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Keywords: insulin resistance
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Articles
Clin Sci (Lond) (2022) 136 (21): 1535–1549.
Published: 03 November 2022
... secretion and more pronounced glucose intolerance in GDM as compared with healthy pregnancy. * These authors share senior authorship. Correspondence: Laura B James-Allan ( laurajamesallan@hotmail.co.uk ) or Carlos Salomon ( c.salomongallo@uq.edu.au ) glucose homeostasis insulin resistance...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (2): 327–346.
Published: 22 January 2021
... A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) have been shown to abolish inflammation...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (22): 3047–3062.
Published: 24 November 2020
... leading to protection from pathological muscle remodelling and muscle insulin resistance. In contrast, there is relatively little evidence to support the protective role of ACE2 in skeletal muscle. The potential contribution of endogenous ACE2 to the regulation of Ang 1-7-mediated protection...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (21): 2789.
Published: 02 November 2020
... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Green tea polyphenols insulin receptor substrate-1 insulin resistance obesity protein kinase C-θ Zucker fatty rats The Editorial Office has been made aware of potential issues...
Articles
Clin Sci (Lond) (2020) 134 (16): 2117–2135.
Published: 21 August 2020
...Frédéric Clarembeau; Georgia Bale; Nicolas Lanthier End-stage chronic liver diseases are often associated with insulin resistance (IR) and diabetes mellitus (DM). Indeed, to quantify insulin sensitivity the euglycemic clamp technique was utilized, allowing the following to be stated: in small...
Articles
Clin Sci (Lond) (2020) 134 (10): 1167–1180.
Published: 27 May 2020
...) levels. Homoeostasis model assessment of insulin resistance (HOMA-IR), a measure of insulin resistance, was lower ( P <0.01) in GTP-treated animals compared with ZF controls. Moreover, insulin-stimulated glucose uptake by isolated soleus muscle was increased ( P <0.05) in GTP-ZF rats compared...
Articles
Clin Sci (Lond) (2020) 134 (6): 571–592.
Published: 18 March 2020
... peripheral insulin resistance, thought to be driven by low-grade maternal inflammation. Nobiletin, a polymethoxylated flavonoid, possesses potent glucose-sensitizing and anti-inflammatory properties; however, its effects in GDM have not been assessed. The present study aimed to determine the effects...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (24): 2431–2447.
Published: 16 December 2019
...Chayodom Maneechote; Siripong Palee; Nattayaporn Apaijai; Sasiwan Kerdphoo; Thidarat Jaiwongkam; Siriporn C. Chattipakorn; Nipon Chattipakorn Obese insulin resistance impairs cardiac mitochondrial dynamics by increasing mitochondrial fission and decreasing mitochondrial fusion, leading...
Articles
Clin Sci (Lond) (2019) 133 (17): 1883–1899.
Published: 10 September 2019
... tissue High fat diet Insulin resistance Renin-angiotensin system Salt Sympathetic reflex Obesity is characterized by excessive accumulation of white adipose tissue due to an imbalance between food intake and energy expenditure [ 1 ]. People with obesity often have insulin resistance (IR) [ 2...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (15): 1685–1698.
Published: 14 August 2018
... sensitive (IS) ( n =10), obese IS ( n =10), and obese insulin resistant (IR) ( n =10) men. Obese men participated in a 12-week exercise training intervention to determine the effects on SCAT lipolysis. Abdominal SCAT extracellular glycerol concentration and blood flow (ATBF) were investigated using...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (11): 1085–1095.
Published: 05 June 2018
... the insulin resistance (IR) are available as research tool but are very difficult to implement in the clinical practice. Therefore, a better understanding of the key players contributing to IR may lead to the development of new non-invasive tools to assess organ-specific insulin sensitivity (IS). We...
Articles
Clin Sci (Lond) (2018) 132 (10): 1039–1054.
Published: 25 May 2018
... of BAT tissue, introduce challenges in longitudinal and intervention studies. Further studies are required to determine whether this limitation can be addressed. brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (24): 2901–2910.
