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Keywords: lactate
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Clin Sci (Lond) (2015) 129 (4): 375–384.
Published: 27 May 2015
...Jonathan Grip; Towe Jakobsson; Christina Hebert; Maria Klaude; Gustaf Sandström; Jan Wernerman; Olav Rooyackers Plasma lactate is widely used as a biomarker in critical illness. The aims of the present study were to elucidate the usefulness of a three-compartment model for muscle lactate kinetics...
Clin Sci (Lond) (2009) 117 (9): 339–344.
Published: 01 September 2009
... after 5, 10, 15, 20, 25 and 30 min of reperfusion. The biopsies were analysed for glutathione, amino acids and lactate. Median ischaemia time was 28 (range, 15–36) min. Lactate increased 266% at maximal ischaemia ( P <0.05). No alterations in glutathione concentrations or the redox status...
Clin Sci (Lond) (2001) 101 (4): 377–383.
Published: 14 September 2001
... catecholamines domperidone hypoxia lactate noradrenaline 377Clinical Science (2001) 101, 377 383 (Printed in Great Britain) Heart rate response to hypoxic exercise: role of dopamine D2-receptors and effect of oxygen supplementation Carsten LUNDBY*, Peter MØLLER , Inge-Lis KANSTRUP and Niels Vidiendal...
Clin Sci (Lond) (2001) 101 (1): 37–43.
Published: 24 May 2001
... catheter technique. Haemodynamic state was assessed with the aid of Swan–Ganz catheters. High-dose GIK caused a shift towards carbohydrate utilization, with significant lactate uptake throughout the study period and significant uptake of glucose after 4 h. Arterial levels of non-esterified fatty acids...
Clin Sci (Lond) (1998) 94 (2): 157–163.
Published: 01 February 1998
...P. King; M.-F. Kong; H. Parkin; I. A. MacDonald; C. Barber; R. B. Tattersall 1. Intravenous lactate prevents cerebral dysfunction during hypoglycaemia in healthy volunteers. This study examines whether this also occurs in insulin-dependent diabetes. Changes in four-choice reaction time, auditory...
Clin Sci (Lond) (1997) 92 (5): 493–496.
Published: 01 May 1997
... acids, lactate and pyruvate change during the menstrual cycle. 2. Microdialysis was performed twice during the menstrual cycle in eight healthy women, in the breast and subcutaneous fat. Amino acids, lactate and pyruvate were analysed by HPLC. 3. None of the women showed any complications...
Clin Sci (Lond) (1994) 86 (1): 15–25.
Published: 01 January 1994
..., intermittent isometric exercise, lactate. microdialysis probe. Abbmviatiom: KHB. Krebs-tlenseleit buffer; MVC, maximal voluntary isometric contraction force. Correspondence: Dr JM Henrikrron, Department d Physiology 111. Karolinska Institutet. Box 5626, 5-1 14 84 Stockholm, Sweden. 16 R. C. Hickner et al. Xe...
Clin Sci (Lond) (1992) 83 (5): 607–614.
Published: 01 November 1992
... area is less well characterized. We were specifically interested in substrate flux across the spleen as it is an organ with important immunological functions. 2. Therefore, hindquarter, gut, spleen and liver fluxes of amino acids, ammonia, glucose, lactate and blood gases were measured for 4 days after...
Clin Sci (Lond) (1992) 83 (5): 597–605.
Published: 01 November 1992
... to triacylglycerol. cirrhosis C-peptide C-peptide metabolic clearance rate glucose glycerol 3-hydroxybutyrate insulin secretion lactate non-esterified fatty acids triacylglycerol Clinical Science (1992) 83, 5 9 7 4 5 (Printed in Great Britain) 597 Twenty-four hour Gpeptide and insulin secretion rates...
Clin Sci (Lond) (1992) 82 (1): 63–70.
Published: 01 January 1992
..., was lower in acute illness than in convalescence [16.1 (7.0) versus 23.9 (7.2) ml min −1 kg −1 , mean ( sd )], but this difference was not statistically significant ( P = 0.15). There was a significant inverse correlation between admission venous plasma lactate concentrations and the liver blood flow...
Clin Sci (Lond) (1990) 79 (1): 81–87.
Published: 01 July 1990
... occlusions. 3. The concentrations of glucose, lactate and glycerol, as well as blood gas variables, in arterial and femoral venous blood did not change during the study or decreased so slightly (pH and lactate) that the arteriovenous difference was not influenced. 4. We conclude that the blood flow...
Clin Sci (Lond) (1989) 77 (6): 663–670.
Published: 01 December 1989
... the adipose tissue showed marked positive carbon balance (net substrate deposition). 7 6 1989 23 6 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 adipose tissue free fatty acids glucose glycerol insulin lactate muscle triacylglycerol Clinical Science...
Clin Sci (Lond) (1989) 76 (5): 509–516.
Published: 01 May 1989
... increased after glucose ingestion. Although lactate was produced throughout, its molar ratio to glucose uptake was less than that reported for other superficial sites, suggesting only a minor contribution of skin metabolism. Forearm muscle showed a larger and more prolonged increase in arteriovenous...
