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Articles

Genetically inducing renal lymphangiogenesis attenuates hypertension in mice

Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (23): 1759–1772.

DOI: https://doi.org/10.1042/CS20220547

Published: 02 December 2022

... kidney-specific overexpression of VEGF-D (KidVD) experience renal lymphangiogenesis upon doxycycline administration. HTN was induced in KidVD+ and KidVD- mice by subcutaneous release of angiotensin II, administration of the nitric oxide synthase inhibitor L-NAME, or consumption of a 4% salt diet...

View article titled, Genetically inducing renal lymphangiogenesis attenuates hypertension in mice

Includes: Supplementary data

Articles

G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation

Fuwei Zhang, Lifu Lei, Juan Huang, Weiwei Wang, Qian Su, Hongjia Yan, Caiyu Chen, Shuo Zheng, Hongmei Ren, Zhuxin Li, Pedro A. Jose, Yijie Hu, Liangyi Si, Chunyu Zeng, Jian Yang

Clin Sci (Lond) (2022) 136 (12): 989–1003.

DOI: https://doi.org/10.1042/CS20220236

Published: 29 June 2022

... or/and activity of G-protein-coupled receptor kinase 4 (GRK4) or genetic variants (e.g., GRK4γ142V) cause sodium retention and hypertension. Whether GRK4 plays a role in the regulation of AT 2 R in the kidney remains unknown. In the present study, we found that spontaneously hypertensive rats (SHRs) had increased...

View article titled, G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation

Includes: Supplementary data

Articles

Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females

Riyaz Mohamed, Gene R. Crislip, Sarah McLarnon, Qingqing Wei, Paul M. O’Connor, Jennifer C. Sullivan

Clin Sci (Lond) (2022) 136 (11): 825–840.

DOI: https://doi.org/10.1042/CS20220002

Published: 01 June 2022

...Riyaz Mohamed; Gene R. Crislip; Sarah McLarnon; Qingqing Wei; Paul M. O’Connor; Jennifer C. Sullivan Acute kidney injury (AKI) due to ischemia is a serious and frequent clinical complication with mortality rates as high as 80%. Vascular congestion in the renal outer medulla occurs early after...

View article titled, Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females

Articles

Paternal long-term PM 2.5 exposure causes hypertension via increased renal AT 1 R expression and function in male offspring

Cuimei Hu, Yu Tao, Yi Deng, Qi Cai, Hongmei Ren, Cheng Yu, Shuo Zheng, Jian Yang, Chunyu Zeng

Clin Sci (Lond) (2021) 135 (22): 2575–2588.

DOI: https://doi.org/10.1042/CS20210802

Published: 26 November 2021

.... Treatment with tempol in paternal rats also reversed the increased expressions of AT 1 R and GRK4 in the kidney of their offspring. We suggest that paternal PM 2.5 exposure causes hypertension in offspring. The mechanism may be involved that paternal PM 2.5 exposure-associated oxidative stress induces...

View article titled, Paternal long-term PM 2.5 exposure causes hypertension via increased renal AT 1 R expression and function in male offspring

Articles

Recent advances in understanding ion transport mechanisms in polycystic kidney disease

Anastasia V. Sudarikova, Valeriia Y. Vasileva, Regina F. Sultanova, Daria V. Ilatovskaya

Clin Sci (Lond) (2021) 135 (21): 2521–2540.

DOI: https://doi.org/10.1042/CS20210370

Published: 09 November 2021

...) and recessive (AR) forms of polycystic kidney disease (PKD). We provide here a basic overview of the origins and clinical aspects of ARPKD and ADPKD and discuss the implications of electrolyte transport in cystogenesis. Special attention is devoted to intracellular calcium handling by the cystic cells...

View article titled, Recent advances in understanding ion transport mechanisms in polycystic kidney disease

Articles

Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats

Ellen E. Gillis, Kasey Belanger, Mahmoud Abdelbary, Riyaz Mohamed, Jingping Sun, Michael W. Brands, Jennifer C. Sullivan

Clin Sci (Lond) (2021) 135 (19): 2329–2339.

DOI: https://doi.org/10.1042/CS20210469

Published: 13 October 2021

... 2 weeks, kidneys were harvested for flow cytometric analysis of T cells. Splenectomy increased BP in both sexes after 2 weeks. Renal Tregs decreased in both sexes after splenectomy, abolishing the sex differences in renal Tregs. In conclusion, splenic Tregs were comparable in male and female SHRs...

