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Articles

Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye

Clin Sci (Lond) (2022) 136 (22): 1711–1730.

DOI: https://doi.org/10.1042/CS20220242

Published: 30 November 2022

... evidenced that during HFD-induced obesity, there was elevation of nucleus protein acetylation. Analysis of liver tissue showed that among all SIRT members, SIRT6 expression was significantly down-regulated during HFD feeding, which was sustained to regular level with metformin administration. Our result...

View article titled, Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

Includes: Supplementary data

Articles

Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis

Federico F. De Ponti, Charlotte L. Scott

Clin Sci (Lond) (2022) 136 (15): 1111–1115.

DOI: https://doi.org/10.1042/CS20220258

Published: 01 August 2022

...Federico F. De Ponti; Charlotte L. Scott Non-alcoholic steatohepatitis (NASH) and associated end-stage liver disease is a growing cause of concern throughout the Western world. It constitutes a significant clinical burden for which therapeutic approaches are very limited. Over the last years...

View article titled, Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis

Articles

DUSP12 protects against hepatic ischemia–reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo

Tao Qiu, Tianyu Wang, Jiangqiao Zhou, Zhongbao Chen, Jilin Zou, Long Zhang, Xiaoxiong Ma

Clin Sci (Lond) (2020) 134 (17): 2279–2294.

DOI: https://doi.org/10.1042/CS20191272

Published: 03 September 2020

...Tao Qiu; Tianyu Wang; Jiangqiao Zhou; Zhongbao Chen; Jilin Zou; Long Zhang; Xiaoxiong Ma Hepatic ischemia–reperfusion (I/R) injury is an important risk factor resulting in liver failure during liver surgery. However, there is still lack of effective therapeutic methods to treat hepatic I/R injury...

View article titled, DUSP12 protects against hepatic ischemia–reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo

Includes: Supplementary data

Articles

GDF11 impairs liver regeneration in mice after partial hepatectomy

Wenjie Wang, Xiao Yang, Jiankun Yang, Shenpei Liu, Yongman Lv, Cuntai Zhang, Wei Dong, Anding Liu

Clin Sci (Lond) (2019) 133 (20): 2069–2084.

DOI: https://doi.org/10.1042/CS20190441

Published: 22 October 2019

... in liver regeneration is unclear. Here, we investigated the pathophysiologic role of GDF11, as well as its plausible signaling mechanisms in a mouse model of partial hepatectomy (PH). We demonstrated that both serum and hepatic GDF11 protein expression increased following PH. Treatment with adeno...

View article titled, GDF11 impairs liver regeneration in mice after partial hepatectomy

Includes: Supplementary data

Articles

USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling

Jiangqiao Zhou, Tao Qiu, Tianyu Wang, Zhongbao Chen, Xiaoxiong Ma, Long Zhang, Jilin Zou

Clin Sci (Lond) (2019) 133 (2): 335–349.

DOI: https://doi.org/10.1042/CS20180959

Published: 30 January 2019

... results indicated that USP4 was significantly up-regulated in liver of mice subjected to hepatic I/R injury. USP4 knockout mice exhibited exacerbated hepatic I/R injury, as evidenced by enhanced liver inflammation via the nuclear factor κB (NF-κB) signalling pathway and increased hepatocyte apoptosis...

View article titled, USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling

Articles

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

Tong-Yan Liu, Chang-Xiang Shi, Run Gao, Hai-Jian Sun, Xiao-Qing Xiong, Lei Ding, Qi Chen, Yue-Hua Li, Jue-Jin Wang, Yu-Ming Kang, Guo-Qing Zhu

Clin Sci (Lond) (2015) 129 (10): 839–850.

DOI: https://doi.org/10.1042/CS20150009

Published: 19 August 2015

... and G6Pase expression in the liver. Irisin improves glucose homoeostasis by reducing gluconeogenesis via PI3K/Akt/FOXO1-mediated PEPCK and G6Pase down-regulation and increasing glycogenesis via PI3K/Akt/GSK3-mediated GS activation. Irisin may be regarded as a novel therapeutic strategy for insulin resistance...

View article titled, Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

Includes: Supplementary data

Articles

Feasibility of global miRNA analysis from fine-needle biopsy FFPE material in patients with hepatocellular carcinoma treated with sorafenib

Jan Peveling-Oberhag, Claudia Döring, Sylvia Hartmann, Natalie Filmann, Angelika Mertens, Albrecht Piiper, Eva Herrmann, Martin-Leo Hansmann, Stefan Zeuzem, Jörg Trojan, Martin-Walter Welker

Clin Sci (Lond) (2015) 128 (1): 29–37.

