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Keywords: hypoxia
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Clin Sci (Lond) (2021) 135 (24): 2781–2791.
Published: 22 December 2021
... (S1P) are associated with disrupted endothelial cell (EC) barriers, lymphopenia and reduced responsivity to hypoxia. Total S1P levels were also reduced in 23 critically ill patients with coronavirus disease 2019 (COVID-19), and the two main S1P carriers, serum albumin (SA) and high-density lipoprotein...
Clin Sci (Lond) (2021) 135 (23): 2607–2618.
Published: 08 December 2021
... via treated-cell administration and stabilised hypoxia-inducible factor (HIF)-1α HPC, or mimicked HPC. The purpose of this review is to present the latest developments in the literature on HPC in the context of renal IRI in pre-clinical models. The data we compiled suggest that preconditional...
Clin Sci (Lond) (2020) 134 (6): 593–607.
Published: 24 March 2020
... within sEVs isolated from HTR-8/SVneo cells (a commonly used EVT model) cultured at 1% (hypoxia) compared with 8% (normoxia) oxygen. Among these differentially abundant proteins, 206 were up-regulated and 301 were down-regulated ( P < 0.05), and they were mainly implicated in inflammation-related...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (12): 1271–1280.
Published: 17 June 2019
... rate with some strains reported as being totally drug resistant. Host-directed therapies (HDTs) attempt to overcome the evolution of antibiotic resistance by targeting relatively immutable host processes. Here, I hypothesise the induction of hypoxia via anti-angiogenic therapy will be an efficacious...
Clin Sci (Lond) (2018) 132 (20): 2261–2267.
Published: 29 October 2018
... (SMCs) is regulated by hypoxia and through the endothelin A (ET A ) receptor. SMCs from fibroids (fSMC) and the adjacent myometrium smooth muscle cells (mSMCs) were extracted from ten women undergoing hysterectomy for uterine fibroids and cultured with or without 1.0 µM of an ET A receptor antagonist...
Clin Sci (Lond) (2018) 132 (2): 273–284.
Published: 25 January 2018
... the impact of maternal hypoxia-induced IUGR on airway responsiveness in male and female mice during juvenility and adulthood. Pregnant BALB/c mice were housed under hypoxic conditions for gestational days 11–17.5 and then returned to normoxic conditions for the remainder of pregnancy. A control group...
Clin Sci (Lond) (2017) 131 (20): 2503–2524.
Published: 13 October 2017
.... Here we consider the potential pathogenic role of tissue hypoxia in lesion development, arising partly from the vascular anatomy of the affected white matter. Specifically, these regions are supplied by a sparse vasculature fed by long, narrow end arteries/arterioles that are vulnerable to oxygen...
Clin Sci (Lond) (2017) 131 (1): 27–36.
Published: 09 December 2016
...% compared with 50%, P =0.04). Subcutaneous tumour volume was increased in HFD mice (+64% compared with FR and SC, P =0.03). Metformin significantly decreased subcutaneous tumour growth via cell-cycle block and mammalian target of rapamycin (mTOR) pathway inhibition, and also induced hypoxia and decreased...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (4): 363–374.
Published: 27 May 2015
...Jong-Shyan Wang; Ya-Lun Chang; Yi-Ching Chen; Hsing-Hua Tsai; Tieh-Cheng Fu Exercise and hypoxia paradoxically modulate vascular thrombotic risks. The shedding of procoagulant-rich microparticles from monocytes may accelerate the pathogenesis of atherothrombosis. The present study explores...
Clin Sci (Lond) (2015) 128 (11): 805–823.
Published: 19 March 2015
... review is to discuss the implication of PEDF in diabetic and hypoxia-induced angiogenesis, and the pathways mediating PEDF's effects under these conditions. Furthermore, the regulatory mechanisms of PEDF expression, function and degradation are also reviewed. Finally, the therapeutic potential of PEDF...
Clin Sci (Lond) (2015) 128 (7): 425–436.
Published: 16 December 2014
... or MCT effectively ameliorates neutrophil/NDMP-promoted TG by down-regulating expression of procoagulant factors during HE, which may reduce thrombotic risk evoked by hypoxia. Moreover, either AIT or MCT effectively ameliorates neutrophil/NDMP-promoted TG by down-regulating expression of procoagulant...
Clin Sci (Lond) (2014) 126 (9): 661–670.