Published: 04 December 2017
...Eleni Rebelos; Brenno Astiarraga; Roberto Bizzotto; Andrea Mari; Maria Laura Manca; Alex Gonzalez; Armando Mendez; Claudia A. Martinez; Barry E. Hurwitz; Ele Ferrannini Previous work has shown that potentiation of insulin release is impaired in non-diabetic insulin resistance; we tested...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (22): 2701–2704.
Published: 06 November 2017
...Amalia Gastaldelli Whether non-alcoholic fatty liver disease (NAFLD) precedes insulin resistance (IR) or IR preludes/causes NAFLD has been long debated. Recent studies have shown that there are two phenotypes of NAFLD, ‘genetic’ vs ‘metabolic’ NAFLD. The former patients are more at risk...
Articles
Clin Sci (Lond) (2017) 131 (15): 1905–1917.
Published: 07 July 2017
...), hepatic insulin resistance index (HIR i ) ( r =0.576, P =0.001), and Δ R d ( r =−0.653, P <0.001) correlated with IHL content. Individuals with NAFL suffer from metabolic perturbations to a similar degree as T2DM patients. NAFL is an important feature leading to severe insulin resistance and should...
Articles
Clin Sci (Lond) (2017) 131 (3): 239–246.
Published: 18 January 2017
... demonstrated the relationship of circulating BMP-9 levels with insulin resistance (IR) or Type 2 diabetes mellitus (T2DM) in humans. The objective of the present study was to investigate the relationship between BMP-9 and IR in cross-sectional and interventional studies. Circulating BMP-9 levels were analysed...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (1): 37–47.
Published: 09 December 2016
...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (18): 1603–1614.
Published: 08 August 2016
...Matthias Blüher The worldwide obesity epidemic has become a major health concern, because it contributes to higher mortality due to an increased risk for noncommunicable diseases including cardiovascular diseases, type 2 diabetes, musculoskeletal disorders and some cancers. Insulin resistance may...
Articles
Clin Sci (Lond) (2016) 130 (14): 1257–1268.
Published: 13 June 2016
... demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet (HFD)-induced insulin resistance and chronic inflammation, characterized by the elevation of proinflammatory cytokines in the blood, liver and white adipose tissue, as well as a proinflammatory profile of immune cells in visceral...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (2): 93–104.
Published: 09 December 2015
... (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise is an effective treatment for lowering liver fat but its effect on IR in NAFLD is unknown. We aimed to determine whether supervised exercise in NAFLD would reduce liver fat and improve hepatic and peripheral (skeletal muscle...
Articles
Clin Sci (Lond) (2015) 129 (12): 1083–1096.
Published: 13 October 2015
... inflammation, which also manifests within metabolic tissues such as adipose tissue and liver. This metabolic inflammation can promote insulin resistance and dysglycaemia. However, the obesity and metabolic disease-related immune responses that are compartmentalized in the intestinal environment do...
Articles
Clin Sci (Lond) (2015) 129 (12): 1025–1036.
Published: 18 September 2015
...Lina Zhao; Zhuo Fu; Jing Wu; Kevin W. Aylor; Eugene J. Barrett; Wenhong Cao; Zhenqi Liu Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. In the present study, we investigate the temporal relationship between vascular insulin resistance...
Articles
Clin Sci (Lond) (2015) 129 (10): 839–850.
Published: 19 August 2015
..., induces the browning of white adipose tissue, but its effects on gluconeogenesis and glycogenesis are unknown. In the present study, we investigated the effects and underlying mechanisms of irisin on gluconeogenesis and glycogenesis in hepatocytes with insulin resistance, and its therapeutic role in type...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (5): 405–414.
Published: 11 June 2015
...Camilla Kappe; Liselotte Fransson; Petra Wolbert; Henrik Ortsäter Evidence indicates that subtle abnormalities in GC (glucocorticoid) plasma concentrations and/or in tissue sensitivity to GCs are important in the metabolic syndrome, and it is generally agreed that GCs induce insulin resistance...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (11): 789–803.
Published: 19 March 2015
... (eHSP70) has a pro-inflammatory function, resulting in local and systemic inflammation. We have recently identified a divergence in the levels of eHSP70 and iHSP70 in subjects with diabetes compared with healthy subjects and also reported that eHSP70 was correlated with insulin resistance and pancreatic β...
Articles
Clin Sci (Lond) (2015) 128 (9): 609–618.