View article titled, Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats

Articles

Autoimmune-mediated renal disease and hypertension

Erika I. Boesen, Rahul M. Kakalij

Clin Sci (Lond) (2021) 135 (17): 2165–2196.

DOI: https://doi.org/10.1042/CS20200955

Published: 17 September 2021

...Erika I. Boesen; Rahul M. Kakalij Hypertension is a major risk factor for cardiovascular disease, chronic kidney disease (CKD), and mortality. Troublingly, hypertension is highly prevalent in patients with autoimmune renal disease and hastens renal functional decline. Although progress has been...

View article titled, Autoimmune-mediated renal disease and hypertension

Articles

Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT 1a receptors in the proximal tubule of the kidney

Ana Paula Oliveira Leite, Xiao C. Li, Rumana Hassan, Xiaowen Zheng, Barbara Alexander, Dulce Elena Casarini, Jia L. Zhuo

Clin Sci (Lond) (2021) 135 (15): 1825–1843.

DOI: https://doi.org/10.1042/CS20201574

Published: 04 August 2021

...Ana Paula Oliveira Leite; Xiao C. Li; Rumana Hassan; Xiaowen Zheng; Barbara Alexander; Dulce Elena Casarini; Jia L. Zhuo In the present study, we tested the hypothesis that there are significant sex differences in angiotensin II (Ang II)-induced hypertension and kidney injury using male and female...

View article titled, Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT 1a receptors in the proximal tubule of the kidney

Articles

Absence of interleukin-10 reduces progression of shiga toxin-induced hemolytic uremic syndrome

Gonzalo Ezequiel Pineda, Bárbara Rearte, María Florencia Todero, Andrea Cecilia Bruballa, Alan Mauro Bernal, Romina Jimena Fernandez-Brando, Martin Amadeo Isturiz, Elsa Zotta, Catalina Dirney Alba-Soto, Marina Sandra Palermo, María Victoria Ramos

Clin Sci (Lond) (2021) 135 (3): 575–588.

DOI: https://doi.org/10.1042/CS20200468

Published: 10 February 2021

... conclude that IL-10 absence has a protective role in an experimental model of HUS by reducing PMN recruitment into kidney and renal damage, and increasing mice survival. © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Correspondence: María...

View article titled, Absence of interleukin-10 reduces progression of shiga toxin-induced hemolytic uremic syndrome

Articles

Developmental programming of cardiovascular function: a translational perspective

Stephane L. Bourque, Sandra T. Davidge

Clin Sci (Lond) (2020) 134 (22): 3023–3046.

DOI: https://doi.org/10.1042/CS20191210

Published: 24 November 2020

.... Bourque ( sbourque@ualberta.ca ) 28 09 2020 07 11 2020 10 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Cardiovascular Developmental programming Heart Kidney Vasculature Three and half decades have...

View article titled, Developmental programming of cardiovascular function: a translational perspective

Articles

GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension

Yan Zhang, Shaoxiong Wang, Hefei Huang, Andi Zeng, Yu Han, Cindy Zeng, Shuo Zheng, Hongmei Ren, Yajing Wang, Yu Huang, Pedro A. Jose, Xin-Liang Ma, Chunyu Zeng, Ken Chen

Clin Sci (Lond) (2020) 134 (18): 2453–2467.

DOI: https://doi.org/10.1042/CS20200671

Published: 25 September 2020

...). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adiponectin adipose tissue GRK4 hypertension kidney renal proximal tubule Hypertension is a major modifiable risk factor for cardiovascular and renal diseases. Approximately 7.6 million premature deaths each...

View article titled, GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension

Includes: Supplementary data

Articles

Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury

Riyaz Mohamed, Olga Rafikova, Paul M. O’Connor, Jennifer C. Sullivan

Clin Sci (Lond) (2020) 134 (13): 1751–1762.

DOI: https://doi.org/10.1042/CS20200575

Published: 10 July 2020

...Riyaz Mohamed; Olga Rafikova; Paul M. O’Connor; Jennifer C. Sullivan Renal ischemia is the most common cause of acute kidney injury. Damage-associated molecular patterns (DAMPs) initiate an inflammatory response and contribute to ischemia–reperfusion (IR) injury in males, yet the contribution...