DOI: https://doi.org/10.1042/CS20140007

Published: 27 August 2014

... patients with advanced HCC treated with sorafenib were included. RNA was extracted from formalin-fixed paraffin-embedded (FFPE) liver biopsies. miRNA expression profiling of 818 mature miRNAs was performed using GeneChip® miRNA Array 2.0 (Affymetrix). Global miRNA patterns were assessed using unsupervised...

View article titled, Feasibility of global miRNA analysis from fine-needle biopsy FFPE material in patients with hepatocellular carcinoma treated with sorafenib

Includes: Supplementary data

Articles

Differential bradykinin B 1 and B 2 receptor regulation in cell death induced by hepatic ischaemia/reperfusion injury

Mayra A. Paio, Maria Kouyoumdjian, Durval R. Borges, Marcia R. Nagaoka

Clin Sci (Lond) (2014) 127 (6): 405–413.

DOI: https://doi.org/10.1042/CS20130313

Published: 29 May 2014

.... The aim of the present study was to analyse the role of B 1 R and B 2 R in liver cell death induced by IRI. Livers from Wistar rats were submitted to ischaemia (4°C) for 4 or 24 h. After this period, livers were reperfused ex vivo with Krebs–Henseleit solution (37°C). BK or DABK was then injected...

View article titled, Differential bradykinin B 1 and B 2 receptor regulation in cell death induced by hepatic ischaemia/reperfusion injury

Articles

Radiofrequency ablation suppresses distant tumour growth in a novel rat model of multifocal hepatocellular carcinoma

Caroline Erös de Bethlenfalva-Hora, Joachim C. Mertens, Anne-Christine Piguet, Joachim Kettenbach, Johannes Schmitt, Luigi Terracciano, Rosemarie Weimann, Jean-François Dufour, Andreas Geier

Clin Sci (Lond) (2014) 126 (3): 243–252.

DOI: https://doi.org/10.1042/CS20130089

Published: 09 October 2013

... inhibitor sorafenib prolongs survival in advanced HCC. We examined the effects of RFA alone and in combination with sorafenib on a bystanding tumour in a two-tumour rat model of HCC. A total of 80 rats were implanted with two liver tumours and randomized to four treatment groups: vehicle and sham operation...

View article titled, Radiofrequency ablation suppresses distant tumour growth in a novel rat model of multifocal hepatocellular carcinoma

Includes: Supplementary data

Articles

Ubiquitin–proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms

Susagna Padrissa-Altés, Mohamed Amine Zaouali, Ramon Bartrons, Joan Roselló-Catafau

Clin Sci (Lond) (2012) 123 (2): 93–98.

DOI: https://doi.org/10.1042/CS20110093

Published: 23 March 2012

... (ischaemia/reperfusion) injury in the liver. I/R is the main cause of primary liver failure and, consequently, minimizing the detrimental effects of this process could increase the number of suitable transplantation grafts and also enhance the survival rate of patients after liver transplantation...

View article titled, Ubiquitin–proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms

Articles

Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids: effects of monogenic disturbances in high-density lipoprotein metabolism

Carine Steiner, Adriaan G. Holleboom, Ratna Karuna, Mohammad M. Motazacker, Jan Albert Kuivenhoven, Ruth Frikke-Schmidt, Anne Tybjaerg-Hansen, Lucia Rohrer, Katharina M. Rentsch, Arnold von Eckardstein

Clin Sci (Lond) (2012) 122 (8): 385–400.

DOI: https://doi.org/10.1042/CS20110482

Published: 14 December 2011

... Arnold von Eckardstein (email arnold.voneckardstein@usz.ch ). 16 9 2011 19 10 2011 20 10 2011 20 10 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 bile acid (BA) high-density lipoprotein liver plasma reverse cholesterol transport RCT...

View article titled, Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids: effects of monogenic disturbances in high-density lipoprotein metabolism

Includes: Supplementary data

Articles

Role of Toll-like receptors in liver health and disease

Ruth Broering, Mengji Lu, Joerg F. Schlaak

Clin Sci (Lond) (2011) 121 (10): 415–426.

DOI: https://doi.org/10.1042/CS20110065

Published: 25 July 2011

... between innate and adaptive immunity. In the liver, TLRs play an important role in the wound healing and regeneration processes, but they are also involved in the pathogenesis and progression of various inflammatory liver diseases, including autoimmune liver disease, alcoholic liver disease, non-alcoholic...

View article titled, Role of Toll-like receptors in liver health and disease

Articles

Remote hindlimb preconditioning and hepatoprotection: NO-table strides against liver ischaemia/reperfusion injury

Narci C. Teoh

Clin Sci (Lond) (2011) 121 (6): 253–255.

DOI: https://doi.org/10.1042/CS20110243

Published: 27 May 2011

...Narci C. Teoh Hepatic IR (ischaemia/reperfusion) injury is an important clinical problem complicating liver surgery and transplantation. IPC (ischaemic preconditioning) is a strategy whereby brief episodes of IR in an organ can induce an adaptive response to protect against subsequent prolonged IR...

