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Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Siddhi Jain, Pritam Saha, Nayadi Parambil Syamprasad, Samir Rajan Panda, Bishal Rajdev, Arun Kumar Jannu, Pawan Sharma, Vegi Ganga Modi Naidu

Clin Sci (Lond) (2023) 137 (10): 785–805.

DOI: https://doi.org/10.1042/CS20220625

Published: 23 May 2023

... inflammation. Chlorogenic acid (CGA) has been shown to possess potent antioxidant, anti-inflammatory, and immunoprotective properties. However, the protective effect of CGA on viral and bacterial-induced ALI/ARDS is not yet explored. Hence, the current study is aimed to evaluate the preclinical efficacy of CGA...

View article titled, Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Includes: Supplementary data

Articles

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B Graham

Clin Sci (Lond) (2023) 137 (8): 617–631.

DOI: https://doi.org/10.1042/CS20220642

Published: 21 April 2023

... access agreement between Portland Press and the University of California. Fibrosis Inflammation Pulmonary hypertension Schistosomiasis Vascular remodeling Pulmonary hypertension (PH) is characterized by vascular remodeling, right ventricular (RV) hypertrophy, and perivascular fibrosis...

View article titled, Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Includes: Supplementary data

Articles

By what molecular mechanisms do social determinants impact cardiometabolic risk?

Yvonne Baumer, Mario A. Pita, Andrew S. Baez, Lola R. Ortiz-Whittingham, Manuel A. Cintron, Rebecca R. Rose, Veronica C. Gray, Foster Osei Baah, Tiffany M. Powell-Wiley

Clin Sci (Lond) (2023) 137 (6): 469–494.

DOI: https://doi.org/10.1042/CS20220304

Published: 24 March 2023

... of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic–pituitary–adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked...

View article titled, By what molecular mechanisms do social determinants impact cardiometabolic risk?

Includes: Supplementary data

Articles

PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB

Honglin Li, Zhiwen Liu, Ying Wang, Hui Wang, Juan Cai, Chengyuan Tang, Zheng Dong

Clin Sci (Lond) (2022) 136 (24): 1877–1891.

DOI: https://doi.org/10.1042/CS20220493

Published: 22 December 2022

... with wild-type (WT) mice, Park7 -deficient mice experienced aggravated kidney tissue damage and dysfunction, and enhanced tubular apoptosis and inflammation following LPS treatment. Consistently, LPS-induced apoptosis and inflammation in renal tubular cells in vitro were exacerbated by Park7 knockdown...

View article titled, PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB

Articles

Dysregulated haemostasis in thrombo-inflammatory disease

Paula A. Klavina, Gemma Leon, Annie M. Curtis, Roger J.S. Preston

Clin Sci (Lond) (2022) 136 (24): 1809–1829.

DOI: https://doi.org/10.1042/CS20220208

Published: 16 December 2022

... mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution. In addition, we consider how lifestyle...

View article titled, Dysregulated haemostasis in thrombo-inflammatory disease

Articles

Genetically inducing renal lymphangiogenesis attenuates hypertension in mice

Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (23): 1759–1772.

DOI: https://doi.org/10.1042/CS20220547

Published: 02 December 2022

... 11 2022 08 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 hypertension immunity inflammation kidney lymphatics Hypertension (HTN), defined by the American Heart Association as having a blood pressure of 130/80...

View article titled, Genetically inducing renal lymphangiogenesis attenuates hypertension in mice

Includes: Supplementary data

Articles

New mechanisms for the kidney-protective effect of alkali in chronic kidney disease

Paul M. O’Connor, Elinor C. Mannon

Clin Sci (Lond) (2022) 136 (20): 1433–1437.

DOI: https://doi.org/10.1042/CS20220395

Published: 18 October 2022

... of adhesion molecules in the injured kidney. This, the authors speculate, may prevent inflammation from driving the functional decline of the kidney. Identifying these novel pathways represents an important step forward harnessing the potential benefits of alkali therapy in CKD. Interestingly, Pastor Arroyo...

View article titled, New mechanisms for the kidney-protective effect of alkali in chronic kidney disease

Articles

Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

Antonio L. Teixeira, Lais B. Martins, Michael Berk, Moisés E. Bauer

Clin Sci (Lond) (2022) 136 (17): 1257–1280.