View article titled, Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury

Articles

Renal functional effects of the highly selective AT 2 R agonist, β-Pro 7 Ang III, in normotensive rats

Lucinda M. Hilliard Krause, Brandon A. Kemp, Amanda Suan Jui Tan, Emma S. Jones, Mark P. Del Borgo, Marie-Isabel Aguilar, Kate M. Denton, Robert M. Carey, Robert E. Widdop

Clin Sci (Lond) (2020) 134 (7): 871–884.

DOI: https://doi.org/10.1042/CS20200153

Published: 14 April 2020

... target. Furthermore, our findings provide further evidence of a sex-specific influence of AT 2 R stimulation on renal function. angiotensin III AT2 receptor agonist kidney natriuresis vasodilation Upon completion of surgery, the selective non-peptide AT 2 R antagonist, PD-123319 (PD; 1 mg...

View article titled, Renal functional effects of the highly selective AT 2 R agonist, β-Pro 7 Ang III, in normotensive rats

Articles

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Lucas F. Almeida, Signe S. Tofteng, Kirsten Madsen, Boye L. Jensen

Clin Sci (Lond) (2020) 134 (6): 641–656.

DOI: https://doi.org/10.1042/CS20190765

Published: 27 March 2020

... of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin–angiotensin–aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation...

View article titled, Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Articles

A protective role of renalase in diabetic nephropathy

Jianyong Yin, Xuanchen Liu, Ting Zhao, Rulian Liang, Rui Wu, Fangfei Zhang, Yiwei Kong, Limei Liu, Tao Xing, Niansong Wang, Qing Zhao, Feng Wang

Clin Sci (Lond) (2020) 134 (1): 75–85.

DOI: https://doi.org/10.1042/CS20190995

Published: 17 January 2020

... was measured in human kidney biopsies with DN and in kidneys of db/db mice. The role of Renalase in the development of DN was examined using a genetically engineered mouse model: Renalase knockout mice with db/db background. The renoprotective effects of Renalase in DN was evaluated in db/db mice with Renalase...

View article titled, A protective role of renalase in diabetic nephropathy

Includes: Supplementary data

Articles

Sodium 4-phenylbutyrate treatment protects against renal injury in NZBWF1 mice

Mathilde L. Bonnemaison, Eileen S. Marks-Nelson, Erika I. Boesen

Clin Sci (Lond) (2019) 133 (2): 167–180.

DOI: https://doi.org/10.1042/CS20180562

Published: 18 January 2019

...Mathilde L. Bonnemaison; Eileen S. Marks-Nelson; Erika I. Boesen Systemic lupus erythematosus (SLE) is an autoimmune disease predominantly affecting women and often leading to lupus nephritis and kidney damage. Endoplasmic reticulum (ER) stress has been implicated in several forms of kidney disease...

View article titled, Sodium 4-phenylbutyrate treatment protects against renal injury in NZBWF1 mice

Articles

Histamine and diabetic nephropathy: an up-to-date overview

Alessandro Pini, Roberta Verta, Cristina Grange, Maura Gurrieri, Arianna Carolina Rosa

Clin Sci (Lond) (2019) 133 (1): 41–54.

DOI: https://doi.org/10.1042/CS20180839

Published: 03 January 2019

..., an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine...

View article titled, Histamine and diabetic nephropathy: an up-to-date overview

Articles

The use of hydrogels for cell-based treatment of chronic kidney disease

Meg L. McFetridge, Mark P. Del Borgo, Marie-Isabel Aguilar, Sharon D. Ricardo

Clin Sci (Lond) (2018) 132 (17): 1977–1994.

DOI: https://doi.org/10.1042/CS20180434

Published: 14 September 2018

...Meg L. McFetridge; Mark P. Del Borgo; Marie-Isabel Aguilar; Sharon D. Ricardo Chronic kidney disease (CKD) is a major and growing public health concern with increasing incidence and prevalence worldwide. The therapeutic potential of stem cell therapy, including mesenchymal stem cells (MSCs...

View article titled, The use of hydrogels for cell-based treatment of chronic kidney disease

Articles

Sodium bicarbonate loading limits tubular cast formation independent of glomerular injury and proteinuria in Dahl salt-sensitive rats

Sarah C. Ray, Bansari Patel, Debra L. Irsik, Jingping Sun, Hiram Ocasio, Gene R. Crislip, Chunhua H. Jin, JianKang Chen, Babak Baban, Aaron J. Polichnowski, Paul M. O’Connor

Clin Sci (Lond) (2018) 132 (11): 1179–1197.

