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NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose

Alena Karnošová, Veronika Strnadová, Blanka Železná, Jaroslav Kuneš, Petr Kašpárek, Lenka Maletínská

Clin Sci (Lond) (2023) 137 (10): 847–862.

DOI: https://doi.org/10.1042/CS20220880

Published: 31 May 2023

.... In addition, reduced insulin pathway signaling proteins in NPFFR2 KO mice fed a HFD resulted in the development of hypothalamic insulin resistance. HFD feeding did not cause liver steatosis in NPFFR2 KO mice of either sex, but NPFFR2 KO male mice fed a HFD had lower body weights, white adipose tissues...

View article titled, NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose

Includes: Supplementary data

Articles

A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice

In Collection

Reproductive Physiology and Disease

Laura B James-Allan, Frederick J Rosario, Lana Madi, Kelsey Barner, Soumyalekshmi Nair, Andrew Lai, Flavio Carrion, Theresa L Powell, Carlos Salomon, Thomas Jansson

Clin Sci (Lond) (2022) 136 (21): 1535–1549.

DOI: https://doi.org/10.1042/CS20220484

Published: 03 November 2022

... of University of Queensland in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. glucose homeostasis insulin resistance microparticles pancreatic beta cell Gestational diabetes mellitus (GDM) is defined...

View article titled, A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice

Includes: Supplementary data

Articles

Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Osvaldo Rivera-Gonzalez, Natalie A. Wilson, Laura E. Coats, Erin B. Taylor, Joshua S. Speed

Clin Sci (Lond) (2021) 135 (14): 1773–1789.

DOI: https://doi.org/10.1042/CS20210549

Published: 30 July 2021

..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...

View article titled, Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Includes: Supplementary data

Articles

β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat

James T. Pearson, Hamish P. Thambyah, Mark T. Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P. Ngo, Connie P.C. Ow, Takashi Sonobe, Yi Ching Chen, Amanda J. Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J. Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

Clin Sci (Lond) (2021) 135 (2): 327–346.

DOI: https://doi.org/10.1042/CS20201441

Published: 22 January 2021

... A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) have been shown to abolish inflammation...

View article titled, β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat

Includes: Supplementary data

Articles

ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

Koichi Yamamoto, Hikari Takeshita, Hiromi Rakugi

Clin Sci (Lond) (2020) 134 (22): 3047–3062.

DOI: https://doi.org/10.1042/CS20200486

Published: 24 November 2020

... leading to protection from pathological muscle remodelling and muscle insulin resistance. In contrast, there is relatively little evidence to support the protective role of ACE2 in skeletal muscle. The potential contribution of endogenous ACE2 to the regulation of Ang 1-7-mediated protection...

View article titled, ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19

Includes: Supplementary data

Articles

Expression of Concern: Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker Fatty Rats

Clin Sci (Lond) (2020) 134 (21): 2789.

DOI: https://doi.org/10.1042/CS-20200107_EOC

Published: 02 November 2020

... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Green tea polyphenols insulin receptor substrate-1 insulin resistance obesity protein kinase C-θ Zucker fatty rats The Editorial Office has been made aware of potential issues...

View article titled, Expression of Concern: Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker Fatty Rats

Articles

Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments

Frédéric Clarembeau, Georgia Bale, Nicolas Lanthier

Clin Sci (Lond) (2020) 134 (16): 2117–2135.

DOI: https://doi.org/10.1042/CS20200022

Published: 21 August 2020

...Frédéric Clarembeau; Georgia Bale; Nicolas Lanthier End-stage chronic liver diseases are often associated with insulin resistance (IR) and diabetes mellitus (DM). Indeed, to quantify insulin sensitivity the euglycemic clamp technique was utilized, allowing the following to be stated: in small...

View article titled, Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments

Articles

Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats

Jing Cheng, Yi Tan, Jiong Zhou, Linda Xiao, Michael Johnson, Xianqin Qu

Clin Sci (Lond) (2020) 134 (10): 1167–1180.

DOI: https://doi.org/10.1042/CS20200107

Published: 27 May 2020

...) levels. Homoeostasis model assessment of insulin resistance (HOMA-IR), a measure of insulin resistance, was lower ( P <0.01) in GTP-treated animals compared with ZF controls. Moreover, insulin-stimulated glucose uptake by isolated soleus muscle was increased ( P <0.05) in GTP-ZF rats compared...

