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Keywords: indomethacin
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Articles
Pietro Di Pasquale, Sergio Cannizzaro, Sergio Fasullo, Filippo Ganci, Giorgio Marenghini, Sebastiano Scalzo, Francesco Giambanco, Giuseppe Vitale, Giovanni Polizzi, Salvatore Paterna
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (11): 443–448.
Published: 01 November 2007
...Pietro Di Pasquale; Sergio Cannizzaro; Sergio Fasullo; Filippo Ganci; Giorgio Marenghini; Sebastiano Scalzo; Francesco Giambanco; Giuseppe Vitale; Giovanni Polizzi; Salvatore Paterna The aim of the present study was to evaluate the safety and efficacy of the combination of indomethacin and statin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (4): 491–501.
Published: 15 March 2006
... dialysis patients and 13 healthy control subjects (Study 1), and in 15 healthy control subjects, who participated in a randomized placebo-controlled cross-over study after treatment with indomethacin and placebo (Study 2). Plasma concentrations of ANP and BNP were determined by RIAs, and the results were...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (3): 281–289.
Published: 24 August 2004
... of these cells. In the present study, we investigated the effect of glutamine on indomethacin-induced changes in the small intestinal mucosa. Rats were given 2% glutamine or glutamic acid or isonitrogenous amino acids, glycine or alanine, in the diet for 7 days. Indomethacin was then administered orally...
Articles
Niels Vidiendal OLSEN, Niels Georg JENSEN, Jesper Melchior HANSEN, Niels Juel CHRISTENSEN, Niels FOGH-ANDERSEN, Inge-Lis KANSTRUP
Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (4): 457–465.
Published: 24 August 1999
...Niels Vidiendal OLSEN; Niels Georg JENSEN; Jesper Melchior HANSEN; Niels Juel CHRISTENSEN; Niels FOGH-ANDERSEN; Inge-Lis KANSTRUP Nabumetone, a newer non-steroidal anti-inflammatory drug (NSAID) which preferentially blocks cyclo-oxygenase-2 activity, may be less nephrotoxic than indomethacin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 95 (3): 377–383.
Published: 01 September 1998
.... The response was inhibited by indomethacin, whereas the addition of cimetidine and propranolol had no effect on basal or thrombocyte-stimulated cAMP. 5. We conclude that noradrenaline in LP is a marker of the number of residual thrombocytes. The addition of thrombocytes to LP increased cAMP in lymphocytes...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (3): 225–229.
Published: 01 March 1998
...-oxygenase products to this modulation in small coronary arteries (approximately 200 μm internal diameter) from 20-week-old SHR and WKY under pressurized, no-flow conditions in an arteriograph. 2. Active pressure—diameter relationships were uninfluenced by the cyclo-oxygenase inhibitor indomethacin (10 μmol...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (4): 409–414.
Published: 01 April 1997
..., a dopadecarboxylase inhibitor, and indomethacin, an inhibitor of prostaglandin synthetase. 2. In a placebo-controlled, randomized study, 13 subjects received carbidopa (100 mg) and 12 received indomethacin (50 mg). Proximal and distal renal tubular Na + reabsorption were determined using exogenous lithium clearance...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (5): 525–529.
Published: 01 May 1993
...-oxygenase inhibitor indomethacin (3 mg/kg intravenously) restored pressor sensitivity to angiotensin II to normal, suggesting that cyclo-oxygenase products, possibily vasodilator prostaglandins, may be involved in mediating pressor resistance to this hormone in vivo. 23 12 1992 25 1 1993 ©...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (3): 307–311.
Published: 01 September 1992
...Pnina Scherzer; Hanna Wald; Dvora Rubinger; Mordecai M. Popovtzer 1. To further explore the Na + -retaining effect of indomethacin along the whole length of the nephron, the Na + -K + -ATPase activity of isolated tubules from indomethacin-pretreated rats was compared with that of tubules isolated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (3): 427–432.