DOI: https://doi.org/10.1042/CS20171630

Published: 15 June 2018

...Sarah C. Ray; Bansari Patel; Debra L. Irsik; Jingping Sun; Hiram Ocasio; Gene R. Crislip; Chunhua H. Jin; JianKang Chen; Babak Baban; Aaron J. Polichnowski; Paul M. O’Connor Sodium bicarbonate (NaHCO 3 ) slows the decline in kidney function in patients with chronic kidney disease (CKD), yet...

View article titled, Sodium bicarbonate loading limits tubular cast formation independent of glomerular injury and proteinuria in Dahl salt-sensitive rats

Articles

Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease

Bryna S.M. Chow, Terri J. Allen

Clin Sci (Lond) (2016) 130 (15): 1307–1326.

DOI: https://doi.org/10.1042/CS20160243

Published: 29 June 2016

... receptors involved in the RAS will specifically be discussed. Correspondence: Terri J. Allen (email terri.allen@bakeridi.edu.au ). 30 3 2016 25 4 2016 6 5 2016 AT2 receptor AT2R agonism cardiovascular compound 21 kidney The biological actions of the renin...

View article titled, Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease

Articles

Role of the potassium channel K Ca 3.1 in diabetic nephropathy

Chunling Huang, Carol A. Pollock, Xin-Ming Chen

Clin Sci (Lond) (2014) 127 (7): 423–433.

DOI: https://doi.org/10.1042/CS20140075

Published: 17 June 2014

... nephropathy calcium-activated potassium channel inflammatory cell K Ca 3.1 kidney renal fibrosis It has been known that the EDHF-mediated vasodilatory pathways mediate endothelial dysfunction and abnormal arterial tone observed in human and experimental models of chronic renal failure [ 126 , 127...

View article titled, Role of the potassium channel K Ca 3.1 in diabetic nephropathy

Articles

Integrin-linked kinase: a new member of the kinases involved in hypertensive end-organ damage?

Takashi Obama, Satoru Eguchi

Clin Sci (Lond) (2014) 127 (1): 15–17.

DOI: https://doi.org/10.1042/CS20140081

Published: 10 March 2014

... in the cardiovascular and renal system, its involvement in hypertensive organ dysfunctions, such as those that occur in kidney, has not been investigated. In the present issue of Clinical Science , Alique and co-workers have demonstrated that angiotensin II-induced renal inflammatory responses were attenuated in mice...

View article titled, Integrin-linked kinase: a new member of the kinases involved in hypertensive end-organ damage?

Articles

Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation

Matilde Alique, Esther Civantos, Elsa Sanchez-Lopez, Carolina Lavoz, Sandra Rayego-Mateos, Raquel Rodrigues-Díez, Ana Belén García-Redondo, Jesús Egido, Alberto Ortiz, Diego Rodríguez-Puyol, Manuel Rodríguez-Puyol, Marta Ruiz-Ortega

Clin Sci (Lond) (2014) 127 (1): 19–31.

DOI: https://doi.org/10.1042/CS20130412

Published: 10 March 2014

... blockers are renoprotective and down-regulate ILK in experimental kidney disease, but the involvement of ILK in the actions of AngII in the kidney has not been addressed. Therefore we have investigated whether ILK signalling modulates the kidney response to systemic AngII infusion in wild-type and ILK...

View article titled, Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation

Includes: Supplementary data

Articles

Role of Toll-like receptors in diabetic nephropathy

Harshini Mudaliar, Carol Pollock, Usha Panchapakesan

Clin Sci (Lond) (2014) 126 (10): 685–694.

DOI: https://doi.org/10.1042/CS20130267

Published: 27 January 2014

...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...

View article titled, Role of Toll-like receptors in diabetic nephropathy

Articles

Functions of the podocyte proteins nephrin and Neph3 and the transcriptional regulation of their genes

Mervi Ristola, Sanna Lehtonen

Clin Sci (Lond) (2014) 126 (5): 315–328.

DOI: https://doi.org/10.1042/CS20130258

Published: 25 October 2013

... factors and agents that control nephrin and Neph3 gene expression. glomerulus kidney KIRREL2 (kin of IRRE-like 2) nephrin NPHS1 (nephrosis 1, congenital, Finnish type) podocyte transcriptional regulation transcription factor The glomerulus is the filtering unit of the kidney...