View article titled, Remote hindlimb preconditioning and hepatoprotection: NO-table strides against liver ischaemia/reperfusion injury

Articles

Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury

Mahmoud Abu-Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Achala De Mel, Niteen Tapuria, Alexander Seifalian, Brian Davidson, Barry Fuller

Clin Sci (Lond) (2011) 121 (6): 257–266.

DOI: https://doi.org/10.1042/CS20100598

Published: 27 May 2011

...Mahmoud Abu-Amara; Shi Yu Yang; Alberto Quaglia; Peter Rowley; Achala De Mel; Niteen Tapuria; Alexander Seifalian; Brian Davidson; Barry Fuller NO (nitric oxide) may protect the liver from IR (ischaemia/reperfusion) injury. RIPC (remote ischaemic preconditioning) also protects against liver IR...

View article titled, Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury

Articles

Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets

Matthew J. Hyde, Julian L. Griffin, Emilio Herrera, Christopher D. Byrne, Lynne Clarke, Paul R. Kemp

Clin Sci (Lond) (2010) 118 (1): 47–59.

DOI: https://doi.org/10.1042/CS20090169

Published: 02 October 2009

... with metabolomic and genomic approaches. Hepatic lipid in the CS piglets at 7 days post-partum was in excess of 5 mg/g of liver consistent with hepatic steatosis, whereas in the VD piglets the amount of lipid was markedly lower (3 mg/g of liver) and below the threshold for a diagnosis of steatosis. Metabolomic...

View article titled, Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets

Includes: Supplementary data

Articles

Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations

David Preiss, Naveed Sattar

Clin Sci (Lond) (2008) 115 (5): 141–150.

DOI: https://doi.org/10.1042/CS20070402

Published: 01 August 2008

...David Preiss; Naveed Sattar The global increase in the prevalence of obesity has heralded a rise in associated liver injury namely NAFLD (non-alcoholic fatty liver disease). It is estimated that 20–30% of adult populations in developed countries have NAFLD and, although high quality data...

View article titled, Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations

Articles

Decreased hepatosplanchnic antioxidant uptake during hepatic ischaemia/reperfusion in patients undergoing liver resection

Marcel C. G. van de POLL, Cornelis H. C. Dejong, Marc A. J. G. Fischer, Aalt Bast, Ger H. Koek

Clin Sci (Lond) (2008) 114 (8): 553–560.

DOI: https://doi.org/10.1042/CS20070317

Published: 13 March 2008

... preconditioning. The extent and source of oxidative stress and its effect on antioxidant status in the human liver during intermittent ischaemia and reperfusion remains ill-defined. Therefore the aim of the present study was to investigate the occurrence of oxidative stress in humans undergoing liver resection...

View article titled, Decreased hepatosplanchnic antioxidant uptake during hepatic ischaemia/reperfusion in patients undergoing liver resection

Articles

Targeting vessels to treat hepatocellular carcinoma

Pamela Romanque, Anne-Christine Piguet, Jean-François Dufour

Clin Sci (Lond) (2008) 114 (7): 467–477.

DOI: https://doi.org/10.1042/CS20070310

Published: 29 February 2008

... hepatocellular carcinoma (HCC) inflammation liver vascular endothelial growth factor (VEGF) Blood vessels arise from endothelial precursors, which share a common origin with haemopoietic progenitors. These progenitors assemble into an early vascular labyrinth of small capillaries. At this stage...

View article titled, Targeting vessels to treat hepatocellular carcinoma

Articles

Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats

Alain da Silva Morais, Alain Saliez, Isabelle Leclercq, Yves Horsmans, Peter Stärkel

Clin Sci (Lond) (2008) 114 (1): 73–83.

DOI: https://doi.org/10.1042/CS20070152

Published: 30 November 2007

... 5 2007 5 7 2007 3 8 2007 3 8 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 cell cycle S -farnesylthiosalicylic acid (FTS) hepatocellular carcinoma liver mitogen-activated protein kinase (MAPK) partial hepatectomy Ras...

View article titled, Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats

Articles

Five-year follow-up of waist circumference, insulin and ALT levels in familial combined hyperlipidaemia

Martijn C. G. J. Brouwers, Marleen M. J. van Greevenbroek, Vicky M. M.-J. Vermeulen, Josephine M. J. P. van Lin, Carla J. H. van der Kallen, Tjerk W. A. de Bruin

Clin Sci (Lond) (2007) 113 (9): 375–381.

DOI: https://doi.org/10.1042/CS20070101

Published: 01 October 2007

.... Additionally, the association of ALT with the switch in triacylglycerol phenotype suggests a central role of the liver in the pathogenesis of FCHL. 1 Present address: Translational Medicine and Genetics, GlaxoSmithKline, Research Triangle Park, NC 27713, U.S.A. Correspondence: Dr Martijn C. G. J...

