1-50 of 328
Keywords: inflammation
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles

USP38 regulates inflammatory cardiac remodeling after myocardial infarction

Yang Gong, Bin Kong, Wei Shuai, Tao Chen, Jing Jing Zhang, He Huang
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1665–1681.
https://doi.org/10.1042/CS20230728
Published: 15 November 2023
... of the Biochemical Society 2023 cardiac arrhythmia inflammation myocardial remodeling Sudden cardiac death (SCD) is a major life-threatening health problem worldwide, and approximately 80% of SCDs are caused by malignant ventricular arrhythmias (VAs) secondary to acute myocardial infarction (MI) [ 1...
View article titled, USP38 regulates inflammatory cardiac remodeling after myocardial infarction
Open the PDF for USP38 regulates inflammatory cardiac remodeling after myocardial infarction in another window
Includes: Supplementary data
Articles

Colchicine protects against the development of experimental abdominal aortic aneurysm

Yi Zhao, Qi-Rui Shen, Yu-Xin Chen, Yu Shi, Wen-Bing Wu, Qiao Li, Dong-Jie Li, Fu-Ming Shen, Hui Fu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (19): 1533–1545.
https://doi.org/10.1042/CS20230499
Published: 03 October 2023
... the phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state during AAA. In addition, it was demonstrated that colchicine was able to reduce vascular inflammation, oxidative stress, cell pyroptosis and immune cells infiltration to the aortic wall in the AAA mice model. Finally...
View article titled, Colchicine protects against the development of experimental abdominal aortic aneurysm
Open the PDF for Colchicine protects against the development of experimental abdominal aortic aneurysm in another window
Includes: Supplementary data
Articles

Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury

Jun Pei, Xiaomao Tian, Chengjun Yu, Jin Luo, Yifan Hong, Jie Zhang, Sheng Wen, Yi Hua, Guanghui Wei
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (18): 1477–1498.
https://doi.org/10.1042/CS20230818
Published: 22 September 2023
... experiments, we found that Gpx3 might serve as a key gene for the regulation of selenomethionine in renal IRIs. Selenomethionine may exert a protective effect against renal IRI by up-regulating GPX3, inhibiting the MAPK signaling pathway, increased production of antioxidants, decreasing inflammation levels...
View article titled, Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury
Open the PDF for Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury in another window
Articles

B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated with chronic kidney disease

Nuria Dolade, Sandra Rayego-Mateos, Alicia Garcia-Carrasco, Maryse Guerin, Jose-Luis Martín-Ventura, Marta Ruiz-Ortega, Pierre-Louis Tharaux, Jose Manuel Valdivielso
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1409–1429.
https://doi.org/10.1042/CS20230399
Published: 13 September 2023
... 2023 31 07 2023 01 09 2023 01 09 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 atherosclerosis Chronic Kidney disease inflammation Chronic kidney disease (CKD) is a high impact-disease worldwide...
View article titled, B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated with chronic kidney disease
Open the PDF for B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated with chronic kidney disease in another window
Includes: Supplementary data
Articles

The immunology of heart failure with preserved ejection fraction

Charles Duncan Smart, Meena S. Madhur
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1225–1247.
https://doi.org/10.1042/CS20230226
Published: 22 August 2023
... therapies. Inflammation has emerged as a potential contributor to the pathogenesis of HFpEF. Many of the risk factors for HFpEF are also associated with chronic inflammation, such as obesity, hypertension, aging, and renal dysfunction. A large amount of preclinical evidence suggests that immune cells...
View article titled, The immunology of heart failure with preserved ejection fraction
Open the PDF for The immunology of heart failure with preserved ejection fraction in another window
Articles

Renal ischemia alters the transcriptomic and epigenetic profile of inflammatory genes in swine scattered tubular-like cells