View article titled, Functions of the podocyte proteins nephrin and Neph3 and the transcriptional regulation of their genes

Articles

An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II)

Jabed A. Chowdhury, Che-Hsiung Liu, Annie M. Zuber, Kevin M. O’Shaughnessy

Clin Sci (Lond) (2013) 124 (12): 701–710.

DOI: https://doi.org/10.1042/CS20120430

Published: 26 February 2013

... lines demonstrated similar elevations of BP (blood pressure) and plasma potassium after 4 weeks of TG induction. Withdrawal of doxycycline switched off mutant TG expression and the disappearance of the PHAII phenotype. Western blotting of microdissected kidney nephron segments confirmed that expression...

View article titled, An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II)

Includes: Supplementary data

Articles

Insulin signalling to the kidney in health and disease

Lorna J. Hale, Richard J. M. Coward

Clin Sci (Lond) (2013) 124 (6): 351–370.

DOI: https://doi.org/10.1042/CS20120378

Published: 27 November 2012

... by its action on a restricted number of tissues; however, it has now become clear that this hormone controls an array of cellular processes in many different tissues. The present review will focus on the role of insulin in the kidney in health and disease. Correspondence: Dr Richard Coward (email...

View article titled, Insulin signalling to the kidney in health and disease

Articles

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

Mona Sedeek, Alex Gutsol, Augusto C. Montezano, Dylan Burger, Aurelie Nguyen Dinh Cat, Chris R. J. Kennedy, Kevin D. Burns, Mark E. Cooper, Karin Jandeleit-Dahm, Patrick Page, Cedric Szyndralewiez, Freddy Heitz, Richard L. Hebert, Rhian M. Touyz

Clin Sci (Lond) (2013) 124 (3): 191–202.

DOI: https://doi.org/10.1042/CS20120330

Published: 17 October 2012

... species) have been implicated in the development of diabetic nephropathy. Of the Nox isoforms in the kidney, Nox4 is important because of its renal abundance. In the present study, we tested the hypothesis that GKT136901, a Nox1/4 inhibitor, prevents the development of nephropathy in db / db (diabetic...

View article titled, Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

Includes: Supplementary data

Articles

Angiotensin-(1–7) in kidney disease: a review of the controversies

Danielle Zimmerman, Kevin D. Burns

Clin Sci (Lond) (2012) 123 (6): 333–346.

DOI: https://doi.org/10.1042/CS20120111

Published: 29 May 2012

...Danielle Zimmerman; Kevin D. Burns Ang-(1–7) [angiotensin-(1–7)] is a biologically active heptapeptide component of the RAS (renin–angiotensin system), and is generated in the kidney at relatively high levels, via enzymatic pathways that include ACE2 (angiotensin-converting enzyme 2...

View article titled, Angiotensin-(1–7) in kidney disease: a review of the controversies

Articles

Drug-induced alterations in Mg 2+ homoeostasis

Anke L. Lameris, Leo A. Monnens, René J. Bindels, Joost G. J. Hoenderop

Clin Sci (Lond) (2012) 123 (1): 1–14.

DOI: https://doi.org/10.1042/CS20120045

Published: 12 March 2012

...Anke L. Lameris; Leo A. Monnens; René J. Bindels; Joost G. J. Hoenderop Magnesium (Mg 2+ ) balance is tightly regulated by the concerted actions of the intestine, bone and kidneys. This balance can be disturbed by a broad variety of drugs. Diuretics, modulators of the EGFR (epidermal growth factor...

View article titled, Drug-induced alterations in Mg 2+ homoeostasis

Articles

Inhibition of soluble epoxide hydrolase by cis -4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension

Jan Neckář, Libor Kopkan, Zuzana Husková, František Kolář, František Papoušek, Herbert J. Kramer, Sung Hee Hwang, Bruce D. Hammock, John D. Imig, Jiří Malý, Ivan Netuka, Bohuslav Ošťádal, Luděk Červenka

Clin Sci (Lond) (2012) 122 (11): 513–527.

DOI: https://doi.org/10.1042/CS20110622

Published: 10 February 2012

... of previously ischaemic tissue continued for 3 h. angiotensin II epoxyeicosatrienoic acid hypertension kidney myocardial ischaemia/reperfusion injury soluble epoxide hydrolase inhibitor Ischaemic heart disease is the leading cause of mortality in industrialized nations [ 1 ]. Hypertension...