View article titled, Five-year follow-up of waist circumference, insulin and ALT levels in familial combined hyperlipidaemia

Articles

Familial combined hyperlipidaemia: how can genetic disorders be common, complex and comprehensible?

Allan Sniderman, Swneke D. Bailey, C. Jamie Engert

Clin Sci (Lond) (2007) 113 (9): 365–367.

DOI: https://doi.org/10.1042/CS20070220

Published: 01 October 2007

... to the central role of the liver in defining the FCHL phenotypes and demonstrates how they vary over time in relation to energy excess. On the basis of their work and that of others, we propose that FCHL is a multiple gene/multiple pathway/multiple phenotype disease. The key feature of this model of common...

View article titled, Familial combined hyperlipidaemia: how can genetic disorders be common, complex and comprehensible?

Articles

Liver fibrosis: a balance of ACEs?

Fiona J. Warner, John S. Lubel, Geoffrey W. McCaughan, Peter W. Angus

Clin Sci (Lond) (2007) 113 (3): 109–118.

DOI: https://doi.org/10.1042/CS20070026

Published: 02 July 2007

...Fiona J. Warner; John S. Lubel; Geoffrey W. McCaughan; Peter W. Angus There is an increasing body of evidence to suggest that the RAS (renin–angiotensin system) contributes to tissue injury and fibrosis in chronic liver disease. A number of studies have shown that components of a local hepatic RAS...

View article titled, Liver fibrosis: a balance of ACEs?

Articles

Liver fibrosis: cellular mechanisms of progression and resolution

Neil C. Henderson, John P. Iredale

Clin Sci (Lond) (2007) 112 (5): 265–280.

DOI: https://doi.org/10.1042/CS20060242

Published: 01 February 2007

...Neil C. Henderson; John P. Iredale Liver fibrosis represents a major worldwide health care burden. The last 15 years have seen a rapid growth in our understanding of the pathogenesis of this clinically relevant model of inflammation and repair. This work is likely to inform the design of effective...

View article titled, Liver fibrosis: cellular mechanisms of progression and resolution

Articles

Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis

Maria J. Monte, Maria Fernandez-Tagarro, Rocio I. R. Macias, Felipe Jimenez, Francisco Gonzalez-San Martin, Jose J. G. Marin

Clin Sci (Lond) (2005) 109 (2): 199–207.

DOI: https://doi.org/10.1042/CS20050035

Published: 25 July 2005

...Maria J. Monte; Maria Fernandez-Tagarro; Rocio I. R. Macias; Felipe Jimenez; Francisco Gonzalez-San Martin; Jose J. G. Marin The relationship between BA (bile acid) secretion (measured by GC–MS) and the expression of genes (measured by reverse transcription real-time PCR) involved in liver BA...

View article titled, Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis

Articles

Therapeutic potential of transdifferentiated cells

Zoë D. BURKE, David TOSH

Clin Sci (Lond) (2005) 108 (4): 309–321.

DOI: https://doi.org/10.1042/CS20040335

Published: 22 March 2005

... of transdifferentiation, describe the theoretical and practical issues involved in transdifferentiation research and comment on the long-term therapeutic possibilities. Correspondence: Dr David Tosh (email d.tosh@bath.ac.uk ). 24 11 2004 21 1 2005 The Biochemical Society 2005 liver...

View article titled, Therapeutic potential of transdifferentiated cells

Articles

Effect of ischaemic preconditioning on hepatic oxygenation, microcirculation and function in a rat model of moderate hepatic steatosis

Rahul S. KOTI, Wenxuan YANG, Georgios GLANTZOUNIS, Alberto QUAGLIA, Brian R. DAVIDSON, Alexander M. SEIFALIAN

Clin Sci (Lond) (2005) 108 (1): 55–63.

DOI: https://doi.org/10.1042/CS20040130

Published: 15 December 2004

...Rahul S. KOTI; Wenxuan YANG; Georgios GLANTZOUNIS; Alberto QUAGLIA; Brian R. DAVIDSON; Alexander M. SEIFALIAN IPC (ischaemic preconditioning) may protect the steatotic liver, which is particularly susceptible to I/R (ischaemia/reperfusion) injury. Hepatic steatosis was induced in Sprague–Dawley...

View article titled, Effect of ischaemic preconditioning on hepatic oxygenation, microcirculation and function in a rat model of moderate hepatic steatosis

Articles

Liver albumin synthesis in sepsis in the rat: influence of parenteral nutrition, glutamine and growth hormone

Michael J. O'LEARY, Michael KOLL, Colin N. FERGUSON, John H. COAKLEY, Charles J. HINDS, Victor R. PREEDY, Peter J. GARLICK

Clin Sci (Lond) (2003) 105 (6): 691–698.