Sara Kazeminia, Xiang Y. Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Sandra M. Herrmann, Alejandro R. Chade, Maria V. Irazabal, Lilach O. Lerman, Alfonso Eirin
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1265–1283.
https://doi.org/10.1042/CS20230555
Published: 22 August 2023
...://pantherdb.org/ ) [ 33 ], and by their biological process using GSEA. 24 05 2023 31 07 2023 11 08 2023 11 08 2023 Epigenetics Inflammation MeDIP-seq Methylation Scattered tubular-like cells Renal artery stenosis (RAS), often caused by atherosclerosis, is the narrowing...
View article titled, Renal ischemia alters the transcriptomic and epigenetic profile of inflammatory genes in swine scattered tubular-like cells
Open the PDF for Renal ischemia alters the transcriptomic and epigenetic profile of inflammatory genes in swine scattered tubular-like cells in another window
Includes: Supplementary data
Articles

Ovarian cancer G protein-coupled receptor 1 deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice

Nima Yassini, Janine Sprenger, Eva Maria Pastor Arroyo, Christiane Krudewig, Giovanni Pellegrini, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (14): 1013–1025.
https://doi.org/10.1042/CS20230421
Published: 25 July 2023
... protein-coupled receptors that are stimulated upon increased extracellular acidity. These receptors have various physiological and pathophysiological roles in renal acid–base physiology, tissue inflammation, and fibrosis among others. Their function in injured renal tissue, however, remains mostly unclear...
View article titled, Ovarian cancer G protein-coupled receptor 1 deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice
Open the PDF for Ovarian cancer G protein-coupled receptor 1 deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice in another window
Includes: Supplementary data
Articles

ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE −/− mice

Huahui Yu, Xiaolu Jiao, Yunyun Yang, Qianwen Lv, Zhiyong Du, Linyi Li, Chaowei Hu, Yunhui Du, Jing Zhang, Fan Li, Qiuju Sun, Yu Wang, Dong Chen, Xiaoping Zhang, Yanwen Qin
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (12): 979–993.
https://doi.org/10.1042/CS20230031
Published: 28 June 2023
...Huahui Yu; Xiaolu Jiao; Yunyun Yang; Qianwen Lv; Zhiyong Du; Linyi Li; Chaowei Hu; Yunhui Du; Jing Zhang; Fan Li; Qiuju Sun; Yu Wang; Dong Chen; Xiaoping Zhang; Yanwen Qin Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose metabolism, inflammation, and cell...
View article titled, ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE −/− mice
Open the PDF for ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE −/− mice in another window
Includes: Supplementary data
Articles

Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Siddhi Jain, Pritam Saha, Nayadi Parambil Syamprasad, Samir Rajan Panda, Bishal Rajdev, Arun Kumar Jannu, Pawan Sharma, Vegi Ganga Modi Naidu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 785–805.
https://doi.org/10.1042/CS20220625
Published: 23 May 2023
... inflammation. Chlorogenic acid (CGA) has been shown to possess potent antioxidant, anti-inflammatory, and immunoprotective properties. However, the protective effect of CGA on viral and bacterial-induced ALI/ARDS is not yet explored. Hence, the current study is aimed to evaluate the preclinical efficacy of CGA...
View article titled, Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis
Open the PDF for Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis in another window
Includes: Supplementary data
Articles

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B Graham
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 617–631.
https://doi.org/10.1042/CS20220642
Published: 21 April 2023
... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Open access for this article was enabled through a transformative open access agreement between Portland Press and the University of California. Fibrosis Inflammation Pulmonary hypertension Schistosomiasis Vascular remodeling Here, we...
View article titled, Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension
Open the PDF for Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension in another window
Includes: Supplementary data
Articles

By what molecular mechanisms do social determinants impact cardiometabolic risk?