Published: 17 January 2014
... was maintained by increased CBF. Cerebral metabolic rates for oxygen, glucose and lactate remained unaltered during progressive hypoxia. Consequently, cerebral glucose delivery was in excess of that required, and net lactate efflux increased slightly in severe hypoxia, as reflected by a small increase in jugular...
Clin Sci (Lond) (2014) 126 (6): 425–440.
Published: 25 November 2013
... on HDAC2 (histone deacetylase 2) modification and activation of the Nrf2 (nuclear factor erythroid-related factor 2) and HIF-1α (hypoxia-inducible factor-1α) signalling pathways. Male C57BL/6 mice were exposed to ozone (3 p.p.m.) for 3 h a day, twice a week for a period of 1, 3 or 6 weeks. Control mice...
Clin Sci (Lond) (2014) 126 (5): 367–375.
Published: 13 November 2013
...Kou-Gi Shyu; Wen-Pin Cheng; Bao-Wei Wang; Hang Chang The expression of MURC (muscle-restricted coiled-coil protein), a hypertrophy-regulated gene, increases during pressure overload. Hypoxia can cause myocardial hypertrophy; however, how hypoxia affects the regulation of MURC in cardiomyocytes...
Clin Sci (Lond) (2013) 125 (10): 461–470.
Published: 16 July 2013
... and functions in a hypoxic environment. The resident chondrocytes have adapted to hypoxia and use it to drive their tissue-specific functions. In the present study, we explored directly in normal articular chondrocytes isolated from a range of human donors the effect of hypoxia on PTHrP expression and whether...
Includes: Supplementary data
Clin Sci (Lond) (2013) 124 (10): 639–649.
Published: 04 February 2013
...Yu-Wen Chen; Yi-Ching Chen; Jong-Shyan Wang HS (high shear) stress associated with artery stenosis facilitates TG (thrombin generation) by increasing the release of procoagulant PDMPs (platelet-derived microparticles). Physical exercise and hypoxia may paradoxically modulate vascular thrombotic...
Clin Sci (Lond) (2013) 124 (1): 53–63.
Published: 07 September 2012
... into the molecular events underlying the association between liver enzymes and CVD, we developed an HFD (high-fat diet)-induced NAFLD in the SHR (spontaneously hypertensive rat) and its control WKY (Wistar–Kyoto) rat strain. We hypothesized that hepatic induction of Hif1a (hypoxia-inducible factor 1α) might...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (3): 121–132.
Published: 11 October 2011
..., the effect of ischaemia and reperfusion on PVs and the atria has not yet been fully elucidated. In the present study, conventional microelectrodes were used to record the APs (action potentials) in isolated rabbit PV, LA (left atrium) and RA (right atrium) specimens during hypoxia and reoxygenation...
Clin Sci (Lond) (2011) 121 (8): 343–353.
Published: 24 June 2011
...Jong-Shyan Wang; Tzu-Pin Weng The cytotoxic functions of NKs (natural killer cells) are critical in enabling the immune system to cope efficiently with malignancy. In the present study, we compared how various exercise regimens without/with hypoxia influence phenotypic characteristics of NK subsets...
Clin Sci (Lond) (2009) 116 (11): 805–817.
Published: 01 May 2009
...Jong-Shyan Wang; Huang-Chun Liu ROS (reactive oxygen species) generated by hypoxia facilitate the vascular inflammatory response, but whether systemic hypoxia influences leucocyte bactericidal activity by modulating circulatory redox status remains unclear. The present study elucidates how various...
Clin Sci (Lond) (2007) 113 (8): 357–364.
Published: 12 September 2007
.... This was associated with a significant attenuation of both basal and hypoxia/re-oxygenation-induced collagen production by the fibroblasts. Cytokine production, specifically TGFβ (transforming growth factor β), by these cells was also significantly attenuated by ACE2 expression. Collectively, these results indicate...
Clin Sci (Lond) (2006) 111 (1): 61–70.
Published: 14 June 2006
...Jens Michelsen; Helle Thiesson; Steen Walter; Peter D. Ottosen; Ole Skøtt; Boye L. Jensen The peptide AM (adrenomedullin) is stimulated by hypoxia through HIF-1 (hypoxia-inducible factor-1). The majority of human CC-RCCs (clear cell renal cell carcinomas) display mutations in the tumour suppressor...
Clin Sci (Lond) (2006) 110 (6): 683–692.
Published: 15 May 2006
... muscle. Correspondence: Dr Charles S. Fulco (email Charles.fulco@us.army.mil ). 28 7 2005 25 1 2006 27 2 2006 27 2 2006 The Biochemical Society 2006 acute mountain sickness acetazolamide fatigue hypoxia isolated muscle exercise metabolic acidosis ventilation...
