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Clin Sci (Lond) (2016) 130 (24): 2277–2278.
Published: 10 November 2016
...Charles S. Redwood Cardiac troponin I (cTnI) is a key component of the Ca 2+ -regulatory mechanism of cardiac contractility. It is released into the circulation upon ischaemia and has become established as one of the principal diagnostic biomarkers of myocardial damage. The release of cTnI results...
Jacqueline M. Ku, Mohammadali Taher, Kai Yee Chin, Tom Barsby, Victoria Austin, Connie H.Y. Wong, Zane B. Andrews, Sarah J. Spencer, Alyson A. Miller
Clin Sci (Lond) (2016) 130 (17): 1545–1558.
Published: 26 July 2016
... ischaemia/reperfusion-induced brain injury and swelling, and BBB disruption, by reducing oxidative and/or nitrosative damage. 2 2 2016 26 5 2016 13 6 2016 14 6 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 Stroke...
Clin Sci (Lond) (2015) 128 (9): 537–558.
Published: 27 January 2015
... therapies for patients. These include the small therapeutic window in conditions such as acute stroke and critical limb ischaemia, since interventions introduced in such patients need to act rapidly and be safe in elderly patients with many co-morbidities. Pre-clinical animal experiments have also reported...
Ting-Hsing Chao, Shih-Ya Tseng, Yi-Heng Li, Ping-Yen Liu, Chung-Lung Cho, Guey-Yueh Shi, Hua-Lin Wu, Jyh-Hong Chen
Clin Sci (Lond) (2012) 123 (3): 147–159.
Published: 05 April 2012
... angiogenesis. In the present study, we have investigated the effect of cilostazol in promoting angiogenesis and vasculogenesis in a hindlimb ischaemia model and have also examined its potential mechanism of action in vitro and in vivo . We found that cilostazol treatment significantly increased colony...
Ellen H. A. M. Elsenberg, Dik Versteeg, Jan-Willem Sels, Pieter-Jan J. Vlaar, Monique G. G. Hobbelink, Maarten-Jan M. Cramer, Dominique P. V. de Kleijn, René A. Tio, Bart J. G. L. de Smet, Pieter A. Doevendans, Imo E. Hoefer, Gerard Pasterkamp
Clin Sci (Lond) (2012) 122 (11): 527–533.
Published: 10 February 2012
... is negatively correlated with fractional flow reserve, suggesting that chronic ischaemia can elicit an enhanced inflammatory response. In the present study, we assessed the association between leucocyte TLR-2 and TLR-4 responsiveness and pre-existent and inducible ischaemia in patients undergoing SPECT (single...
Clin Sci (Lond) (2009) 117 (5): 201–208.
Published: 03 August 2009
... Laboratories Discovery software. GAPDH (glyceraldehyde-3-phosphate dehydrogenase) was used as the loading control. angiogenesis collateralization ischaemia ischaemic exercise training remote angiogenic effect vascular endothelial growth factor (VEGF) PAD (peripheral arterial disease) due...
Clin Sci (Lond) (2009) 116 (2): 157–164.
Published: 15 December 2008
...Marlies Bosselaar; Paul Smits; Cees J. Tack Ischaemia, like muscle contraction, has been reported to induce skeletal muscle glucose uptake in in vitro models. This stimulating effect appears independent of insulin and is probably mediated by activation of AMPK (AMP-activated protein kinase...
Clin Sci (Lond) (2008) 114 (1): 37–47.
Published: 30 November 2007
... of aldosterone in the cerebral vasculature and how that might affect the outcome of cerebral ischaemia. We will also discuss potential mechanisms for aldosterone-induced vascular changes and review the evidence that, in some models of hypertension, the MR is activated not by aldosterone but by glucocorticoids...
Kazuto Nakamura, Masataka Sata, Hiroshi Iwata, Yoshiki Sakai, Yasunobu Hirata, Kiyotaka Kugiyama, Ryozo Nagai
Clin Sci (Lond) (2007) 112 (12): 607–616.
Published: 14 May 2007
... ameliorated left ventricular enlargement after 28 days and improved survival rate. In conclusion, our results indicate that ONO-1301 up-regulated endogenous growth factors and promoted angiogenesis in response to acute ischaemia. Therefore ONO-1301 might have a therapeutic potential in treating ischaemic...
Jorge Berlanga, Danay Cibrian, Luis Guevara, Heberto Dominguez, Jose S. Alba, Alina Seralena, Gerardo Guillén, Ernesto López-Mola, Pedro López-Saura, Alberto Rodriguez, Brumny Perez, Diana Garcia, Nelson S. Vispo
Clin Sci (Lond) (2007) 112 (4): 241–250.
