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Keywords: kidney
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Clin Sci (Lond) (2022) 136 (23): 1759–1772.
Published: 02 December 2022
... kidney-specific overexpression of VEGF-D (KidVD) experience renal lymphangiogenesis upon doxycycline administration. HTN was induced in KidVD+ and KidVD- mice by subcutaneous release of angiotensin II, administration of the nitric oxide synthase inhibitor L-NAME, or consumption of a 4% salt diet...
Includes: Supplementary data
Clin Sci (Lond) (2022) 136 (12): 989–1003.
Published: 29 June 2022
... or/and activity of G-protein-coupled receptor kinase 4 (GRK4) or genetic variants (e.g., GRK4γ142V) cause sodium retention and hypertension. Whether GRK4 plays a role in the regulation of AT 2 R in the kidney remains unknown. In the present study, we found that spontaneously hypertensive rats (SHRs) had increased...
Includes: Supplementary data
Clin Sci (Lond) (2022) 136 (11): 825–840.
Published: 01 June 2022
...Riyaz Mohamed; Gene R. Crislip; Sarah McLarnon; Qingqing Wei; Paul M. O’Connor; Jennifer C. Sullivan Acute kidney injury (AKI) due to ischemia is a serious and frequent clinical complication with mortality rates as high as 80%. Vascular congestion in the renal outer medulla occurs early after...
Clin Sci (Lond) (2021) 135 (22): 2575–2588.
Published: 26 November 2021
.... Treatment with tempol in paternal rats also reversed the increased expressions of AT 1 R and GRK4 in the kidney of their offspring. We suggest that paternal PM 2.5 exposure causes hypertension in offspring. The mechanism may be involved that paternal PM 2.5 exposure-associated oxidative stress induces...
Clin Sci (Lond) (2021) 135 (21): 2521–2540.
Published: 09 November 2021
...) and recessive (AR) forms of polycystic kidney disease (PKD). We provide here a basic overview of the origins and clinical aspects of ARPKD and ADPKD and discuss the implications of electrolyte transport in cystogenesis. Special attention is devoted to intracellular calcium handling by the cystic cells...
Clin Sci (Lond) (2021) 135 (19): 2329–2339.
Published: 13 October 2021
... 2 weeks, kidneys were harvested for flow cytometric analysis of T cells. Splenectomy increased BP in both sexes after 2 weeks. Renal Tregs decreased in both sexes after splenectomy, abolishing the sex differences in renal Tregs. In conclusion, splenic Tregs were comparable in male and female SHRs...
Clin Sci (Lond) (2021) 135 (17): 2165–2196.
Published: 17 September 2021
...Erika I. Boesen; Rahul M. Kakalij Hypertension is a major risk factor for cardiovascular disease, chronic kidney disease (CKD), and mortality. Troublingly, hypertension is highly prevalent in patients with autoimmune renal disease and hastens renal functional decline. Although progress has been...
Clin Sci (Lond) (2021) 135 (15): 1825–1843.
Published: 04 August 2021
...Ana Paula Oliveira Leite; Xiao C. Li; Rumana Hassan; Xiaowen Zheng; Barbara Alexander; Dulce Elena Casarini; Jia L. Zhuo In the present study, we tested the hypothesis that there are significant sex differences in angiotensin II (Ang II)-induced hypertension and kidney injury using male and female...
Clin Sci (Lond) (2021) 135 (3): 575–588.
Published: 10 February 2021
... conclude that IL-10 absence has a protective role in an experimental model of HUS by reducing PMN recruitment into kidney and renal damage, and increasing mice survival. Correspondence: María Victoria Ramos ( toresani7@hotmail.com , mvramos.mvr@gmail.com ) 16 04 2020 15 01 2021 26 01...
Clin Sci (Lond) (2020) 134 (22): 3023–3046.
Published: 24 November 2020
... a lifetime. Correspondence: Stephane L. Bourque ( sbourque@ualberta.ca ) 28 09 2020 07 11 2020 10 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Cardiovascular Developmental programming Heart Kidney...
Clin Sci (Lond) (2020) 134 (18): 2453–2467.
Published: 25 September 2020
... ) * These authors contributed equally to this work. 21 05 2020 15 09 2020 17 09 2020 17 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adiponectin adipose tissue GRK4 hypertension kidney renal proximal tubule...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (13): 1751–1762.