DOI: https://doi.org/10.1042/CS20211106

Published: 05 September 2022

... overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets. Correspondence...

View article titled, Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

Articles

The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease

Jonatan Barrera-Chimal, Casimiro Gerarduzzi, Patrick Rossignol, Frédéric Jaisser

Clin Sci (Lond) (2022) 136 (12): 1005–1017.

DOI: https://doi.org/10.1042/CS20220212

Published: 29 June 2022

... that aldosterone stimulation leads to an upregulation of collagen synthesis (I, III, and IV), fibronectin, and osteopontin [ 21–25 ]. Regarding inflammation, several studies have characterized the pro-inflammatory effects of aldosterone-MR activation in the kidney. This includes the up-regulation of NLRP3...

View article titled, The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease

Articles

Molecular and cellular regulation of psoriatic inflammation

Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann

Clin Sci (Lond) (2022) 136 (12): 935–952.

DOI: https://doi.org/10.1042/CS20210916

Published: 22 June 2022

...Tom Macleod; Charles Bridgewood; Isabel Hyde; Megan Heague; Philip Helliwell; Martin Stacey; Miriam Wittmann This review highlights the molecular and cellular mechanisms underlying psoriatic inflammation with an emphasis on recent developments which may impact on treatment approaches...

View article titled, Molecular and cellular regulation of psoriatic inflammation

Articles

Autophagy in asthma and chronic obstructive pulmonary disease

Peter J. Barnes, Jonathan Baker, Louise E. Donnelly

Clin Sci (Lond) (2022) 136 (10): 733–746.

DOI: https://doi.org/10.1042/CS20210900

Published: 24 May 2022

... to the pathogenesis of many chronic diseases, including asthma and chronic obstructive pulmonary disease (COPD). In asthma, increased autophagy plays a role in promoting type 2 immune responses and eosinophilic inflammation, whereas decreased autophagy may be important in neutrophilic asthma. Acute exposure...

View article titled, Autophagy in asthma and chronic obstructive pulmonary disease

Articles

Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

... ( pedrohenrique.imenezsilva@uzh.ch ) 09 02 2022 24 03 2022 07 04 2022 07 04 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 acid-base balance alkali therapy chronic kidney disease crystal nephropathy inflammation metabolism...

View article titled, Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Includes: Supplementary data

Articles

Emergent players in renovascular disease

Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman

Clin Sci (Lond) (2022) 136 (3): 239–256.

DOI: https://doi.org/10.1042/CS20210509

Published: 07 February 2022

..., leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury...

View article titled, Emergent players in renovascular disease

Articles

Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm

Clin Sci (Lond) (2022) 136 (2): 167–180.

DOI: https://doi.org/10.1042/CS20210865

Published: 20 January 2022

... the impact of NLRP3 inhibition on renal inflammation and associated pathology in DKD. We identified an adverse effect of MCC950 on renal pathology in diabetic animals. Indeed, MCC950-treated diabetic animals showed increased renal inflammation and macrophage infiltration in association with enhanced...

View article titled, Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Includes: Supplementary data

Articles

Mechanisms of immune aging in HIV

Manon Chauvin, Delphine Sauce

Clin Sci (Lond) (2022) 136 (1): 61–80.

DOI: https://doi.org/10.1042/CS20210344

Published: 05 January 2022

...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...

View article titled, Mechanisms of immune aging in HIV

Articles

WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway

Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue

Clin Sci (Lond) (2022) 136 (1): 29–44.

DOI: https://doi.org/10.1042/CS20210663

Published: 05 January 2022

...Bo Wang; Chenguang Ding; Xiaoming Ding; Greg Tesch; Jin Zheng; PuYun Tian; Yang Li; Sharon Ricardo; Hsin-Hui Shen; Wujun Xue Inflammation is a pathological feature of kidney injury and its progression correlates with the development of kidney fibrosis which can lead to kidney function impairment...

View article titled, WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway

Includes: Supplementary data

Articles

Blocking of interleukin-1 suppresses angiotensin II-induced renal injury

Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino

Clin Sci (Lond) (2021) 135 (17): 2035–2048.