Yvonne Baumer, Mario A. Pita, Andrew S. Baez, Lola R. Ortiz-Whittingham, Manuel A. Cintron, Rebecca R. Rose, Veronica C. Gray, Foster Osei Baah, Tiffany M. Powell-Wiley
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 469–494.
https://doi.org/10.1042/CS20220304
Published: 24 March 2023
... of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic–pituitary–adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked...
View article titled, By what molecular mechanisms do social determinants impact cardiometabolic risk?
Open the PDF for By what molecular mechanisms do social determinants impact cardiometabolic risk? in another window
Includes: Supplementary data
Articles

PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB

Honglin Li, Zhiwen Liu, Ying Wang, Hui Wang, Juan Cai, Chengyuan Tang, Zheng Dong
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1877–1891.
https://doi.org/10.1042/CS20220493
Published: 22 December 2022
... with wild-type (WT) mice, Park7 -deficient mice experienced aggravated kidney tissue damage and dysfunction, and enhanced tubular apoptosis and inflammation following LPS treatment. Consistently, LPS-induced apoptosis and inflammation in renal tubular cells in vitro were exacerbated by Park7 knockdown...
View article titled, PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB
Open the PDF for PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB in another window
Articles

Dysregulated haemostasis in thrombo-inflammatory disease

Paula A. Klavina, Gemma Leon, Annie M. Curtis, Roger J.S. Preston
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1809–1829.
https://doi.org/10.1042/CS20220208
Published: 16 December 2022
... mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution. In addition, we consider how lifestyle...
View article titled, Dysregulated haemostasis in thrombo-inflammatory disease
Open the PDF for Dysregulated haemostasis in thrombo-inflammatory disease in another window
Articles

Genetically inducing renal lymphangiogenesis attenuates hypertension in mice

Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (23): 1759–1772.
https://doi.org/10.1042/CS20220547
Published: 02 December 2022
...) as the endogenous control. Forward and reverse primer sequences were generated using NCBI Gene DataBase and PrimerBank. These sequences are listed in Online Table IV. hypertension immunity inflammation kidney lymphatics Hypertension (HTN), defined by the American Heart Association as having a blood...
View article titled, Genetically inducing renal lymphangiogenesis attenuates hypertension in mice
Open the PDF for Genetically inducing renal lymphangiogenesis attenuates hypertension in mice in another window
Includes: Supplementary data
Articles

New mechanisms for the kidney-protective effect of alkali in chronic kidney disease

Paul M. O’Connor, Elinor C. Mannon
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (20): 1433–1437.
https://doi.org/10.1042/CS20220395
Published: 18 October 2022
... of adhesion molecules in the injured kidney. This, the authors speculate, may prevent inflammation from driving the functional decline of the kidney. Identifying these novel pathways represents an important step forward harnessing the potential benefits of alkali therapy in CKD. References 1. Hill...
View article titled, New mechanisms for the kidney-protective effect of alkali in chronic kidney disease
Open the PDF for New mechanisms for the kidney-protective effect of alkali in chronic kidney disease in another window
Articles

Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

Antonio L. Teixeira, Lais B. Martins, Michael Berk, Moisés E. Bauer
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1257–1280.
https://doi.org/10.1042/CS20211106
Published: 05 September 2022
... overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets. Correspondence...
View article titled, Severe psychiatric disorders and general medical comorbidities: <span class="search-highlight">inflammation</span>-related mechanisms and therapeutic opportunities
Open the PDF for Severe psychiatric disorders and general medical comorbidities: <span class="search-highlight">inflammation</span>-related mechanisms and therapeutic opportunities in another window
Articles

The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease

Jonatan Barrera-Chimal, Casimiro Gerarduzzi, Patrick Rossignol, Frédéric Jaisser
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 1005–1017.
https://doi.org/10.1042/CS20220212
Published: 29 June 2022
... of the main drivers for testing the efficacy of finerenone in non-diabetic CKD patients in the ongoing FIND-CKD trial. aldosterone fibrosis inflammation Chronic kidney disease (CKD) is a growing health problem, with an estimated global prevalence of 11% and affecting approximately 850 million...
View article titled, The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease
Open the PDF for The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease in another window
Articles