Published: 01 September 1991
...A. A. El Sayed; J. Haylor; A. M. El Nahas 1. The response of the isolated rat kidney to a mixed amino acid solution was examined in the presence of three renal autacoid inhibitors, indomethacin (a cyclo-oxygenase inhibitor), sulpiride (a dopamine antagonist) and l -nitroarginine methyl ester...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (3): 367–372.
Published: 01 September 1991
...Jan E. Heeg; Paul E. de Jong; Dick de Zeeuw 1. Both the angiotensin-converting enzyme inhibitor, lisinopril, and the non-steroidal anti-inflammatory drug, indomethacin, lower urinary protein excretion in renal disease and improve the selectivity of the residual proteinuria. Despite the clearly...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 80 (5): 481–488.
Published: 01 May 1991
... of indomethacin, an inhibitor of prostaglandin synthesis, on the renal response to head-out water immersion in six healthy subjects on a 200 mmol of sodium/day diet and on a 40 mmol of sodium/day diet. 2. Indomethacin caused a similar degree of sodium retention on each of these two diets. 3. During the 40 mmol...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (2): 147–149.
Published: 01 August 1988
.... Indomethacin added to the serosal fluid reversed the direction of net Na + flux in secreting gallbladders and caused an absorption of Na + . In Na + -absorbing gallbladders, indomethacin caused a slight reduction in Na + absorption. No change in Na + flux was induced in gallbladders with no initial net Na...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 73 (4): 365–370.
Published: 01 October 1987
... increased significantly the fractional albumin and IgG clearances. The fractional dextran clearances of molecules with a radius ≥ 5.4 run also increased significantly after frusemide injection. Pretreatment with indomethacin partly inhibited the increments in clearances of macromolecules. 3. The changes...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 73 (4): 395–399.
Published: 01 October 1987
...Shozo Torikai 1. In order to explore the involvement of endogenous prostaglandin E 2 (PGE 2 ) in the urine concentration defect after ureteral occlusion, PGE 2 production by isolated collecting ducts in vitro and effects of indomethacin on urine osmolality in vivo were examined. 2. Twenty-four...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 73 (2): 151–157.
Published: 01 August 1987
...R. F. Jeffrey; T. M. MacDonald; M. Rutter; S. Freestone; J. Brown; R. R. Samson; M. R. Lee 1. The urine dopamine response to intravenous frusemide (30 mg) was investigated in 15 salt replete male volunteers. The effects of oral indomethacin (100 mg) and oral carbidopa (100 mg) given before...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 73 (1): 69–75.
Published: 01 July 1987
...M. A. McNurlan; K. C. McHardy; J. Broom; E. Milne; L. M. Fearns; P. J. Reeds; P. J. Garlick 1. Protein synthesis was measured in muscle of fed and fasted rats. Synthesis rates were 29% higher with feeding. Treatment with indomethacin before feeding completely blocked the stimulation of protein...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (5): 409–416.
Published: 01 May 1986
... were given from zero to 12 fmol min −1 kg −1 . Second, the AVP infusions were repeated after pretreatment with indomethacin, 150 mg daily for 36 h. 2. After the AVP infusions, plasma AVP concentrations did not change significantly and remained within the physiological range; in contrast, urinary AVP...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (3): 293–298.
Published: 01 September 1985
... studies were performed on indomethacin treated (prostaglandin deficient) and control anaesthetized water diuretic rats both before and during the addition of vasopressin in maximal (10 m-units) and supramaximal (100 m-units) concentrations. 3. Before the addition of vasopressin, indomethacin treatment...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (3): 327–336.
Published: 01 September 1985
.... Indomethacin is a NSAI drug with both renal and extrarenal cyclo-oxygenase inhibition properties. Sulindac is a relatively selective cyclooxygenase inhibitor said not to affect urinary prostaglandin excretion. 3. This study examines the relative effect on blood pressure of 4 weeks' treatment, with indomethacin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (5): 605–607.
