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Martin Sebastian Winkler, Ralf Alexander Claus, Mareike Schilder, Stefan Pöhlmann, Sina M. Coldewey, Julian Grundmann, Torben Fricke, Onnen Moerer, Konrad Meissner, Michael Bauer, Heike Hofmann-Winkler, Markus H. Gräler
Clin Sci (Lond) (2021) 135 (24): 2781–2791.
Published: 22 December 2021
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . endothelial cell barrier erythrocytes high-density lipoprotein hypoxia infection SARS-CoV-2 The clinical course of severe...
Brianna Atto, Mathew Suji Eapen, Pawan Sharma, Urs Frey, Alaina J. Ammit, James Markos, Collin Chia, Josie Larby, Greg Haug, Heinrich C. Weber, George Mabeza, Stephen Tristram, Stephen Myers, Dominic P. Geraghty, Katie L. Flanagan, Philip M. Hansbro, Sukhwinder Singh Sohal
Clin Sci (Lond) (2019) 133 (14): 1663–1703.
Published: 25 July 2019
... with accelerated loss of lung function, increased mortality, decreased health-related quality of life and significant economic costs. Infections with a small subgroup of pathogens precipitate the majority of AEs and consequently constitute a significant comorbidity in COPD. However, current pharmacological...
Clin Sci (Lond) (2018) 132 (3): 375–379.
Published: 08 February 2018
...Mathew Suji Eapen; Sukhwinder Singh Sohal Airway infections are considered as one of the vital factors driving the pathophysiology of chronic lung disease with significant influences on disease trajectory. Opportunistic lung microbes in diseased conditions induce excessive exacerbations...
Clin Sci (Lond) (2017) 131 (17): 2201–2221.
Published: 10 August 2017
...Sheila V. Graham HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately linked to epithelial differentiation. There are over 200 different HPV genotypes identified to date and each displays a strict tissue specificity for infection. HPV infection can result...
Clin Sci (Lond) (2017) 131 (4): 269–283.
Published: 20 January 2017
...Suzanne L. Cole; Ling-Pei Ho Influenza A viruses (IAVs) cause respiratory illness of varying severity based on the virus strains, host predisposition and pre-existing immunity. Ultimately, outcome and recovery from infection rely on an effective immune response comprising both innate and adaptive...
Clin Sci (Lond) (2015) 129 (7): 601–672.
Published: 14 July 2015
... utility as a therapeutic target. Correspondence: Dr Shane R. Thomas ( firstname.lastname@example.org ). 19 2 2015 17 4 2015 15 5 2015 © 2015 Authors; published by Portland Press Limited 2015 cancer immune suppression indoleamine 2 3-dioxygenase infection inflammation...
Includes: Supplementary data
Angela L. Man, Eugenio Bertelli, Silvia Rentini, Mari Regoli, Graham Briars, Mario Marini, Alastair J. M. Watson, Claudio Nicoletti
Clin Sci (Lond) (2015) 129 (7): 515–527.
Published: 03 July 2015
... individuals the integrity of the epithelial barrier appear to be partially compromised and immune responses to certain microbial antigen show signs of decline. aging infection innate immunity interleukin 6 intestinal permeability intestine • The effects of aging on physical...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (6): 337–347.
Published: 28 November 2014
...Nathalie Grandvaux; Mélissa Mariani; Karin Fink Determining the role of NADPH oxidases in the context of virus infection is an emerging area of research and our knowledge is still sparse. The expression of various isoforms of NOX/DUOX (NADPH oxidase/dual oxidase) in the epithelial cells (ECs...
Clin Sci (Lond) (2013) 124 (2): 77–85.
Published: 12 September 2012
...Daniel Grimm; Maximilian Heeg; Robert Thimme Owing to the major limitations of current antiviral therapies in HBV (hepatitis B virus) infection, there is a strong need for novel therapeutic approaches to this major health burden. Stimulation of the host's innate and adaptive immune responses...