View article titled, Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats

Articles

Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes

In Collection

Clinical and translational research highlights

Caitlyn Nguyen-Ngo, Carlos Salomon, Stephanie Quak, Andrew Lai, Jane C Willcox, Martha Lappas

Clin Sci (Lond) (2020) 134 (6): 571–592.

DOI: https://doi.org/10.1042/CS20191099

Published: 18 March 2020

... peripheral insulin resistance, thought to be driven by low-grade maternal inflammation. Nobiletin, a polymethoxylated flavonoid, possesses potent glucose-sensitizing and anti-inflammatory properties; however, its effects in GDM have not been assessed. The present study aimed to determine the effects...

View article titled, Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes

Includes: Supplementary data

Articles

Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats

Chayodom Maneechote, Siripong Palee, Nattayaporn Apaijai, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn

Clin Sci (Lond) (2019) 133 (24): 2431–2447.

DOI: https://doi.org/10.1042/CS20190960

Published: 16 December 2019

...Chayodom Maneechote; Siripong Palee; Nattayaporn Apaijai; Sasiwan Kerdphoo; Thidarat Jaiwongkam; Siriporn C. Chattipakorn; Nipon Chattipakorn Obese insulin resistance impairs cardiac mitochondrial dynamics by increasing mitochondrial fission and decreasing mitochondrial fusion, leading...

View article titled, Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats

Articles

Adipocytes initiate an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high-fat feeding

Wei Cao, Meng Shi, Liling Wu, Jiaxin Li, Zhichen Yang, Youhua Liu, Christopher S. Wilcox, Fan Fan Hou

Clin Sci (Lond) (2019) 133 (17): 1883–1899.

DOI: https://doi.org/10.1042/CS20190412

Published: 10 September 2019

... resistance Renin-angiotensin system Salt Sympathetic reflex Obesity is characterized by excessive accumulation of white adipose tissue due to an imbalance between food intake and energy expenditure [ 1 ]. People with obesity often have insulin resistance (IR) [ 2 ]. Obesity increases the activity...

View article titled, Adipocytes initiate an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high-fat feeding

Includes: Supplementary data

Articles

Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training

Kenneth Verboven, Rudi Stinkens, Dominique Hansen, Inez Wens, Ines Frederix, Bert O. Eijnde, Johan W.E. Jocken, Gijs H. Goossens, Ellen E. Blaak

Clin Sci (Lond) (2018) 132 (15): 1685–1698.

DOI: https://doi.org/10.1042/CS20180453

Published: 14 August 2018

... sensitive (IS) ( n =10), obese IS ( n =10), and obese insulin resistant (IR) ( n =10) men. Obese men participated in a 12-week exercise training intervention to determine the effects on SCAT lipolysis. Abdominal SCAT extracellular glycerol concentration and blood flow (ATBF) were investigated using...

View article titled, Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training

Includes: Supplementary data

Articles

Probing insulin sensitivity in diabetic kidney disease: is there a stronger role for functional imaging?

Michael L. Granda, Pooja Amarapurkar, Alessia Fornoni

Clin Sci (Lond) (2018) 132 (11): 1085–1095.

DOI: https://doi.org/10.1042/CS20171490

Published: 05 June 2018

... the insulin resistance (IR) are available as research tool but are very difficult to implement in the clinical practice. Therefore, a better understanding of the key players contributing to IR may lead to the development of new non-invasive tools to assess organ-specific insulin sensitivity (IS). We...

View article titled, Probing insulin sensitivity in diabetic kidney disease: is there a stronger role for functional imaging?

Articles

Recent advances in the detection of brown adipose tissue in adult humans: a review

Frank J. Ong, Basma A. Ahmed, Stephan M. Oreskovich, Denis P. Blondin, Tahniyah Haq, Norman B. Konyer, Michael D. Noseworthy, Francois Haman, Andre C. Carpentier, Katherine M. Morrison, Gregory R. Steinberg

Clin Sci (Lond) (2018) 132 (10): 1039–1054.

DOI: https://doi.org/10.1042/CS20170276

Published: 25 May 2018

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of functional brown adipose tissue (BAT) in adult humans...

