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Keywords: inflammation
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Articles
Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
... with wild-type (WT) mice, Park7 -deficient mice experienced aggravated kidney tissue damage and dysfunction, and enhanced tubular apoptosis and inflammation following LPS treatment. Consistently, LPS-induced apoptosis and inflammation in renal tubular cells in vitro were exacerbated by Park7 knockdown...
Articles
Clin Sci (Lond) (2022) 136 (24): 1809–1829.
Published: 16 December 2022
... mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution. In addition, we consider how lifestyle...
Articles
Clin Sci (Lond) (2022) 136 (23): 1759–1772.
Published: 02 December 2022
... 11 2022 08 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 hypertension immunity inflammation kidney lymphatics Hypertension (HTN), defined by the American Heart Association as having a blood pressure of 130/80...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (20): 1433–1437.
Published: 18 October 2022
... of adhesion molecules in the injured kidney. This, the authors speculate, may prevent inflammation from driving the functional decline of the kidney. Identifying these novel pathways represents an important step forward harnessing the potential benefits of alkali therapy in CKD. Correspondence: Paul M...
Articles
Clin Sci (Lond) (2022) 136 (17): 1257–1280.
Published: 05 September 2022
... overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets. Correspondence...
Articles
Clin Sci (Lond) (2022) 136 (12): 1005–1017.
Published: 29 June 2022
... on behalf of the Biochemical Society 2022 aldosterone fibrosis inflammation Chronic kidney disease (CKD) is a growing health problem, with an estimated global prevalence of 11% and affecting approximately 850 million patients [ 1 ]. Type 2 diabetes (T2D) is the main cause of CKD...
Articles
Clin Sci (Lond) (2022) 136 (12): 935–952.
Published: 22 June 2022
...Tom Macleod; Charles Bridgewood; Isabel Hyde; Megan Heague; Philip Helliwell; Martin Stacey; Miriam Wittmann This review highlights the molecular and cellular mechanisms underlying psoriatic inflammation with an emphasis on recent developments which may impact on treatment approaches...
Articles
Clin Sci (Lond) (2022) 136 (10): 733–746.
Published: 24 May 2022
... to the pathogenesis of many chronic diseases, including asthma and chronic obstructive pulmonary disease (COPD). In asthma, increased autophagy plays a role in promoting type 2 immune responses and eosinophilic inflammation, whereas decreased autophagy may be important in neutrophilic asthma. Acute exposure...
Articles
Clin Sci (Lond) (2022) 136 (8): 557–577.
Published: 21 April 2022
... ( pedrohenrique.imenezsilva@uzh.ch ) 09 02 2022 24 03 2022 07 04 2022 07 04 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 acid-base balance alkali therapy chronic kidney disease crystal nephropathy inflammation metabolism...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (3): 239–256.
Published: 07 February 2022
..., leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury...
Articles
Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... the impact of NLRP3 inhibition on renal inflammation and associated pathology in DKD. We identified an adverse effect of MCC950 on renal pathology in diabetic animals. Indeed, MCC950-treated diabetic animals showed increased renal inflammation and macrophage infiltration in association with enhanced...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
...Bo Wang; Chenguang Ding; Xiaoming Ding; Greg Tesch; Jin Zheng; PuYun Tian; Yang Li; Sharon Ricardo; Hsin-Hui Shen; Wujun Xue Inflammation is a pathological feature of kidney injury and its progression correlates with the development of kidney fibrosis which can lead to kidney function impairment...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (1): 61–80.
Published: 05 January 2022
...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...
Articles
Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
...Koji Akita; Kikuo Isoda; Fumie Ohtomo; Sarasa Isobe; Tomiharu Niida; Yayoi Sato-Okabayashi; Motoaki Sano; Kazunori Shimada; Yoichiro Iwakura; Tohru Minamino Clinical hypertension (HT) is associated with renal inflammation and elevated circulating levels of proinflammatory cytokines. Interleukin (IL...
Articles
Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
... inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular...
Articles
Clin Sci (Lond) (2021) 135 (11): 1389–1408.
Published: 04 June 2021
...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...
Articles
Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Ageing Biomimetics chronic kidney disease Inflammation life style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per...
Articles
Clin Sci (Lond) (2021) 135 (7): 925–941.
Published: 14 April 2021
..., it is generally accepted that inflammation is commonly involved in the pathogenesis. Ongoing inflammatory responses exacerbate liver injury, or even result in fibrosis and cirrhosis. Here we report that roscovitine, a cyclin-dependent kinase (CDK) inhibitor, exerts beneficial effects on acute and chronic liver...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (6): 731–752.