Clin Sci (Lond) (1986) 70 (2): 207–210.
Published: 01 February 1986
... after 10 min maximal exercise (arm ergometer). The proportion of PDH in the active form increased least after immobilization (to 52 ± 13.6%), compared with control (95 ± 11.7%) and post-training (98 ± 6.6%). 4. After exercise muscle glycogen fell to the greatest extent and lactate rose the least...
Clin Sci (Lond) (1986) 70 (1): 19–22.
Published: 01 January 1986
...Leif Sestoft; Michael O. Marshall 1. The effect of pH on lactate uptake was studied in perfused liver of rats starved for 48 h. 2. At both low pH (6.8) and normal pH (7.4) lactate uptake was a linear function of lactate concentration in input medium in the range 0.4–1.5 mmol/l. 2. In the lower...
Clin Sci (Lond) (1984) 66 (2): 179–186.
Published: 01 February 1984
...% above control level. 6. Plasma glucose and glycerol concentrations remained unchanged, and plasma non-esterified fatty acids, lactate and noradrenaline concentrations increased slightly but significantly. 7. Biopsies taken from the hot interscapular areas did not contain brown adipose tissue. 8...
Clin Sci (Lond) (1984) 66 (1): 87–90.
Published: 01 January 1984
... an accelerated clearance of adrenaline by exercising tissue. The clearance rate of adrena- line from plasma is reduced during exercise. 5. There is no significant increase in secretion by the adrenal medulla in response to the stimulus of mild or moderate exercise. Key words: adrenaline, exercise, lactate...
Clin Sci (Lond) (1983) 65 (3): 247–253.
Published: 01 September 1983
.... There was a small increase in arterial blood glucose concentration, and a decrease in blood alanine concentration during drug infusion. Blood lactate was not affected by phentolamine. The arterial concentrations of free fatty acids and glycerol increased, and the concentration of triglycerides decreased during...
Clin Sci (Lond) (1983) 64 (1): 33–40.
Published: 01 January 1983
...A. R. Thomassen; T. T. Nielsen; J. P. Bagger; P. Henningsen 1. Myocardial exchanges of plasma alanine, glutamate, citrate, lactate, glucose and free fatty acids were determined in 17 patients with coronary artery disease and in seven control subjects during rest, atrial pacing and recovery. 2...
Clin Sci (Lond) (1982) 63 (1): 87–92.
Published: 01 July 1982
... duration ( n = 3), only 39 ± 1% of the enzyme was in the active form. 6. Muscle glycogen depletion was greatest with intermittent exercise and least with isometric maximal exercise; in contrast, the increase in muscle lactate was least with progressive exercise (1·3 to 9·4 μmol/g), intermediate...
Clin Sci (Lond) (1982) 62 (4): 411–420.
Published: 01 April 1982
...J. P. Monson; J. A. Smith; R. D. Cohen; R. A. Iles 1. The rate of uptake in 15 s of l - and d -lactate was studied in isolated hepatocyte preparations from starved rats. 2. Observations were also made of the effect of different concentrations of unlabelled l - and d -lactate on l -[ 14 C]- and d...
Clin Sci (Lond) (1982) 62 (2): 131–136.
Published: 01 February 1982
... substrates lactate and glycerol. 2. To determine whether the effect of non-selective β-adrenoceptor blockade on glucose recovery could be associated with diminished availability of gluconeogenic substrates, lactate and glycerol were infused during hypoglycaemia in four insulin-dependent diabetic patients...
Clin Sci (Lond) (1980) 59 (6): 469–478.
Published: 01 December 1980
...) and 70% maximum power (heavy work) on separate days, after an overnight fast. 2. A steady state was achieved in both studies between 20 and 40 min in: oxygen intake (1.42 and 2.64 litres/min respectively); respiratory exchange ratio (0.89 and 1.01); plasma lactate concentration (1.78 and 9.94 mmol/l). 3...
Clin Sci (Lond) (1980) 59 (3): 191–198.
Published: 01 September 1980
... of the glucose load metabolized in peripheral tissues. Values in cirrhotic patients and control subjects (5614 ± 1630 compared with 5344 ± 672 μmol of glucose min −1 1 −1 of forearm in 3 h) were similar despite higher glucose levels and sustained high insulin levels in the cirrhotic patients. 4. Peak lactate...
Clin Sci (Lond) (1980) 59 (1): 19–27.
Published: 01 July 1980
...H. B. Stoner; K. N. Frayn; R. A. Little; C. J. Threlfall; D. W. Yates; R. N. Barton; D. F. Heath 1. Plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, insulin and cortisol were measured in 43 elderly patients with hypothermia. In 15...
Clin Sci (Lond) (1980) 58 (2): 153–155.
Published: 01 February 1980
...M. Nattrass; Karen Sizer; K. G. M. M. Alberti 1. Circulating concentrations of intermediary metabolites have been measured after administration of 50 mg of phenformin to normal subjects. 2. Phenformin caused a significant increase in blood lactate, alanine and the lactate/pyruvate ratio but did...