View article titled, Recent advances in the detection of brown adipose tissue in adult humans: a review

Includes: Supplementary data

Articles

GLP-1 response to sequential mixed meals: influence of insulin resistance

Eleni Rebelos, Brenno Astiarraga, Roberto Bizzotto, Andrea Mari, Maria Laura Manca, Alex Gonzalez, Armando Mendez, Claudia A. Martinez, Barry E. Hurwitz, Ele Ferrannini

Clin Sci (Lond) (2017) 131 (24): 2901–2910.

DOI: https://doi.org/10.1042/CS20171409

Published: 04 December 2017

...Eleni Rebelos; Brenno Astiarraga; Roberto Bizzotto; Andrea Mari; Maria Laura Manca; Alex Gonzalez; Armando Mendez; Claudia A. Martinez; Barry E. Hurwitz; Ele Ferrannini Previous work has shown that potentiation of insulin release is impaired in non-diabetic insulin resistance; we tested...

View article titled, GLP-1 response to sequential mixed meals: influence of insulin resistance

Includes: Supplementary data

Articles

Insulin resistance and reduced metabolic flexibility: cause or consequence of NAFLD?

Amalia Gastaldelli

Clin Sci (Lond) (2017) 131 (22): 2701–2704.

DOI: https://doi.org/10.1042/CS20170987

Published: 06 November 2017

...Amalia Gastaldelli Whether non-alcoholic fatty liver disease (NAFLD) precedes insulin resistance (IR) or IR preludes/causes NAFLD has been long debated. Recent studies have shown that there are two phenotypes of NAFLD, ‘genetic’ vs ‘metabolic’ NAFLD. The former patients are more at risk...

View article titled, Insulin resistance and reduced metabolic flexibility: cause or consequence of NAFLD?

Articles

Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes

Bram Brouwers, Vera B. Schrauwen-Hinderling, Tomas Jelenik, Anne Gemmink, Bas Havekes, Yvonne Bruls, Dennis Dahlmans, Michael Roden, Matthijs K.C. Hesselink, Patrick Schrauwen

Clin Sci (Lond) (2017) 131 (15): 1905–1917.

DOI: https://doi.org/10.1042/CS20170261

Published: 07 July 2017

...), hepatic insulin resistance index (HIR i ) ( r =0.576, P =0.001), and Δ R d ( r =−0.653, P <0.001) correlated with IHL content. Individuals with NAFL suffer from metabolic perturbations to a similar degree as T2DM patients. NAFL is an important feature leading to severe insulin resistance and should...

View article titled, Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes

Articles

Decreased circulating BMP-9 levels in patients with Type 2 diabetes is a signature of insulin resistance

Yong Luo, Ling Li, Xiaohui Xu, Tong Wu, Mengliu Yang, Cheng Zhang, Huaming Mou, Tingting Zhou, Yanjun Jia, Chenrongrong Cai, Hua Liu, Gangyi Yang, Xianxiang Zhang

Clin Sci (Lond) (2017) 131 (3): 239–246.

DOI: https://doi.org/10.1042/CS20160543

Published: 18 January 2017

... demonstrated the relationship of circulating BMP-9 levels with insulin resistance (IR) or Type 2 diabetes mellitus (T2DM) in humans. The objective of the present study was to investigate the relationship between BMP-9 and IR in cross-sectional and interventional studies. Circulating BMP-9 levels were analysed...

View article titled, Decreased circulating BMP-9 levels in patients with Type 2 diabetes is a signature of insulin resistance

Includes: Supplementary data

Articles

Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes

Rikke Kruse, Andreas J.T. Pedersen, Jonas M. Kristensen, Stine J. Petersson, Jørgen F.P. Wojtaszewski, Kurt Højlund

Clin Sci (Lond) (2017) 131 (1): 37–47.

DOI: https://doi.org/10.1042/CS20160736

Published: 09 December 2016

...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...

View article titled, Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes

Includes: Supplementary data

Articles

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

Matthias Blüher

Clin Sci (Lond) (2016) 130 (18): 1603–1614.

DOI: https://doi.org/10.1042/CS20160005

Published: 08 August 2016

...Matthias Blüher The worldwide obesity epidemic has become a major health concern, because it contributes to higher mortality due to an increased risk for noncommunicable diseases including cardiovascular diseases, type 2 diabetes, musculoskeletal disorders and some cancers. Insulin resistance may...

