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Keywords: insulin
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Clin Sci (Lond) (2023) 137 (6): 415–434.
Published: 21 March 2023
...Zhipeng Tao; Zhiyong Cheng Hormonal signaling plays key roles in tissue and metabolic homeostasis. Accumulated evidence has revealed a great deal of insulin and estrogen signaling pathways and their interplays in the regulation of mitochondrial, cellular remodeling, and macronutrient metabolism...
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Clin Sci (Lond) (2019) 133 (22): 2317–2327.
Published: 26 November 2019
... to its ability to produce and secrete insulin, has been identified as a target for several adipokines. This review will focus on how adipokines affect pancreatic β cell function and their impact on pancreatic β cell survival in disease contexts such as diabetes. Initially, the “classic” adipokines...
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Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
... mediates islet lipid metabolism in lipotoxicity-treated cells and animal models. Rat β-cell line (INS-1E cells) and islets isolated from C57/BL6J mice were exposed to palmitic acid (PA) with/without FGF21, mimicking lipotoxic conditions. Resultant insulin secretion and intracellular signaling were analyzed...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (12): 1329–1342.
Published: 07 June 2017
... The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 fatty acids glucocorticoids glucose glutamine inflammasomes inflammation insulin lipids macrophages thyroid hormones Figure 2 Glucose, glutamine and palmitic acid metabolism and association...
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Clin Sci (Lond) (2017) 131 (2): 105–111.
Published: 14 December 2016
... metabolism. Mandibuloacral dysplasia type A (MADA) is a rare and complex disease identified by postnatal growth retardation, bone reabsorption at defined regions such as phalanges, mandible and clavicles, anomalous skin pigmentation, partial lipodystrophy and insulin resistance. Some MADA cases also show...
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Clin Sci (Lond) (2016) 130 (8): 601–612.
Published: 08 March 2016
... the phenotype of ATMs (adipose tissue macrophages) and its effect on glucose and insulin metabolism. PARFKO (PAFR-knockout) and WT (wild-type) mice were fed on an SD (standard diet) or an HFD (high-fat diet). Glucose and insulin tolerance tests were performed by blood monitoring. ATMs were evaluated by FACS...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (9): 613–630.
Published: 14 January 2014
... condition is linked to a cluster of metabolic disorders, such as obesity, systemic hypertension and dyslipidaemia, defined as the metabolic syndrome. Insulin resistance has been proposed as the key mediator of all of these features and contributes to the associated high cardiovascular morbidity...
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Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
...Lorna J. Hale; Richard J. M. Coward Ninety-one years ago insulin was discovered, which was one of the most important medical discoveries in the past century, transforming the lives of millions of diabetic patients. Initially insulin was considered only important for rapid control of blood glucose...
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Clin Sci (Lond) (2010) 119 (11): 465–466.
Published: 17 August 2010
... of CHF. These changes result in abnormal glucose and lipid metabolism, and the associated insulin resistance, which contribute to progression of skeletal muscle catabolism and development of muscle atrophy in patients with advanced HF. In the present issue of Clinical Science , Toth and co-workers...
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Clin Sci (Lond) (2010) 119 (1): 37–44.
Published: 07 April 2010
...Stefano Di Marco; Beatrice Boldrini; Umberto Conti; Gabriella Marcucci; Cecilia Morgantini; Ele Ferrannini; Andrea Natali Despite the evidence in experimental animal models that insulin, or GIK (glucose–insulin–potassium), improves left ventricular function and perfusion during both acute...
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Clin Sci (Lond) (2010) 118 (5): 315–332.
Published: 23 November 2009
...Ian F. Godsland Experimental, epidemiological and clinical evidence implicates insulin resistance and its accompanying hyperinsulinaemia in the development of cancer, but the relative importance of these disturbances in cancer remains unclear. There are, however, theoretical mechanisms by which...
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Clin Sci (Lond) (2010) 118 (1): 43–45.
Published: 02 October 2009
... Journal compilation © 2010 Biochemical Society 2010 blood pressure fat emulsion fatty acid hypertension insulin sympathetic nerve activity The metabolic syndrome represents a major public health burden due to its high prevalence in the general population and its association...
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Clin Sci (Lond) (2010) 118 (1): 61–69.
Published: 02 October 2009
... <0.05), and total MSNA (frequency×amplitude) was augmented 65% ( P <0.001), with no change during placebo infusion. Lipid infusion increased insulin, aldosterone and F 2 -isoprostane, but not leptin, concentrations. On the basis of the concomitant increase in BP, MSNA and SVR, we conclude...
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Clin Sci (Lond) (2009) 116 (8): 669–680.
Published: 16 March 2009
..., insulin, leptin and lipid levels, liver adipose tissue and muscle lipid and protein contents, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food intake was also evaluated. The cafeteria diet induced a significant increase in maternal body...