Molecular and cellular regulation of psoriatic inflammation

Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 935–952.
https://doi.org/10.1042/CS20210916
Published: 22 June 2022
...Tom Macleod; Charles Bridgewood; Isabel Hyde; Megan Heague; Philip Helliwell; Martin Stacey; Miriam Wittmann This review highlights the molecular and cellular mechanisms underlying psoriatic inflammation with an emphasis on recent developments which may impact on treatment approaches...
View article titled, Molecular and cellular regulation of psoriatic <span class="search-highlight">inflammation</span>
Open the PDF for Molecular and cellular regulation of psoriatic <span class="search-highlight">inflammation</span> in another window
Articles

Autophagy in asthma and chronic obstructive pulmonary disease

Peter J. Barnes, Jonathan Baker, Louise E. Donnelly
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (10): 733–746.
https://doi.org/10.1042/CS20210900
Published: 24 May 2022
... to the pathogenesis of many chronic diseases, including asthma and chronic obstructive pulmonary disease (COPD). In asthma, increased autophagy plays a role in promoting type 2 immune responses and eosinophilic inflammation, whereas decreased autophagy may be important in neutrophilic asthma. Acute exposure...
View article titled, Autophagy in asthma and chronic obstructive pulmonary disease
Open the PDF for Autophagy in asthma and chronic obstructive pulmonary disease in another window
Articles

Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (8): 557–577.
https://doi.org/10.1042/CS20220095
Published: 21 April 2022
... ( pedrohenrique.imenezsilva@uzh.ch ) 09 02 2022 24 03 2022 07 04 2022 07 04 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 acid-base balance alkali therapy chronic kidney disease crystal nephropathy inflammation metabolism...
View article titled, Alkali therapy protects renal function, suppresses <span class="search-highlight">inflammation</span>, and improves cellular metabolism in kidney disease
Open the PDF for Alkali therapy protects renal function, suppresses <span class="search-highlight">inflammation</span>, and improves cellular metabolism in kidney disease in another window
Includes: Supplementary data
Articles

Emergent players in renovascular disease

Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (3): 239–256.
https://doi.org/10.1042/CS20210509
Published: 07 February 2022
..., leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury...
View article titled, Emergent players in renovascular disease
Open the PDF for Emergent players in renovascular disease in another window
Articles

Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (2): 167–180.
https://doi.org/10.1042/CS20210865
Published: 20 January 2022
... the impact of NLRP3 inhibition on renal inflammation and associated pathology in DKD. We identified an adverse effect of MCC950 on renal pathology in diabetic animals. Indeed, MCC950-treated diabetic animals showed increased renal inflammation and macrophage infiltration in association with enhanced...
View article titled, Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease
Open the PDF for Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease in another window
Includes: Supplementary data
Articles

WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway

Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 29–44.
https://doi.org/10.1042/CS20210663
Published: 05 January 2022
...Bo Wang; Chenguang Ding; Xiaoming Ding; Greg Tesch; Jin Zheng; PuYun Tian; Yang Li; Sharon Ricardo; Hsin-Hui Shen; Wujun Xue Inflammation is a pathological feature of kidney injury and its progression correlates with the development of kidney fibrosis which can lead to kidney function impairment...
View article titled, WNT1-inducible signaling pathway protein 1 regulates kidney <span class="search-highlight">inflammation</span> through the NF-κB pathway
Open the PDF for WNT1-inducible signaling pathway protein 1 regulates kidney <span class="search-highlight">inflammation</span> through the NF-κB pathway in another window
Includes: Supplementary data
Articles

Mechanisms of immune aging in HIV

Manon Chauvin, Delphine Sauce
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 61–80.
https://doi.org/10.1042/CS20210344
Published: 05 January 2022
...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...
View article titled, Mechanisms of immune aging in HIV
Open the PDF for Mechanisms of immune aging in HIV in another window
Articles