DOI: https://doi.org/10.1042/CS20030128

Published: 01 December 2003

...Michael J. O'LEARY; Michael KOLL; Colin N. FERGUSON; John H. COAKLEY; Charles J. HINDS; Victor R. PREEDY; Peter J. GARLICK The effect of sepsis on liver synthesis of albumin remains controversial, with studies in man suggesting that synthesis increases, whereas in animals increased, decreased...

View article titled, Liver albumin synthesis in sepsis in the rat: influence of parenteral nutrition, glutamine and growth hormone

Articles

Effect of maternal obstructive cholestasis during pregnancy on the biliary transport of horseradish peroxidase in the rat offspring

Maria J. MONTE, Gloria R. VILLANUEVA, Rocio I. R. MACIAS, David J. VAZQUEZ, Marta TOLEDO, Mercedes DOMINGUEZ, Jose J. G. MARIN

Clin Sci (Lond) (2003) 105 (3): 347–353.

DOI: https://doi.org/10.1042/CS20030114

Published: 01 September 2003

... liver microtubule transcytosis tubulin Clinical Science (2003) 105, 347 353 (Printed in Great Britain) 347 Effect of maternal obstructive cholestasis during pregnancy on the biliary transport of horseradish peroxidase in the rat offspring Maria J. MONTE , Gloria R. VILLANUEVA , Rocio I. R. MACIAS...

View article titled, Effect of maternal obstructive cholestasis during pregnancy on the biliary transport of horseradish peroxidase in the rat offspring

Articles

Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis

Maaike J. BRUINS, Nicolaas E.P. DEUTZ, Peter B. SOETERS

Clin Sci (Lond) (2003) 104 (2): 127–141.

DOI: https://doi.org/10.1042/cs1040127

Published: 10 January 2003

...-constant infusions of p -aminohippurate and 3 H-labelled isotopes were used to measure glucose, amino acid and protein metabolism across the portal-drained viscera, liver and hindquarters (to represent muscle) at 0 and 24h of endotoxaemia. Whole-body protein and glucose flux were increased during...

View article titled, Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis

Articles

Pathobiology and experimental therapeutics in hepatocellular cholestasis: lessons from the hepatocyte couplet model

Piotr MILKIEWICZ, Marcelo G. ROMA, Elwyn ELIAS, Roger COLEMAN

Clin Sci (Lond) (2002) 102 (6): 603–614.

DOI: https://doi.org/10.1042/cs1020603

Published: 30 April 2002

...Piotr MILKIEWICZ; Marcelo G. ROMA; Elwyn ELIAS; Roger COLEMAN Preparations of isolated liver cells, either freshly prepared or in culture, have been available for many years; however, because they lack the polarization of the cell in the tissue, their application to the study of processes involved...

View article titled, Pathobiology and experimental therapeutics in hepatocellular cholestasis: lessons from the hepatocyte couplet model

Articles

Liver electrolysis: pH can reliably monitor the extent of hepatic ablation in pigs

J. Guy FINCH, Beverley FOSH, Adrian ANTHONY, Eric SLIMANI, Michael TEXLER, David P. BERRY, Ashley R. DENNISON, Guy J. MADDERN

Clin Sci (Lond) (2002) 102 (4): 389–395.

DOI: https://doi.org/10.1042/cs1020389

Published: 04 March 2002

... and humans have shown that it is a safe, predictable and effective process for destroying normal and tumour-bearing liver in a linear, dose-dependent manner. Presently, the amount of current that is applied (in coulombs) has to be calculated using historical data, with inherent inaccuracy. The present study...

View article titled, Liver electrolysis: pH can reliably monitor the extent of hepatic ablation in pigs

Articles

Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: effects of glutamine

Michele A. MARKLEY, Agostino PIERRO, Simon EATON

Clin Sci (Lond) (2002) 102 (3): 337–344.

DOI: https://doi.org/10.1042/cs1020337

Published: 15 February 2002

... liver oxygen consumption. 337Clinical Science (2002) 102, 337 344 (Printed in Great Britain) Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: effects of glutamine Michele A. MARKLEY, Agostino PIERRO and Simon EATON Department of Paediatric Surgery, Institute of Child...

View article titled, Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: effects of glutamine

Articles

The response of liver albumin synthesis to infection in rats varies with the phase of the inflammatory process

Benoît RUOT, Fabienne BÉCHEREAU, Gérard BAYLE, Denis BREUILLÉ, Christiane OBLED

Clin Sci (Lond) (2002) 102 (1): 107–114.