Published: 10 July 2020
...Riyaz Mohamed; Olga Rafikova; Paul M. O’Connor; Jennifer C. Sullivan Renal ischemia is the most common cause of acute kidney injury. Damage-associated molecular patterns (DAMPs) initiate an inflammatory response and contribute to ischemia–reperfusion (IR) injury in males, yet the contribution...
Clin Sci (Lond) (2020) 134 (7): 871–884.
Published: 14 April 2020
... of Monash University in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. After the kidney sections had been spotted onto slides and washed with TBS, they were permeabilized with 0.2% Triton-X in TBS in TBS for 10...
Clin Sci (Lond) (2020) 134 (6): 641–656.
Published: 27 March 2020
... of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin–angiotensin–aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation...
Clin Sci (Lond) (2020) 134 (1): 75–85.
Published: 17 January 2020
... was measured in human kidney biopsies with DN and in kidneys of db/db mice. The role of Renalase in the development of DN was examined using a genetically engineered mouse model: Renalase knockout mice with db/db background. The renoprotective effects of Renalase in DN was evaluated in db/db mice with Renalase...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (2): 167–180.
Published: 18 January 2019
...Mathilde L. Bonnemaison; Eileen S. Marks-Nelson; Erika I. Boesen Systemic lupus erythematosus (SLE) is an autoimmune disease predominantly affecting women and often leading to lupus nephritis and kidney damage. Endoplasmic reticulum (ER) stress has been implicated in several forms of kidney disease...
Clin Sci (Lond) (2019) 133 (1): 41–54.
Published: 03 January 2019
..., an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine...
Clin Sci (Lond) (2018) 132 (17): 1977–1994.
Published: 14 September 2018
...Meg L. McFetridge; Mark P. Del Borgo; Marie-Isabel Aguilar; Sharon D. Ricardo Chronic kidney disease (CKD) is a major and growing public health concern with increasing incidence and prevalence worldwide. The therapeutic potential of stem cell therapy, including mesenchymal stem cells (MSCs...
Clin Sci (Lond) (2018) 132 (11): 1179–1197.
Published: 15 June 2018
...Sarah C. Ray; Bansari Patel; Debra L. Irsik; Jingping Sun; Hiram Ocasio; Gene R. Crislip; Chunhua H. Jin; JianKang Chen; Babak Baban; Aaron J. Polichnowski; Paul M. O’Connor Sodium bicarbonate (NaHCO 3 ) slows the decline in kidney function in patients with chronic kidney disease (CKD), yet...
Clin Sci (Lond) (2016) 130 (15): 1307–1326.
Published: 29 June 2016
... 6 5 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 AT2 receptor AT2R agonism cardiovascular compound 21 kidney The biological actions of the renin–angiotensin system (RAS) are regarded to be primarily mediated...
Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
.... Correspondence: Professor Carol A. Pollock (email carol.pollock@sydney.edu.au ). 29 1 2014 24 3 2014 16 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 diabetic nephropathy calcium-activated potassium channel inflammatory cell K Ca 3.1 kidney renal...
Clin Sci (Lond) (2014) 127 (1): 15–17.
Published: 10 March 2014
... in the cardiovascular and renal system, its involvement in hypertensive organ dysfunctions, such as those that occur in kidney, has not been investigated. In the present issue of Clinical Science , Alique and co-workers have demonstrated that angiotensin II-induced renal inflammatory responses were attenuated in mice...
Clin Sci (Lond) (2014) 127 (1): 19–31.
Published: 10 March 2014
... blockers are renoprotective and down-regulate ILK in experimental kidney disease, but the involvement of ILK in the actions of AngII in the kidney has not been addressed. Therefore we have investigated whether ILK signalling modulates the kidney response to systemic AngII infusion in wild-type and ILK...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (10): 685–694.
Published: 27 January 2014
...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...
Clin Sci (Lond) (2014) 126 (5): 315–328.
Published: 25 October 2013
... factors and agents that control nephrin and Neph3 gene expression. Correspondence: Dr Sanna Lehtonen (email sanna.h.lehtonen@helsinki.fi ). 28 5 2013 9 8 2013 21 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 glomerulus kidney KIRREL2 (kin...
Clin Sci (Lond) (2013) 124 (12): 701–710.
Published: 26 February 2013
... lines demonstrated similar elevations of BP (blood pressure) and plasma potassium after 4 weeks of TG induction. Withdrawal of doxycycline switched off mutant TG expression and the disappearance of the PHAII phenotype. Western blotting of microdissected kidney nephron segments confirmed that expression...