DOI: https://doi.org/10.1042/CS20201406

Published: 31 August 2021

...Koji Akita; Kikuo Isoda; Fumie Ohtomo; Sarasa Isobe; Tomiharu Niida; Yayoi Sato-Okabayashi; Motoaki Sano; Kazunori Shimada; Yoichiro Iwakura; Tohru Minamino Clinical hypertension (HT) is associated with renal inflammation and elevated circulating levels of proinflammatory cytokines. Interleukin (IL...

View article titled, Blocking of interleukin-1 suppresses angiotensin II-induced renal injury

Articles

Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Osvaldo Rivera-Gonzalez, Natalie A. Wilson, Laura E. Coats, Erin B. Taylor, Joshua S. Speed

Clin Sci (Lond) (2021) 135 (14): 1773–1789.

DOI: https://doi.org/10.1042/CS20210549

Published: 30 July 2021

..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...

View article titled, Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Includes: Supplementary data

Articles

Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt

Clin Sci (Lond) (2021) 135 (13): 1563–1590.

DOI: https://doi.org/10.1042/CS20190768

Published: 07 July 2021

... inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular...

View article titled, Nutrient regulation of inflammatory signalling in obesity and vascular disease

Articles

Cholesterol metabolism: a new molecular switch to control inflammation

Diana Cardoso, Esperanza Perucha

Clin Sci (Lond) (2021) 135 (11): 1389–1408.

DOI: https://doi.org/10.1042/CS20201394

Published: 04 June 2021

...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...

View article titled, Cholesterol metabolism: a new molecular switch to control inflammation

Articles

A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases

Lu Dai, Leon Schurgers, Paul G. Shiels, Peter Stenvinkel

Clin Sci (Lond) (2021) 135 (10): 1251–1272.

DOI: https://doi.org/10.1042/CS20201452

Published: 26 May 2021

... 04 05 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Ageing Biomimetics chronic kidney disease Inflammation life...

View article titled, A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases

Articles

Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury

Yanjun Liu, Jiacheng Li, Liping Liao, Heming Huang, Shijie Fan, Rong Fu, Jing Huang, Cuicui Shi, Liang Yu, Kai-xian Chen, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li

Clin Sci (Lond) (2021) 135 (7): 925–941.

DOI: https://doi.org/10.1042/CS20201111

Published: 14 April 2021

..., it is generally accepted that inflammation is commonly involved in the pathogenesis. Ongoing inflammatory responses exacerbate liver injury, or even result in fibrosis and cirrhosis. Here we report that roscovitine, a cyclin-dependent kinase (CDK) inhibitor, exerts beneficial effects on acute and chronic liver...

View article titled, Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury

Includes: Supplementary data

Articles

The complex role of adipokines in obesity, inflammation, and autoimmunity

Erin B. Taylor

Clin Sci (Lond) (2021) 135 (6): 731–752.

DOI: https://doi.org/10.1042/CS20200895

Published: 17 March 2021

... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge...

View article titled, The complex role of adipokines in obesity, inflammation, and autoimmunity

Articles

Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor

Priscila Andrade Ranéia e Silva, Dhêmerson Souza de Lima, João Paulo Mesquita Luiz, Niels Olsen Saraiva Câmara, José Carlos Farias Alves-Filho, Alessandra Pontillo, Karina Ramalho Bortoluci, Eliana L. Faquim-Mauro

Clin Sci (Lond) (2021) 135 (5): 687–701.

DOI: https://doi.org/10.1042/CS20201419

Published: 09 March 2021

.... Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, is a K49-phospholipase A 2 (PLA 2 ) that induces a massive muscle tissue injury, and, consequently, local inflammatory reaction. The NLRP3 inflammasome is a sensor that triggers inflammation by activating caspase 1 and releasing interleukin (IL)-1β...

View article titled, Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor

Articles

Retraction: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Clin Sci (Lond) (2021) 135 (1): 229.

DOI: https://doi.org/10.1042/CS-20200249_RET

Published: 11 January 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...

View article titled, Retraction: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Articles

Inflammation: a putative link between phosphate metabolism and cardiovascular disease

Jakob Voelkl, Daniela Egli-Spichtig, Ioana Alesutan, Carsten A. Wagner

Clin Sci (Lond) (2021) 135 (1): 201–227.