View article titled, Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

Articles

Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice

Xia Kang, Along Hou, Rui Wang, Da Liu, Wei Xiang, Qingyun Xie, Bo Zhang, Lixia Gan, Wei Zheng, Hongming Miao

Clin Sci (Lond) (2016) 130 (14): 1257–1268.

DOI: https://doi.org/10.1042/CS20160192

Published: 13 June 2016

... demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet (HFD)-induced insulin resistance and chronic inflammation, characterized by the elevation of proinflammatory cytokines in the blood, liver and white adipose tissue, as well as a proinflammatory profile of immune cells in visceral...

View article titled, Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice

Includes: Supplementary data

Articles

Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease

Daniel J. Cuthbertson, Fariba Shojaee-Moradie, Victoria S. Sprung, Helen Jones, Christopher J.A. Pugh, Paul Richardson, Graham J. Kemp, Mark Barrett, Nicola C. Jackson, E. Louise Thomas, Jimmy D. Bell, A. Margot Umpleby

Clin Sci (Lond) (2016) 130 (2): 93–104.

DOI: https://doi.org/10.1042/CS20150447

Published: 09 December 2015

... (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise is an effective treatment for lowering liver fat but its effect on IR in NAFLD is unknown. We aimed to determine whether supervised exercise in NAFLD would reduce liver fat and improve hepatic and peripheral (skeletal muscle...

View article titled, Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease

Articles

Immunometabolism of obesity and diabetes: microbiota link compartmentalized immunity in the gut to metabolic tissue inflammation

Joseph B. McPhee, Jonathan D. Schertzer

Clin Sci (Lond) (2015) 129 (12): 1083–1096.

DOI: https://doi.org/10.1042/CS20150431

Published: 13 October 2015

... inflammation, which also manifests within metabolic tissues such as adipose tissue and liver. This metabolic inflammation can promote insulin resistance and dysglycaemia. However, the obesity and metabolic disease-related immune responses that are compartmentalized in the intestinal environment do...

View article titled, Immunometabolism of obesity and diabetes: microbiota link compartmentalized immunity in the gut to metabolic tissue inflammation

Articles

Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity

Lina Zhao, Zhuo Fu, Jing Wu, Kevin W. Aylor, Eugene J. Barrett, Wenhong Cao, Zhenqi Liu

Clin Sci (Lond) (2015) 129 (12): 1025–1036.

DOI: https://doi.org/10.1042/CS20150143

Published: 18 September 2015

...Lina Zhao; Zhuo Fu; Jing Wu; Kevin W. Aylor; Eugene J. Barrett; Wenhong Cao; Zhenqi Liu Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. In the present study, we investigate the temporal relationship between vascular insulin resistance...

View article titled, Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity

Articles

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

Tong-Yan Liu, Chang-Xiang Shi, Run Gao, Hai-Jian Sun, Xiao-Qing Xiong, Lei Ding, Qi Chen, Yue-Hua Li, Jue-Jin Wang, Yu-Ming Kang, Guo-Qing Zhu

Clin Sci (Lond) (2015) 129 (10): 839–850.

DOI: https://doi.org/10.1042/CS20150009

Published: 19 August 2015

..., induces the browning of white adipose tissue, but its effects on gluconeogenesis and glycogenesis are unknown. In the present study, we investigated the effects and underlying mechanisms of irisin on gluconeogenesis and glycogenesis in hepatocytes with insulin resistance, and its therapeutic role in type...

View article titled, Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

Includes: Supplementary data

Articles

Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects

Camilla Kappe, Liselotte Fransson, Petra Wolbert, Henrik Ortsäter

Clin Sci (Lond) (2015) 129 (5): 405–414.

DOI: https://doi.org/10.1042/CS20140719

Published: 11 June 2015

...Camilla Kappe; Liselotte Fransson; Petra Wolbert; Henrik Ortsäter Evidence indicates that subtle abnormalities in GC (glucocorticoid) plasma concentrations and/or in tissue sensitivity to GCs are important in the metabolic syndrome, and it is generally agreed that GCs induce insulin resistance...

View article titled, Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects

Includes: Supplementary data

Articles

The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes

Mauricio Krause, Patricia Martins Bock, Hilton Kenji Takahashi, Paulo Ivo Homem De Bittencourt, Jr, Philip Newsholme

Clin Sci (Lond) (2015) 128 (11): 789–803.

