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Keywords: inflammation
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Clin Sci (Lond) (2023) 137 (8): 617–631.
Published: 21 April 2023
... access agreement between Portland Press and the University of California. Fibrosis Inflammation Pulmonary hypertension Schistosomiasis Vascular remodeling Pulmonary hypertension (PH) is characterized by vascular remodeling, right ventricular (RV) hypertrophy, and perivascular fibrosis...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (6): 469–494.
Published: 24 March 2023
... of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic–pituitary–adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
... with wild-type (WT) mice, Park7 -deficient mice experienced aggravated kidney tissue damage and dysfunction, and enhanced tubular apoptosis and inflammation following LPS treatment. Consistently, LPS-induced apoptosis and inflammation in renal tubular cells in vitro were exacerbated by Park7 knockdown...
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Clin Sci (Lond) (2022) 136 (24): 1809–1829.
Published: 16 December 2022
... mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution. In addition, we consider how lifestyle...
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Clin Sci (Lond) (2022) 136 (23): 1759–1772.
Published: 02 December 2022
... 11 2022 08 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 hypertension immunity inflammation kidney lymphatics Hypertension (HTN), defined by the American Heart Association as having a blood pressure of 130/80...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (20): 1433–1437.
Published: 18 October 2022
... of adhesion molecules in the injured kidney. This, the authors speculate, may prevent inflammation from driving the functional decline of the kidney. Identifying these novel pathways represents an important step forward harnessing the potential benefits of alkali therapy in CKD. Interestingly, Pastor Arroyo...
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Clin Sci (Lond) (2022) 136 (12): 935–952.
Published: 22 June 2022
...Tom Macleod; Charles Bridgewood; Isabel Hyde; Megan Heague; Philip Helliwell; Martin Stacey; Miriam Wittmann This review highlights the molecular and cellular mechanisms underlying psoriatic inflammation with an emphasis on recent developments which may impact on treatment approaches...
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Clin Sci (Lond) (2022) 136 (10): 733–746.
Published: 24 May 2022
... to the pathogenesis of many chronic diseases, including asthma and chronic obstructive pulmonary disease (COPD). In asthma, increased autophagy plays a role in promoting type 2 immune responses and eosinophilic inflammation, whereas decreased autophagy may be important in neutrophilic asthma. Acute exposure...
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Clin Sci (Lond) (2022) 136 (3): 239–256.
Published: 07 February 2022
..., leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury...
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Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... the impact of NLRP3 inhibition on renal inflammation and associated pathology in DKD. We identified an adverse effect of MCC950 on renal pathology in diabetic animals. Indeed, MCC950-treated diabetic animals showed increased renal inflammation and macrophage infiltration in association with enhanced...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (1): 61–80.
Published: 05 January 2022
...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...
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Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
...Bo Wang; Chenguang Ding; Xiaoming Ding; Greg Tesch; Jin Zheng; PuYun Tian; Yang Li; Sharon Ricardo; Hsin-Hui Shen; Wujun Xue Inflammation is a pathological feature of kidney injury and its progression correlates with the development of kidney fibrosis which can lead to kidney function impairment...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
...Koji Akita; Kikuo Isoda; Fumie Ohtomo; Sarasa Isobe; Tomiharu Niida; Yayoi Sato-Okabayashi; Motoaki Sano; Kazunori Shimada; Yoichiro Iwakura; Tohru Minamino Clinical hypertension (HT) is associated with renal inflammation and elevated circulating levels of proinflammatory cytokines. Interleukin (IL...
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Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
... inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular...
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Clin Sci (Lond) (2021) 135 (11): 1389–1408.
Published: 04 June 2021
...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...
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Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... 04 05 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Ageing Biomimetics chronic kidney disease Inflammation life...
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Clin Sci (Lond) (2021) 135 (6): 731–752.
Published: 17 March 2021
... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge...
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Clin Sci (Lond) (2021) 135 (1): 229.
Published: 11 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
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Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... indicates a link between disturbances in phosphate homeostasis and inflammation. The present review focuses on critical interactions of phosphate homeostasis, inflammation, vascular calcification and CVD. Especially, pro-inflammatory responses mediating hyperphosphatemia-related development of vascular...
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Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
... to the AT 2 R and those connected to Mas/MrgD, reinforce each other by various ways of cross-talk. The main examples of this type of cross-talk are discussed in the following paragraphs: angiotensin converting enzyme 2 AT2 receptor COVID-19 inflammation There are multiple publications...
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Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Published: 25 September 2020
... volume. Correspondence: Gavin Y. Oudit ( gavin.oudit@ualberta.ca ) 02 09 2020 15 09 2020 17 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adipose tissue inflammation Maternal programming obesity...
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Clin Sci (Lond) (2020) 134 (15): 2053.
Published: 10 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
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Clin Sci (Lond) (2020) 134 (13): 1751–1762.
Published: 10 July 2020
.... Neutralization of HMGB1 attenuated IR-induced increases in plasma creatinine, blood urea nitrogen (BUN), inflammation, tubular damage and tubular cell death only in male SHR. In conclusion, our data demonstrate that there is a sex difference in the contribution of HMGB1 to IR-induced injury, where males exhibit...
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Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... inflammation oxidative stress retinal degeneration Diabetic retinopathy (DR) is the leading cause of vision loss in working-age people in developed countries [ 1 ]. Non-proliferative DR (NPDR) presents with progressive intra-retinal leukocyte adherence, retinal neuron degeneration, capillary...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Published: 18 June 2020
...Simeng Liu; Zhimin Huang; Anna Tang; Xiaoqing Wu; Jeffrey Aube; Liang Xu; Changying Xing; Yufeng Huang Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation...
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Clin Sci (Lond) (2020) 134 (12): 1357–1376.
Published: 18 June 2020
... fundamental cellular events. In response to the pro-fibrotic stimuli, the unresolved and persistent inflammation serves as the trigger of fibrosis. Then the fibrogenic genes were up-regulated in the injured tubular epithelial cells [ 3 ]. Recently, the pathogenic role of metabolic reprogramming in energy...
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Clin Sci (Lond) (2020) 134 (12): 1319–1331.
Published: 16 June 2020
.... aldosterone cardiac remodeling inflammation microRNA-34a TRIF Cardiac pathophysiological remodeling is one of the major characteristics in the development of heart failure. There has been a sustained effort to develop novel strategies to protect against cardiomyopathy. Among them, agents...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (1): 3–13.
Published: 03 January 2020
... to promote inflammation and angiogenesis, and PVAT phenotypic changes occurring in the setting of obesity, hyperlipidemia etc., are fundamentally important in determining a pathogenic versus protective role of PVAT in vascular disease. Recent discoveries have advanced our understanding of the role...
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Clin Sci (Lond) (2019) 133 (23): 2379–2400.
Published: 04 December 2019
...Ratana Lim; Caitlyn Nguyen-Ngo; Martha Lappas Preterm birth is a global healthcare challenge. Spontaneous preterm birth (sPTB) is commonly caused by inflammation, yet there are currently no effective therapies available. The Bromodomain and Extra-Terminal motif (BET) proteins, Bromodomain...
Includes: Supplementary data
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