barrett's metaplasia, sometimes...
Clin Sci (Lond) (2005) 108 (1): 55–63.
Published: 15 December 2004
...Rahul S. KOTI; Wenxuan YANG; Georgios GLANTZOUNIS; Alberto QUAGLIA; Brian R. DAVIDSON; Alexander M. SEIFALIAN IPC (ischaemic preconditioning) may protect the steatotic liver, which is particularly susceptible to I/R (ischaemia/reperfusion) injury. Hepatic steatosis was induced in Sprague–Dawley...
Clin Sci (Lond) (2003) 105 (6): 691–698.
Published: 01 December 2003
...Michael J. O'LEARY; Michael KOLL; Colin N. FERGUSON; John H. COAKLEY; Charles J. HINDS; Victor R. PREEDY; Peter J. GARLICK The effect of sepsis on liver synthesis of albumin remains controversial, with studies in man suggesting that synthesis increases, whereas in animals increased, decreased...
Clin Sci (Lond) (2003) 105 (3): 347–353.
Published: 01 September 2003
... liver microtubule transcytosis tubulin Clinical Science (2003) 105, 347 353 (Printed in Great Britain) 347 Effect of maternal obstructive cholestasis during pregnancy on the biliary transport of horseradish peroxidase in the rat offspring Maria J. MONTE , Gloria R. VILLANUEVA , Rocio I. R. MACIAS...
Clin Sci (Lond) (2003) 104 (2): 127–141.
Published: 10 January 2003
...-constant infusions of p -aminohippurate and 3 H-labelled isotopes were used to measure glucose, amino acid and protein metabolism across the portal-drained viscera, liver and hindquarters (to represent muscle) at 0 and 24h of endotoxaemia. Whole-body protein and glucose flux were increased during...
Clin Sci (Lond) (2002) 102 (6): 603–614.
Published: 30 April 2002
...Piotr MILKIEWICZ; Marcelo G. ROMA; Elwyn ELIAS; Roger COLEMAN Preparations of isolated liver cells, either freshly prepared or in culture, have been available for many years; however, because they lack the polarization of the cell in the tissue, their application to the study of processes involved...
Clin Sci (Lond) (2002) 102 (4): 389–395.
Published: 04 March 2002
... and humans have shown that it is a safe, predictable and effective process for destroying normal and tumour-bearing liver in a linear, dose-dependent manner. Presently, the amount of current that is applied (in coulombs) has to be calculated using historical data, with inherent inaccuracy. The present study...
Clin Sci (Lond) (2002) 102 (3): 337–344.
Published: 15 February 2002
... liver oxygen consumption. 337Clinical Science (2002) 102, 337 344 (Printed in Great Britain) Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: effects of glutamine Michele A. MARKLEY, Agostino PIERRO and Simon EATON Department of Paediatric Surgery, Institute of Child...
Clin Sci (Lond) (2002) 102 (1): 107–114.
Published: 10 December 2001
...Benoît RUOT; Fabienne BÉCHEREAU; Gérard BAYLE; Denis BREUILLÉ; Christiane OBLED To discriminate between the effects of infection and of anorexia associated with infection, liver albumin synthesis was measured in well-fed rats, in rats injected with live Escherichia coli and in pair-fed rats...
Clin Sci (Lond) (2001) 101 (3): 295–304.
Published: 15 August 2001
... was lower at 72 and 96 h, than in sham-operated animals. CLP was associated with increased liver protein synthesis at all time points, whereas there was no change after sham operation. Liver protein content did not change after CLP, but was lower at 72 and 96 h after sham operation than in non-operated...
Clin Sci (Lond) (2000) 98 (2): 167–174.
Published: 19 January 2000
...Susanne LEIJ-HALFWERK; Pieter C. DAGNELIE; J. Willem O. VAN DEN BERG; J. H. Paul WILSON; Paul E. SIJENS Stable-isotope tracers were used to assess whether levels of phosphomonoesters (PME) and phosphodiesters (PDE) in the livers of lung cancer patients, as observed by 31 P magnetic resonance (MR...
Clin Sci (Lond) (1997) 93 (5): 453–462.
Published: 01 November 1997
... distribution of newly absorbed radioiron suggested that significant redistribution of iron from liver to pancreas (rather than direct dietary iron sources) must be invoked to explain the rate of pancreatic iron loading in hypotransferrinaemic mice. 4. Pancreatic epithelial cells first showed altered morphology...
Clin Sci (Lond) (1997) 93 (1): 81–88.
Published: 01 July 1997
...Etsuro Hatano; Tetsuya Kiuchi; Akira Tanaka; Hisashi Shinohara; Toshiyuki Kitai; Seiji Satoh; Takuya Inomoto; Hiroto Egawa; Shinji Uemoto; Yukihiro Inomata; Hauke Lang; Karl J Oldhafer; Bruckhardt Ringe; Rudolf Pichlmayr; Koichi Tanaka; Yoshio Yamaoka 1. Living-related liver transplantation has...
Clin Sci (Lond) (1996) 91 (5): 551–558.