View article titled, Inhibition of soluble epoxide hydrolase by cis -4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension

Includes: Supplementary data

Articles

Translational study of microRNAs and its application in kidney disease and hypertension research

Alison J. Kriegel, Domagoj Mladinov, Mingyu Liang

Clin Sci (Lond) (2012) 122 (10): 439–447.

DOI: https://doi.org/10.1042/CS20110159

Published: 20 January 2012

... microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges...

View article titled, Translational study of microRNAs and its application in kidney disease and hypertension research

Articles

Prenatal programming of renal salt wasting resets postnatal salt appetite, which drives food intake in the rat

Saleh H. Alwasel, David J. P. Barker, Nick Ashton

Clin Sci (Lond) (2012) 122 (6): 281–288.

DOI: https://doi.org/10.1042/CS20110266

Published: 11 November 2011

... developmental programming extracellular fluid hyperphagia kidney salt appetite Prenatal exposure to an adverse environment has a marked impact upon the developing kidney. People whose birthweights were towards the lower end of the normal range have fewer nephrons [ 1 ] and are at greater risk...

View article titled, Prenatal programming of renal salt wasting resets postnatal salt appetite, which drives food intake in the rat

Articles

Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition

Elena Velkoska, Rachael G. Dean, Luke Burchill, Vicki Levidiotis, Louise M. Burrell

Clin Sci (Lond) (2010) 118 (4): 269–279.

DOI: https://doi.org/10.1042/CS20090318

Published: 16 November 2009

...Elena Velkoska; Rachael G. Dean; Luke Burchill; Vicki Levidiotis; Louise M. Burrell Alterations within the RAS (renin–angiotensin system) are pivotal for the development of renal disease. ACE2 (angiotensin-converting enzyme 2) is expressed in the kidney and converts the vasoconstrictor AngII...

View article titled, Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition

Articles

C-type natriuretic peptide production by the human kidney is blunted in chronic heart failure

Paul R. Kalra, Jonathan R. Clague, Andrew J. Coats, Stefan D. Anker, Philip A. Poole-Wilson, Allan D. Struthers

Clin Sci (Lond) (2010) 118 (1): 71–77.

DOI: https://doi.org/10.1042/CS20090092

Published: 02 October 2009

...Paul R. Kalra; Jonathan R. Clague; Andrew J. Coats; Stefan D. Anker; Philip A. Poole-Wilson; Allan D. Struthers CNP (C-type natriuretic peptide) is a vasodilatory peptide produced by vascular endothelium and the human heart with a short half-life. CNP has been identified within the human kidney...

View article titled, C-type natriuretic peptide production by the human kidney is blunted in chronic heart failure

Articles

Hereditary tubular transport disorders: implications for renal handling of Ca 2+ and Mg 2+

Henrik Dimke, Joost G. Hoenderop, René J. Bindels

Clin Sci (Lond) (2010) 118 (1): 1–18.

DOI: https://doi.org/10.1042/CS20090086

Published: 28 September 2009

...Henrik Dimke; Joost G. Hoenderop; René J. Bindels The kidney plays an important role in maintaining the systemic Ca 2+ and Mg 2+ balance. Thus the renal reabsorptive capacity of these cations can be amended to adapt to disturbances in plasma Ca 2+ and Mg 2+ concentrations. The reabsorption of Ca 2...

View article titled, Hereditary tubular transport disorders: implications for renal handling of Ca 2+ and Mg 2+

Articles

Prenatal programming of renal sodium handling in the rat

Saleh H. Alwasel, Nick Ashton

Clin Sci (Lond) (2009) 117 (2): 75–84.

DOI: https://doi.org/10.1042/CS20080294

Published: 15 June 2009

... + . Western blotting and quantitative PCR showed that NKCC2 expression was increased, whereas NCC mRNA was not up-regulated. Na + /K + ATPase α 1 subunit expression did not differ from controls; however, there was a significant reduction in whole kidney pump activity (23.4±1.8 and 17.7±1.2 nmol...

View article titled, Prenatal programming of renal sodium handling in the rat

Articles

Effects of chronic L-NAME on nitrotyrosine expression and renal vascular reactivity in rats with chronic bile-duct ligation

Antonia Alcaraz, David Hernández, David Iyú, Rubén Mota, Noemí M. Atucha, Antonio J. Ortiz, Joaquín García-Estañ, María C. Ortiz

Clin Sci (Lond) (2008) 115 (2): 57–68.