Published: 17 January 2007
... quantitative histopathology, local IGF-I (insulin-growth factor-I) expression and oxidative stress markers. GHRP6 treatment did not have any influence on mortality during surgery associated with rhythm and conductance disturbances during ischaemia. Infarct mass and thickness were reduced by 78% and 50...
Minami Abe, Masataka Sata, Etsu Suzuki, Ryo Takeda, Masao Takahashi, Hiroaki Nishimatsu, Daisuke Nagata, Kenji Kangawa, Hisayuki Matsuo, Ryozo Nagai, Yasunobu Hirata
Clin Sci (Lond) (2006) 111 (6): 381–387.
Published: 14 November 2006
... of adrenomedullin on collateral formation and circulating bone-marrow-derived cells after acute tissue ischaemia. Bone marrow of 8–10-week-old female C57BL/6J mice was replaced with that from GFP (green fluorescent protein) transgenic mice (GFP mice). At 8 weeks after transplantation, hindlimb ischaemia was induced...
Clin Sci (Lond) (2005) 108 (4): 357–363.
Published: 22 March 2005
...Felix BÖHM; Magnus SETTERGREN; Adrian T. GONON; John PERNOW Endothelial dysfunction may contribute to the extent of ischaemia/reperfusion injury. ET (endothelin)-1 receptor antagonism protects against myocardial ischaemia/reperfusion injury in animal models. The present study investigated whether...
Clin Sci (Lond) (2004) 107 (5): 477–484.
Published: 26 October 2004
...@sheffield.ac.uk ). 30 4 2004 21 7 2004 28 7 2004 28 7 2004 The Biochemical Society 2004 B-group vitamin C-reactive protein homocysteine ischaemia stroke malondialdehyde total antioxidant capacity Stroke is the third most common cause of death in most Western...
Clin Sci (Lond) (2004) 106 (5): 439–442.
Published: 01 May 2004
... endothelial proliferation and suppress tumour growth. However, to date, little is known about the pathophysiology of endostatin in ischaemia/reperfusion. To investigate the mechanisms of angiogenesis induced by myocardial ischaemia/reperfusion in more detail, we studied the circulating levels of endostatin...
Clin Sci (Lond) (2004) 106 (2): 147–154.
Published: 01 February 2004
...Sherif F. NAGUEH; Liyun RAO; Julia SOTO; Katherine J. MIDDLETON; Dirar S. KHOURY In the present study, we performed simultaneous epicardial echocardiography and left heart catheterization on ten adult dogs to investigate the effects of ischaemia and tachycardia on the mitral annulus early (E...
Frank WEIDEMANN, Jens BROSCHEIT, Nicole EBERBACH, Paul STEENDIJK, Wolfram VOELKER, Clemens GREIM, Georg ERTL, Norbert ROEWER, Jörg M STROTMANN
Clin Sci (Lond) (2004) 106 (2): 173–181.
Published: 01 February 2004
... and regional ischaemia of the posterior wall. These parameters were compared with global contractility [E ES (end-systolic elastance)] measured by a conductance catheter. Ischaemia was induced by an active coronary hypoperfusion in the circumflex coronary artery. Measurements were done at baseline, during...
Clin Sci (Lond) (2003) 105 (4): 473–482.
Published: 01 October 2003
... of Sprague—Dawley rats were studied at 1, 2 and 5 week intervals after iliac artery ligation. Muscle VEGF protein levels (as determined by Western-blot analysis) increased only after 2 (60%) and 5 (80%) weeks, with more capillaries positively immunostained for VEGF than in control muscles. Ischaemia-induced...
Andrew T. GOODWIN, Mohamed AMRANI, Caroline C. GRAY, Jay JAYAKUMAR, Adrian J. MARCHBANK, Magdi H. YACOUB
Clin Sci (Lond) (2002) 103 (s2002): 189S–193S.
Published: 01 September 2002
...Andrew T. GOODWIN; Mohamed AMRANI; Caroline C. GRAY; Jay JAYAKUMAR; Adrian J. MARCHBANK; Magdi H. YACOUB Endothelin (ET) may have both detrimental (reduced coronary flow) and beneficial effects (positive inotrope, reduced arrhythmogenesis) following ischaemia. We examined the effects of ET...
Violetta KÉKESI, Endre ZIMA, Erzsébet BARÁT, Éva HUSZÁR, Andrea NAGY, László LOSONCZI, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Clin Sci (Lond) (2002) 103 (s2002): 198S–201S.
Published: 01 September 2002
... plasma. A further increase in the pericardial adenosine concentration was also demonstrated in myocardial ischaemia or hypoxia. It was proposed that pericardial nucleoside levels may represent the interstitial concentrations of the adenine nucleosides. An experimental model was designed to determine...
