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Keywords: kallikrein
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Articles
Clin Sci (Lond) (1994) 87 (5): 567–574.
Published: 01 November 1994
... enzyme activity angiotensin-converting enzyme inhibitors bradykinin antisera kallikrein kinin assay renin Clinical Science (1994) 87, 567-574 (Printed in Great Britain) 567 Plasma kini ns increase after angiotensi wconverti ng enzyme inhibition in human subjects Andrea PELLACANI*, Hans R. BRUNNER...
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Clin Sci (Lond) (1991) 80 (5): 427–433.
Published: 01 May 1991
... in circulatory volume were minimised by infusion of crystalloid to maintain pulmonary artery occlusion pressure, measured using a Swann-Ganz pulmonary artery catheter. 3. After plasmapheresis, there was no significant change in creatinine clearance, sodium excretion, plasma renin activity or urinary kallikrein...
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Clin Sci (Lond) (1990) 79 (2): 117–121.
Published: 01 August 1990
...Derek G. Waller; Satvinder S. Bhatia; Sara K. Campbell; Janet D. M. Albano; J. Gavin B. Millar 1. The urinary excretion of active and inactive kallikrein was studied in volunteers during diuresis induced by water loading or oral frusemide and during antidiuresis induced by desamino-d-arginine...
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Clin Sci (Lond) (1988) 75 (5): 527–534.
Published: 01 November 1988
...-prostaglandin F 1α (the stable hydrolysis product of prostacyclin) and kallikrein excretion were significantly elevated in rats receiving potassium. 3. No difference was observed in sodium excretion during the initial days of potassium supplementation; however, the potassium-supplemented animals excreted...
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Clin Sci (Lond) (1987) 73 (3): 259–265.
Published: 01 September 1987
... kallikrein excretion in diabetic patients with autonomic neuropathy, and urinary kallikrein output correlated significantly with urine volume but not with urinary sodium excretion. 4. The diurnal patterns of excretion of urinary prostaglandin E 2 and 6-keto-PGF 1α were not significantly different in diabetic...
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Clin Sci (Lond) (1986) 70 (5): 409–416.
Published: 01 May 1986
... was reduced by an average of 40%) at the zero and 2 fmol min −1 kg −1 infusion rates of AVP. At higher AVP infusion rates, no significant inhibition of PGE 2 was observed. 6. Urinary kallikrein excretion rate decreased steadily to one-third of its original value after AVP and this change remained unaltered...
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Clin Sci (Lond) (1986) 70 (1): 13–17.
Published: 01 January 1986
...Axel Overlack; Evita Bäcker-Kreutz; Christa Ressel; Hans-Michael Müller; Rainer Kolloch; Klaus-O. Stumpe 1. Kinins have been considered to be involved in the escape from the sodium retaining effects of mineralocorticoids. In a metabolic study in rats, the importance of the kallikrein-kinin system...
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Clin Sci (Lond) (1985) 68 (5): 537–543.
Published: 01 May 1985
... was not statistically significant. Significant increases in urine flow, sodium excretion, urinary kallikrein excretion and urinary excretion of dinor-6-keto prostaglandin (PG) F 1α , a measure of systemic PGI 2 synthesis, were noted. Plasma renin activity and plasma protein concentration were significantly lowered...
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Clin Sci (Lond) (1985) 68 (2): 159–164.
Published: 01 February 1985
... to frusemide were the same as in 10 normal subjects. 3. Frusemide-induced changes in urinary PGE and kallikrein excretion were also the same as in normal subjects. 4. Impaired renal release of vasodilator prostaglandins in essential hypertension is likely to be secondary to the hypertension rather than...
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Clin Sci (Lond) (1983) 65 (1): 37–42.
Published: 01 July 1983
... increased. The plasma renin activity and plasma aldosterone were unchanged. However, the urinary excretions of prostaglandin E 2 (U PGE2 V ) and kallikrein ( U kall. V ) were markedly decreased throughout the experiment. 2. With concurrent administration of captopril, the elevation of blood pressure...
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Clin Sci (Lond) (1982) 63 (s8): 447s–450s.
Published: 01 October 1982
... activity. 3. A short-term natriuresis followed nifedipine ingestion in spite of increased aldosterone excretion during the low sodium diet and a decrease in urinary kallikrein during the low and high sodium diets. 4. Nifedipine increased urinary volume only during the high sodium intake. 5. Apart from...