DOI: https://doi.org/10.1042/cs1020107

Published: 10 December 2001

...Benoît RUOT; Fabienne BÉCHEREAU; Gérard BAYLE; Denis BREUILLÉ; Christiane OBLED To discriminate between the effects of infection and of anorexia associated with infection, liver albumin synthesis was measured in well-fed rats, in rats injected with live Escherichia coli and in pair-fed rats...

View article titled, The response of liver albumin synthesis to infection in rats varies with the phase of the inflammatory process

Articles

Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat

Michael J. O'LEARY, Colin N. FERGUSON, Michael J. RENNIE, Charles J. HINDS, John H. COAKLEY, Victor R. PREEDY

Clin Sci (Lond) (2001) 101 (3): 295–304.

DOI: https://doi.org/10.1042/cs1010295

Published: 15 August 2001

... was lower at 72 and 96 h, than in sham-operated animals. CLP was associated with increased liver protein synthesis at all time points, whereas there was no change after sham operation. Liver protein content did not change after CLP, but was lower at 72 and 96 h after sham operation than in non-operated...

View article titled, Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat

Articles

Hepatic sugar phosphate levels reflect gluconeogenesis in lung cancer: simultaneous turnover measurements and 31P magnetic resonance spectroscopy in vivo

Susanne LEIJ-HALFWERK, Pieter C. DAGNELIE, J. Willem O. VAN DEN BERG, J. H. Paul WILSON, Paul E. SIJENS

Clin Sci (Lond) (2000) 98 (2): 167–174.

DOI: https://doi.org/10.1042/cs0980167

Published: 19 January 2000

...Susanne LEIJ-HALFWERK; Pieter C. DAGNELIE; J. Willem O. VAN DEN BERG; J. H. Paul WILSON; Paul E. SIJENS Stable-isotope tracers were used to assess whether levels of phosphomonoesters (PME) and phosphodiesters (PDE) in the livers of lung cancer patients, as observed by 31 P magnetic resonance (MR...

View article titled, Hepatic sugar phosphate levels reflect gluconeogenesis in lung cancer: simultaneous turnover measurements and 31P magnetic resonance spectroscopy in vivo

Articles

Time-Course of Iron Overload and Biochemical, Histopathological and Ultrastructural Evidence of Pancreatic Damage in Hypotransferrinaemic Mice

Robert J. Simpson, Jean Deenmamode, Andrew T. McKie, Kishor B. Raja, Jonathan R. Salisbury, Theodore C. Iancu, Timothy J. Peters

Clin Sci (Lond) (1997) 93 (5): 453–462.

DOI: https://doi.org/10.1042/cs0930453

Published: 01 November 1997

... distribution of newly absorbed radioiron suggested that significant redistribution of iron from liver to pancreas (rather than direct dietary iron sources) must be invoked to explain the rate of pancreatic iron loading in hypotransferrinaemic mice. 4. Pancreatic epithelial cells first showed altered morphology...

View article titled, Time-Course of Iron Overload and Biochemical, Histopathological and Ultrastructural Evidence of Pancreatic Damage in Hypotransferrinaemic Mice

Articles

Hepatic Preservation with Histidine—Tryptophan—Ketoglutarate Solution in Living-Related and Cadaveric Liver Transplantation

Etsuro Hatano, Tetsuya Kiuchi, Akira Tanaka, Hisashi Shinohara, Toshiyuki Kitai, Seiji Satoh, Takuya Inomoto, Hiroto Egawa, Shinji Uemoto, Yukihiro Inomata, Hauke Lang, Karl J Oldhafer, Bruckhardt Ringe, Rudolf Pichlmayr, Koichi Tanaka, Yoshio Yamaoka

Clin Sci (Lond) (1997) 93 (1): 81–88.

DOI: https://doi.org/10.1042/cs0930081

Published: 01 July 1997

...Etsuro Hatano; Tetsuya Kiuchi; Akira Tanaka; Hisashi Shinohara; Toshiyuki Kitai; Seiji Satoh; Takuya Inomoto; Hiroto Egawa; Shinji Uemoto; Yukihiro Inomata; Hauke Lang; Karl J Oldhafer; Bruckhardt Ringe; Rudolf Pichlmayr; Koichi Tanaka; Yoshio Yamaoka 1. Living-related liver transplantation has...

View article titled, Hepatic Preservation with Histidine—Tryptophan—Ketoglutarate Solution in Living-Related and Cadaveric Liver Transplantation

Articles

T-Cell Autoimmunity in Primary Biliary Cirrhosis

David E. J. Jones

Clin Sci (Lond) (1996) 91 (5): 551–558.

DOI: https://doi.org/10.1042/cs0910551

Published: 01 November 1996

...David E. J. Jones 1. Primary biliary cirrhosis is a chronic cholestatic liver disease with an autoimmune aetiology. The classical histopathological lesion, of portal tract biliary epithelial cell damage, is accompanied by a T-cell-rich mononuclear cell infiltrate and upregulation of cell surface...