Endre ZIMA, Violetta KÉKESI, Andrea NAGY, László LOSONCZI, Ildikó TOMA, Pál SOÓS, Erzsébet Barát, Éva HUSZÁR, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Clin Sci (Lond) (2002) 103 (s2002): 202S–205S.
Published: 01 September 2002
... with C2, while the endocardial monophasic action potential duration and upstroke velocity did not show ischaemia-related changes. The results suggest that intrapericardial administration of ET-1 induces subepicardial ischaemia, with parallel activation of coronary metabolic adaptive and cardiac self...
Yasuo MATSUMURA, Junji YAMASHITA, Satomi KITA, Takahiro IWAMOTO, Masaya OGATA, Masanori TAKAOKA, Koji WAKIMOTO, Munekazu SHIGEKAWA, Issei KOMURO
Clin Sci (Lond) (2002) 103 (s2002): 389S–392S.
Published: 01 September 2002
... in ischaemia/reperfusion-induced renal injury was investigated. Since NCX1 -/- homozygous mice die of heart failure before birth, we utilized NCX1 +/- heterozygous mice. The ischaemia/reperfusion-induced renal dysfunction in heterozygous mice were significantly attenuated compared with cases in wild-type mice...
Clin Sci (Lond) (2002) 103 (s2002): 434S–437S.
Published: 01 September 2002
... clearance were measured to test the effectiveness of the steroid hormone. Renal function in ARF rats markedly decreased 24h after reperfusion. The ischaemia/reperfusion-induced renal dysfunction was dose-dependently improved by pretreatment with 17β-oestradiol (20 or 100 µ g/kg, intravenously...
Clin Sci (Lond) (2001) 100 (4): 423–432.
Published: 09 March 2001
... ischaemia left ventricle long axis stress echocardiography 423Clinical Science (2001) 100, 423 432 (Printed in Great Britain) Assessment of regional long-axis function during dobutamine echocardiography Peter CAIN, Thomas H. MARWICK, Colin CASE, Terri BAGLIN, Jared DART, Leanne SHORT and Bjorn OLSTAD...
Clin Sci (Lond) (2000) 99 (5): 443–453.
Published: 27 October 2000
...Jin-Gang ZHANG; Sudip GHOSH; Colin D. OCKLEFORD; Manuel GALIÑANES The mechanisms underlying myocardial ischaemia and reperfusion-induced injury have been investigated, mainly by using animal experimental preparations in vitro and in vivo , but little is known of the process in human myocardium...
Clin Sci (Lond) (2000) 98 (6): 703–711.
Published: 10 May 2000
...-artery myocardial infarction leading to asymptomatic LV dysfunction. experimental haemodynamics heart heart failure ischaemia pathophysiology reperfusion Correspondence : Dr C. J. Charles (e-mail firstname.lastname@example.org ). 25 8 1999 4 1 2000 1 3 2000...
E. P. A. van der Heijden, A. B. A. Kroese, P. M. N. Werker, P. D. Grabietz, M. B. De Jong, P. R. Bär, M. Kon
Clin Sci (Lond) (1998) 94 (3): 271–278.
Published: 01 March 1998
... of the solutions used. Both UW and HTK were most effective ( P 0 > 50% of control) in preserving muscle function. 27 10 1997 27 10 1997 © 1998 The Biochemical Society and the Medical Research Society 1998 direct electrical stimulation ischaemia isolated muscle muscle contractility...
Clin Sci (Lond) (1996) 91 (4): 459–466.
Published: 01 October 1996
...Y.-H. Feng; G. Hart 1. Polymorphonuclear leucocytes are a major source of toxic oxidants in vivo , causing tissue injury in certain circumstances such as ischaemia and reperfusion. Calcium ions are a key mediator in the production of oxidants by these cells. The aim of this study was to examine...
Clin Sci (Lond) (1996) 91 (1): 51–58.
Published: 01 July 1996
... descending coronary artery occlusion was induced to produce periods of ischaemia lasting between 24 s and 13.5 min ( n = 13). The changes in deoxyhaemoglobin, oxyhaemoglobin and cytochrome aa 3 measured during occlusion were all highly significant compared with baseline variation. In all occlusions ( n = 13...
Clin Sci (Lond) (1996) 90 (6): 447–452.
Published: 01 June 1996
... be expected to influence myocardial conduction and the arrhythmogenic substrate. © 1996 The Biochemical Society and the Medical Research Society 1996 connexin43 gap junction myocardium human ischaemia hypertrophy Clinical Science (1996) 90, 447452 (Printed in Great Britain) 447 Glaxo/M RS...
D. L. Vaughan, Y. A. B. D. Wickramasinghe, G. I. Russell, M. S. Thorniley, R. F. Houston, E. Ruban, P. Rolfe
Clin Sci (Lond) (1995) 88 (3): 359–364.