DOI: https://doi.org/10.1042/CS20190895

Published: 08 January 2021

... indicates a link between disturbances in phosphate homeostasis and inflammation. The present review focuses on critical interactions of phosphate homeostasis, inflammation, vascular calcification and CVD. Especially, pro-inflammatory responses mediating hyperphosphatemia-related development of vascular...

View article titled, Inflammation: a putative link between phosphate metabolism and cardiovascular disease

Articles

Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads

Shobana Navaneethabalakrishnan, Bethany L. Goodlett, Alexandra H. Lopez, Joseph M. Rutkowski, Brett M. Mitchell

Clin Sci (Lond) (2020) 134 (24): 3237–3257.

DOI: https://doi.org/10.1042/CS20201023

Published: 21 December 2020

... of hypertension on gonads in more detail on a molecular basis remain scarce. Hence, the aim of the current review is to address and summarize the effects of hypertension on reproductive health, and highlight the importance of research on the effects of hypertension on gonadal inflammation and lymphatics...

View article titled, Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads

Articles

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu

Clin Sci (Lond) (2020) 134 (23): 3175–3193.

DOI: https://doi.org/10.1042/CS20201207

Published: 09 December 2020

...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...

View article titled, Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Includes: Supplementary data

Articles

Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT 2 -receptor agonists

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

U. Muscha Steckelings, Colin Sumners

Clin Sci (Lond) (2020) 134 (22): 2987–3006.

DOI: https://doi.org/10.1042/CS20200922

Published: 19 November 2020

... to the AT 2 R and those connected to Mas/MrgD, reinforce each other by various ways of cross-talk. The main examples of this type of cross-talk are discussed in the following paragraphs: angiotensin converting enzyme 2 AT2 receptor COVID-19 inflammation There are multiple publications...

View article titled, Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT 2 -receptor agonists

Articles

The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

Anissa Viveiros, Gavin Y. Oudit

Clin Sci (Lond) (2020) 134 (18): 2447–2451.

DOI: https://doi.org/10.1042/CS20201028

Published: 25 September 2020

... volume. Correspondence: Gavin Y. Oudit ( gavin.oudit@ualberta.ca ) 02 09 2020 15 09 2020 17 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adipose tissue inflammation Maternal programming obesity...

View article titled, The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

Articles

Expression of Concern: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Clin Sci (Lond) (2020) 134 (15): 2053.

DOI: https://doi.org/10.1042/CS-20200249_EOC

Published: 10 August 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...

View article titled, Expression of Concern: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Articles

Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies

In Collection

Coronavirus

Thiago Gomes Heck, Mirna Stela Ludwig, Matias Nunes Frizzo, Alberto Antonio Rasia-Filho, Paulo Ivo Homem de Bittencourt, Jr

Clin Sci (Lond) (2020) 134 (15): 1991–2017.

DOI: https://doi.org/10.1042/CS20200596

Published: 04 August 2020

... the characteristic of being chronic degenerative diseases of inflammatory nature associated with defective heat shock response (HSR). The molecular components of the HSR, the principal metabolic pathway leading to the physiological resolution of inflammation, is an anti-inflammatory biochemical pathway that involves...

View article titled, Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies

Articles

DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway

Hai-Di Li, Xin Chen, Jie-Jie Xu, Xiao-Sa Du, Yang Yang, Juan-Juan Li, Xiao-Juan Yang, Hui-Min Huang, Xiao-Feng Li, Ming-Fei Wu, Chong Zhang, Chao Zhang, Zeng Li, Hua Wang, Xiao-Ming Meng, Cheng Huang, Jun Li

Clin Sci (Lond) (2020) 134 (14): 1935–1956.

DOI: https://doi.org/10.1042/CS20200031

Published: 23 July 2020

... in alcoholic liver disease (ALD) and aberrant macrophage DNA methylation is associated with inflammation. Our preliminary screening results of macrophage methylation in the present study demonstrated the zinc finger SWI2/SNF2 and MuDR (SWIM)-domain containing 3 (ZSWIM3) were hypermethylated in the 5...

View article titled, DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway

Includes: Supplementary data

Articles

α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome

Zhukai Cong, Dan Li, Xiangpeng Lv, Cui Yang, Qiang Zhang, Changyi Wu, Zongyu Wang, Xi Zhu

Clin Sci (Lond) (2020) 134 (14): 1957–1971.