Visith Thongboonkerd, Wararat Chiangjong, Jan Mares, Jiri Moravec, Zdenek Tuma, Thomas Karvunidis, Supachok Sinchaikul, Shui-Tein Chen, Karel Opatrný, Jr, Martin Matejovic
Clin Sci (Lond) (2009) 116 (9): 721–730.
Published: 02 April 2009
...Visith Thongboonkerd; Wararat Chiangjong; Jan Mares; Jiri Moravec; Zdenek Tuma; Thomas Karvunidis; Supachok Sinchaikul; Shui-Tein Chen; Karel Opatrný, Jr; Martin Matejovic Sepsis is a systemic response to infection commonly found in critically ill patients and is associated with multi-organ failure...
Includes: Supplementary data
Clin Sci (Lond) (2008) 114 (8): 509–531.
Published: 13 March 2008
... 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 Figure 1 Inflammation as a response to vascular injury C. pneumoniae gains entry into the vessel wall by extravasation of infected blood monocytes. C. pneumoniae infection of ECs stimulates the secretion...
Clin Sci (Lond) (2006) 110 (5): 503–524.
Published: 11 April 2006
... and maintaining iron. These competitive mechanisms are highly complex, existing within an interacting matrix of absorption, transport, storage and detoxification systems, each of which are iron-responsive and thus able to adapt to the different phases of infection. Considerable genetic polymorphism in some...
Includes: Supplementary data
Clin Sci (Lond) (2006) 110 (5): 525–541.
Published: 11 April 2006
...John Doorbar HPVs (human papillomaviruses) infect epithelial cells and cause a variety of lesions ranging from common warts/verrucas to cervical neoplasia and cancer. Over 100 different HPV types have been identified so far, with a subset of these being classified as high risk. High-risk HPV DNA...
Clin Sci (Lond) (2006) 110 (3): 379–386.
Published: 10 February 2006
... coxsackievirus B3 inflammation infection lymphocyte myocarditis oxidative stress Ang II (angiotensin II) has been shown to play a pivotal role in the pathophysiology of various organs, especially the cardiovascular system. The effects of ARBs (Ang II receptor blockers) in the treatment...
Clin Sci (Lond) (2005) 109 (2): 125–133.
Published: 25 July 2005
..., and these signals have important roles in the activation of host defence. TLRs may also respond to products of tissue damage, providing them with roles in infective and sterile inflammation. Their role as detectors of pathogens and pathogen-associated molecules provides molecular mechanisms to underpin...
Clin Sci (Lond) (2002) 102 (1): 107–114.
Published: 10 December 2001
...Benoît RUOT; Fabienne BÉCHEREAU; Gérard BAYLE; Denis BREUILLÉ; Christiane OBLED To discriminate between the effects of infection and of anorexia associated with infection, liver albumin synthesis was measured in well-fed rats, in rats injected with live Escherichia coli and in pair-fed rats...
Clin Sci (Lond) (2001) 100 (4): 395–400.
Published: 26 February 2001
... Staphylococcus aureus and Escherichia coli at doses lower than those required to increase skin blood flow. The vasodilatory and anti-microbial effects of this system may be useful as a patch-based topical therapy for skin ulceration, particularly when there is concomitant ischaemia and infection...
Nicholas I. PATON, Brian ANGUS, Wipada CHAOWAGUL, Andrew J. SIMPSON, Yupin SUPUTTAMONGKOL, Marinos ELIA, Graham CALDER, Eric MILNE, Nicholas J. WHITE, George E. GRIFFIN
Clin Sci (Lond) (2001) 100 (1): 101–110.
Published: 13 December 2000
...Nicholas I. PATON; Brian ANGUS; Wipada CHAOWAGUL; Andrew J. SIMPSON; Yupin SUPUTTAMONGKOL; Marinos ELIA; Graham CALDER; Eric MILNE; Nicholas J. WHITE; George E. GRIFFIN Chronic infection is often accompanied by a wasting process, the metabolic basis of which is not fully understood. The aims...
