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Keywords: inflammation
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1665–1681.
Published: 15 November 2023
... of the Biochemical Society 2023 cardiac arrhythmia inflammation myocardial remodeling Sudden cardiac death (SCD) is a major life-threatening health problem worldwide, and approximately 80% of SCDs are caused by malignant ventricular arrhythmias (VAs) secondary to acute myocardial infarction (MI) [ 1...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (19): 1533–1545.
Published: 03 October 2023
... the phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state during AAA. In addition, it was demonstrated that colchicine was able to reduce vascular inflammation, oxidative stress, cell pyroptosis and immune cells infiltration to the aortic wall in the AAA mice model. Finally...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (18): 1477–1498.
Published: 22 September 2023
... experiments, we found that Gpx3 might serve as a key gene for the regulation of selenomethionine in renal IRIs. Selenomethionine may exert a protective effect against renal IRI by up-regulating GPX3, inhibiting the MAPK signaling pathway, increased production of antioxidants, decreasing inflammation levels...
Articles
Nuria Dolade, Sandra Rayego-Mateos, Alicia Garcia-Carrasco, Maryse Guerin, Jose-Luis Martín-Ventura, Marta Ruiz-Ortega, Pierre-Louis Tharaux, Jose Manuel Valdivielso
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1409–1429.
Published: 13 September 2023
... 2023 31 07 2023 01 09 2023 01 09 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 atherosclerosis Chronic Kidney disease inflammation Chronic kidney disease (CKD) is a high impact-disease worldwide...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1225–1247.
Published: 22 August 2023
... therapies. Inflammation has emerged as a potential contributor to the pathogenesis of HFpEF. Many of the risk factors for HFpEF are also associated with chronic inflammation, such as obesity, hypertension, aging, and renal dysfunction. A large amount of preclinical evidence suggests that immune cells...
Articles
Sara Kazeminia, Xiang Y. Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Sandra M. Herrmann, Alejandro R. Chade, Maria V. Irazabal, Lilach O. Lerman, Alfonso Eirin
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1265–1283.
Published: 22 August 2023
...://pantherdb.org/ ) [ 33 ], and by their biological process using GSEA. 24 05 2023 31 07 2023 11 08 2023 11 08 2023 Epigenetics Inflammation MeDIP-seq Methylation Scattered tubular-like cells Renal artery stenosis (RAS), often caused by atherosclerosis, is the narrowing...
Includes: Supplementary data
Articles
Nima Yassini, Janine Sprenger, Eva Maria Pastor Arroyo, Christiane Krudewig, Giovanni Pellegrini, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (14): 1013–1025.
Published: 25 July 2023
... protein-coupled receptors that are stimulated upon increased extracellular acidity. These receptors have various physiological and pathophysiological roles in renal acid–base physiology, tissue inflammation, and fibrosis among others. Their function in injured renal tissue, however, remains mostly unclear...
Includes: Supplementary data
Articles
Huahui Yu, Xiaolu Jiao, Yunyun Yang, Qianwen Lv, Zhiyong Du, Linyi Li, Chaowei Hu, Yunhui Du, Jing Zhang, Fan Li, Qiuju Sun, Yu Wang, Dong Chen, Xiaoping Zhang, Yanwen Qin
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (12): 979–993.
Published: 28 June 2023
...Huahui Yu; Xiaolu Jiao; Yunyun Yang; Qianwen Lv; Zhiyong Du; Linyi Li; Chaowei Hu; Yunhui Du; Jing Zhang; Fan Li; Qiuju Sun; Yu Wang; Dong Chen; Xiaoping Zhang; Yanwen Qin Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose metabolism, inflammation, and cell...
Includes: Supplementary data
Articles
Siddhi Jain, Pritam Saha, Nayadi Parambil Syamprasad, Samir Rajan Panda, Bishal Rajdev, Arun Kumar Jannu, Pawan Sharma, Vegi Ganga Modi Naidu
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (10): 785–805.
Published: 23 May 2023
... inflammation. Chlorogenic acid (CGA) has been shown to possess potent antioxidant, anti-inflammatory, and immunoprotective properties. However, the protective effect of CGA on viral and bacterial-induced ALI/ARDS is not yet explored. Hence, the current study is aimed to evaluate the preclinical efficacy of CGA...