View article titled, T-Cell Autoimmunity in Primary Biliary Cirrhosis

Articles

Differential Effects of a Novel Non-Peptide Endothelin Receptor Antagonist (Bosentan) in Rat Liver and Vasculature

Paddy A. Phillips, John Risvanis, Kathryn Aldred, Louise M. Burrell, Briony Bartholomeusz

Clin Sci (Lond) (1995) 89 (6): 575–579.

DOI: https://doi.org/10.1042/cs0890575

Published: 01 December 1995

... and hepatic membranes by bosentan in vitro was similar. 5. Since bosentan is significantly excreted by the liver, the prolonged hepatic 125 I-ET-1 binding by bosentan presumably represents hepatic accumulation of bosentan, which may have implications for bosentan antagonizing the actions of ET in the liver...

View article titled, Differential Effects of a Novel Non-Peptide Endothelin Receptor Antagonist (Bosentan) in Rat Liver and Vasculature

Articles

Regional Sympathetic Nervous Activation after a Large Meal in Humans

Helen S. Cox, David M. Kaye, Jane M. Thompson, Andrea G. Turner, Garry L. Jennings, Catherine Itsiopoulos, Murray D. Esler

Clin Sci (Lond) (1995) 89 (2): 145–154.

DOI: https://doi.org/10.1042/cs0890145

Published: 01 August 1995

... nervous activity in healthy, lean subjects. 2. In nine male subjects, noradrenaline spillover was measured from the heart, kidney and liver using isotope dilution, both while fasting and after consumption of a high-energy liquid meal of composition 53% carbohydrate, 32% fat and 15% protein (energy value...

View article titled, Regional Sympathetic Nervous Activation after a Large Meal in Humans

Articles

Cellular Localization of Inducible Nitric Oxide Synthase in Experimental Endotoxic Shock in the Rat

H. Terence Cook, Alison J. Bune, Albertine S. Jansen, G. Michael Taylor, Rashpal K. Loi, Victoria Cattell

Clin Sci (Lond) (1994) 87 (2): 179–186.

DOI: https://doi.org/10.1042/cs0870179

Published: 01 August 1994

... induction was monocytes and macrophages in multiple organs, principally liver and spleen. Bronchial, bile duct, intestinal and bladder epithelium and some hepatocytes also expressed inducible NO synthase. Expression peaked at 5 h and had returned to normal by 12 h except in spleen. 3. After priming with C...

View article titled, Cellular Localization of Inducible Nitric Oxide Synthase in Experimental Endotoxic Shock in the Rat

Articles

Loop—Sheet Polymerization: The Structural Basis of Z α 1 -Anti Trypsin Accumulation in the Liver

David A. Lomas

Clin Sci (Lond) (1994) 86 (5): 489–495.

DOI: https://doi.org/10.1042/cs0860489

Published: 01 May 1994

... the liver of a Z homozygote. 2. That loop—sheet polymerization is a more general phenomenon was shown by the examination of a second deficiency variant, antitrypsin S iiyama (Ser-53→Phe), which is also associated with liver inclusions. Electron microscopy confirmed that isolated antitrypsin S iiyama from...

View article titled, Loop—Sheet Polymerization: The Structural Basis of Z α 1 -Anti Trypsin Accumulation in the Liver

Articles

Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats

Sylvia Heeneman, Nicolaas E. P. Deutz

Clin Sci (Lond) (1993) 85 (4): 437–444.

DOI: https://doi.org/10.1042/cs0850437

Published: 01 October 1993

... for 4 days. Glutamine consumption in portal-drained viscera and liver was measured after an overnight fast by determining fluxes and intracellular concentrations in normal rats, methionine sulphoximine-treated rats and pair-fed controls. Moreover, fluxes and intracellular concentrations of several other...

View article titled, Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats

Articles

Responses of Tissue Protein Synthesis to Nutrient Intake in Rats Exposed to Interleukin-1 β Or Turpentine

Peter E. Ballmer, Margaret A. McNurlan, Ian Grant, Peter J. Garlick

Clin Sci (Lond) (1993) 85 (3): 337–342.

DOI: https://doi.org/10.1042/cs0850337

Published: 01 September 1993

...Peter E. Ballmer; Margaret A. McNurlan; Ian Grant; Peter J. Garlick 1. The influence of an acute-phase reaction on the ability of protein synthesis rates in liver and three different muscles (gastrocnemius, soleus and heart) to respond to a short intravenous infusion of nutrients (glucose plus...