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Clin Sci (Lond) (1982) 63 (s8): 249s–251s.
Published: 01 October 1982
...Héctor Nolly; M. Cristina Lama 1. The present study was undertaken to examine whether there is a kallikrein-like enzyme in vascular tissue. Isolated saline-perfused rat mesenteric arteries were used and arterial homogenate was incubated with heat-treated dog plasma and citrate/phosphate buffer (pH...
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Clin Sci (Lond) (1982) 63 (s8): 265s–267s.
Published: 01 October 1982
... < 0.02). Heart rate did not change. Plasma renin activity (PRA) increased ( P < 0.002), and plasma and urinary aldosterone as well as plasma 18-hydroxycorticosterone (18- OH-B) decreased after captopril ( P < 0.02). Prostaglandin (PG) E 2 , kallikrein, urine volume, sodium and potassium excretion...
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Clin Sci (Lond) (1982) 63 (s8): 167s–170s.
Published: 01 October 1982
..., acid-activated renin was reversibly inactivated in a time-dependent manner during incubation at 37°C above pH 5. The maximal rate of reversal occurred in the pH 7–8 range. Reversal was prevented by prior incubation with trypsin, plasmin, glandular kallikrein or plasma kallikrein. 4. By kinetic analysis...
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Clin Sci (Lond) (1982) 63 (2): 217–218.
Published: 01 August 1982
...A. Martínez Seeber; S. B. Vila; O. L. Catanzaro 1. In male Wistar rats urinary kallikrein excretion was positively correlated with urinary flow and glomerular filtration rate (GFR). 2. Osmotic diuresis produced by a 30% (w/v) glucose solution increased urinary kallikrein, and a positive correlation...
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Clin Sci (Lond) (1982) 62 (4): 361–366.
Published: 01 April 1982
... or aprotinin. Blood pressure at 24 h was normal and did not differ significantly from that of unclipped rats given a glucose infusion. 5. The fall in blood pressure produced by unclipping therefore did not appear to be mediated via the prostaglandin or kallikrein systems. aprotinin Goldblatt hypertension...
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Clin Sci (Lond) (1981) 61 (s7): 295s–298s.
Published: 01 December 1981
...F. H. M. Derkx; M. P. A. Schalekamp; M. A. D. H. Schalekamp 1. Inactive renin in human plasma can be activated by pH 3.3-dialysis (generation of acid-activated renin), by clotting factor XII-mediated prekallikrein to kallikrein conversion after pH has been restored to neutral (generation of acid...
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Clin Sci (Lond) (1981) 61 (1): 61–67.
Published: 01 July 1981
... 1981 The Biochemical Society and the Medical Research Society 1981 arginine vasopressin desaminoarginine vasopressin diabetes insipidus kallikrein plasma renin activity prostaglandins renal function CIinicalScience (1981) 61,61-67 61 Renal prostaglandins and water balance: studies...
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Clin Sci (Lond) (1981) 60 (2): 199–205.
Published: 01 February 1981
...Naotika Toki; Hiroyuki Sumi; Sumiyoshi Takasugi 1. A kallikrein-like enzyme in plasma of patients with acute pancreatitis was further purified by successive hydroxyapatite/cellulose and Sepharose-4B column chromatography. 2. By these procedures 0.26 mg of purified enzyme with a specific activity...
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Clin Sci (Lond) (1979) 57 (s5): 247s–250s.
Published: 01 December 1979
...H. Zschiedrich; P. Fleckenstein; R. Geiger; E. Fink; K. Sinterhauf; TH. Philipp; A. Distler; H. P. Wolff 1. Excretion of urinary kallikrein was normal in 13 out of 15 patients with uncomplicated essential hypertension. 2. Frusemide increased urinary kallikrein excretion in normotensive subjects...
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Clin Sci (Lond) (1979) 57 (s5): 255s–258s.
Published: 01 December 1979
...T. C. Lee; T. Kushiro; J.-P. Gassia; J.-P. Girolami; A. N. Lupu; M. H. Maxwell 1. The acute effects of the kallikrein inhibitor aprotinin (498 ki.u./min), and the kininase II inhibitor SQ 14 225 (250 μg), given intravenously during saralasin-induced angiotensin blockade, were studied in conscious...
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Clin Sci (Lond) (1979) 57 (s5): 259s–261s.