DOI: https://doi.org/10.1042/CS20140695

Published: 19 March 2015

... (eHSP70) has a pro-inflammatory function, resulting in local and systemic inflammation. We have recently identified a divergence in the levels of eHSP70 and iHSP70 in subjects with diabetes compared with healthy subjects and also reported that eHSP70 was correlated with insulin resistance and pancreatic β...

View article titled, The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes

Articles

Metabolic alterations, HFE gene mutations and atherogenic lipoprotein modifications in patients with primary iron overload

Tomás Meroño, Fernando Brites, Carolane Dauteuille, Marie Lhomme, Martín Menafra, Alejandra Arteaga, Marcelo Castro, María Soledad Saez, Esteban González Ballerga, Patricia Sorroche, Jorge Rey, Philippe Lesnik, Juan Andrés Sordá, M. John Chapman, Anatol Kontush, Jorge Daruich

Clin Sci (Lond) (2015) 128 (9): 609–618.

DOI: https://doi.org/10.1042/CS20140300

Published: 11 February 2015

... efflux and antioxidative activity) were studied. IO patients compared with controls exhibited insulin resistance (HOMA-IR (homoeostasis model assessment-estimated insulin resistance): +93%, P < 0.001). Metabolic profiles differed across HFE genotypes. C282Y homozygotes ( n =7) presented a reduced β...

View article titled, Metabolic alterations, HFE gene mutations and atherogenic lipoprotein modifications in patients with primary iron overload

Includes: Supplementary data

Articles

Macrophage CGI-58 deficiency promotes IL-1β transcription by activating the SOCS3–FOXO1 pathway

Hongming Miao, Juanjuan Ou, Xuan Zhang, Yujuan Chen, Bingzhong Xue, Hang Shi, Lixia Gan, Liqing Yu, Houjie Liang

Clin Sci (Lond) (2015) 128 (8): 493–506.

DOI: https://doi.org/10.1042/CS20140414

Published: 23 January 2015

... with a FOXO1 inhibitor, an antioxidant that inhibits FOXO1 or IL-1 receptor antagonist alleviates chronic inflammation and insulin resistance in high-fat diet (HFD)-fed mice. Collectively, our data suggest that obesity-associated factors such as NEFA and lipopolysaccharide (LPS) probably adopt this vicious...

View article titled, Macrophage CGI-58 deficiency promotes IL-1β transcription by activating the SOCS3–FOXO1 pathway

Includes: Supplementary data

Articles

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects

Mariëtte R. Boon, Leontine E. H. Bakker, Mariëlle C. Haks, Edwin Quinten, Gert Schaart, Lianne Van Beek, Yanan Wang, Linda Van Schinkel, Vanessa Van Harmelen, A. Edo Meinders, Tom H. M. Ottenhoff, Ko Willems Van Dijk, Bruno Guigas, Ingrid M. Jazet, Patrick C. N. Rensen

Clin Sci (Lond) (2015) 128 (2): 143–151.

DOI: https://doi.org/10.1042/CS20140179

Published: 19 September 2014

... <0.001) levels together with homoeostasis model assessment of insulin resistance (HOMA-IR) (+48%, P <0.001), suggesting development of insulin resistance (IR). Furthermore, the HFHC-diet markedly increased HTG (+118%, P <0.001) and plasma CETP levels (+21%, P <0.001), a marker of liver...

View article titled, Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects

Includes: Supplementary data

Articles

Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice

Vanessa Legry, Derrick M. Van Rooyen, Barbara Lambert, Christine Sempoux, Laurence Poekes, Regina Español-Suñer, Olivier Molendi-Coste, Yves Horsmans, Geoffrey C. Farrell, Isabelle A. Leclercq

Clin Sci (Lond) (2014) 127 (7): 507–518.

DOI: https://doi.org/10.1042/CS20140026

Published: 25 June 2014

...)] are hepatic complications of the metabolic syndrome. Endoplasmic reticulum (ER) stress is proposed as a crucial disease mechanism in obese and insulin-resistant animals (such as ob/ob mice) with simple steatosis, but its role in NASH remains controversial. We therefore evaluated the role of ER stress...