Includes: Supplementary data
Articles
Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B Graham
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (8): 617–631.
Published: 21 April 2023
... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Open access for this article was enabled through a transformative open access agreement between Portland Press and the University of California. Fibrosis Inflammation Pulmonary hypertension Schistosomiasis Vascular remodeling Here, we...
Includes: Supplementary data
Articles
Yvonne Baumer, Mario A. Pita, Andrew S. Baez, Lola R. Ortiz-Whittingham, Manuel A. Cintron, Rebecca R. Rose, Veronica C. Gray, Foster Osei Baah, Tiffany M. Powell-Wiley
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (6): 469–494.
Published: 24 March 2023
... of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic–pituitary–adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
... with wild-type (WT) mice, Park7 -deficient mice experienced aggravated kidney tissue damage and dysfunction, and enhanced tubular apoptosis and inflammation following LPS treatment. Consistently, LPS-induced apoptosis and inflammation in renal tubular cells in vitro were exacerbated by Park7 knockdown...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1809–1829.
Published: 16 December 2022
... mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution. In addition, we consider how lifestyle...
Articles
Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (23): 1759–1772.
Published: 02 December 2022
...) as the endogenous control. Forward and reverse primer sequences were generated using NCBI Gene DataBase and PrimerBank. These sequences are listed in Online Table IV. hypertension immunity inflammation kidney lymphatics Hypertension (HTN), defined by the American Heart Association as having a blood...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (20): 1433–1437.
Published: 18 October 2022
... of adhesion molecules in the injured kidney. This, the authors speculate, may prevent inflammation from driving the functional decline of the kidney. Identifying these novel pathways represents an important step forward harnessing the potential benefits of alkali therapy in CKD. References 1. Hill...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1257–1280.
Published: 05 September 2022
... overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets. Correspondence...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (12): 1005–1017.
Published: 29 June 2022
... of the main drivers for testing the efficacy of finerenone in non-diabetic CKD patients in the ongoing FIND-CKD trial. aldosterone fibrosis inflammation Chronic kidney disease (CKD) is a growing health problem, with an estimated global prevalence of 11% and affecting approximately 850 million...
Articles
Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (12): 935–952.
Published: 22 June 2022
...Tom Macleod; Charles Bridgewood; Isabel Hyde; Megan Heague; Philip Helliwell; Martin Stacey; Miriam Wittmann This review highlights the molecular and cellular mechanisms underlying psoriatic inflammation with an emphasis on recent developments which may impact on treatment approaches...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (10): 733–746.
Published: 24 May 2022
... to the pathogenesis of many chronic diseases, including asthma and chronic obstructive pulmonary disease (COPD). In asthma, increased autophagy plays a role in promoting type 2 immune responses and eosinophilic inflammation, whereas decreased autophagy may be important in neutrophilic asthma. Acute exposure...
Articles
Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 557–577.
Published: 21 April 2022
... ( pedrohenrique.imenezsilva@uzh.ch ) 09 02 2022 24 03 2022 07 04 2022 07 04 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 acid-base balance alkali therapy chronic kidney disease crystal nephropathy inflammation metabolism...
Includes: Supplementary data
Articles
Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (3): 239–256.
Published: 07 February 2022
..., leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury...
Articles
Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... the impact of NLRP3 inhibition on renal inflammation and associated pathology in DKD. We identified an adverse effect of MCC950 on renal pathology in diabetic animals. Indeed, MCC950-treated diabetic animals showed increased renal inflammation and macrophage infiltration in association with enhanced...
Includes: Supplementary data
Articles
Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
...Bo Wang; Chenguang Ding; Xiaoming Ding; Greg Tesch; Jin Zheng; PuYun Tian; Yang Li; Sharon Ricardo; Hsin-Hui Shen; Wujun Xue Inflammation is a pathological feature of kidney injury and its progression correlates with the development of kidney fibrosis which can lead to kidney function impairment...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 61–80.
Published: 05 January 2022
...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...