Blocking of interleukin-1 suppresses angiotensin II-induced renal injury

Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2035–2048.
https://doi.org/10.1042/CS20201406
Published: 31 August 2021
...Koji Akita; Kikuo Isoda; Fumie Ohtomo; Sarasa Isobe; Tomiharu Niida; Yayoi Sato-Okabayashi; Motoaki Sano; Kazunori Shimada; Yoichiro Iwakura; Tohru Minamino Clinical hypertension (HT) is associated with renal inflammation and elevated circulating levels of proinflammatory cytokines. Interleukin (IL...
View article titled, Blocking of interleukin-1 suppresses angiotensin II-induced renal injury
Open the PDF for Blocking of interleukin-1 suppresses angiotensin II-induced renal injury in another window
Articles

Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Osvaldo Rivera-Gonzalez, Natalie A. Wilson, Laura E. Coats, Erin B. Taylor, Joshua S. Speed
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1773–1789.
https://doi.org/10.1042/CS20210549
Published: 30 July 2021
..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...
View article titled, Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue <span class="search-highlight">inflammation</span> in obese mice
Open the PDF for Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue <span class="search-highlight">inflammation</span> in obese mice in another window
Includes: Supplementary data
Articles

Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
https://doi.org/10.1042/CS20190768
Published: 07 July 2021
... inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular...
View article titled, Nutrient regulation of inflammatory signalling in obesity and vascular disease
Open the PDF for Nutrient regulation of inflammatory signalling in obesity and vascular disease in another window
Articles

Cholesterol metabolism: a new molecular switch to control inflammation

Diana Cardoso, Esperanza Perucha
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1389–1408.
https://doi.org/10.1042/CS20201394
Published: 04 June 2021
...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...
View article titled, Cholesterol metabolism: a new molecular switch to control <span class="search-highlight">inflammation</span>
Open the PDF for Cholesterol metabolism: a new molecular switch to control <span class="search-highlight">inflammation</span> in another window
Articles

A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases

Lu Dai, Leon Schurgers, Paul G. Shiels, Peter Stenvinkel
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1251–1272.
https://doi.org/10.1042/CS20201452
Published: 26 May 2021
... Biomimetics chronic kidney disease Inflammation life style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050...
View article titled, A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases
Open the PDF for A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases in another window
Articles

Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury

Yanjun Liu, Jiacheng Li, Liping Liao, Heming Huang, Shijie Fan, Rong Fu, Jing Huang, Cuicui Shi, Liang Yu, Kai-xian Chen, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 925–941.
https://doi.org/10.1042/CS20201111
Published: 14 April 2021
..., it is generally accepted that inflammation is commonly involved in the pathogenesis. Ongoing inflammatory responses exacerbate liver injury, or even result in fibrosis and cirrhosis. Here we report that roscovitine, a cyclin-dependent kinase (CDK) inhibitor, exerts beneficial effects on acute and chronic liver...
View article titled, Cyclin-dependent kinase inhibitor roscovitine attenuates liver <span class="search-highlight">inflammation</span> and fibrosis by influencing initiating steps of liver injury
Open the PDF for Cyclin-dependent kinase inhibitor roscovitine attenuates liver <span class="search-highlight">inflammation</span> and fibrosis by influencing initiating steps of liver injury in another window
Includes: Supplementary data
Articles

The complex role of adipokines in obesity, inflammation, and autoimmunity

Erin B. Taylor
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 731–752.
https://doi.org/10.1042/CS20200895
Published: 17 March 2021
... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge...
View article titled, The complex role of adipokines in obesity, <span class="search-highlight">inflammation</span>, and autoimmunity
Open the PDF for The complex role of adipokines in obesity, <span class="search-highlight">inflammation</span>, and autoimmunity in another window
Articles

Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor

Priscila Andrade Ranéia e Silva, Dhêmerson Souza de Lima, João Paulo Mesquita Luiz, Niels Olsen Saraiva Câmara, José Carlos Farias Alves-Filho, Alessandra Pontillo, Karina Ramalho Bortoluci, Eliana L. Faquim-Mauro
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (5): 687–701.
https://doi.org/10.1042/CS20201419
Published: 09 March 2021
.... Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, is a K49-phospholipase A 2 (PLA 2 ) that induces a massive muscle tissue injury, and, consequently, local inflammatory reaction. The NLRP3 inflammasome is a sensor that triggers inflammation by activating caspase 1 and releasing interleukin (IL)-1β...
View article titled, Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor
Open the PDF for Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor in another window
Articles