DOI: https://doi.org/10.1042/CS20200586

Published: 23 July 2020

... to assess the underlying mechanisms. We found that α 2A -AR deficiency decreased the permeability of the alveolar capillary barrier in ARDS mice and suppressed lung inflammation by reducing inflammatory cell infiltration and the production of TNF-α, interleukin (IL)-6, and CXCL2/MIP-2. LPS stimulation...

View article titled, α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome

Articles

Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury

Riyaz Mohamed, Olga Rafikova, Paul M. O’Connor, Jennifer C. Sullivan

Clin Sci (Lond) (2020) 134 (13): 1751–1762.

DOI: https://doi.org/10.1042/CS20200575

Published: 10 July 2020

.... Neutralization of HMGB1 attenuated IR-induced increases in plasma creatinine, blood urea nitrogen (BUN), inflammation, tubular damage and tubular cell death only in male SHR. In conclusion, our data demonstrate that there is a sex difference in the contribution of HMGB1 to IR-induced injury, where males exhibit...

View article titled, Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury

Articles

Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice

Lingling Shu, Ling Zhong, Yang Xiao, Xiaoping Wu, Yang Liu, Xue Jiang, Tao Tang, RubyLaiChong Hoo, Zhiguang Zhou, Aimin Xu

Clin Sci (Lond) (2020) 134 (13): 1679–1696.

DOI: https://doi.org/10.1042/CS20200021

Published: 07 July 2020

.... NE pharmacological inhibitor (sivelestat) or biological inhibitor (elafin) was supplemented into NOD mice to evaluate their effects on islet inflammation and diabetogenesis. The impact of NE inhibition on innate and adaptive immune cells was measured with flow cytometry and immunohistochemistry...

View article titled, Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice

Includes: Supplementary data

Articles

Pathogenic role of human C-reactive protein in diabetic retinopathy

Fangfang Qiu, Xiang Ma, Young-Hwa Shin, Jianglei Chen, Qian Chen, Kelu Zhou, Wenjing Wu, Wentao Liang, Yalin Wu, Qing Song, Jian-Xing Ma

Clin Sci (Lond) (2020) 134 (13): 1613–1629.

DOI: https://doi.org/10.1042/CS20200085

Published: 30 June 2020

... inflammation oxidative stress retinal degeneration Diabetic retinopathy (DR) is the leading cause of vision loss in working-age people in developed countries [ 1 ]. Non-proliferative DR (NPDR) presents with progressive intra-retinal leukocyte adherence, retinal neuron degeneration, capillary...

View article titled, Pathogenic role of human C-reactive protein in diabetic retinopathy

Includes: Supplementary data

Articles

Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis

Simeng Liu, Zhimin Huang, Anna Tang, Xiaoqing Wu, Jeffrey Aube, Liang Xu, Changying Xing, Yufeng Huang

Clin Sci (Lond) (2020) 134 (12): 1433–1448.

DOI: https://doi.org/10.1042/CS20200193

Published: 18 June 2020

...Simeng Liu; Zhimin Huang; Anna Tang; Xiaoqing Wu; Jeffrey Aube; Liang Xu; Changying Xing; Yufeng Huang Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation...

View article titled, Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis

Articles

Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells

Ran You, Wei Zhou, Yanwei Li, Yue Zhang, Songming Huang, Zhanjun Jia, Aihua Zhang

Clin Sci (Lond) (2020) 134 (12): 1357–1376.

DOI: https://doi.org/10.1042/CS20200030

Published: 18 June 2020

... fundamental cellular events. In response to the pro-fibrotic stimuli, the unresolved and persistent inflammation serves as the trigger of fibrosis. Then the fibrogenic genes were up-regulated in the injured tubular epithelial cells [ 3 ]. Recently, the pathogenic role of metabolic reprogramming in energy...

View article titled, Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells

Articles

TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Shaojun Li, Wei Cao, Bai Wang, Enbo Zhan, Jian Xu, Shufeng Li

Clin Sci (Lond) (2020) 134 (12): 1319–1331.

DOI: https://doi.org/10.1042/CS20200249

Published: 16 June 2020

.... aldosterone cardiac remodeling inflammation microRNA-34a TRIF Cardiac pathophysiological remodeling is one of the major characteristics in the development of heart failure. There has been a sustained effort to develop novel strategies to protect against cardiomyopathy. Among them, agents...

