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Keywords: insulin
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Clin Sci (Lond) (2020) 134 (11): 1219–1242.
Published: 05 June 2020
... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cirrhosis diabetes angiogenesis portosystemic collaterals insulin The authors of the original article “Insulin reverses the major portal hypertension-related derangements in rats...
Clin Sci (Lond) (2019) 133 (22): 2317–2327.
Published: 26 November 2019
... to its ability to produce and secrete insulin, has been identified as a target for several adipokines. This review will focus on how adipokines affect pancreatic β cell function and their impact on pancreatic β cell survival in disease contexts such as diabetes. Initially, the “classic” adipokines...
Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
... mediates islet lipid metabolism in lipotoxicity-treated cells and animal models. Rat β-cell line (INS-1E cells) and islets isolated from C57/BL6J mice were exposed to palmitic acid (PA) with/without FGF21, mimicking lipotoxic conditions. Resultant insulin secretion and intracellular signaling were analyzed...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (22): 2391–2405.
Published: 19 November 2018
... abnormal vasoresponsiveness and angiogenesis that can be ameliorated by glucose control. However, the relevant presentation is not clear in those with cirrhosis and diabetes, in whom insulin is the treatment of choice. Liver cirrhosis was induced in Sprague–Dawley rats with common bile duct ligation (BDL...
Clin Sci (Lond) (2017) 131 (12): 1329–1342.
Published: 07 June 2017
... The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 fatty acids glucocorticoids glucose glutamine inflammasomes inflammation insulin lipids macrophages thyroid hormones Macrophages are uniquely equipped to detect and respond to tissue invasion...
Clin Sci (Lond) (2017) 131 (2): 105–111.
Published: 14 December 2016
... of the Biochemical Society 2016 cell cycle insulin laminopathies lamins metabolism mTOR nuclear organization • Lamins are nuclear intermediate filaments that are involved in over 17 different diseases, termed laminopathies. Metabolic laminopathies include Dunningan type familiar partial...
Clin Sci (Lond) (2016) 130 (8): 601–612.
Published: 08 March 2016
... the phenotype of ATMs (adipose tissue macrophages) and its effect on glucose and insulin metabolism. PARFKO (PAFR-knockout) and WT (wild-type) mice were fed on an SD (standard diet) or an HFD (high-fat diet). Glucose and insulin tolerance tests were performed by blood monitoring. ATMs were evaluated by FACS...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (12): 1115–1129.
Published: 22 October 2015
.../year in the U.S.A. alone, in addition to the morbidity and mortality that occur when the burns are extensive. We previously showed that insulin, when topically applied to skin excision wounds, accelerates re-epithelialization and stimulates angiogenesis. More recently, we developed an alginate sponge...
Clin Sci (Lond) (2014) 126 (9): 613–630.
Published: 14 January 2014
... condition is linked to a cluster of metabolic disorders, such as obesity, systemic hypertension and dyslipidaemia, defined as the metabolic syndrome. Insulin resistance has been proposed as the key mediator of all of these features and contributes to the associated high cardiovascular morbidity...
Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
...Lorna J. Hale; Richard J. M. Coward Ninety-one years ago insulin was discovered, which was one of the most important medical discoveries in the past century, transforming the lives of millions of diabetic patients. Initially insulin was considered only important for rapid control of blood glucose...
Clin Sci (Lond) (2012) 123 (11): 635–647.
Published: 01 August 2012
...Radko Komers; Shaunessy Rogers; Terry T. Oyama; Bei Xu; Chao-Ling Yang; James McCormick; David H. Ellison In the present study, we investigated the activity of the thiazide-sensitive NCC (Na + –Cl − co-transporter) in experimental metabolic syndrome and the role of insulin in NCC activation. Renal...
Clin Sci (Lond) (2010) 119 (11): 465–466.
Published: 17 August 2010
... of CHF. These changes result in abnormal glucose and lipid metabolism, and the associated insulin resistance, which contribute to progression of skeletal muscle catabolism and development of muscle atrophy in patients with advanced HF. In the present issue of Clinical Science , Toth and co-workers...
Clin Sci (Lond) (2010) 119 (11): 467–476.
Published: 17 August 2010
... (insulin and amino acids) and whether alterations in protein metabolism correlate to circulating cytokine levels. No differences in phenylalanine balance, rate of appearance or rate of disappearance were found between patients and controls under fasting conditions. However, the anabolic response...
Clin Sci (Lond) (2010) 119 (1): 37–44.
Published: 07 April 2010
...Stefano Di Marco; Beatrice Boldrini; Umberto Conti; Gabriella Marcucci; Cecilia Morgantini; Ele Ferrannini; Andrea Natali Despite the evidence in experimental animal models that insulin, or GIK (glucose–insulin–potassium), improves left ventricular function and perfusion during both acute...