Published: 17 March 2021
... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge...
Articles
Clin Sci (Lond) (2021) 135 (5): 687–701.
Published: 09 March 2021
.... Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, is a K49-phospholipase A 2 (PLA 2 ) that induces a massive muscle tissue injury, and, consequently, local inflammatory reaction. The NLRP3 inflammasome is a sensor that triggers inflammation by activating caspase 1 and releasing interleukin (IL)-1β...
Articles
Clin Sci (Lond) (2021) 135 (1): 229.
Published: 11 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
Articles
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... indicates a link between disturbances in phosphate homeostasis and inflammation. The present review focuses on critical interactions of phosphate homeostasis, inflammation, vascular calcification and CVD. Especially, pro-inflammatory responses mediating hyperphosphatemia-related development of vascular...
Articles
Clin Sci (Lond) (2020) 134 (24): 3237–3257.
Published: 21 December 2020
... of hypertension on gonads in more detail on a molecular basis remain scarce. Hence, the aim of the current review is to address and summarize the effects of hypertension on reproductive health, and highlight the importance of research on the effects of hypertension on gonadal inflammation and lymphatics. 04...
Articles
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
...). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiotensin converting enzyme 2 AT2 receptor COVID-19 inflammation The discovery in 2003...
Articles
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Published: 25 September 2020
... increase in adipogenesis and transient adipocyte remodeling and inflammation with overnutrition may maintain a metabolically healthy phenotype, as in female animals in the present study [ 6 , 8 ]. There has been enhanced interest in elucidating the physiological mechanisms that foster effective energy...
Articles
Clin Sci (Lond) (2020) 134 (15): 2053.
Published: 10 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
Articles
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Clin Sci (Lond) (2020) 134 (15): 1991–2017.
Published: 04 August 2020
... the characteristic of being chronic degenerative diseases of inflammatory nature associated with defective heat shock response (HSR). The molecular components of the HSR, the principal metabolic pathway leading to the physiological resolution of inflammation, is an anti-inflammatory biochemical pathway that involves...
Articles
Clin Sci (Lond) (2020) 134 (14): 1935–1956.
Published: 23 July 2020
... in alcoholic liver disease (ALD) and aberrant macrophage DNA methylation is associated with inflammation. Our preliminary screening results of macrophage methylation in the present study demonstrated the zinc finger SWI2/SNF2 and MuDR (SWIM)-domain containing 3 (ZSWIM3) were hypermethylated in the 5...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (14): 1957–1971.
Published: 23 July 2020
... to assess the underlying mechanisms. We found that α 2A -AR deficiency decreased the permeability of the alveolar capillary barrier in ARDS mice and suppressed lung inflammation by reducing inflammatory cell infiltration and the production of TNF-α, interleukin (IL)-6, and CXCL2/MIP-2. LPS stimulation...
Articles
Clin Sci (Lond) (2020) 134 (13): 1751–1762.
Published: 10 July 2020
.... Neutralization of HMGB1 attenuated IR-induced increases in plasma creatinine, blood urea nitrogen (BUN), inflammation, tubular damage and tubular cell death only in male SHR. In conclusion, our data demonstrate that there is a sex difference in the contribution of HMGB1 to IR-induced injury, where males exhibit...
Articles
Clin Sci (Lond) (2020) 134 (13): 1679–1696.
Published: 07 July 2020
.... NE pharmacological inhibitor (sivelestat) or biological inhibitor (elafin) was supplemented into NOD mice to evaluate their effects on islet inflammation and diabetogenesis. The impact of NE inhibition on innate and adaptive immune cells was measured with flow cytometry and immunohistochemistry...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... to elevated oxidative stress and inflammation in the retina plays a key role in DR [ 5–7 ]. angiogenesis c-reactive protein diabetic retinopathy inflammation oxidative stress retinal degeneration © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Published: 18 June 2020
...Simeng Liu; Zhimin Huang; Anna Tang; Xiaoqing Wu; Jeffrey Aube; Liang Xu; Changying Xing; Yufeng Huang Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation...
Articles
Clin Sci (Lond) (2020) 134 (12): 1357–1376.
Published: 18 June 2020
... of the Biochemical Society 2020 inflammation KD025 metabolism ROCK2 tubulointerstitial fibrosis Epidemiological studies have demonstrated that the prevalence of chronic kidney disease (CKD) is approximately 8–16% worldwide [ 1 , 2 ]. Renal fibrosis, especially tubulointerstitial fibrosis...