Published: 01 December 1979
...P. C. Weber; B. Scherer; E. Held; W. Siess; H. Stoffel 1. Urinary prostaglandins (PG), kallikrein and plasma renin activity (PRA) were measured in 35 patients with essential hypertension and 22 normotensive controls before and 15 min after frusemide (40 mg intravenously). 2. PGE 2 and kallikrein...
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Clin Sci (Lond) (1979) 57 (s5): 89s–92s.
Published: 01 December 1979
... of active kallikrein to pH 3·3-pretreated Hageman factor-deficient plasma caused complete activation of renin. In contrast, the addition of active Hageman factor fragment to pH 3·3-pretreated Fletcher factor-deficient plasma had little or no effect. 3. Plasmin, streptokinase-activated plasminogen...
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Clin Sci (Lond) (1979) 57 (s5): 239s–241s.
Published: 01 December 1979
...T. B. Ørstavik; K. Nustad; P. Brandtzaeg 1. The cellular localization of kallikrein was investigated in rat and human exocrine glands and kidney by a direct immunofluorescence technique. 2. Kallikrein was found in the duct system of the rat and human major salivary glands. 3. Kallikrein was found...
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Clin Sci (Lond) (1979) 57 (s5): 97s–99s.
Published: 01 December 1979
... of prekallikrein, which, in turn, leads to prorenin activation. 2. Since plasma kallikrein can activate plasminogen, the present studies were designed to evaluate whether alkaline-phase activation of prorenin by plasma kallikrein is mediated via plasminogen activation. 3. We demonstrated that plasminogen...
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Clin Sci (Lond) (1979) 57 (s5): 243s–245s.
Published: 01 December 1979
...H. R. Croxatto; G. Silva; M. Boric 1. Rat kidney extracts obtained at successive stages of a purification procedure, which allows the separation of renin and kallikrein, were used in order to investigate their effect upon urinary excretion of kallikrein, sodium, potassium and water in hyperhydrated...
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Clin Sci (Lond) (1979) 57 (4): 351–357.
Published: 01 October 1979
... to the conversion of inactive renin into the active form with simultaneous generation of kallikrein activity. 2. The endogenous activator of inactive renin has the same pH profile and inhibitor spectrum as plasma kallikrein. 3. Inactive renin can also be activated by exposure of plasma to exogenous trypsin...
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Clin Sci Mol Med (1978) 55 (6): 561–565.
Published: 01 December 1978
...K. D. Bhoola; R. W. Matthews; Fiona Roberts 1. The values for kallikrein, amylase and protein were determined in samples of saliva obtained from 220 girls aged 14–18 years. 2. The concentrations of protein and amylase and kallikrein activities (per ml of saliva) were considerably more variable...
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Clin Sci Mol Med (1978) 54 (1): 39–45.
Published: 01 January 1978
...S. B. Levy; R. P. Frigon; R. A. Stone 1. We measured urinary kallikrein (kininogenin) excretion in black and white normotensive subjects during a variety of manipulations of salt and water balance. 2. A large intravenous saline load administered while the subjects were on an unrestricted sodium...
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Clin Sci Mol Med (1976) 51 (s3): 279s–282s.
Published: 01 December 1976
...H. S. Margolius; Julie Chao; T. Kaizu 1. A technique has been developed for the measurement of kallikrein ‘production’ in rat renal cortical cells in suspension. 2. After preparative steps, column chromatography on DEAE-cellulose yielded a peak of α- N -tosyl-l-arginine methyl ester (Tos-Arg-OMe...
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Clin Sci Mol Med (1975) 49 (1): 69–71.
Published: 01 July 1975
...S. Favaro; B. Baggio; A. Antonello; A. Zen; G. Cannella; S. Todesco; A. Borsatti 1. The kallikrein content of kidneys from spontaneously hypertensive and normal rats at birth and at age 37 days was determined. 2. Kallikrein values were significantly lower in the hypertensive rats. 3...
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Clin Sci Mol Med (1973) 45 (4): 429–438.
Published: 01 October 1973
...M. Malofiejew 1. The plasma of non-pregnant women contains practically no kinins and only traces of kallikrein. Treatment of the plasma with kaolin produces additional amounts of kallikrein from prekallikrein and of kinin from kininogen. 2. During the second stage of labour, plasma kallikrein...