Clin Sci (Lond) (2010) 118 (5): 315–332.
Published: 23 November 2009
...Ian F. Godsland Experimental, epidemiological and clinical evidence implicates insulin resistance and its accompanying hyperinsulinaemia in the development of cancer, but the relative importance of these disturbances in cancer remains unclear. There are, however, theoretical mechanisms by which...
Clin Sci (Lond) (2010) 118 (1): 43–45.
Published: 02 October 2009
... Journal compilation © 2010 Biochemical Society 2010 blood pressure fat emulsion fatty acid hypertension insulin sympathetic nerve activity The metabolic syndrome represents a major public health burden due to its high prevalence in the general population and its association...
Clin Sci (Lond) (2010) 118 (1): 61–69.
Published: 02 October 2009
... <0.05), and total MSNA (frequency×amplitude) was augmented 65% ( P <0.001), with no change during placebo infusion. Lipid infusion increased insulin, aldosterone and F 2 -isoprostane, but not leptin, concentrations. On the basis of the concomitant increase in BP, MSNA and SVR, we conclude...
Clin Sci (Lond) (2009) 116 (8): 669–680.
Published: 16 March 2009
..., insulin, leptin and lipid levels, liver adipose tissue and muscle lipid and protein contents, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food intake was also evaluated. The cafeteria diet induced a significant increase in maternal body...
Clin Sci (Lond) (2009) 116 (1): 1–16.
Published: 28 November 2008
... and prevention of obesity and diabetes, which partially result from the metabolic action of n −3 LC-PUFAs in adipose tissue. Recent studies highlight the importance of mitochondria in adipose tissue for the maintenance of systemic insulin sensitivity. For instance, both n −3 LC-PUFAs and the antidiabetic drugs...
Clin Sci (Lond) (2008) 115 (12): 361–369.
Published: 12 November 2008
... the effect of acute variations in plasma glucose and insulin on plasma ADMA levels in young people with T1D (Type 1 diabetes). Fifteen young patients (ten males) with T1D, median age 18.3 (13.2–24.4) years, HbA 1c (glycated haemoglobin) 9% (6.4–13.6%), underwent an overnight (18:00–08:00 hours) variable...
Clin Sci (Lond) (2008) 115 (12): 371–378.
Published: 12 November 2008
...Dan Berndtson; Joel Olsson; Robert G. Hahn High-dose intravenous infusion of 5% glucose promotes rebound hypoglycaemia and hypovolaemia in healthy volunteers. To study whether such effects occur in response to glucose/insulin, 12 healthy firemen (mean age, 39 years) received three infusions over 1...
Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
...Xiao C. Li; Jia L. Zhuo Pancreatic bi-hormones insulin and glucagon are the Yin and Yang in the regulation of glucose metabolism and homoeostasis. Insulin is synthesized primarily by pancreatic β-cells and is released in response to an increase in blood glucose levels (hyperglycaemia). By contrast...
Clin Sci (Lond) (2007) 112 (9): 493–498.
Published: 02 April 2007
... the curve in response to glucose administration was significantly ( P <0.0001) greater in the overweight group for both glucose and insulin. The FMD area under the curve was not significantly different at baseline or between time points after glucose ingestion, nor was there a difference in response...
Clin Sci (Lond) (2007) 112 (8): 457–466.
Published: 13 March 2007
...Georgie C. Vollus; Eloise A. Bradley; Merren K. Roberts; John M. B. Newman; Stephen M. Richards; Stephen Rattigan; Eugene J. Barrett; Michael G. Clark Insulin increases capillary recruitment in vivo and impairment of this may contribute to muscle insulin resistance by limiting either insulin...
Clin Sci (Lond) (2006) 110 (4): 475–482.
Published: 15 March 2006
...% carbohydrate and 27.8% protein). On the other day, they had a similar breakfast after which they fasted. Postprandial FMD values (both after breakfast and after lunch) were similar to baseline FMD. FMD showed a 28% hourly variation and 27% weekly variation. Variation in plasma levels of insulin ( P =0.02...
Clin Sci (Lond) (2005) 109 (4): 405–411.
Published: 23 September 2005
...% carbohydrates, 20% fat and 35% protein), for breakfast on separate days. The test meals were administered 1 month apart. Blood samples were withdrawn immediately before and at 15, 30, 60, 120 and 180 min after the test meal for measurement of plasma acylated ghrelin, as well as serum glucose, insulin...
Clin Sci (Lond) (2005) 108 (2): 113–119.
Published: 21 January 2005
... (eprosartan), the primary aim of this study was to clarify if EPRO inhibits sympathetic reactivity in humans as determined by the effect of EPRO on insulin-induced catecholamine release. Sixteen healthy male volunteers were randomized in a double-blind cross-over study to receive a single dose of EPRO (600 mg...