Includes: Supplementary data
Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
... by its action on a restricted number of tissues; however, it has now become clear that this hormone controls an array of cellular processes in many different tissues. The present review will focus on the role of insulin in the kidney in health and disease. Correspondence: Dr Richard Coward (email...
Clin Sci (Lond) (2013) 124 (3): 191–202.
Published: 17 October 2012
... species) have been implicated in the development of diabetic nephropathy. Of the Nox isoforms in the kidney, Nox4 is important because of its renal abundance. In the present study, we tested the hypothesis that GKT136901, a Nox1/4 inhibitor, prevents the development of nephropathy in db / db (diabetic...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (6): 333–346.
Published: 29 May 2012
...Danielle Zimmerman; Kevin D. Burns Ang-(1–7) [angiotensin-(1–7)] is a biologically active heptapeptide component of the RAS (renin–angiotensin system), and is generated in the kidney at relatively high levels, via enzymatic pathways that include ACE2 (angiotensin-converting enzyme 2...
Clin Sci (Lond) (2012) 123 (1): 1–14.
Published: 12 March 2012
...Anke L. Lameris; Leo A. Monnens; René J. Bindels; Joost G. J. Hoenderop Magnesium (Mg 2+ ) balance is tightly regulated by the concerted actions of the intestine, bone and kidneys. This balance can be disturbed by a broad variety of drugs. Diuretics, modulators of the EGFR (epidermal growth factor...
Clin Sci (Lond) (2012) 122 (11): 513–527.
Published: 10 February 2012
... kidney myocardial ischaemia/reperfusion injury soluble epoxide hydrolase inhibitor Ischaemic heart disease is the leading cause of mortality in industrialized nations [ 1 ]. Hypertension and hypertension-induced LVH [LV (left ventricular) hypertrophy] have been recognized in the Framingham...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (10): 439–447.
Published: 20 January 2012
... microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges...
Clin Sci (Lond) (2012) 122 (6): 281–288.
Published: 11 November 2011
... developmental programming extracellular fluid hyperphagia kidney salt appetite Prenatal exposure to an adverse environment has a marked impact upon the developing kidney. People whose birthweights were towards the lower end of the normal range have fewer nephrons [ 1 ] and are at greater risk...
Clin Sci (Lond) (2010) 118 (4): 269–279.
Published: 16 November 2009
...Elena Velkoska; Rachael G. Dean; Luke Burchill; Vicki Levidiotis; Louise M. Burrell Alterations within the RAS (renin–angiotensin system) are pivotal for the development of renal disease. ACE2 (angiotensin-converting enzyme 2) is expressed in the kidney and converts the vasoconstrictor AngII...
Clin Sci (Lond) (2010) 118 (1): 71–77.
Published: 02 October 2009
...Paul R. Kalra; Jonathan R. Clague; Andrew J. Coats; Stefan D. Anker; Philip A. Poole-Wilson; Allan D. Struthers CNP (C-type natriuretic peptide) is a vasodilatory peptide produced by vascular endothelium and the human heart with a short half-life. CNP has been identified within the human kidney...
Clin Sci (Lond) (2010) 118 (1): 1–18.
Published: 28 September 2009
...Henrik Dimke; Joost G. Hoenderop; René J. Bindels The kidney plays an important role in maintaining the systemic Ca 2+ and Mg 2+ balance. Thus the renal reabsorptive capacity of these cations can be amended to adapt to disturbances in plasma Ca 2+ and Mg 2+ concentrations. The reabsorption of Ca 2...
Clin Sci (Lond) (2009) 117 (2): 75–84.
Published: 15 June 2009
... + . Western blotting and quantitative PCR showed that NKCC2 expression was increased, whereas NCC mRNA was not up-regulated. Na + /K + ATPase α 1 subunit expression did not differ from controls; however, there was a significant reduction in whole kidney pump activity (23.4±1.8 and 17.7±1.2 nmol...
Clin Sci (Lond) (2008) 115 (2): 57–68.
Published: 12 June 2008
... (phenylephrine) and ACh (acetylcholine) in isolated perfused kidneys were measured. NO levels were calculated as 24-h urinary excretion of nitrites, ROS as TBARS (thiobarbituric acid-reacting substances), and peroxynitrite formation as the renal expression of nitrotyrosine. BDL rats had progressive sodium...
Clin Sci (Lond) (2008) 114 (9): 589–590.