View article titled, TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Includes: Supplementary data

Articles

IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture

Rana Ghali, Nada J. Habeichi, Abdullah Kaplan, Cynthia Tannous, Emna Abidi, Amira Bekdash, Rima Farhat, Hana Itani, Abdo Jurjus, George W. Booz, Ziad Mallat, Fouad A. Zouein

Clin Sci (Lond) (2020) 134 (11): 1191–1218.

DOI: https://doi.org/10.1042/CS20200402

Published: 03 June 2020

... 2020 eosinophils inflammation Interleukin 33 myocardial infarction ST2 ventricular remodeling Cardiovascular diseases, primarily acute myocardial infarction (MI) and stroke, represent the leading cause of mortality in the Western world and are on the rise in developing countries...

View article titled, IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture

Includes: Supplementary data

Articles

Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes

In Collection

Clinical and translational research highlights

Caitlyn Nguyen-Ngo, Carlos Salomon, Stephanie Quak, Andrew Lai, Jane C Willcox, Martha Lappas

Clin Sci (Lond) (2020) 134 (6): 571–592.

DOI: https://doi.org/10.1042/CS20191099

Published: 18 March 2020

... peripheral insulin resistance, thought to be driven by low-grade maternal inflammation. Nobiletin, a polymethoxylated flavonoid, possesses potent glucose-sensitizing and anti-inflammatory properties; however, its effects in GDM have not been assessed. The present study aimed to determine the effects...

View article titled, Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes

Includes: Supplementary data

Articles

Myriocin and d-PDMP ameliorate atherosclerosis in ApoE−/− mice via reducing lipid uptake and vascular inflammation

Zemou Yu, Qing Peng, Songyue Li, Hongjun Hao, Jianwen Deng, Lingbing Meng, Zhiyuan Shen, Weiwei Yu, Ding Nan, Yu Bai, Yining Huang

Clin Sci (Lond) (2020) 134 (5): 439–458.

DOI: https://doi.org/10.1042/CS20191028

Published: 04 March 2020

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis inflammation lipid uptake sphingolipid inhibitors Atherosclerosis is the fundamental pathological process underlying cardio-cerebral vascular diseases (CVDs), which are the leading cause of morbidity...

View article titled, Myriocin and d-PDMP ameliorate atherosclerosis in ApoE−/− mice via reducing lipid uptake and vascular inflammation

Includes: Supplementary data

Articles

SULT2B1b inhibits reverse cholesterol transport and promotes cholesterol accumulation and inflammation in lymphocytes from AMI patients with low LDL-C levels

Yanan Zhang, Zhongzhou Guo, Tongwei Wu, Jichen Liu, Bin Zhang, Wenyan Lai, Wenwei Tu, Zhigang Guo, Tiantian Luo

Clin Sci (Lond) (2020) 134 (2): 273–287.

DOI: https://doi.org/10.1042/CS20190459

Published: 29 January 2020

... by increasing liver X receptor (LXR)-β levels. Furthermore, the degree of CpG island methylation in the SULT2B1b promoter was reduced in cells from AMI patients. In conclusion, SULT2B1b up-regulation due to hypomethylation of its promoter promotes cholesterol accumulation and inflammation by inhibiting LXR-β...

View article titled, SULT2B1b inhibits reverse cholesterol transport and promotes cholesterol accumulation and inflammation in lymphocytes from AMI patients with low LDL-C levels

Includes: Supplementary data

Articles

Transcriptome sequencing of circular RNA reveals a novel circular RNA-has_circ_0114427 in the regulation of inflammation in acute kidney injury

Yiling Cao, Xuhua Mi, Dongmei Zhang, Zheng Wang, Yongdi Zuo, Wanxin Tang

Clin Sci (Lond) (2020) 134 (2): 139–154.

DOI: https://doi.org/10.1042/CS20190990

Published: 23 January 2020

... 09 2019 04 01 2020 13 01 2020 13 01 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Acute kidney injury circ-0114427 circular RNA inflammation next-generation sequencing Acute kidney injury (AKI...