View article titled, Responses of Tissue Protein Synthesis to Nutrient Intake in Rats Exposed to Interleukin-1 β Or Turpentine

Articles

Electron paramagnetic resonance spectroscopy of stable free radicals in the liver compared with ultrastructural and functional damage in a rat model of alcohol- and iron-overload

Graham P. Butcher, Nigel Deighton, Roger M. Batt, Boliang Ding, Susan Haywood, John Hoffman, Malcolm J. Jackson, Martyn C. R. Symons, Jonathan M. Rhodes

Clin Sci (Lond) (1993) 84 (3): 339–348.

DOI: https://doi.org/10.1042/cs0840339

Published: 01 March 1993

...Graham P. Butcher; Nigel Deighton; Roger M. Batt; Boliang Ding; Susan Haywood; John Hoffman; Malcolm J. Jackson; Martyn C. R. Symons; Jonathan M. Rhodes 1. Electron paramagnetic resonance spectroscopy was used to study free-radical signals in freeze-clamped frozen liver tissue from rats after a 1...

View article titled, Electron paramagnetic resonance spectroscopy of stable free radicals in the liver compared with ultrastructural and functional damage in a rat model of alcohol- and iron-overload

Articles

Studies of human zinc kinetics using the stable isotope 70 Zn

N. M. Lowe, A. Green, J. M. Rhodes, M. Lombard, R. Jalan, M. J. Jackson

Clin Sci (Lond) (1993) 84 (1): 113–117.

DOI: https://doi.org/10.1042/cs0840113

Published: 01 January 1993

...N. M. Lowe; A. Green; J. M. Rhodes; M. Lombard; R. Jalan; M. J. Jackson 1. The short-term (120 min) kinetics of Zn turnover has been studied in control subjects and patients with alcoholic liver disease after intravenous injection of 0.5 mg of 96.5% enriched 70 ZnCl 2 . 2. The 70 Zn enrichment...

View article titled, Studies of human zinc kinetics using the stable isotope 70 Zn

Articles

Evidence for the indirect utilization of glucose for the synthesis of hepatic glycogen in man

R. F. G. J. King, M. Madan, D. Alexander, A. Boyd, K. Ibrahim, M. J. McMahon, D. Johnston

Clin Sci (Lond) (1992) 83 (6): 677–682.

DOI: https://doi.org/10.1042/cs0830677

Published: 01 December 1992

...R. F. G. J. King; M. Madan; D. Alexander; A. Boyd; K. Ibrahim; M. J. McMahon; D. Johnston 1. This study was designed to test the hypothesis that three-carbon intermediates can be used in the ‘indirect’ pathway of glycogen synthesis in human liver (i.e. a route additional to the use of glucose...

View article titled, Evidence for the indirect utilization of glucose for the synthesis of hepatic glycogen in man

Articles

Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs

N. E. P. Deutz, P. L. M. Reijven, G. Athanasas, P. B. Soeters

Clin Sci (Lond) (1992) 83 (5): 607–614.

DOI: https://doi.org/10.1042/cs0830607

Published: 01 November 1992

... area is less well characterized. We were specifically interested in substrate flux across the spleen as it is an organ with important immunological functions. 2. Therefore, hindquarter, gut, spleen and liver fluxes of amino acids, ammonia, glucose, lactate and blood gases were measured for 4 days after...

View article titled, Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs

Articles

Effects of endothelin in portal hypertensive rats

Pi-Chin Yu, Jon-Son Kuo, Han-Chieh Lin, May C. M. Yang

Clin Sci (Lond) (1992) 83 (2): 165–170.

DOI: https://doi.org/10.1042/cs0830165

Published: 01 August 1992

... 1992 blood pressure liver portal pressure splanchnic bed vascular reactivity Clinical Science (1992) 83, 165-170 (Printed in Great Britain) I65 Effects of endothelin in portal hypertensive rats PiChin YU', Jon-Son KUOz, HanChieh LIN3 and May C. M. YANG' 'Department of Medical Research...

View article titled, Effects of endothelin in portal hypertensive rats

Articles

Effect of l-alanine infusion on 31P nuclear magnetic resonance spectra of normal human liver: towards biochemical pathology in vivo

P. C. Dagnelie, D. K. Menon, I. J. Cox, J. D. Bell, J. Sargentoni, G. A. Coutts, J. Urenjak, R. A. Iles

Clin Sci (Lond) (1992) 83 (2): 183–190.

DOI: https://doi.org/10.1042/cs0830183

Published: 01 August 1992

...P. C. Dagnelie; D. K. Menon; I. J. Cox; J. D. Bell; J. Sargentoni; G. A. Coutts; J. Urenjak; R. A. Iles 1. 31 P n.m.r. spectroscopy in vivo was used to study the effect of l -alanine infusion on the concentrations of gluconeogenic intermediates in normal human liver. Studies were performed in six...

View article titled, Effect of l-alanine infusion on 31P nuclear magnetic resonance spectra of normal human liver: towards biochemical pathology in vivo

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