View article titled, Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice

Includes: Supplementary data

Articles

GdCl 3 reduces hyperglycaemia through Akt/FoxO1-induced suppression of hepatic gluconeogenesis in Type 2 diabetic mice

Qian Wang, Ning Wang, Mei Dong, Fang Chen, Zhong Li, Yuanyuan Chen

Clin Sci (Lond) (2014) 127 (2): 91–100.

DOI: https://doi.org/10.1042/CS20130670

Published: 17 March 2014

... according to the trapezoidal rule [ 24 ]. HOMA-IR (homoeostasis model assessment of insulin resistance) was calculated as fasting glycaemia (mmol/l)×fasting insulinaemia (pmol/l)/22.5 [ 19 , 25 ]. Blood glucose levels were measured using a One Touch Ultra meter (Lifescan). The American Diabetes...

View article titled, GdCl 3 reduces hyperglycaemia through Akt/FoxO1-induced suppression of hepatic gluconeogenesis in Type 2 diabetic mice

Articles

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

Mauricio Krause, Kevin Keane, Josianne Rodrigues-Krause, Domenico Crognale, Brendan Egan, Giuseppe De Vito, Colin Murphy, Philip Newsholme

Clin Sci (Lond) (2014) 126 (10): 739–752.

DOI: https://doi.org/10.1042/CS20130678

Published: 03 February 2014

... aging is associated with a low-grade inflammation and IR (insulin resistance), we aimed to: (i) analyse the concentration of eHSP72 in elderly people and determine correlation with insulin resistance, and (ii) determine the effects of eHSP72 on β-cell function and viability in human and rodent...

View article titled, Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

Articles

Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice

Valérie Lebrun, Olivier Molendi-Coste, Nicolas Lanthier, Christine Sempoux, Patrice D. Cani, Nico van Rooijen, Peter Stärkel, Yves Horsmans, Isabelle A. Leclercq

Clin Sci (Lond) (2013) 125 (11): 501–511.

DOI: https://doi.org/10.1042/CS20130064

Published: 25 July 2013

... (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression. In NAFLD, steatosis, lipotoxicity and liver inflammation participate to hepatic insulin resistance. The aim of the present study was to verify...

View article titled, Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice

Includes: Supplementary data

Articles

Apocynin administration prevents the changes induced by a fructose-rich diet on rat liver metabolism and the antioxidant system

María Cecilia Castro, Flavio Francini, Guillermo Schinella, Claudia Inés Caldiz, María Guillermina Zubiría, Juan José Gagliardino, María Laura Massa

Clin Sci (Lond) (2012) 123 (12): 681–692.

DOI: https://doi.org/10.1042/CS20110665

Published: 10 August 2012

... 2012 28 6 2012 28 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apocynin fructose hepatic metabolic disorder insulin resistance NADPH oxidase pre-diabetes • The growing prevalence of T2DM and IGT is attaining epidemic proportions and some...

View article titled, Apocynin administration prevents the changes induced by a fructose-rich diet on rat liver metabolism and the antioxidant system

Articles

The long and winding TRAIL to weight loss

Regje M. E. Blümer, Gregory R. Steinberg

Clin Sci (Lond) (2012) 123 (9): 545–546.

DOI: https://doi.org/10.1042/CS20120356

Published: 13 July 2012

... TNF-related apoptosis-inducing ligand References 1 Hardy O. T. Czech M. P. Corvera S. What causes the insulin resistance underlying obesity? Curr. Opin. Endocrinol. Diabetes Obes. 2012 19 81 87 2 Bernardi S. Zauli G. Tikellis C. Candido R...

View article titled, The long and winding TRAIL to weight loss

Articles

TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation

Stella Bernardi, Giorgio Zauli, Christos Tikellis, Riccardo Candido, Bruno Fabris, Paola Secchiero, Mark E. Cooper, Merlin C. Thomas

Clin Sci (Lond) (2012) 123 (9): 547–555.

DOI: https://doi.org/10.1042/CS20120176

Published: 13 July 2012

... 23 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis high-fat diet inflammation insulin resistance obesity treatment tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) Type 2 diabetes mellitus TRAIL [TNF (tumour necrosis...

View article titled, TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation

Articles

Beneficial effects of rosuvastatin on insulin resistance, adiposity, inflammatory markers and non-alcoholic fatty liver disease in mice fed on a high-fat diet

Julio Cesar Fraulob, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda

Clin Sci (Lond) (2012) 123 (4): 259–270.