DOI: https://doi.org/10.1042/CS20070312

Published: 12 June 2008

... (phenylephrine) and ACh (acetylcholine) in isolated perfused kidneys were measured. NO levels were calculated as 24-h urinary excretion of nitrites, ROS as TBARS (thiobarbituric acid-reacting substances), and peroxynitrite formation as the renal expression of nitrotyrosine. BDL rats had progressive sodium...

View article titled, Effects of chronic L-NAME on nitrotyrosine expression and renal vascular reactivity in rats with chronic bile-duct ligation

Articles

Glucagon and hyperglycaemia in diabetes

Philip E. Cryer

Clin Sci (Lond) (2008) 114 (9): 589–590.

DOI: https://doi.org/10.1042/CS20070434

Published: 02 April 2008

... 2008 glucagon glucose tolerance insulin deficiency kidney microalbuminuria Type 2 diabetes The role of glucagon in the physiological defence against hypoglycaemia is well established [ 8 ]. Although the first defence against falling plasma glucose concentrations is a decrease in insulin...

View article titled, Glucagon and hyperglycaemia in diabetes

Articles

Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice

Xiao C. Li, Tang-dong Liao, Jia L. Zhuo

Clin Sci (Lond) (2008) 114 (9): 591–601.

DOI: https://doi.org/10.1042/CS20070257

Published: 02 April 2008

... increased serum glucagon by 129% ( P <0.05), raised systolic BP (blood pressure) by 21 mmHg ( P <0.01), elevated fasting blood glucose by 42% ( P <0.01), impaired glucose tolerance ( P <0.01), increased the kidney weight/body weight ratio ( P <0.05) and 24 h urinary albumin excretion by 108...

View article titled, Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice

Articles

Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL

Angela Schulz, Maria Schlesener, Judith Weiss, Jonna Hänsch, Norbert Wendt, Peter Kossmehl, Daniela Grimm, Roland Vetter, Reinhold Kreutz

Clin Sci (Lond) (2008) 114 (4): 305–311.

DOI: https://doi.org/10.1042/CS20070300

Published: 15 January 2008

... compared with SHRs ( P <0.0001). UAE was significantly higher in male (7-fold) compared with female MWF rats (162.6±15.9 compared with 24.0±5.5 mg/24 h respectively; P <0.0001), and only male MWF rats developed significant glomerulosclerosis and tubulointerstitial damage in the kidney ( P <0.0001...

View article titled, Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL

Articles

Prostaglandins in the kidney: developments since Y2K

Rania Nasrallah, Jordan Clark, Richard L. Hébert

Clin Sci (Lond) (2007) 113 (7): 297–311.

DOI: https://doi.org/10.1042/CS20070089

Published: 03 September 2007

... of the literature since Y2K (year 2000) is provided, with a general overview of PGs and their synthesis enzymes, and then specific considerations of each PG/prostanoid receptor system in the kidney. © The Authors Journal compilation © 2007 Biochemical Society 2007 More recent studies have also revealed...

View article titled, Prostaglandins in the kidney: developments since Y2K

Articles

The α-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure

Linda S. Pescatello, Bruce E. Blanchard, Gregory J. Tsongalis, Carl M. Maresh, Ann O'Connell, Paul D. Thompson

Clin Sci (Lond) (2007) 113 (5): 251–258.

DOI: https://doi.org/10.1042/CS20060345

Published: 01 August 2007

... Biochemical Society 2007 α-adducin blood pressure hypertension kidney physical activity polymorphism postexercise hypotension sodium Adducin is an essential protein for assembly of the spectrin–actin network and cell signal transduction in the kidney [ 1 , 2 ]. Single nucleotide...

View article titled, The α-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure

Articles

The dopaminergic system in hypertension

Chunyu Zeng, Meng Zhang, Laureano D. Asico, Gilbert M. Eisner, Pedro A. Jose

Clin Sci (Lond) (2007) 112 (12): 583–597.

DOI: https://doi.org/10.1042/CS20070018

Published: 14 May 2007

.... artery blood pressure central nervous system dopamine receptor hypertension kidney sodium homoeostasis Dopamine is synthesized not only in noradrenergic and dopaminergic nerves, but also in non-neural tissues, such as the kidney and gastrointestinal tract. The synthesis of dopamine...

