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Keywords: hypoxia-inducible factors
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Clin Sci (Lond) (2021) 135 (19): 2285–2305.
Published: 13 October 2021
... by pharmacologically raising levels of its transducers, the hypoxia-inducible factors (HIFs). We aimed to assess the potential role of a selective inhibitor of HIF degradation in 70% hepatectomy (70%Hx). Methods: In a pilot study, we tested the required dose of roxadustat to stabilize liver HIF1α. We then performed 70...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (7): 621–623.
Published: 17 March 2017
... has been confirmed. More specifically, the transcription factor, hypoxia-inducible factor-1α (HIF1α), was demonstrated to be a necessary component for regulating the expression of extracellular matrix modifying enzymes and their endogenous inhibitors in these cells. This new discovery may lead...