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Clin Sci (Lond) (2009) 116 (1): 1–16.
Published: 28 November 2008
... and prevention of obesity and diabetes, which partially result from the metabolic action of n −3 LC-PUFAs in adipose tissue. Recent studies highlight the importance of mitochondria in adipose tissue for the maintenance of systemic insulin sensitivity. For instance, both n −3 LC-PUFAs and the antidiabetic drugs...
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Clin Sci (Lond) (2008) 115 (12): 371–378.
Published: 12 November 2008
...Dan Berndtson; Joel Olsson; Robert G. Hahn High-dose intravenous infusion of 5% glucose promotes rebound hypoglycaemia and hypovolaemia in healthy volunteers. To study whether such effects occur in response to glucose/insulin, 12 healthy firemen (mean age, 39 years) received three infusions over 1...
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Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
...Xiao C. Li; Jia L. Zhuo Pancreatic bi-hormones insulin and glucagon are the Yin and Yang in the regulation of glucose metabolism and homoeostasis. Insulin is synthesized primarily by pancreatic β-cells and is released in response to an increase in blood glucose levels (hyperglycaemia). By contrast...
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Clin Sci (Lond) (2007) 112 (9): 493–498.
Published: 02 April 2007
... the curve in response to glucose administration was significantly ( P <0.0001) greater in the overweight group for both glucose and insulin. The FMD area under the curve was not significantly different at baseline or between time points after glucose ingestion, nor was there a difference in response...
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Clin Sci (Lond) (2007) 112 (8): 457–466.
Published: 13 March 2007
...Georgie C. Vollus; Eloise A. Bradley; Merren K. Roberts; John M. B. Newman; Stephen M. Richards; Stephen Rattigan; Eugene J. Barrett; Michael G. Clark Insulin increases capillary recruitment in vivo and impairment of this may contribute to muscle insulin resistance by limiting either insulin...
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Clin Sci (Lond) (2006) 110 (4): 475–482.
Published: 15 March 2006
...% carbohydrate and 27.8% protein). On the other day, they had a similar breakfast after which they fasted. Postprandial FMD values (both after breakfast and after lunch) were similar to baseline FMD. FMD showed a 28% hourly variation and 27% weekly variation. Variation in plasma levels of insulin ( P =0.02...
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Clin Sci (Lond) (2005) 109 (4): 405–411.
Published: 23 September 2005
...% carbohydrates, 20% fat and 35% protein), for breakfast on separate days. The test meals were administered 1 month apart. Blood samples were withdrawn immediately before and at 15, 30, 60, 120 and 180 min after the test meal for measurement of plasma acylated ghrelin, as well as serum glucose, insulin...
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Clin Sci (Lond) (2005) 108 (2): 113–119.
Published: 21 January 2005
... (eprosartan), the primary aim of this study was to clarify if EPRO inhibits sympathetic reactivity in humans as determined by the effect of EPRO on insulin-induced catecholamine release. Sixteen healthy male volunteers were randomized in a double-blind cross-over study to receive a single dose of EPRO (600 mg...
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Clin Sci (Lond) (2004) 107 (6): 519–532.
Published: 24 November 2004
..., is associated with obesity, insulin resistance and Type II diabetes. Insulin has been demonstrated to have direct effects on the endothelium to increase NO bioavailability. Therefore altered insulin signalling in the endothelium represents a candidate mechanism underlying the association between insulin...
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Clin Sci (Lond) (2004) 107 (2): 191–196.
Published: 27 July 2004
...Aris SIAFARIKAS; Katie WATTS; Petra BEYE; Timothy W. JONES; Elizabeth A. DAVIS; Daniel J. GREEN The aim of the present study was to investigate the impact of an oral glucose load on circulating insulin and glucose levels and arterial function in healthy non-diabetic subjects. Thirty-nine non-obese...
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Clin Sci (Lond) (2004) 107 (2): 213–220.
Published: 27 July 2004
...Ole FRØBERT; Jens P. BAGGER; Ulf SIMONSEN; Sten LUND; Claus H. GRAVHOLT In acute ischaemia, glucose–insulin–potassium administration reduces mortality and β-adrenoceptor antagonists have favourable effects on the outcome of ischaemic heart disease. The present study was designed to investigate...
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Clin Sci (Lond) (2004) 106 (5): 547–548.
Published: 01 May 2004
... by Fugmann et al. [1] when interpreting these mostly in terms of skeletal muscle haemodynamics (the calf, after all, comprises more than muscle). We note the observation by Fugmann et al. [1] that normoglycaemic hyperinsulinaemia most closely mimics the postprandial state and their conclusion that insulin...
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Clin Sci (Lond) (2004) 106 (1): 99–106.