Published: 11 February 2015
... efflux and antioxidative activity) were studied. IO patients compared with controls exhibited insulin resistance (HOMA-IR (homoeostasis model assessment-estimated insulin resistance): +93%, P < 0.001). Metabolic profiles differed across HFE genotypes. C282Y homozygotes ( n =7) presented a reduced β...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (8): 493–506.
Published: 23 January 2015
... with a FOXO1 inhibitor, an antioxidant that inhibits FOXO1 or IL-1 receptor antagonist alleviates chronic inflammation and insulin resistance in high-fat diet (HFD)-fed mice. Collectively, our data suggest that obesity-associated factors such as NEFA and lipopolysaccharide (LPS) probably adopt this vicious...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (2): 143–151.
Published: 19 September 2014
... <0.001) levels together with homoeostasis model assessment of insulin resistance (HOMA-IR) (+48%, P <0.001), suggesting development of insulin resistance (IR). Furthermore, the HFHC-diet markedly increased HTG (+118%, P <0.001) and plasma CETP levels (+21%, P <0.001), a marker of liver...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 507–518.
Published: 25 June 2014
...)] are hepatic complications of the metabolic syndrome. Endoplasmic reticulum (ER) stress is proposed as a crucial disease mechanism in obese and insulin-resistant animals (such as ob/ob mice) with simple steatosis, but its role in NASH remains controversial. We therefore evaluated the role of ER stress...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (2): 91–100.
Published: 17 March 2014
... ( G6pase ) insulin resistance Type 2 diabetes • Type 2 diabetes is a worldwide disease characterized by hyperglycaemia, which is contributed to, at least in part, by hepatic glucose production. Gadolinium is one of the lanthanides and its compounds have been used in medical practice for a long...
Articles
Clin Sci (Lond) (2014) 126 (10): 739–752.
Published: 03 February 2014
... aging is associated with a low-grade inflammation and IR (insulin resistance), we aimed to: (i) analyse the concentration of eHSP72 in elderly people and determine correlation with insulin resistance, and (ii) determine the effects of eHSP72 on β-cell function and viability in human and rodent...
Articles
Clin Sci (Lond) (2013) 125 (11): 501–511.
Published: 25 July 2013
... (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression. In NAFLD, steatosis, lipotoxicity and liver inflammation participate to hepatic insulin resistance. The aim of the present study was to verify...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (12): 681–692.
Published: 10 August 2012
.... Gagliardino (email cenexa@speedy.com.ar ). 16 12 2011 25 6 2012 28 6 2012 28 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apocynin fructose hepatic metabolic disorder insulin resistance NADPH oxidase pre-diabetes • The growing...
Articles
Clin Sci (Lond) (2012) 123 (9): 545–546.
Published: 13 July 2012
... Journal compilation © 2012 Biochemical Society 2012 apoptosis high-fat diet inflammation insulin resistance obesity tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) Type 2 diabetes mellitus Obesity has reached epidemic proportions worldwide. Obesity is an increasingly...
Articles
Clin Sci (Lond) (2012) 123 (9): 547–555.
Published: 13 July 2012
... 23 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis high-fat diet inflammation insulin resistance obesity treatment tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) Type 2 diabetes mellitus TRAIL [TNF (tumour necrosis...
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Clin Sci (Lond) (2012) 123 (4): 259–270.
Published: 30 April 2012
...Julio Cesar Fraulob; Vanessa Souza-Mello; Marcia Barbosa Aguila; Carlos Alberto Mandarim-de-Lacerda The aim of the present study was to evaluate the effects of ST (rosuvastatin) and GZ (rosiglitazone) on IR (insulin resistance) and on liver as well as adipose tissue in mice fed on an HF (high-fat...
Articles
Clin Sci (Lond) (2012) 122 (5): 203–214.
Published: 28 October 2011
... 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative stress Toll-like receptor Type 2 diabetes Diabetes affects more than 348 million people worldwide and around 36 million in the U.S.A. [ 1 , 2 ]. The prevalence of diabetes is increasing...
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Clin Sci (Lond) (2011) 121 (4): 179–189.