Articles
Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
...Koji Akita; Kikuo Isoda; Fumie Ohtomo; Sarasa Isobe; Tomiharu Niida; Yayoi Sato-Okabayashi; Motoaki Sano; Kazunori Shimada; Yoichiro Iwakura; Tohru Minamino Clinical hypertension (HT) is associated with renal inflammation and elevated circulating levels of proinflammatory cytokines. Interleukin (IL...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
... inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1389–1408.
Published: 04 June 2021
...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... Biomimetics chronic kidney disease Inflammation life style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050...
Articles
Yanjun Liu, Jiacheng Li, Liping Liao, Heming Huang, Shijie Fan, Rong Fu, Jing Huang, Cuicui Shi, Liang Yu, Kai-xian Chen, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 925–941.
Published: 14 April 2021
..., it is generally accepted that inflammation is commonly involved in the pathogenesis. Ongoing inflammatory responses exacerbate liver injury, or even result in fibrosis and cirrhosis. Here we report that roscovitine, a cyclin-dependent kinase (CDK) inhibitor, exerts beneficial effects on acute and chronic liver...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (6): 731–752.
Published: 17 March 2021
... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge...
Articles
Priscila Andrade Ranéia e Silva, Dhêmerson Souza de Lima, João Paulo Mesquita Luiz, Niels Olsen Saraiva Câmara, José Carlos Farias Alves-Filho, Alessandra Pontillo, Karina Ramalho Bortoluci, Eliana L. Faquim-Mauro
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (5): 687–701.
Published: 09 March 2021
.... Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, is a K49-phospholipase A 2 (PLA 2 ) that induces a massive muscle tissue injury, and, consequently, local inflammatory reaction. The NLRP3 inflammasome is a sensor that triggers inflammation by activating caspase 1 and releasing interleukin (IL)-1β...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 229.
Published: 11 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... indicates a link between disturbances in phosphate homeostasis and inflammation. The present review focuses on critical interactions of phosphate homeostasis, inflammation, vascular calcification and CVD. Especially, pro-inflammatory responses mediating hyperphosphatemia-related development of vascular...
Articles
Shobana Navaneethabalakrishnan, Bethany L. Goodlett, Alexandra H. Lopez, Joseph M. Rutkowski, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (24): 3237–3257.
Published: 21 December 2020
... of hypertension on gonads in more detail on a molecular basis remain scarce. Hence, the aim of the current review is to address and summarize the effects of hypertension on reproductive health, and highlight the importance of research on the effects of hypertension on gonadal inflammation and lymphatics...
Articles
Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
Includes: Supplementary data
Articles
In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
,
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
... for the loss of natural Ang-(1-7) protective mechanisms in COVID-19 disease. These AT 2 R actions are discussed in more detail in later sections of this review. angiotensin converting enzyme 2 AT2 receptor COVID-19 inflammation The discovery in 2003 of angiotensin converting enzyme (ACE) 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Published: 25 September 2020
... volume. Correspondence: Gavin Y. Oudit ( gavin.oudit@ualberta.ca ) 02 09 2020 15 09 2020 17 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adipose tissue inflammation Maternal programming obesity...
Articles
Expression of Concern: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2053.
Published: 10 August 2020
... The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. aldosterone cardiac remodeling inflammation microRNA-34a TRIF ©...
Articles
In Collection
Coronavirus
Thiago Gomes Heck, Mirna Stela Ludwig, Matias Nunes Frizzo, Alberto Antonio Rasia-Filho, Paulo Ivo Homem de Bittencourt, Jr
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 1991–2017.
Published: 04 August 2020
... the characteristic of being chronic degenerative diseases of inflammatory nature associated with defective heat shock response (HSR). The molecular components of the HSR, the principal metabolic pathway leading to the physiological resolution of inflammation, is an anti-inflammatory biochemical pathway that involves...
Articles
Hai-Di Li, Xin Chen, Jie-Jie Xu, Xiao-Sa Du, Yang Yang, Juan-Juan Li, Xiao-Juan Yang, Hui-Min Huang, Xiao-Feng Li, Ming-Fei Wu, Chong Zhang, Chao Zhang, Zeng Li, Hua Wang, Xiao-Ming Meng, Cheng Huang, Jun Li
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1935–1956.