DOI: https://doi.org/10.1042/CS20110373

Published: 30 April 2012

...Julio Cesar Fraulob; Vanessa Souza-Mello; Marcia Barbosa Aguila; Carlos Alberto Mandarim-de-Lacerda The aim of the present study was to evaluate the effects of ST (rosuvastatin) and GZ (rosiglitazone) on IR (insulin resistance) and on liver as well as adipose tissue in mice fed on an HF (high-fat...

View article titled, Beneficial effects of rosuvastatin on insulin resistance, adiposity, inflammatory markers and non-alcoholic fatty liver disease in mice fed on a high-fat diet

Articles

Toll-like receptors and diabetes: a therapeutic perspective

Mohan R. Dasu, Sandra Ramirez, Roslyn R. Isseroff

Clin Sci (Lond) (2012) 122 (5): 203–214.

DOI: https://doi.org/10.1042/CS20110357

Published: 28 October 2011

...), and oxidative (p47 phox and ROS) and inflammatory effects (NF-κB) of high-fat and high-carbohydrate meals [ 66 – 68 ]. 12 7 2011 1 9 2011 8 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative...

View article titled, Toll-like receptors and diabetes: a therapeutic perspective

Articles

Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine

Satish C. Kalhan, John Edmison, Susan Marczewski, Srinivasan Dasarathy, Lourdes L. Gruca, Carole Bennett, Clarita Duenas, Rocio Lopez

Clin Sci (Lond) (2011) 121 (4): 179–189.

DOI: https://doi.org/10.1042/CS20110060

Published: 04 May 2011

... with estimates of whole body rate of protein turnover and urea synthesis in clinically stable biopsy-confirmed subjects with NASH (non-alcoholic steatohepatitis). Subjects with NASH were more insulin-resistant and had significantly higher plasma concentrations of usCRP (ultrasensitive C-reactive protein), TNFα...

View article titled, Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine

Articles

Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome

Yi Tan, Mohammad A. Kamal, Zheng-Zhong Wang, Wei Xiao, John P. Seale, Xianqin Qu

Clin Sci (Lond) (2011) 120 (7): 297–305.

DOI: https://doi.org/10.1042/CS20100441

Published: 13 December 2010

... 2010 15 10 2010 15 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 adiposity Chinese herbal extract insulin resistance metabolic syndrome thiazolidinedione visceral obesity The metabolic syndrome represents a cluster of cardiometabolic risk...

View article titled, Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome

Articles

Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats

Bárbara Maiztegui, María I. Borelli, Viviana G. Madrid, Héctor Del Zotto, María A. Raschia, Flavio Francini, María L. Massa, Luis E. Flores, Oscar R. Rebolledo, Juan J. Gagliardino

Clin Sci (Lond) (2011) 120 (2): 73–80.

DOI: https://doi.org/10.1042/CS20100372

Published: 08 October 2010

... (homoeostasis model assessment) for insulin resistance], HOMA-β (HOMA for β-cell function) and liver triacylglycerol content were measured. Pancreas immunomorphometric analyses were also performed. IGT (impaired glucose tolerance), plasma triacylglycerol, fructosamine and insulin levels, HOMA-IR and HOMA-β...

View article titled, Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats

Articles

Regulation of subcutaneous adipose tissue blood flow is related to measures of vascular and autonomic function

Jun-ichi Funada, A. Louise Dennis, Rachel Roberts, Fredrik Karpe, Keith N. Frayn

Clin Sci (Lond) (2010) 119 (8): 313–322.

DOI: https://doi.org/10.1042/CS20100066

Published: 06 July 2010

... healthy subjects [ 3 , 4 ]. However, regulation of ATBF is impaired in obese or otherwise insulin-resistant people [ 4 – 6 ]. This observation suggests a parallel with endothelial function, which is an important component of cardiovascular health and is known to be impaired in the early stages...

View article titled, Regulation of subcutaneous adipose tissue blood flow is related to measures of vascular and autonomic function

Articles

Pioglitazone in addition to metformin improves erythrocyte deformability in patients with Type 2 diabetes mellitus

Thomas Forst, Matthias M. Weber, Mirjam Löbig, Ute Lehmann, Jürgen Müller, Cloth Hohberg, Christiane Friedrich, Winfried Fuchs, Andreas Pfützner

Clin Sci (Lond) (2010) 119 (8): 345–351.