Articles
Clin Sci (Lond) (2020) 134 (12): 1319–1331.
Published: 16 June 2020
... License 4.0 (CC BY-NC-ND) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF Cardiac pathophysiological remodeling is one of the major characteristics in the development of heart failure. There has been a sustained effort to develop novel strategies to protect against...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (11): 1191–1218.
Published: 03 June 2020
... eosinophils inflammation Interleukin 33 myocardial infarction ST2 ventricular remodeling Cardiovascular diseases, primarily acute myocardial infarction (MI) and stroke, represent the leading cause of mortality in the Western world and are on the rise in developing countries. Despite improved...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (6): 571–592.
Published: 18 March 2020
... peripheral insulin resistance, thought to be driven by low-grade maternal inflammation. Nobiletin, a polymethoxylated flavonoid, possesses potent glucose-sensitizing and anti-inflammatory properties; however, its effects in GDM have not been assessed. The present study aimed to determine the effects...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (5): 439–458.
Published: 04 March 2020
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis inflammation lipid uptake sphingolipid inhibitors Atherosclerosis is the fundamental pathological process underlying cardio-cerebral vascular diseases (CVDs), which are the leading cause of morbidity...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 273–287.
Published: 29 January 2020
... by increasing liver X receptor (LXR)-β levels. Furthermore, the degree of CpG island methylation in the SULT2B1b promoter was reduced in cells from AMI patients. In conclusion, SULT2B1b up-regulation due to hypomethylation of its promoter promotes cholesterol accumulation and inflammation by inhibiting LXR-β...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 139–154.
Published: 23 January 2020
... function was adjusted, with P value<0.05. Acute kidney injury circ-0114427 circular RNA inflammation next-generation sequencing Acute kidney injury (AKI) is a complicated disease characterized by a rapid decrease in glomerular filtration rate (GFR) and an increase in serum...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (1): 15–32.
Published: 03 January 2020
... Fibroblast growth factor 23 (FGF23) increases phosphorus excretion and decreases calcitriol (1,25(OH) 2 D) levels. FGF23 increases from early stages of renal failure. We evaluated whether strict control of phosphorus intake in renal failure prevents the increase in FGF23 and to what extent inflammation...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (1): 3–13.
Published: 03 January 2020
... to promote inflammation and angiogenesis, and PVAT phenotypic changes occurring in the setting of obesity, hyperlipidemia etc., are fundamentally important in determining a pathogenic versus protective role of PVAT in vascular disease. Recent discoveries have advanced our understanding of the role...
Articles
Clin Sci (Lond) (2019) 133 (23): 2379–2400.
Published: 04 December 2019
...Ratana Lim; Caitlyn Nguyen-Ngo; Martha Lappas Preterm birth is a global healthcare challenge. Spontaneous preterm birth (sPTB) is commonly caused by inflammation, yet there are currently no effective therapies available. The Bromodomain and Extra-Terminal motif (BET) proteins, Bromodomain...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (22): 2345–2360.
Published: 28 November 2019
...-3 FA levels, mainly docosahexaenoic acid (DHA), in comparison with WT mice. FAT-1 mice had increased myeloperoxidase (MPO) activity and content of CXCL-1 and CXCL-2, and reduced IL-10 in the skin wound tissue three days after the wound induction. Inflammation was maintained by an elevated TNF-α...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (22): 2283–2299.
Published: 21 November 2019
...Apabrita Ayan Das; Devasmita Chakravarty; Debmalya Bhunia; Surajit Ghosh; Prakash C. Mandal; Khawer N. Siddiqui; Arun Bandyopadhyay The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (22): 2245–2264.
Published: 19 November 2019
... and concerted action of factors that contribute to the development of liver inflammation and eventually fibrosis. Here, we summarize fundamental molecular mechanisms underlying the pathogenesis of non-alcoholic steatohepatitis (NASH), how they are interrelated and possible translation to clinical applications...
Articles
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
.... Genetic disorders and insulin receptor disorders, environmental factors, lifestyle choices and toxins are key factors that contribute to DM. While it is often referred to as a metabolic disorder, modern lifestyle choices and nutrient excess induce a state of systemic chronic inflammation that results...
Articles
Clin Sci (Lond) (2019) 133 (20): 2061–2067.
Published: 18 October 2019
... of the Biochemical Society 2019 arterial stiffness inflammation nitric oxide renal sympathetic nerves resistant hypertension Resistant hypertension is defined as hypertension that is not controlled with three or more antihypertensive medications [ 1 , 2 ]. While the data on the prevalence...