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Keywords: innate immunity
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Articles
Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... by Portland Press Limited on behalf of the Biochemical Society 2020 angiotensin II angiotensin-(1-7) cardiovascular disease coronavirus chymase innate immunity Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly around the world, causing a pandemic that threatens...
Articles
Clin Sci (Lond) (2020) 134 (13): 1679–1696.
Published: 07 July 2020
... ( amxu@hku.hk ) * These authors contributed equally to this work. 12 01 2020 16 06 2020 25 06 2020 25 06 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 autoimmune diabetes inflammation innate immunity...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1549–1565.
Published: 17 July 2019
...Jan Černý; Ilja Stříž The innate immunity is frequently accepted as a first line of relatively primitive defense interfering with the pathogen invasion until the mechanisms of ‘privileged’ adaptive immunity with the production of antibodies and activation of cytotoxic lymphocytes ‘steal the show...
Articles
Clin Sci (Lond) (2018) 132 (13): 1433–1438.
Published: 18 July 2018
... that extracellular and intracellular protein aggregates represent damage-associated molecular patterns (DAMPs) and result in chronic activation of the innate immune system through pattern recognition receptors (PRRs) [ 22–25 ]. Amyloid and oligomeric assemblies of amyloidogenic proteins have been shown to bind...
Articles
Clin Sci (Lond) (2017) 131 (16): 2183–2199.
Published: 31 July 2017
... Society 2017 diabetic nephropathy inflammation innate immunity Diabetic nephropathy is the most prevalent chronic kidney disease and is the major cause of end-stage renal disease (ESRD) worldwide. This is predominantly due to the growing incidence of Type 2 diabetes associated with obesity...
Articles
Clin Sci (Lond) (2017) 131 (16): 2145–2159.
Published: 24 July 2017
... innate immunity non alcoholic fatty liver disease necroptosis Toll-like receptors Among patients with non-alcoholic fatty liver disease (NAFLD), adverse liver outcomes are confined to those (10–25%) with steatohepatitis (non-alcoholic steatohepatitis, NASH) [ 1 ]. The essential difference...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 2047–2058.
Published: 17 July 2017
...Piyali Chatterjee; Valorie L. Chiasson; Geetha Seerangan; Eugene De Guzman; Moheb Milad; Kelsey R. Bounds; Olga Gasheva; Richard P. Tobin; Mohamad Hatahet; Shelley Kopriva; Kathleen A. Jones; M. Karen Newell-Rogers; Brett M. Mitchell Excessive innate immune system activation and inflammation during...
Articles
Clin Sci (Lond) (2017) 131 (4): 269–283.
Published: 20 January 2017
... components. The innate immune response provides the first line of defence and is crucial to the outcome of infection. Airway epithelial cells are the first cell type to encounter the virus in the lungs, providing antiviral and chemotactic molecules that shape the ensuing immune response by rapidly recruiting...
Articles
Clin Sci (Lond) (2015) 129 (9): 785–796.
Published: 05 August 2015
... of innate immune cellular sources, intracellular IL-17A staining was performed. In the present study, we demonstrate that CS exposure primes natural killer (NK), natural killer T (NKT) and γδ T-cells to produce more IL-17A protein and CS alone increased the frequency of IL17 + γδ T-cells in the lung...
Articles
Clin Sci (Lond) (2015) 129 (7): 515–527.
Published: 03 July 2015
... individuals the integrity of the epithelial barrier appear to be partially compromised and immune responses to certain microbial antigen show signs of decline. aging infection innate immunity interleukin 6 intestinal permeability intestine • The effects of aging on physical...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (2): 187–198.
Published: 30 April 2015
... contribute to adverse ventricular remodelling. Such inflammation is initiated by molecular danger signals released by damaged myocardium, which induce innate immune responses by activating toll-like receptors (TLRs). Detrimental roles have been recently reported for TLR2, TLR3 and TLR4. The role of other...
Articles
Clin Sci (Lond) (2011) 121 (5): 205–214.
Published: 20 May 2011
...Vincent P.W. Scholtes; Dik Versteeg; Jean-Paul P.M. de Vries; Imo E. Hoefer; Arjan H. Schoneveld; Pieter R. Stella; Pieter A.F.M. Doevendans; Karlijn J.K. van Keulen; Dominique P.V. de Kleijn; Frans L. Moll; Gerard Pasterkamp The innate immune response elicited by activation of TLRs (Toll-like...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 120 (10): 441–450.
Published: 28 January 2011
...Alessandro Lambiase; Alessandra Micera; Marta Sacchetti; Flavio Mantelli; Stefano Bonini The ocular surface is the first line of defence in the eye against environmental microbes. The ocular innate immune system consists of a combination of anatomical, mechanical and immunological defence...
Articles
Clin Sci (Lond) (2009) 116 (6): 479–492.
Published: 12 February 2009
.... In spite of our greater understanding of this complication, the intimate mechanisms leading to the development and progression of renal injury are not well understood. New perspectives in activated innate immunity and inflammation appear to be relevant factors in the pathogenesis of diabetes. Moreover...
Articles
Clin Sci (Lond) (2008) 114 (7): 457–466.
Published: 29 February 2008
...Mark G. Swain The innate immune system represents a critical first line of host response to infectious, injurious and inflammatory insults. NKT cells (natural killer T-cells) are an important, but relatively poorly understood, component of the innate immune response. Moreover, NKT cells...
Articles
Clin Sci (Lond) (2008) 114 (5): 347–360.
Published: 01 February 2008
...E. Ann Misch; Thomas R. Hawn Although several lines of evidence suggest that variation in human inflammation is genetically controlled, the genes which regulate these responses are largely unknown. TLRs (Toll-like receptors) mediate recognition of microbes, regulate activation of the innate immune...
Articles
Clin Sci (Lond) (2006) 110 (1): 21–35.
Published: 12 December 2005
... functioning of the innate immune system, and may have further importance in the integration of this system with the adaptive immune response. Recent interest has focused on the influence of inflamed tissues on the recruitment and phenotypic modulation of cells of the adaptive immune system and, indeed...