Published: 02 April 2008
... 2008 glucagon glucose tolerance insulin deficiency kidney microalbuminuria Type 2 diabetes The existence of a second pancreatic hormone, one that raises plasma glucose concentrations, in addition to the glucose-lowering hormone insulin was deduced early in the 20th century and fully...
Clin Sci (Lond) (2008) 114 (9): 591–601.
Published: 02 April 2008
... increased serum glucagon by 129% ( P <0.05), raised systolic BP (blood pressure) by 21 mmHg ( P <0.01), elevated fasting blood glucose by 42% ( P <0.01), impaired glucose tolerance ( P <0.01), increased the kidney weight/body weight ratio ( P <0.05) and 24 h urinary albumin excretion by 108...
Clin Sci (Lond) (2008) 114 (4): 305–311.
Published: 15 January 2008
... compared with SHRs ( P <0.0001). UAE was significantly higher in male (7-fold) compared with female MWF rats (162.6±15.9 compared with 24.0±5.5 mg/24 h respectively; P <0.0001), and only male MWF rats developed significant glomerulosclerosis and tubulointerstitial damage in the kidney ( P <0.0001...
Clin Sci (Lond) (2007) 113 (7): 297–311.
Published: 03 September 2007
... of the literature since Y2K (year 2000) is provided, with a general overview of PGs and their synthesis enzymes, and then specific considerations of each PG/prostanoid receptor system in the kidney. Correspondence: Dr Richard L. Hébert (email rlhebert@uottawa.ca ). 14 3 2007 11 4 2007 25 4...
Clin Sci (Lond) (2007) 113 (5): 251–258.
Published: 01 August 2007
... 2 5 2007 2 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 α-adducin blood pressure hypertension kidney physical activity polymorphism postexercise hypotension sodium Adducin is an essential protein for assembly of the spectrin–actin network...
Clin Sci (Lond) (2007) 112 (12): 583–597.
Published: 14 May 2007
... Society 2007 artery blood pressure central nervous system dopamine receptor hypertension kidney sodium homoeostasis Essential hypertension affects 25% of the adult population and constitutes a major risk factor for stroke, myocardial infarction, heart failure and kidney failure [ 1 – 3...
Clin Sci (Lond) (2007) 112 (6): 337–344.
Published: 12 February 2007
... 3 10 2006 The Biochemical Society 2007 arterial hypotension blood pressure circadian variation kidney normal pressure glaucoma orthostatic test sodium handling For several decades, COAG (chronic open angle glaucoma) has been considered as a disease essentially due...
Clin Sci (Lond) (2006) 111 (1): 21–34.
Published: 14 June 2006
...) hypertension kidney metabolic syndrome obesity Eicosanoids refer to C 20 metabolites generated by three major enzymatic pathways: COX (cyclo-oxygenase), LOX (lipoxygenase) and CYP450 (cytochrome P450). The major biological eicosanoids are derived from arachidonic acid released from membrane...
Clin Sci (Lond) (2006) 111 (1): 61–70.
Published: 14 June 2006
... protein von Hippel–Lindau, which leads to constitutively elevated HIF-1. We hypothesized that AM is increased in CC-RCC tumours and that AM is a plasma biomarker for CC-RCC. Tumours and non-malignant kidney tissue were obtained from patients that underwent unilateral nephrectomy. Blood samples were drawn...
Clin Sci (Lond) (2005) 109 (6): 503–511.
Published: 23 November 2005
... 10 viral particles) significantly increased β-AR density in the kidney, lung and liver, but was without effect on physiological and plasma biochemical parameters. Moreover, this dose of virus did not cause any of the potential toxic responses of viral administration, such as inflammation and tissue...
Clin Sci (Lond) (2004) 107 (2): 159–165.
Published: 27 July 2004
...@ucl.ac.uk ). 17 2 2004 15 3 2004 31 3 2004 The Biochemical Society 2004 aluminium Bowman's space kidney loop of Henle micropuncture proximal tubule Aluminium, the most abundant metal in the Earth's crust, is ingested from a variety of sources and undergoes partial...
Clin Sci (Lond) (2004) 106 (3): 337–343.
Published: 01 March 2004
...Leila M. M. PEREIRA; Daniele G. BEZERRA; Denise L. MACHADO; Carlos A. MANDARIM-DE-LACERDA Stereological structural alterations of the heart and kidney were studied in four groups ( n =5) of spontaneously hypertensive rats (SHRs) treated for 30 days: (i) control, (ii) N G -nitro- L -arginine methyl...