Published: 01 January 2004
... biopsies were taken before and after 5 days of creatine loading (20 g·day -1 ) and after 6 weeks of continued supplementation (2 g·day -1 ). Fasting plasma insulin concentrations, muscle creatine, glycogen and GLUT-4 protein content as well as GLUT-4, glycogen synthase-1 (GS-1) and glycogenin-1 (Gln-1...
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Clin Sci (Lond) (2003) 105 (6): 715–721.
Published: 01 December 2003
... to hypertriglyceridaemia (3.9 mmol/l) for 2 h by an infusion of Intralipid® and heparin. Nine subjects received a hyperglycaemic clamp (12.5 mmol/l) with octreotide and low-dose insulin infusion to maintain normoinsulinaemia (10 m-units/l). Ten subjects received saline for 2 h as a control and, thereafter, 2 h...
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Clin Sci (Lond) (2003) 105 (4): 457–466.
Published: 01 October 2003
... with loss of insulin sensitivity, the present study compared the postprandial lipaemic and hormone responses for 9 h following a standard mixed meal in normolipidaemic healthy young and middle-aged men. Lipoprotein lipase (LPL) and hepatic lipase (HL) activities were determined in post-heparin plasma 9 h...
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Clin Sci (Lond) (2003) 105 (1): 81–87.
Published: 01 July 2003
... endothelium fatty acid insulin meal Clinical Science (2003) 105, 81 87 (Printed in Great Britain) 81 The effect of a mixed meal on endothelium- dependent vasodilation is dependent on fat content in healthy humans Peter STEER*, Dennis M. SARABI*, Brita KARLSTRO¨M , Samar BASU , Christian BERNE*, Bengt...
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Clin Sci (Lond) (2003) 104 (2): 195–201.
Published: 17 January 2003
... to increase in the cases (mean change±S.E.M. for aorto-femoral PWV, +0.5±0.4m/s for cases versus -0.3±0.3m/s for controls; P = 0.08). After testosterone suppression, fasting insulin levels increased from 6.89±4.84m-units/l to 11.34±8.16m-units/l (mean±S.D.), total cholesterol increased from 5.32±0.77mmol/l...
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Clin Sci (Lond) (2002) 103 (s2002): 418S–423S.
Published: 01 September 2002
... a significant effect on ET-1-induced glucose uptake. Forskolin, a potent stimulator which stimulates adenylate cyclase and increases the intracellular cAMP level, partially inhibited insulin-stimulated glucose uptake in 3T3-L1 cells, but had no significant impact on the effect of ET-1. Forskolin also did...
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Clin Sci (Lond) (2002) 102 (2): 223–231.
Published: 14 January 2002
...Jason M.R. GILL; Sara L. HERD; Natassa V. TSETSONIS; Adrianne E. HARDMAN Moderate exercise improves insulin sensitivity and reduces triacylglycerol (triglyceride; TG) concentrations. We hypothesized that changes in insulin sensitivity are an important determinant of exercise-induced changes...
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Clin Sci (Lond) (2001) 101 (6): 719–729.
Published: 21 November 2001
... function insulin pregnancy small arteries. Correspondence: Dr M. A. Lumsden (e-mail M.A.Lumsden@clinmed.gla.ac.uk ). The Biochemical Society and the Medical Research Society © 2001 2001 719Clinical Science (2001) 101, 719 729 (Printed in Great Britain) + R E V I E W Diabetes...
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Clin Sci (Lond) (2001) 101 (1): 59–64.
Published: 24 May 2001
... 12 3 2001 3 4 2001 The Biochemical Society and the Medical Research Society © 2001 2001 acetylcholine glucose insulin iontophoresis sodium nitroprusside 59Clinical Science (2001) 101, 59 64 (Printed in Great Britain) Diminished skin blood flow in Type I diabetes: evidence...
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Clin Sci (Lond) (2001) 100 (5): 517–527.
Published: 03 April 2001
... exercise increased postprandial serum 3-hydroxybutyrate and plasma fatty acid concentrations, decreased serum postprandial insulin concentrations and increased exogenous (8 h 13 C breath excretion of 15.1±0.9% of ingested dose compared with 11.9±0.8%; P = 0.00001) and endogenous postprandial fat oxidation...
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Clin Sci (Lond) (2000) 99 (6): 527–534.
Published: 15 November 2000
...Jens H. HENRIKSEN; Jens J. HOLST; Søren MØLLER; Ulrik B. ANDERSEN; Flemming BENDTSEN; Gorm JENSEN Leptin, a peptide hormone produced mainly in fat cells, appears to be important for the regulation of metabolism, insulin secretion/sensitivity and body weight. Recently, elevated plasma leptin levels...
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Clin Sci (Lond) (2000) 99 (5): 351–362.
Published: 03 October 2000
...Pietro GALASSETTI; Stephen N. DAVIS We examined and compared findings from studies aimed at detecting and quantifying an effect of insulin per se on counter-regulatory responses to hypoglycaemia. The experimental protocols used in many of these studies were very different with regard to study...