Published: 04 May 2011
... with estimates of whole body rate of protein turnover and urea synthesis in clinically stable biopsy-confirmed subjects with NASH (non-alcoholic steatohepatitis). Subjects with NASH were more insulin-resistant and had significantly higher plasma concentrations of usCRP (ultrasensitive C-reactive protein), TNFα...
Articles
Clin Sci (Lond) (2011) 120 (7): 297–305.
Published: 13 December 2010
... 2010 15 10 2010 15 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 adiposity Chinese herbal extract insulin resistance metabolic syndrome thiazolidinedione visceral obesity The metabolic syndrome represents a cluster of cardiometabolic risk...
Articles
Clin Sci (Lond) (2011) 120 (2): 73–80.
Published: 08 October 2010
... (homoeostasis model assessment) for insulin resistance], HOMA-β (HOMA for β-cell function) and liver triacylglycerol content were measured. Pancreas immunomorphometric analyses were also performed. IGT (impaired glucose tolerance), plasma triacylglycerol, fructosamine and insulin levels, HOMA-IR and HOMA-β...
Articles
Clin Sci (Lond) (2010) 119 (8): 313–322.
Published: 06 July 2010
... compilation © 2010 Biochemical Society 2010 adipose tissue blood flow (ATBF) body mass index endothelial function flow-mediated vasodilatation heart rate variability insulin resistance Over the past few years, it has been appreciated that blood flow through metabolically active tissues...
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Clin Sci (Lond) (2010) 119 (8): 345–351.
Published: 06 July 2010
.... Correspondence: Professor Thomas Forst (email ThomasF@ikfe.de ). 11 3 2010 20 5 2010 28 5 2010 28 5 1010 © The Authors Journal compilation © 2010 Biochemical Society 2010 adiponectin erythrocyte deformability insulin resistance metformin sulfonylurea thiazolidinedione...
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Clin Sci (Lond) (2010) 119 (6): 239–250.
Published: 08 June 2010
...). Conversely, all drug treatments resulted in significant weight loss, a reversal of insulin resistance, islet and adipocyte hypertrophy, and alleviated hepatic steatosis. Only the HF-T and HF-TS groups had body weights similar to the SC group at the end of the experiment, and the latter treatment reversed...
Articles
Clin Sci (Lond) (2009) 117 (5): 173–190.
Published: 03 August 2009
...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...
Articles
Clin Sci (Lond) (2009) 116 (10): 761–770.
Published: 15 April 2009
...Lisa J. Moran; Samantha K. Hutchison; Caroline Meyer; Sophia Zoungas; Helena J. Teede PCOS (polycystic ovary syndrome) is associated with reproductive abnormalities, IR (insulin resistance) and elevated risk factors for CVD (cardiovascular disease) and Type 2 diabetes, including endothelial...
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Clin Sci (Lond) (2009) 116 (8): 607–620.
Published: 16 March 2009
...-4-imidazolecarboxamide riboside-1-β- D -ribofuranoside (AICAR) AMP-activated protein kinase (AMPK) cardiovascular disease insulin resistance metformin obesity The prevalence of cardiometabolic diseases is reaching epidemic proportions in industrialized nations and in developing...
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Clin Sci (Lond) (2009) 116 (7): 585–592.
Published: 02 March 2009
... resistance. Acylcarnitines have been suggested to play a role in insulin resistance, as well as other long-chain fatty acid metabolites. Plasma levels of long-chain acylcarnitines increase during fasting, but this is unknown for muscle long-chain acylcarnitines. In the present study we investigated whether...
Articles
Clin Sci (Lond) (2009) 116 (6): 531–537.
Published: 12 February 2009
...-fat diet develop fatty liver, but not insulin resistance, suggesting that DGAT2 induces a dissociation between fatty liver and insulin resistance. In the present study, we investigated whether such a phenotype also exists in humans. For this purpose, we determined the relationships between genetic...
Articles
Clin Sci (Lond) (2009) 116 (6): 507–512.
Published: 12 February 2009
... Health and Nutrition Examination Survey), which has released measurements of IGF-I and IGFBP-3. Insulin resistance was estimated using the computer HOMA2 (homoeostatic model assessment 2) model. The updated ATP-III (Adult Treatment Panel III) definition of the metabolic syndrome was used. We applied...