Retraction: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 229.
https://doi.org/10.1042/CS-20200249_RET
Published: 11 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
View article titled, Retraction: TRIF&#x2F;miR-34a mediates aldosterone-induced cardiac <span class="search-highlight">inflammation</span> and remodeling
Open the PDF for Retraction: TRIF/miR-34a mediates aldosterone-induced cardiac <span class="search-highlight">inflammation</span> and remodeling in another window
Articles

Inflammation: a putative link between phosphate metabolism and cardiovascular disease

Jakob Voelkl, Daniela Egli-Spichtig, Ioana Alesutan, Carsten A. Wagner
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 201–227.
https://doi.org/10.1042/CS20190895
Published: 08 January 2021
... indicates a link between disturbances in phosphate homeostasis and inflammation. The present review focuses on critical interactions of phosphate homeostasis, inflammation, vascular calcification and CVD. Especially, pro-inflammatory responses mediating hyperphosphatemia-related development of vascular...
View article titled, <span class="search-highlight">Inflammation</span>: a putative link between phosphate metabolism and cardiovascular disease
Open the PDF for <span class="search-highlight">Inflammation</span>: a putative link between phosphate metabolism and cardiovascular disease in another window
Articles

Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads

Shobana Navaneethabalakrishnan, Bethany L. Goodlett, Alexandra H. Lopez, Joseph M. Rutkowski, Brett M. Mitchell
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (24): 3237–3257.
https://doi.org/10.1042/CS20201023
Published: 21 December 2020
... of hypertension on gonads in more detail on a molecular basis remain scarce. Hence, the aim of the current review is to address and summarize the effects of hypertension on reproductive health, and highlight the importance of research on the effects of hypertension on gonadal inflammation and lymphatics...
View article titled, Hypertension and reproductive dysfunction: a possible role of <span class="search-highlight">inflammation</span> and <span class="search-highlight">inflammation</span>-associated lymphangiogenesis in gonads
Open the PDF for Hypertension and reproductive dysfunction: a possible role of <span class="search-highlight">inflammation</span> and <span class="search-highlight">inflammation</span>-associated lymphangiogenesis in gonads in another window
Articles

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
https://doi.org/10.1042/CS20201207
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
View article titled, Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal <span class="search-highlight">inflammation</span> and fibrosis
Open the PDF for Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal <span class="search-highlight">inflammation</span> and fibrosis in another window
Includes: Supplementary data
Articles

Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT 2 -receptor agonists

In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus
U. Muscha Steckelings, Colin Sumners
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (22): 2987–3006.
https://doi.org/10.1042/CS20200922
Published: 19 November 2020
... for the loss of natural Ang-(1-7) protective mechanisms in COVID-19 disease. These AT 2 R actions are discussed in more detail in later sections of this review. angiotensin converting enzyme 2 AT2 receptor COVID-19 inflammation The discovery in 2003 of angiotensin converting enzyme (ACE) 2...
View article titled, Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT 2 -receptor agonists
Open the PDF for Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT 2 -receptor agonists in another window
Articles

The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

Anissa Viveiros, Gavin Y. Oudit
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
https://doi.org/10.1042/CS20201028
Published: 25 September 2020
... volume. Correspondence: Gavin Y. Oudit ( gavin.oudit@ualberta.ca ) 02 09 2020 15 09 2020 17 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adipose tissue inflammation Maternal programming obesity...
View article titled, The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue
Open the PDF for The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue in another window
Articles

