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Keywords: ischaemic stroke
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Clin Sci (Lond) (2017) 131 (7): 533–552.
Published: 17 March 2017
... in the laboratory. Pharmacological therapies for acute ischaemic stroke are limited. The only pharmacological treatment for stroke approved by the Food and Drug Administration (FDA) is tissue plasminogen activator (tPA), which must be used within hours of stroke onset and has a number of contraindications. Pre...
Clin Sci (Lond) (2014) 127 (12): 679–689.
Published: 08 August 2014
...Zhong-Bao Yang; Zhen Zhang; Ting-Bo Li; Zheng Lou; Shu-Yu Li; Huan Yang; Jie Yang; Xiu-Ju Luo; Jun Peng Recent studies have uncovered that accumulation of glutamate after ischaemic stroke is closely associated with the down-regulation of glutamate transporter-1 (GLT-1) expression, suggesting...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (12): 829–835.
Published: 26 February 2014
...Robert Y. L. Zee; Qing-Mei Wang; Daniel I. Chasman; Paul M Ridker; James K. Liao Recent animal and human studies have demonstrated the importance of the ROCK (RhoA/Rho-associated kinase) pathway in IsST (ischaemic stroke). Whether the genetic variation within ROCK-associated genes modulates...
Clin Sci (Lond) (2013) 125 (1): 27–36.
Published: 13 March 2013
... patients from the European population [ 6 ]. A positive association between shorter telomere length and ischaemic stroke and mortality from all causes has recently been found in the Chinese population by Ding et al. [ 7 ]. However, to date, most studies are limited to ischaemic stroke, with less...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (3): 113–119.
Published: 11 October 2011
... temperature, HT (haemorrhagic transformation) and biomarkers of BBB (blood–brain barrier) damage in patients with acute ischaemic stroke untreated with rtPA (recombinant tissue-type plasminogen activator). We studied 229 patients with ischaemic stroke <12 h from symptom onset. Body temperature...
Clin Sci (Lond) (2011) 121 (1): 11–17.
Published: 18 March 2011
...Francisco Campos; Manuel Rodríguez-Yáñez; Mar Castellanos; Susana Arias; María Pérez-Mato; Tomás Sobrino; Miguel Blanco; Joaquín Serena; José Castillo Ischaemic stroke is associated with an excessive release of glutamate in brain. GOT (glutamate-oxaloacetate transaminase) and GPT (glutamate...
Clin Sci (Lond) (2009) 117 (7): 265–272.
Published: 17 August 2009
..., but it is still very controversial as to whether it is a susceptible gene for stroke in other populations. In the present study, we attempted to explore the role of the gene in the pathogenesis of stroke in the Chinese Han population of eastern China. A total of 649 ischaemic stroke patients and 761 unrelated...
Clin Sci (Lond) (2009) 116 (4): 335–340.
Published: 15 January 2009
... genetic polymorphism haemorrhagic stroke ischaemic stroke phosphodiesterase 4D risk factor Stroke is a major cause of mortality and disability in China. Each year, more than 2.5 million individuals suffer a stroke, 1.5 million die of stroke-related causes, and 7 million have survived a stroke...
Includes: Supplementary data
Clin Sci (Lond) (2006) 111 (3): 171–183.
Published: 15 August 2006
...Mark Slevin; Pat Kumar; John Gaffney; Shant Kumar; Jerzy Krupinski Recent developments in our understanding of the pathophysiological events that follow acute ischaemic stroke suggest an important role for angiogenesis which, through new blood vessel formation, results in improved collateral...