Published: 01 May 1985
...A. Blanchart; N. Hernando; D. Fernández-Muñoz; L. Hernando; J. M. López-Novoa 1. Portal hypertension was produced experimentally in rats by partial constriction of the portal vein. 2. Twelve rats were injected daily with indomethacin, 4 mg/kg body weight, and 12 with the vehicle (80% ethanol, 0.5...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 67 (6): 579–583.
Published: 01 December 1984
...H. Vierhapper; J. Jörg; W. Waldhäusl 1. The effect of acetylsalicylic acid (ASA, 3 g/day for 3 days) and of indomethacin (IND, 150 mg/day for 3 days) on diuresis and on the excretion of prostaglandin E 2 (PGE 2 ) was studied in six healthy, male volunteers. After overnight deprivation the subjects...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 66 (6): 709–715.
Published: 01 June 1984
...L. Monnens; A. Jonkman; C. Thomas 1. Four boys with classical nephrogenic diabetes insipidus have been treated by indomethacin, by hydrochlorothiazide, and by the combination of indomethacin and hydrochlorothiazide. 2. Hydrochlorothiazide treatment was slightly more effective than indomethacin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 66 (4): 443–451.
Published: 01 April 1984
... after aggregation of the platelets produced contractile responses which were significantly greater than those produced by corresponding platelets added 20 min after aggregation. 3. When platelets were aggregated in the presence of indomethacin or the thromboxane synthetase antagonist 1-benzylimidazole...
Articles
Effects of Indomethacin on the Guinea-Pig Pulmonary Response to Intravenous Leukotrienes C 4 and D 4
Journal:
Clinical Science
Clin Sci (Lond) (1983) 65 (3): 281–287.
Published: 01 September 1983
.../kg) to control or indomethacin-pretreated (30 mg/kg) animals. 2. LT infusion to control animals caused decrements in G L , which were maximal at 30 s and persisted for 7.5 min (LTD 4 ) and 15 min (LTC 4 ), decrements in C dyn ., which were maximal at 30 s and persisted for 30 min, and hypotension. 3...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (4): 407–415.
Published: 01 April 1983
...), or triamterene (200 mg) or spironolactone (300 mg); B, the same subjects were pretreated for 3 days with indomethacin (150 mg daily), which was continued during the 3 day administration of the respective diuretics and during a 2 day post-diuretic period. 2. In study A, only triamterene provoked a rise in urinary...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 235s–237s.
Published: 01 October 1982
... < 0.005). 4. The stimulatory effect of arachidonic acid on kallikrein release is mediated by prostaglandins, since it can be prevented by the addition of indomethacin (1 μg/ml). 5. Our results demonstrate that kallikrein is released by the perfused kidney into the renal venous effluent...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 261s–263s.
Published: 01 October 1982
...A. Salvetti; R. Pedrinelli; A. Magagna; P. Ugenti 1. The finding that sulindac, in contrast to indomethacin, does not inhibit renal prostaglandins synthesis in humans, prompted us to study the role that systemic and/or renal prostaglandins can play in the pharmacological responses to captopril...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 265s–267s.
Published: 01 October 1982
...H. Witzgall; B. Scherer; P. C. Weber 1. Haemodynamic and hormonal actions of 100 mg of captopril (SQ 14 225) orally were tested in 12 healthy volunteers with and without indomethacin pretreatment. 2. Without indomethacin, mean arterial blood pressure was reduced at 30 and 60 min after captopril ( P...
Articles
P. E. de Jong, L. T. W. de Jong-Van Den Berg, D. de Zeeuw, A. J. M. Donker, H. Schouten, L. W. Statius van Eps
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (1): 53–58.
Published: 01 July 1982
...P. E. de Jong; L. T. W. de Jong-Van Den Berg; D. de Zeeuw; A. J. M. Donker; H. Schouten; L. W. Statius van Eps 1. The effects of indomethacin on water excretion during both vasopressin stimulation and inhibition were studied in control subjects and in patients with sickle cell anaemia. 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (6): 611–615.