View article titled, Transcriptome sequencing of circular RNA reveals a novel circular RNA-has_circ_0114427 in the regulation of inflammation in acute kidney injury

Includes: Supplementary data

Articles

Inflammation both increases and causes resistance to FGF23 in normal and uremic rats

Maria E. Rodríguez-Ortiz, Juan M. Díaz-Tocados, Juan R. Muñoz-Castañeda, Carmen Herencia, Carmen Pineda, Julio M. Martínez-Moreno, Addy Montes de Oca, Rodrigo López-Baltanás, Juan Alcalá-Díaz, Alberto Ortiz, Escolástico Aguilera-Tejero, Arnold Felsenfeld, Mariano Rodríguez, Yolanda Almadén

Clin Sci (Lond) (2020) 134 (1): 15–32.

DOI: https://doi.org/10.1042/CS20190779

Published: 03 January 2020

... Fibroblast growth factor 23 (FGF23) increases phosphorus excretion and decreases calcitriol (1,25(OH) 2 D) levels. FGF23 increases from early stages of renal failure. We evaluated whether strict control of phosphorus intake in renal failure prevents the increase in FGF23 and to what extent inflammation...

View article titled, Inflammation both increases and causes resistance to FGF23 in normal and uremic rats

Includes: Supplementary data

Articles

Potential role of perivascular adipose tissue in modulating atherosclerosis

In Collection

Adipose biology, cardiovascular and cardiometabolic disease

Samah Ahmadieh, Ha Won Kim, Neal L. Weintraub

Clin Sci (Lond) (2020) 134 (1): 3–13.

DOI: https://doi.org/10.1042/CS20190577

Published: 03 January 2020

... to promote inflammation and angiogenesis, and PVAT phenotypic changes occurring in the setting of obesity, hyperlipidemia etc., are fundamentally important in determining a pathogenic versus protective role of PVAT in vascular disease. Recent discoveries have advanced our understanding of the role...

View article titled, Potential role of perivascular adipose tissue in modulating atherosclerosis

Articles

Targeting bromodomain-containing proteins to prevent spontaneous preterm birth

In Collection

Clinical and translational research highlights

Ratana Lim, Caitlyn Nguyen-Ngo, Martha Lappas

Clin Sci (Lond) (2019) 133 (23): 2379–2400.

DOI: https://doi.org/10.1042/CS20190919

Published: 04 December 2019

...Ratana Lim; Caitlyn Nguyen-Ngo; Martha Lappas Preterm birth is a global healthcare challenge. Spontaneous preterm birth (sPTB) is commonly caused by inflammation, yet there are currently no effective therapies available. The Bromodomain and Extra-Terminal motif (BET) proteins, Bromodomain...

View article titled, Targeting bromodomain-containing proteins to prevent spontaneous preterm birth

Includes: Supplementary data

Articles

Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue

Thamiris Candreva, Carolina M.C. Kühl, Beatriz Burger, Mariah B.P. dos Anjos, Márcio A. Torsoni, Sílvio R. Consonni, Amanda R. Crisma, Helena L. Fisk, Philip C. Calder, Felipe C.P. de Mato, Erica M. Sernaglia, Marco A.R. Vinolo, Hosana G. Rodrigues

Clin Sci (Lond) (2019) 133 (22): 2345–2360.

DOI: https://doi.org/10.1042/CS20190753

Published: 28 November 2019

...-3 FA levels, mainly docosahexaenoic acid (DHA), in comparison with WT mice. FAT-1 mice had increased myeloperoxidase (MPO) activity and content of CXCL-1 and CXCL-2, and reduced IL-10 in the skin wound tissue three days after the wound induction. Inflammation was maintained by an elevated TNF-α...

View article titled, Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue

Includes: Supplementary data

Articles

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

Apabrita Ayan Das, Devasmita Chakravarty, Debmalya Bhunia, Surajit Ghosh, Prakash C. Mandal, Khawer N. Siddiqui, Arun Bandyopadhyay

Clin Sci (Lond) (2019) 133 (22): 2283–2299.

DOI: https://doi.org/10.1042/CS20190999

Published: 21 November 2019

...Apabrita Ayan Das; Devasmita Chakravarty; Debmalya Bhunia; Surajit Ghosh; Prakash C. Mandal; Khawer N. Siddiqui; Arun Bandyopadhyay The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated...

View article titled, Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

Includes: Supplementary data

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