Expression of Concern: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2053.
https://doi.org/10.1042/CS-20200249_EOC
Published: 10 August 2020
... The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. aldosterone cardiac remodeling inflammation microRNA-34a TRIF ©...
View article titled, Expression of Concern: TRIF&#x2F;miR-34a mediates aldosterone-induced cardiac <span class="search-highlight">inflammation</span> and remodeling
Open the PDF for Expression of Concern: TRIF/miR-34a mediates aldosterone-induced cardiac <span class="search-highlight">inflammation</span> and remodeling in another window
Articles

Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies

In Collection
Coronavirus
Thiago Gomes Heck, Mirna Stela Ludwig, Matias Nunes Frizzo, Alberto Antonio Rasia-Filho, Paulo Ivo Homem de Bittencourt, Jr
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (15): 1991–2017.
https://doi.org/10.1042/CS20200596
Published: 04 August 2020
... the characteristic of being chronic degenerative diseases of inflammatory nature associated with defective heat shock response (HSR). The molecular components of the HSR, the principal metabolic pathway leading to the physiological resolution of inflammation, is an anti-inflammatory biochemical pathway that involves...
View article titled, Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies
Open the PDF for Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies in another window
Articles

DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway

Hai-Di Li, Xin Chen, Jie-Jie Xu, Xiao-Sa Du, Yang Yang, Juan-Juan Li, Xiao-Juan Yang, Hui-Min Huang, Xiao-Feng Li, Ming-Fei Wu, Chong Zhang, Chao Zhang, Zeng Li, Hua Wang, Xiao-Ming Meng, Cheng Huang, Jun Li
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1935–1956.
https://doi.org/10.1042/CS20200031
Published: 23 July 2020
... in alcoholic liver disease (ALD) and aberrant macrophage DNA methylation is associated with inflammation. Our preliminary screening results of macrophage methylation in the present study demonstrated the zinc finger SWI2/SNF2 and MuDR (SWIM)-domain containing 3 (ZSWIM3) were hypermethylated in the 5...
View article titled, DNMT3b-mediated methylation of ZSWIM3 enhances <span class="search-highlight">inflammation</span> in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway
Open the PDF for DNMT3b-mediated methylation of ZSWIM3 enhances <span class="search-highlight">inflammation</span> in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway in another window
Includes: Supplementary data
Articles

α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome

Zhukai Cong, Dan Li, Xiangpeng Lv, Cui Yang, Qiang Zhang, Changyi Wu, Zongyu Wang, Xi Zhu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1957–1971.
https://doi.org/10.1042/CS20200586
Published: 23 July 2020
... to assess the underlying mechanisms. We found that α 2A -AR deficiency decreased the permeability of the alveolar capillary barrier in ARDS mice and suppressed lung inflammation by reducing inflammatory cell infiltration and the production of TNF-α, interleukin (IL)-6, and CXCL2/MIP-2. LPS stimulation...
View article titled, α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome
Open the PDF for α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome in another window
Articles

Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury

Riyaz Mohamed, Olga Rafikova, Paul M. O’Connor, Jennifer C. Sullivan
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1751–1762.
https://doi.org/10.1042/CS20200575
Published: 10 July 2020
.... Neutralization of HMGB1 attenuated IR-induced increases in plasma creatinine, blood urea nitrogen (BUN), inflammation, tubular damage and tubular cell death only in male SHR. In conclusion, our data demonstrate that there is a sex difference in the contribution of HMGB1 to IR-induced injury, where males exhibit...
View article titled, Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury
Open the PDF for Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury in another window
Articles

Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice

Lingling Shu, Ling Zhong, Yang Xiao, Xiaoping Wu, Yang Liu, Xue Jiang, Tao Tang, RubyLaiChong Hoo, Zhiguang Zhou, Aimin Xu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1679–1696.
https://doi.org/10.1042/CS20200021
Published: 07 July 2020
.... NE pharmacological inhibitor (sivelestat) or biological inhibitor (elafin) was supplemented into NOD mice to evaluate their effects on islet inflammation and diabetogenesis. The impact of NE inhibition on innate and adaptive immune cells was measured with flow cytometry and immunohistochemistry...
View article titled, Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice
Open the PDF for Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice in another window
Includes: Supplementary data
Articles