Published: 01 June 1982
...H. Witzgall; F. Hirsch; B. Scherer; P. C. Weber 1. The acute haemodynamic and hormonal effects of 100 mg of captopril (SQ 14.225) orally were tested in twelve healthy men in the sodium replete state before and after indomethacin pre-treatment. 2. Without indomethacin, mean arterial blood pressure...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (4): 361–366.
Published: 01 April 1982
... structural vascular changes persisted for much longer. 3. Blood pressure in this model of hypertension was not affected by a 15 h infusion of either indomethacin or aprotinin. 4. The pattern of fall in blood pressure after removal of the clip was similar when animals were infused with either indomethacin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (2): 209–213.
Published: 01 February 1982
...H.-G. Güllner; D. J. Lakatua; F. C. Bartter 1. The effect of inhibition of prostaglandin synthesis on urinary excretion of free dopamine, a catecholamine thought to act as a renal natriuretic hormone, was examined in six normal women. 2. The volunteer subjects were treated with indomethacin (2 mg...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (1): 27–33.
Published: 01 January 1982
...M. L. Watson; A. T. Lambie; A. Thom; A. Ungar 1. Normal male subjects were given a rapid infusion of 3 litres of sodium chloride solution (150 mmol/l) with or without pretreatment with indomethacin. 2. There was marked individual variability in the rate at which the infused sodium chloride solution...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (6): 703–710.
Published: 01 December 1981
..., amounts of total collagenase were reduced. Production of prostaglandin E (PGE) were inhibited in a dose-dependent manner by hydrocortisone. 3. Indomethacin had no consistent effect on the production of TIMP by rheumatoid and osteoarthritic synovia, although it tended to depress production of collagenase...
Articles
M. E. Safar, A. F. Hornych, J. A. Levenson, A. Ch. Simon, G. M. London, J. L. Bariéty, P. L. Milliez
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 323s–325s.
Published: 01 December 1981
.... Indomethacin induced more pronounced haemodynamic changes in borderline than in sustained hypertensive patients, with a significant increase in arterial blood pressure and total peripheral resistance and a significant decrease in stroke volume and cardiac index. 4. Indomethacin significantly decreased arterial...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (5): 535–539.
Published: 01 November 1981
... disturbances associated with liver injury. 1 4 1981 13 4 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 angiotensin blood pressure indomethacin isoprenaline noradrenaline obstructive jaundice β-phenylethylamine tyramine Clinical Science (1981) 61,535...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (5): 641–648.
Published: 01 November 1981
..., indomethacin. 2. Colonic perfusion with sodium deoxycholate (1 and 2 mmol/l) reduced net water and sodium absorption, whereas at a concentration of 5 mmol/l it caused net fluid secretion. Deoxycholate dose-dependently increased protein and deoxyribonucleic acid (DNA) output into the perfusion fluid...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (4): 493–495.
Published: 01 October 1981
...P. L. Padfield; R. J. Grekin 1. The effect of 3 days' treatment with indomethacin on the renal response to infused vasopressin was assessed in eight healthy volunteer subjects. 2. Indomethacin produced significant weight gain and an increase in serum potassium without a change in creatinine...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 60 (5): 479–482.
Published: 01 May 1981
...J. L. Cangiano; Carmen Rodriguez-Sargent; L. Nascimento; M. Martinez-Maldonado 1. The effects of volume contraction and indomethacin on renin response were examined in spontaneously hypertensive rats and Wistar-Kyoto normotensive rats. Volume contraction was induced by frusemide or by salt...
Articles
Keishi Abe, Toru Ito, Makito Sato, Toshiaki Haruyama, KO Sato, Ken Omata, Masao Hiwatari, Yutaka Sakurai, Yutaka Imai, Kaoru Yoshinaga
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 141s–144s.