Published: 23 July 2020
... in alcoholic liver disease (ALD) and aberrant macrophage DNA methylation is associated with inflammation. Our preliminary screening results of macrophage methylation in the present study demonstrated the zinc finger SWI2/SNF2 and MuDR (SWIM)-domain containing 3 (ZSWIM3) were hypermethylated in the 5...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1957–1971.
Published: 23 July 2020
... to assess the underlying mechanisms. We found that α 2A -AR deficiency decreased the permeability of the alveolar capillary barrier in ARDS mice and suppressed lung inflammation by reducing inflammatory cell infiltration and the production of TNF-α, interleukin (IL)-6, and CXCL2/MIP-2. LPS stimulation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1751–1762.
Published: 10 July 2020
.... Neutralization of HMGB1 attenuated IR-induced increases in plasma creatinine, blood urea nitrogen (BUN), inflammation, tubular damage and tubular cell death only in male SHR. In conclusion, our data demonstrate that there is a sex difference in the contribution of HMGB1 to IR-induced injury, where males exhibit...
Articles
Lingling Shu, Ling Zhong, Yang Xiao, Xiaoping Wu, Yang Liu, Xue Jiang, Tao Tang, RubyLaiChong Hoo, Zhiguang Zhou, Aimin Xu
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1679–1696.
Published: 07 July 2020
.... NE pharmacological inhibitor (sivelestat) or biological inhibitor (elafin) was supplemented into NOD mice to evaluate their effects on islet inflammation and diabetogenesis. The impact of NE inhibition on innate and adaptive immune cells was measured with flow cytometry and immunohistochemistry...
Includes: Supplementary data
Articles
Fangfang Qiu, Xiang Ma, Young-Hwa Shin, Jianglei Chen, Qian Chen, Kelu Zhou, Wenjing Wu, Wentao Liang, Yalin Wu, Qing Song, Jian-Xing Ma
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . angiogenesis c-reactive protein diabetic retinopathy inflammation oxidative stress...
Includes: Supplementary data
Articles
Simeng Liu, Zhimin Huang, Anna Tang, Xiaoqing Wu, Jeffrey Aube, Liang Xu, Changying Xing, Yufeng Huang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Published: 18 June 2020
...Simeng Liu; Zhimin Huang; Anna Tang; Xiaoqing Wu; Jeffrey Aube; Liang Xu; Changying Xing; Yufeng Huang Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1357–1376.
Published: 18 June 2020
... Society 2020 inflammation KD025 metabolism ROCK2 tubulointerstitial fibrosis Epidemiological studies have demonstrated that the prevalence of chronic kidney disease (CKD) is approximately 8–16% worldwide [ 1 , 2 ]. Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1319–1331.
Published: 16 June 2020
... License 4.0 (CC BY-NC-ND) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF Cardiac pathophysiological remodeling is one of the major characteristics in the development of heart failure. There has been a sustained effort to develop novel strategies to protect against...
Includes: Supplementary data
Articles
Rana Ghali, Nada J. Habeichi, Abdullah Kaplan, Cynthia Tannous, Emna Abidi, Amira Bekdash, Rima Farhat, Hana Itani, Abdo Jurjus, George W. Booz, Ziad Mallat, Fouad A. Zouein
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1191–1218.
Published: 03 June 2020
... 2020 eosinophils inflammation Interleukin 33 myocardial infarction ST2 ventricular remodeling Cardiovascular diseases, primarily acute myocardial infarction (MI) and stroke, represent the leading cause of mortality in the Western world and are on the rise in developing countries...
Includes: Supplementary data
Articles
In Collection
Clinical and translational research highlights
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (6): 571–592.
Published: 18 March 2020
... peripheral insulin resistance, thought to be driven by low-grade maternal inflammation. Nobiletin, a polymethoxylated flavonoid, possesses potent glucose-sensitizing and anti-inflammatory properties; however, its effects in GDM have not been assessed. The present study aimed to determine the effects...
Includes: Supplementary data
1