Published: 01 November 1996
...David E. J. Jones 1. Primary biliary cirrhosis is a chronic cholestatic liver disease with an autoimmune aetiology. The classical histopathological lesion, of portal tract biliary epithelial cell damage, is accompanied by a T-cell-rich mononuclear cell infiltrate and upregulation of cell surface...
Clin Sci (Lond) (1995) 89 (6): 575–579.
Published: 01 December 1995
... and hepatic membranes by bosentan in vitro was similar. 5. Since bosentan is significantly excreted by the liver, the prolonged hepatic 125 I-ET-1 binding by bosentan presumably represents hepatic accumulation of bosentan, which may have implications for bosentan antagonizing the actions of ET in the liver...
Clin Sci (Lond) (1995) 89 (2): 145–154.
Published: 01 August 1995
... nervous activity in healthy, lean subjects. 2. In nine male subjects, noradrenaline spillover was measured from the heart, kidney and liver using isotope dilution, both while fasting and after consumption of a high-energy liquid meal of composition 53% carbohydrate, 32% fat and 15% protein (energy value...
Clin Sci (Lond) (1994) 87 (2): 179–186.
Published: 01 August 1994
... induction was monocytes and macrophages in multiple organs, principally liver and spleen. Bronchial, bile duct, intestinal and bladder epithelium and some hepatocytes also expressed inducible NO synthase. Expression peaked at 5 h and had returned to normal by 12 h except in spleen. 3. After priming with C...
Clin Sci (Lond) (1994) 86 (5): 489–495.
Published: 01 May 1994
... the liver of a Z homozygote. 2. That loop—sheet polymerization is a more general phenomenon was shown by the examination of a second deficiency variant, antitrypsin S iiyama (Ser-53→Phe), which is also associated with liver inclusions. Electron microscopy confirmed that isolated antitrypsin S iiyama from...
Clin Sci (Lond) (1993) 85 (4): 437–444.
Published: 01 October 1993
... for 4 days. Glutamine consumption in portal-drained viscera and liver was measured after an overnight fast by determining fluxes and intracellular concentrations in normal rats, methionine sulphoximine-treated rats and pair-fed controls. Moreover, fluxes and intracellular concentrations of several other...
Clin Sci (Lond) (1993) 85 (3): 337–342.
Published: 01 September 1993
...Peter E. Ballmer; Margaret A. McNurlan; Ian Grant; Peter J. Garlick 1. The influence of an acute-phase reaction on the ability of protein synthesis rates in liver and three different muscles (gastrocnemius, soleus and heart) to respond to a short intravenous infusion of nutrients (glucose plus...
Clin Sci (Lond) (1993) 84 (3): 339–348.
Published: 01 March 1993
...Graham P. Butcher; Nigel Deighton; Roger M. Batt; Boliang Ding; Susan Haywood; John Hoffman; Malcolm J. Jackson; Martyn C. R. Symons; Jonathan M. Rhodes 1. Electron paramagnetic resonance spectroscopy was used to study free-radical signals in freeze-clamped frozen liver tissue from rats after a 1...
Clin Sci (Lond) (1993) 84 (1): 113–117.
Published: 01 January 1993
...N. M. Lowe; A. Green; J. M. Rhodes; M. Lombard; R. Jalan; M. J. Jackson 1. The short-term (120 min) kinetics of Zn turnover has been studied in control subjects and patients with alcoholic liver disease after intravenous injection of 0.5 mg of 96.5% enriched 70 ZnCl 2 . 2. The 70 Zn enrichment...
Clin Sci (Lond) (1992) 83 (6): 677–682.
Published: 01 December 1992
...R. F. G. J. King; M. Madan; D. Alexander; A. Boyd; K. Ibrahim; M. J. McMahon; D. Johnston 1. This study was designed to test the hypothesis that three-carbon intermediates can be used in the ‘indirect’ pathway of glycogen synthesis in human liver (i.e. a route additional to the use of glucose...
Clin Sci (Lond) (1992) 83 (5): 607–614.
Published: 01 November 1992
... area is less well characterized. We were specifically interested in substrate flux across the spleen as it is an organ with important immunological functions. 2. Therefore, hindquarter, gut, spleen and liver fluxes of amino acids, ammonia, glucose, lactate and blood gases were measured for 4 days after...
Clin Sci (Lond) (1992) 83 (2): 165–170.
Published: 01 August 1992
... (2.68 ± 0.53 fmol/ml). 6. It was concluded that a lower plasma level of endothelin and a reduced vascular responsiveness may contribute, at least in part, to the hyperdynamics of portal hypertension. blood pressure liver portal pressure splanchnic bed vascular reactivity © 1992...
Clin Sci (Lond) (1992) 83 (2): 183–190.
Published: 01 August 1992
...P. C. Dagnelie; D. K. Menon; I. J. Cox; J. D. Bell; J. Sargentoni; G. A. Coutts; J. Urenjak; R. A. Iles 1. 31 P n.m.r. spectroscopy in vivo was used to study the effect of l -alanine infusion on the concentrations of gluconeogenic intermediates in normal human liver. Studies were performed in six...