Published: 01 December 1980
... the inhibition of endogenous prostaglandin synthesis by indomethacin. However, the responses in low renin hypertension were different from those in normal renin hypertension. 4. In low renin hypertensive patients who responded to captopril, the hypotensive effect was abolished after the addition of indomethacin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (5): 397–400.
Published: 01 November 1980
...H.-G. Güllner; M. S. Kafka; F. C. Bartter 1. The effect of indomethacin, an inhibitor of prostaglandin synthesis, on number and sensitivity of α- and β-adrenoreceptors was studied in normal healthy volunteer subjects. 2. The subjects were studied under metabolic conditions. To achieve inhibition...
Articles
P. E. De Jong, L. T. W. De Jong-Van Den Berg, G. S. Sewrajsingh, H. Schouten, A. J. M. Donker, L. W. Statius Van Eps
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (4): 245–250.
Published: 01 October 1980
... excretion were increased. 2. During indomethacin administration there were significant falls in glomerular filtration rate, effective renal blood-flow, creatinine clearance and urea clearance in the patients with sickle cell anaemia; fractional urea excretion also fell markedly. In control subjects none...
Articles
H. J. Kramer, R. Düsing, B. Stinnesbeck, W. Prior, Angela Bäcker, Jutta Eden, J. Kipnowski, K. Glänzer, F. Krück
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (1): 67–70.
Published: 01 July 1980
... but statistically insignificant rise in excretion of prostaglandin F 2α was observed with hydrochlorothiazide. 3. The rise in urinary excretion of sodium after frusemide and hydrochlorothiazide was significantly reduced by indomethacin, which also abolished the potassium-sparing effect of spironolactone...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 58 (5): 415–418.
Published: 01 May 1980
...W. B. Campbell; Judith A. Zimmer 1. Since prostaglandins appear to mediate adrenergically stimulated renin release, the effect of indomethacin was examined on insulin-induced renin and catecholamine release in conscious rats. Insulin (10 units/kg subcutaneously) increased plasma renin activity from...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 58 (4): 337–340.
Published: 01 April 1980
...Elizabeth Craig; G. J. Cooney; A. G. Dawson 1. The metabolism of glycerol by isolated rat-kidney tubules was investigated. 2. Indomethacin, at a concentration of 0.1 mmol/l, markedly inhibited the utilization of glycerol and its conversion into glucose and CO 2 . 3. The glycerol 3-phosphate...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (4): 359–365.
Published: 01 October 1979
...J. Colina-Chourio; J. C. McGiff; A. Nasjletti 1. To test the hypothesis that endogenous prostaglandins contribute to the regulation of blood pressure, we studied the effect of an inhibitor of prostaglandin synthesis, indomethacin, on mean aortic blood pressure in the normotensive, unanaesthetized...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 151s–153s.
Published: 01 December 1978
... (544 μmol)/day; and hydrochlorothiazide, 50 mmol of sodium and indomethacin 100 mg (287 μmol)/day. 2. Although blood pressure remained unchanged and serum potassium fell on diuretic with or without low salt, there was a marked increase of active renin and a lesser increase of inactive renin, resulting...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 155s–157s.
Published: 01 December 1978
...K. W. Rumpf; B. Schächterle; S. Schmidt; K. Becker; F. Scheler 1. The response of active and inactive plasma renin to orthostasis and frusemide and to inhibition of prostaglandin synthesis by indomethacin was tested in normal human volunteers. 2. Active renin increased by orthostasis and frusemide...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 203s–205s.
Published: 01 December 1978
...J. A. Lopez-Ovejero; M. A. Weber; J. I. M. Drayer; J. E. Sealey; J. H. Laragh 1. Indomethacin was administered alone or in addition to either diuretic or propranolol therapy to three groups of patients with essential hypertension on a free sodium diet. 2. Indomethacin administration reduced renin...
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