Pathogenic role of human C-reactive protein in diabetic retinopathy

Fangfang Qiu, Xiang Ma, Young-Hwa Shin, Jianglei Chen, Qian Chen, Kelu Zhou, Wenjing Wu, Wentao Liang, Yalin Wu, Qing Song, Jian-Xing Ma
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1613–1629.
https://doi.org/10.1042/CS20200085
Published: 30 June 2020
... The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . angiogenesis c-reactive protein diabetic retinopathy inflammation oxidative stress...
View article titled, Pathogenic role of human C-reactive protein in diabetic retinopathy
Open the PDF for Pathogenic role of human C-reactive protein in diabetic retinopathy in another window
Includes: Supplementary data
Articles

Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis

Simeng Liu, Zhimin Huang, Anna Tang, Xiaoqing Wu, Jeffrey Aube, Liang Xu, Changying Xing, Yufeng Huang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1433–1448.
https://doi.org/10.1042/CS20200193
Published: 18 June 2020
...Simeng Liu; Zhimin Huang; Anna Tang; Xiaoqing Wu; Jeffrey Aube; Liang Xu; Changying Xing; Yufeng Huang Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation...
View article titled, Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis
Open the PDF for Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis in another window
Articles

Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells

Ran You, Wei Zhou, Yanwei Li, Yue Zhang, Songming Huang, Zhanjun Jia, Aihua Zhang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1357–1376.
https://doi.org/10.1042/CS20200030
Published: 18 June 2020
... Society 2020 inflammation KD025 metabolism ROCK2 tubulointerstitial fibrosis Epidemiological studies have demonstrated that the prevalence of chronic kidney disease (CKD) is approximately 8–16% worldwide [ 1 , 2 ]. Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable...
View article titled, Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells
Open the PDF for Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells in another window
Articles

TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Shaojun Li, Wei Cao, Bai Wang, Enbo Zhan, Jian Xu, Shufeng Li
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1319–1331.
https://doi.org/10.1042/CS20200249
Published: 16 June 2020
... License 4.0 (CC BY-NC-ND) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF Cardiac pathophysiological remodeling is one of the major characteristics in the development of heart failure. There has been a sustained effort to develop novel strategies to protect against...
View article titled, TRIF&#x2F;miR-34a mediates aldosterone-induced cardiac <span class="search-highlight">inflammation</span> and remodeling
Open the PDF for TRIF/miR-34a mediates aldosterone-induced cardiac <span class="search-highlight">inflammation</span> and remodeling in another window
Includes: Supplementary data
Articles

IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture

Rana Ghali, Nada J. Habeichi, Abdullah Kaplan, Cynthia Tannous, Emna Abidi, Amira Bekdash, Rima Farhat, Hana Itani, Abdo Jurjus, George W. Booz, Ziad Mallat, Fouad A. Zouein
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1191–1218.
https://doi.org/10.1042/CS20200402
Published: 03 June 2020
... 2020 eosinophils inflammation Interleukin 33 myocardial infarction ST2 ventricular remodeling Cardiovascular diseases, primarily acute myocardial infarction (MI) and stroke, represent the leading cause of mortality in the Western world and are on the rise in developing countries...
View article titled, IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture
Open the PDF for IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture in another window
Includes: Supplementary data
Articles

Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes

In Collection
Clinical and translational research highlights
Caitlyn Nguyen-Ngo, Carlos Salomon, Stephanie Quak, Andrew Lai, Jane C Willcox, Martha Lappas
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (6): 571–592.
https://doi.org/10.1042/CS20191099
Published: 18 March 2020
... peripheral insulin resistance, thought to be driven by low-grade maternal inflammation. Nobiletin, a polymethoxylated flavonoid, possesses potent glucose-sensitizing and anti-inflammatory properties; however, its effects in GDM have not been assessed. The present study aimed to determine the effects...
View article titled, Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes
Open the PDF for Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes in another window
Includes: Supplementary data