Sun-Sang WANG, Fa-Yauh LEE, Che-Chang CHAN, Rei-Hwa LU, Yee CHAO, Han-Chieh LIN, Shwu-Ling WU, Yang-Te TSAI, Shou-Dong LEE
Clin Sci (Lond) (2000) 98 (4): 419–425.
Published: 08 March 2000
...Sun-Sang WANG; Fa-Yauh LEE; Che-Chang CHAN; Rei-Hwa LU; Yee CHAO; Han-Chieh LIN; Shwu-Ling WU; Yang-Te TSAI; Shou-Dong LEE To delineate the clinical roles of plasma cytokine or endotoxin levels in the natural course of infection in patients with decompensated cirrhosis, 66 cirrhotic patients were...
Clin Sci (Lond) (1998) 94 (4): 413–423.
Published: 01 April 1998
...Denis Breuillé; Maurice Arnal; Fabienne Rambourdin; Gérard Bayle; Didier Levieux; Christiane Obled 1. Sepsis was induced in rats by an intravenous injection of live bacteria. Infected and pair-fed animals were studied before the infection, in an acute septic phase (day 2 post-infection...
J. D. M. Edgar, D. C. Wilson, S. A. McMillan, A. D. Crockard, M. I. Halliday, K. R. Gardiner, B. J. Rowlands, H.L. Halliday, T. A. McNeill
Clin Sci (Lond) (1994) 87 (2): 165–171.
Published: 01 August 1994
...J. D. M. Edgar; D. C. Wilson; S. A. McMillan; A. D. Crockard; M. I. Halliday; K. R. Gardiner; B. J. Rowlands; H.L. Halliday; T. A. McNeill 1. Infection in the neonatal period is difficult to diagnose and is a significant cause of morbidity and mortality in preterm infants. 2. We investigated...
Clin Sci (Lond) (1994) 86 (6): 663–669.
Published: 01 June 1994
..., and protein synthesis measurements were carried out 48 h later. 2. Septic rats exhibited a reduction in food intake to between 10 and 50% of the normal level on the 2 days after infection. Animals lost body weight and the relative organ weight was increased in liver, unchanged in intestine and decreased...
Clin Sci (Lond) (1983) 65 (3): 313–324.
Published: 01 September 1983
...A. M. Tomkins; P. J. Garlick; W. N. Schofield; J. C. Waterlow 1. Twenty-two children were studied as in-patients at a Nigerian Hospital. 2. They were divided into four groups on the basis of weight for age: I, adequately nourished, acutely infected; II, moderately under weight, acutely infected...
Clin Sci (Lond) (1980) 59 (5): 385–387.
Published: 01 November 1980
...G. Birgegård 1. Serum samples were collected from ten patients hospitalized for acute infections and from a control group of seven normal subjects. Tissue ferritin was obtained by purification of ferritin from normal human liver and from the ferritin standard of a commercially available assay kit...
Clin Sci Mol Med (1975) 48 (3): 201–212.
Published: 01 March 1975
... Tetrazolium test infection granulocytes phagocytosis acute phase proteins immune complexes Clinical Science and Molecular Medicine (1975) 48, 201-212. Factors influencing the entry of dye into neutrophil leucocytes in the Nitroblue Tetrazolium test A. W. SEGAL AND A. J. LEVI Northwich Park Hospital...
Clin Sci Mol Med (1973) 45 (6): 817–826.
Published: 01 December 1973
... and/or fibrinogen. 24 7 1973 © 1973 The Biochemical Society and the Medical Research Society 1973 infection granulocytes phagocytosis fibrinogen tetrazolium salts Clinical Science and Molecular Medicine (1973) 45,817-826. THE MECHANISM OF THE ENTRY OF DYE INTO NEUTROPHILS IN THE NITROBLUE...