DOI: https://doi.org/10.1042/CS20100161

Published: 06 July 2010

... to pass through the capillaries in order to supply oxygen to the surrounding tissues, and decreased erythrocyte deformability contributes to an impaired oxygen and nutrition supply in diabetic microangiopathy [ 11 , 12 ]. Insulin resistance as observed in patients with T2DM is associated...

View article titled, Pioglitazone in addition to metformin improves erythrocyte deformability in patients with Type 2 diabetes mellitus

Articles

Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet

Vanessa Souza-Mello, Bianca M. Gregório, Fernando S. Cardoso-de-Lemos, Laís de Carvalho, Márcia B. Aguila, Carlos A. Mandarim-de-Lacerda

Clin Sci (Lond) (2010) 119 (6): 239–250.

DOI: https://doi.org/10.1042/CS20100061

Published: 08 June 2010

...). Conversely, all drug treatments resulted in significant weight loss, a reversal of insulin resistance, islet and adipocyte hypertrophy, and alleviated hepatic steatosis. Only the HF-T and HF-TS groups had body weights similar to the SC group at the end of the experiment, and the latter treatment reversed...

View article titled, Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet

Articles

Effects of insulin resistance on endothelial progenitor cells and vascular repair

Richard M. Cubbon, Matthew B. Kahn, Stephen B. Wheatcroft

Clin Sci (Lond) (2009) 117 (5): 173–190.

DOI: https://doi.org/10.1042/CS20080263

Published: 03 August 2009

...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...

View article titled, Effects of insulin resistance on endothelial progenitor cells and vascular repair

Articles

A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome

Lisa J. Moran, Samantha K. Hutchison, Caroline Meyer, Sophia Zoungas, Helena J. Teede

Clin Sci (Lond) (2009) 116 (10): 761–770.

DOI: https://doi.org/10.1042/CS20080218

Published: 15 April 2009

...Lisa J. Moran; Samantha K. Hutchison; Caroline Meyer; Sophia Zoungas; Helena J. Teede PCOS (polycystic ovary syndrome) is associated with reproductive abnormalities, IR (insulin resistance) and elevated risk factors for CVD (cardiovascular disease) and Type 2 diabetes, including endothelial...

View article titled, A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome

Articles

AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

Aaron K. F. Wong, Jacqueline Howie, John R. Petrie, Chim C. Lang

Clin Sci (Lond) (2009) 116 (8): 607–620.

DOI: https://doi.org/10.1042/CS20080066

Published: 16 March 2009

... deposition of glycogen. Nonetheless, these findings illustrate an important role for AMPK in cardiac hypertrophy and arrhythmias. 5-amino-4-imidazolecarboxamide riboside-1-β- D -ribofuranoside (AICAR) AMP-activated protein kinase (AMPK) cardiovascular disease insulin resistance metformin obesity...

View article titled, AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

Articles

Muscle acylcarnitines during short-term fasting in lean healthy men

Maarten R. Soeters, Hans P. Sauerwein, Marinus Duran, Ronald J. Wanders, Mariëtte T. Ackermans, Eric Fliers, Sander M. Houten, Mireille J. Serlie

Clin Sci (Lond) (2009) 116 (7): 585–592.

DOI: https://doi.org/10.1042/CS20080433

Published: 02 March 2009

... resistance. Acylcarnitines have been suggested to play a role in insulin resistance, as well as other long-chain fatty acid metabolites. Plasma levels of long-chain acylcarnitines increase during fasting, but this is unknown for muscle long-chain acylcarnitines. In the present study we investigated whether...

View article titled, Muscle acylcarnitines during short-term fasting in lean healthy men

Articles

The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans

Konstantinos Kantartzis, Fausto Machicao, Jürgen Machann, Fritz Schick, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan

Clin Sci (Lond) (2009) 116 (6): 531–537.

DOI: https://doi.org/10.1042/CS20080306

Published: 12 February 2009

...-fat diet develop fatty liver, but not insulin resistance, suggesting that DGAT2 induces a dissociation between fatty liver and insulin resistance. In the present study, we investigated whether such a phenotype also exists in humans. For this purpose, we determined the relationships between genetic...

View article titled, The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans

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