Clin Sci (Lond) (2004) 107 (6): 519–532.
Published: 24 November 2004
..., is associated with obesity, insulin resistance and Type II diabetes. Insulin has been demonstrated to have direct effects on the endothelium to increase NO bioavailability. Therefore altered insulin signalling in the endothelium represents a candidate mechanism underlying the association between insulin...
Clin Sci (Lond) (2004) 107 (2): 191–196.
Published: 27 July 2004
...Aris SIAFARIKAS; Katie WATTS; Petra BEYE; Timothy W. JONES; Elizabeth A. DAVIS; Daniel J. GREEN The aim of the present study was to investigate the impact of an oral glucose load on circulating insulin and glucose levels and arterial function in healthy non-diabetic subjects. Thirty-nine non-obese...
Clin Sci (Lond) (2004) 107 (2): 213–220.
Published: 27 July 2004
...Ole FRØBERT; Jens P. BAGGER; Ulf SIMONSEN; Sten LUND; Claus H. GRAVHOLT In acute ischaemia, glucose–insulin–potassium administration reduces mortality and β-adrenoceptor antagonists have favourable effects on the outcome of ischaemic heart disease. The present study was designed to investigate...
Clin Sci (Lond) (2004) 106 (5): 547–548.
Published: 01 May 2004
... by Fugmann et al. [1] when interpreting these mostly in terms of skeletal muscle haemodynamics (the calf, after all, comprises more than muscle). We note the observation by Fugmann et al. [1] that normoglycaemic hyperinsulinaemia most closely mimics the postprandial state and their conclusion that insulin...
Clin Sci (Lond) (2004) 106 (1): 99–106.
Published: 01 January 2004
... biopsies were taken before and after 5 days of creatine loading (20 g·day -1 ) and after 6 weeks of continued supplementation (2 g·day -1 ). Fasting plasma insulin concentrations, muscle creatine, glycogen and GLUT-4 protein content as well as GLUT-4, glycogen synthase-1 (GS-1) and glycogenin-1 (Gln-1...
Clin Sci (Lond) (2003) 105 (6): 715–721.
Published: 01 December 2003
... to hypertriglyceridaemia (3.9 mmol/l) for 2 h by an infusion of Intralipid® and heparin. Nine subjects received a hyperglycaemic clamp (12.5 mmol/l) with octreotide and low-dose insulin infusion to maintain normoinsulinaemia (10 m-units/l). Ten subjects received saline for 2 h as a control and, thereafter, 2 h...
Clin Sci (Lond) (2003) 105 (4): 457–466.
Published: 01 October 2003
... with loss of insulin sensitivity, the present study compared the postprandial lipaemic and hormone responses for 9 h following a standard mixed meal in normolipidaemic healthy young and middle-aged men. Lipoprotein lipase (LPL) and hepatic lipase (HL) activities were determined in post-heparin plasma 9 h...
Clin Sci (Lond) (2003) 105 (3): 315–322.
Published: 01 September 2003
... 5 2003 29 5 2003 © 2003 The Biochemical Society 2003 adrenaline autonomic nervous system counter-regulation hypoglycaemia insulin noradrenaline Clinical Science (2003) 105, 315 322 (Printed in Great Britain) 315 Effects of euglycaemic and hypoglycaemic hyperinsulinaemia...
Clin Sci (Lond) (2003) 105 (1): 81–87.
Published: 01 July 2003
... endothelium fatty acid insulin meal Clinical Science (2003) 105, 81 87 (Printed in Great Britain) 81 The effect of a mixed meal on endothelium- dependent vasodilation is dependent on fat content in healthy humans Peter STEER*, Dennis M. SARABI*, Brita KARLSTRO¨M , Samar BASU , Christian BERNE*, Bengt...
Clin Sci (Lond) (2003) 104 (2): 195–201.
Published: 17 January 2003
... to increase in the cases (mean change±S.E.M. for aorto-femoral PWV, +0.5±0.4m/s for cases versus -0.3±0.3m/s for controls; P = 0.08). After testosterone suppression, fasting insulin levels increased from 6.89±4.84m-units/l to 11.34±8.16m-units/l (mean±S.D.), total cholesterol increased from 5.32±0.77mmol/l...
Clin Sci (Lond) (2002) 103 (s2002): 418S–423S.
Published: 01 September 2002
... a significant effect on ET-1-induced glucose uptake. Forskolin, a potent stimulator which stimulates adenylate cyclase and increases the intracellular cAMP level, partially inhibited insulin-stimulated glucose uptake in 3T3-L1 cells, but had no significant impact on the effect of ET-1. Forskolin also did...
Clin Sci (Lond) (2002) 102 (5): 523–529.