View article titled, The dopaminergic system in hypertension

Articles

Renal sodium handling in patients with normal pressure glaucoma

Antoinette Pechere-Bertschi, Gordana Sunaric-Megevand, Ivan Haefliger, Francesca Panarello, Marc Maillard, Michel Burnier

Clin Sci (Lond) (2007) 112 (6): 337–344.

DOI: https://doi.org/10.1042/CS20060082

Published: 12 February 2007

... 10 2006 The Biochemical Society 2007 arterial hypotension blood pressure circadian variation kidney normal pressure glaucoma orthostatic test sodium handling For several decades, COAG (chronic open angle glaucoma) has been considered as a disease essentially due...

View article titled, Renal sodium handling in patients with normal pressure glaucoma

Articles

Eicosanoids and renal vascular function in diseases

John D. Imig

Clin Sci (Lond) (2006) 111 (1): 21–34.

DOI: https://doi.org/10.1042/CS20050251

Published: 14 June 2006

...) hypertension kidney metabolic syndrome obesity Eicosanoids refer to C 20 metabolites generated by three major enzymatic pathways: COX (cyclo-oxygenase), LOX (lipoxygenase) and CYP450 (cytochrome P450). The major biological eicosanoids are derived from arachidonic acid released from membrane...

View article titled, Eicosanoids and renal vascular function in diseases

Articles

Tissue expression and plasma levels of adrenomedullin in renal cancer patients

Jens Michelsen, Helle Thiesson, Steen Walter, Peter D. Ottosen, Ole Skøtt, Boye L. Jensen

Clin Sci (Lond) (2006) 111 (1): 61–70.

DOI: https://doi.org/10.1042/CS20060030

Published: 14 June 2006

... protein von Hippel–Lindau, which leads to constitutively elevated HIF-1. We hypothesized that AM is increased in CC-RCC tumours and that AM is a plasma biomarker for CC-RCC. Tumours and non-malignant kidney tissue were obtained from patients that underwent unilateral nephrectomy. Blood samples were drawn...

View article titled, Tissue expression and plasma levels of adrenomedullin in renal cancer patients

Articles

Adenoviral delivery of the β 2 -adrenoceptor gene in sepsis: a subcutaneous approach in rat for kidney protection

Akio Nakamura, Akira Imaizumi, Ryo Niimi, Yukishige Yanagawa, Takao Kohsaka, Edward J. Johns

Clin Sci (Lond) (2005) 109 (6): 503–511.

DOI: https://doi.org/10.1042/CS20050088

Published: 23 November 2005

... 10 viral particles) significantly increased β-AR density in the kidney, lung and liver, but was without effect on physiological and plasma biochemical parameters. Moreover, this dose of virus did not cause any of the potential toxic responses of viral administration, such as inflammation and tissue...

View article titled, Adenoviral delivery of the β 2 -adrenoceptor gene in sepsis: a subcutaneous approach in rat for kidney protection

Articles

Renal aluminium handling in the rat: a micropuncture assessment

David G. SHIRLEY, Mary F. WALTER, Stephen J. WALTER, Andrew THEWLES, Christopher J. LOTE

Clin Sci (Lond) (2004) 107 (2): 159–165.

DOI: https://doi.org/10.1042/CS20040052

Published: 27 July 2004

..., is ingested from a variety of sources and undergoes partial absorption from the intestine [ 1 ]. Prevention of harmful aluminium accumulation in the body relies on aluminium excretion by the kidneys. However, only limited information is available concerning the nature of renal aluminium handling, partly...

View article titled, Renal aluminium handling in the rat: a micropuncture assessment

Articles

Enalapril attenuates cardiorenal damage in nitric-oxide-deficient spontaneously hypertensive rats

Leila M. M. PEREIRA, Daniele G. BEZERRA, Denise L. MACHADO, Carlos A. MANDARIM-DE-LACERDA

Clin Sci (Lond) (2004) 106 (3): 337–343.

DOI: https://doi.org/10.1042/CS20030268

Published: 01 March 2004

...Leila M. M. PEREIRA; Daniele G. BEZERRA; Denise L. MACHADO; Carlos A. MANDARIM-DE-LACERDA Stereological structural alterations of the heart and kidney were studied in four groups ( n =5) of spontaneously hypertensive rats (SHRs) treated for 30 days: (i) control, (ii) N G -nitro- L -arginine methyl...

View article titled, Enalapril attenuates cardiorenal damage in nitric-oxide-deficient spontaneously hypertensive rats

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