Published: 01 March 1995
...D. L. Vaughan; Y. A. B. D. Wickramasinghe; G. I. Russell; M. S. Thorniley; R. F. Houston; E. Ruban; P. Rolfe 1. The role of allopurinol in the protection of kidney function following ischaemia—reperfusion injury has been investigated using the novel technique of near-infrared spectroscopy. 2...
Kenneth R. Knight, Karen MacPhadyen, Diana A. Lepore, Noriyuki Kuwata, Patricia A. Eadie, Bernard McC. O'Brien
Clin Sci (Lond) (1991) 81 (1): 31–36.
Published: 01 July 1991
... intravenous treatment. The possible clinical benefits in humans have yet to be demonstrated. 21 1 1991 28 1 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 N -acetylcysteine antioxidant free-radical scavenger ischaemia skin flap thromboxane Clinical...
Clin Sci (Lond) (1989) 77 (1): 77–84.
Published: 01 July 1989
... compositions. 2. Kidneys flushed with PB immediately before 45 min pedicle clamp ischaemia exhibited a post-ischaemic function similar to that of control, non-flushed kidneys: they were isosthenuric and non-oliguric with a clearance of inulin ( C in ) depressed to 10% of the pre-ischaemic value. 3. Kidneys...
Clin Sci (Lond) (1988) 74 (3): 261–268.
Published: 01 March 1988
...-buffered sucrose (PBS50) solution. 2. After ischaemia, unflushed kidneys became oliguric and isosthenuric, with a fall in inulin clearance ( C in ) to 0.1% of the pre-ischaemic value. Removal of the healthy contralateral kidney upon release of the occlusion caused no improvement in immediate post-ischaemic...
Clin Sci (Lond) (1988) 74 (3): 269–274.
Published: 01 March 1988
...A. M. Dart; R. A. Riemersma 1. Reperfusion of the globally ischaemic isolated rat heart is associated with an enhanced overflow of endogenous noradrenaline (NA) after ischaemic periods of 20, 40 or 60 min but not of 10 min. 2. Reperfusion NA overflow, after 40 min of ischaemia, is suppressed...
Clin Sci (Lond) (1987) 72 (4): 475–482.
Published: 01 April 1987
... of AMPD activity in the adenine nucleotide catabolism of skeletal muscle. 24 10 1986 14 11 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 AMP deaminase exercise ischaemia muscle purines CIinicalScience( 1987) 72,475-482 475 AMP deaminase deficiency...
Clin Sci (Lond) (1986) 71 (4): 449–451.
Published: 01 October 1986
...Erica K. Potter; D. I. McCloskey; Gillian P. Courtice 1. The effect of ischaemia of the sino-atrial node on cardiac vagal action was studied in anaesthetized dogs. 2. The cut, cardiac end of the right vagus nerve was stimulated with a standard supramaximal stimulus every 10 s. The arterial supply...
Clin Sci (Lond) (1985) 69 (2): 153–163.
Published: 01 August 1985
... mitochondrial populations and a qualitative improvement of the respiratory activity of the subsarcolemmal mitochondria. 8 2 1985 26 2 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 citrate synthase exercise ischaemia mitochondria oxidative phosphorylation...
Clin Sci (Lond) (1985) 68 (5): 597–600.
Published: 01 May 1985
...-7.1 to about 6.8 after 2 h occlusion. Muscle pH was essentially normalized within 20 min after restoration of the blood flow. energy metabolism intracellular pH ischaemia knee operation skeletal muscle 31 12 1984 3 1 1985 © 1985 The Biochemical Society and the Medical...
Clin Sci (Lond) (1983) 65 (1): 27–32.
Published: 01 July 1983
... sodium intake. 2. Whether inactive renin was activated by acid or trypsin, it tended to be increased by 50–100% in unilateral renal ischaemia patients compared with essential hypertension. Active renin was increased two- to four-fold in unilateral renal ischaemia patients compared with those...
Clin Sci (Lond) (1981) 60 (5): 543–548.
Published: 01 May 1981
... exercise hepatic gluconeogenesis ischaemia lactic acidosis Clinical Science (1981)60, 543-548 The effect of adrenaline on hepatic lactate uptake in the acidotic partially ischaemic rat liver R. A. ILES, R. D. COHEN, P. G. BARON, J. A. SMITH AND R. M. HENDERSON Metabolic and Endocrine Unit, The London...
Clin Sci Mol Med (1977) 53 (6): 513–521.
Published: 01 December 1977
...R. W. Brownsey; R. V. Brunt 1. The isolated perfused non-working rat heart, subjected to low coronary flow, has been used to study the effects of myocardial ischaemia on both the mechanical and metabolic performance of the heart. 2. In this preparation, adrenaline initially increased developed...