Published: 22 April 2002
...Eleanor M. SCOTT; John P. GREENWOOD; Giovanni VACCA; John B. STOKER; Stephen G. GILBEY; David A.S.G. MARY It has been shown that sustained insulin infusion causes an increase in sympathetic vasoconstrictor discharge but, despite this, also causes peripheral vasodilatation. The present study...
Clin Sci (Lond) (2002) 102 (2): 223–231.
Published: 14 January 2002
...Jason M.R. GILL; Sara L. HERD; Natassa V. TSETSONIS; Adrianne E. HARDMAN Moderate exercise improves insulin sensitivity and reduces triacylglycerol (triglyceride; TG) concentrations. We hypothesized that changes in insulin sensitivity are an important determinant of exercise-induced changes...
Clin Sci (Lond) (2001) 101 (6): 719–729.
Published: 21 November 2001
.... A. Lumsden (e-mail M.A.Lumsden@clinmed.gla.ac.uk ). The Biochemical Society and the Medical Research Society © 2001 2001 diabetes endothelial function insulin pregnancy small arteries. 719Clinical Science (2001) 101, 719 729 (Printed in Great Britain) + R E V I E W Diabetes and the maternal...
Clin Sci (Lond) (2001) 101 (6): 551–558.
Published: 26 October 2001
...Daniel LARBAUD; Michèle BALAGE; Daniel TAILLANDIER; Lydie COMBARET; Jean GRIZARD; Didier ATTAIX In order to characterize the poorly defined mechanisms that account for the anti-proteolytic effects of insulin in skeletal muscle, we investigated in rats the effects of a 3h systemic euglycaemic...
Clin Sci (Lond) (2001) 101 (1): 37–43.
Published: 24 May 2001
...Zoltán SZABÓ; Hans ARNQVIST; Erik HÅKANSON; Lennart JORFELDT; Rolf SVEDJEHOLM The effects of glucose–insulin–potassium (GIK) on cardiac metabolism have been studied previously in non-diabetic patients after cardiac surgery. Although patients with diabetes mellitus can be expected to benefit most...
Clin Sci (Lond) (2001) 101 (1): 59–64.
Published: 24 May 2001
... 12 3 2001 3 4 2001 The Biochemical Society and the Medical Research Society © 2001 2001 acetylcholine glucose insulin iontophoresis sodium nitroprusside 59Clinical Science (2001) 101, 59 64 (Printed in Great Britain) Diminished skin blood flow in Type I diabetes: evidence...
Clin Sci (Lond) (2001) 100 (5): 517–527.
Published: 03 April 2001
... exercise increased postprandial serum 3-hydroxybutyrate and plasma fatty acid concentrations, decreased serum postprandial insulin concentrations and increased exogenous (8 h 13 C breath excretion of 15.1±0.9% of ingested dose compared with 11.9±0.8%; P = 0.00001) and endogenous postprandial fat oxidation...
Clin Sci (Lond) (2001) 100 (3): 283–290.
Published: 30 January 2001
...Andrew D. H. CLARK; Eugene J. BARRETT; Stephen RATTIGAN; Michelle G. WALLIS; Michael G. CLARK Insulin-mediated increases in limb blood flow are thought to enhance glucose uptake by skeletal muscle. Using the perfused rat hindlimb, we report that macro laser Doppler flowmetry (LDF) probes positioned...
Clin Sci (Lond) (2000) 99 (6): 527–534.
Published: 15 November 2000
...Jens H. HENRIKSEN; Jens J. HOLST; Søren MØLLER; Ulrik B. ANDERSEN; Flemming BENDTSEN; Gorm JENSEN Leptin, a peptide hormone produced mainly in fat cells, appears to be important for the regulation of metabolism, insulin secretion/sensitivity and body weight. Recently, elevated plasma leptin levels...
Clin Sci (Lond) (2000) 99 (5): 351–362.
Published: 03 October 2000
...Pietro GALASSETTI; Stephen N. DAVIS We examined and compared findings from studies aimed at detecting and quantifying an effect of insulin per se on counter-regulatory responses to hypoglycaemia. The experimental protocols used in many of these studies were very different with regard to study...
Clin Sci (Lond) (2000) 99 (3): 169–174.
Published: 01 August 2000
... ‘insulin resistance syndrome’. The present study aims to investigate how elevated levels of non-esterified fatty acids, hyperinsulinaemia and the combination of these factors affects endothelium-dependent vasodilatation (EDV). Ten volunteers were examined on two occasions. Intralipid ® (plus heparin...
Clin Sci (Lond) (2000) 98 (5): 627–632.
Published: 26 April 2000
...Jan FAGIUS; Christian BERNE Food intake is followed by an increase in baroreflex-governed sympathetic outflow to muscle vessels. It is established that insulin contributes to this stimulation; however, the increase occurs (to a lesser degree) even in the absence of enhanced insulin secretion...