Clin Sci (Lond) (1979) 56 (6): 563–573.
Published: 01 June 1979
...H. B. Stoner; K. N. Frayn; R. N. Barton; C. J. Threlfall; R. A. Little 1. The plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, ethanol, cortisol and insulin were measured in patients within a few hours of injury and before treatment...
Clin Sci (Lond) (1979) 56 (2): 139–146.
Published: 01 February 1979
...W. J. Ryan; J. R. Sutton; C. J. Toews; N. L. Jones 1. The ability to metabolize lactate at rest and during exercise was studied in six male subjects by using a constant infusion of sodium l(+)-lactate at a rate of 0·05 mmol min −1 kg −1 . Twenty minute periods of rest and exercise at two work rates...
Clin Sci Mol Med (1978) 55 (2): 199–204.
Published: 01 August 1978
... with that in the control subjects. 4. Fasting blood glucose, lactate and pyruvate concentrations were similar in all groups, whereas blood ketone bodies were increased in the malnourished and septic groups, and blood alanine was decreased only in the septic group. 5. The changes in hepatic metabolism and function were...
Clin Sci Mol Med (1978) 55 (2): 183–188.
Published: 01 August 1978
...R. A. Iles; P. G. Baron; R. D. Cohen 1. The effects of varying P co 2 on glucose output and the intracellular concentrations of lactate, pyruvate, phosphoenolpyruvate, 2-phosphoglycerate and 3-phosphoglycerate were studied in the isolated rat liver perfused with differing concentrations of lactate...
Clin Sci Mol Med (1978) 55 (2): 175–181.
Published: 01 August 1978
...P. G. Baron; R. A. Iles; R. D. Cohen 1. The effects of varying P co 2 on lactate uptake and intracellular pH (pH l ) were studied in the isolated rat liver perfused with differing concentrations of lactate. 2. In general, pH l and lactate uptake are inversely related to P co 2 , and pH l...
Clin Sci Mol Med (1978) 54 (1): 107–109.
Published: 01 January 1978
...G. Royle; M. G. W. Kettlewell; Vera Ilic; D. H. Williamson 1. Galactose utilization after intravenous injection was measured in fed and fasted man together with changes in blood glucose, lactate and insulin. 2. Feeding did not alter blood galactose half-life. 3. The mean increases in blood glucose...
Clin Sci Mol Med (1976) 50 (6): 493–498.
Published: 01 June 1976
...B. D. Ross 1. Gluconeogenesis from lactate or from glutamine is inhibited by 90–100% by sodium quinolinate (1 mmol/l) or 3-mercaptopicolinate (150 nmol/l) in the perfused rat kidney. l-Tryptophan is not metabolized and is without effect. 2. Lactate uptake and glucose production are inhibited...
Clin Sci Mol Med (1976) 50 (3): 185–194.
Published: 01 March 1976
...J. Yudkin; R. D. Cohen 1. The isolated perfused kidneys of fed rats in normal acid-base status showed a constant rate of lactate removal from the perfusate between 5 and 90 min of perfusion at a perfusate pH of 7·4–7·5. 2. Lactate removal by kidneys of rats in normal acid-base status was stimulated...
Clin Sci Mol Med (1975) 49 (5): 473–479.
Published: 01 November 1975
.... The decreased fractional disappearance rate was partly due to an increase in glucose distribution space and partly due to a decrease in absolute glucose disappearance rate. 4. Impaired gluconeogenesis was suggested by mild fasting hypoglycaemia in four patients and raised fasting blood lactate concentrations...
Clin Sci Mol Med (1974) 47 (5): 493–506.
Published: 01 November 1974
... and in a group of five healthy control subjects. 2. Heart rate, pulmonary oxygen uptake and ventilatory exchange ratio were all significantly higher in the group of patients during exercise. The release of lactate by the exercising leg in the patients exceeded that of the control subjects and was associated...
Clin Sci Mol Med (1974) 47 (3): 249–257.
Published: 01 September 1974
... the isometric exercise. Forearm blood samples were taken from the antecubital vein in both the exercised and non-exercised arm before and 2 min post-exercise for measurement of plasma lactate, osmolality, P v,o 2 , P v,co 2 and pH. 2. During hand grip the heart rate and blood pressure increased significantly...
Clin Sci Mol Med (1973) 45 (5): 677–690.
Published: 01 November 1973
... for the observed glucose disappearance rate, indicating insulin resistance. Serum growth hormone concentrations in male acute hepatitis patients were significantly higher than controls and suppressed poorly. 3. Fasting blood lactate concentrations were significantly elevated and after intravenous glucose...
Clin Sci Mol Med (1973) 45 (4): 543–549.
Published: 01 October 1973
...M. H. Lloyd; R. A. Iles; B. R. Simpson; J. M. Strunin; J. M. Layton; R. D. Cohen 1. The relationship between extracellular pH (pH e ), intracellular pH (pH i ) and lactate uptake was studied in the isolated perfused rat liver during simulated metabolic acidosis. 2. pH i fell to a considerably less...