Clin Sci (Lond) (2006) 110 (1): 133–141.
Published: 12 December 2005
... production. However, the effect of a single bout of moderate aerobic exercise performed in either relative or absolute normobaric hypoxia on free radical production and lipid peroxidation remains unknown. To examine this, we randomly matched {according to their normobaric normoxic V ̇ O 2peak [peak V ̇ O 2...
Clin Sci (Lond) (2005) 109 (3): 319–324.
Published: 24 August 2005
...Colin W. M. Chan; Helen Hoar; Kyle Pattinson; Arthur R. Bradwell; Alexander D. Wright; Christopher H. E. Imray; Expeditionary Society the Birmingham Medical Research Phosphodiesterase-5 inhibitors decrease hypoxic pulmonary vasoconstriction under hypobaric hypoxia, but are not known to affect...
Clin Sci (Lond) (2004) 107 (2): 213–220.
Published: 27 July 2004
... was inserted in the tunica media. Hypoxic vasodilation, interstitial lactate/pyruvate ratio and interstitial glucose were measured at low (2 mM) and high (20 mM) glucose concentrations. Hypoxia (60 min) caused vasodilation and doubled the lactate/pyruvate ratio. Treatment with insulin quadrupled the lactate...
Clin Sci (Lond) (2003) 104 (3): 231–238.
Published: 07 February 2003
... 29 11 2002 The Biochemical Society and the Medical Research Society © 2003 2003 baroreceptor reflex blood pressure heart failure hypoxia sleep apnoea sympathetic nervous system 231Clinical Science (2003) 104, 231 238 (Printed in Great Britain) Augmented sympathetic neural...
Clin Sci (Lond) (2002) 103 (s2002): 464S–466S.
Published: 01 September 2002
...). The results indicate that hypoxia increased the basal level of ET-1 production by HMEC-1 cells after 24 or 48h of treatment. However, the co-incubation of HMEC-1 cells with pRBCs, but not with uninfected RBCs, induced a dose-dependent decrease of both constitutive and hypoxia-induced ET-1 production...
Clin Sci (Lond) (2002) 102 (3): 253–268.
Published: 11 February 2002
... of pulmonary vascular biology and the prospects for improving the treatment of pulmonary hypertension. Correspondence: Professor M. R. Wilkins (e-mail m.wilkins@ic.ac.uk ). The Biochemical Society and the Medical Research Society © 2002 2002 BMP type II receptor genetic predisposition hypoxia...
Clin Sci (Lond) (2001) 101 (5): 465–475.
Published: 21 September 2001
... respectively). During the intermittent phase, the normoxic and hypoxic groups each trained for 4 weeks at the same relative exercise intensity, under conditions of normoxia and hypoxia respectively. During acute exercise under hypoxic conditions, the venous concentrations of lipid hydroperoxides...
Clin Sci (Lond) (2001) 101 (4): 377–383.
Published: 14 September 2001
... the first exercise session. Compared with sea level, hypoxia progressively decreased the maximal heart rate from day 1 and onwards; also, hypoxia by itself increased plasma noradrenaline levels after maximal exercise. Domperidone further increased maximal noradrenaline concentrations, but had no effect...
Clin Sci (Lond) (2000) 98 (4): 375–380.
Published: 24 February 2000
... apoptosis. Altered regulation of apoptosis may play an important pathophysiological role in FGR. As reduced placental perfusion and reduced oxygenation are features of FGR, one aim of this study was to determine the effects of hypoxia on apoptotic activity, as assessed by DNA laddering, of placental tissue...
Clin Sci (Lond) (2000) 98 (3): 329–337.
Published: 10 February 2000
... of hypoxia-induced MVC and M-wave changes. At rest, a significant decrease in M-wave amplitude was noted at 5000 m. This effect was associated with a prolonged M-wave conduction time at 6000 m and an increased M-wave duration at 7000 m, and persisted after the return to 0 m. Re-oxygenation did not modify...
Clin Sci (Lond) (2000) 98 (1): 39–45.
Published: 22 November 1999
... and 2100 m). Five subjects were exposed to normobaric hypoxia ( F I O 2 = 0.159), seven subjects underwent plasmapheresis to reduce plasma volume and eight subjects were time controls for Epo levels. Oxyhaemoglobin saturation was significantly reduced during exercise and during normobaric hypoxia. The time...
Clin Sci (Lond) (1999) 96 (5): 499–506.
Published: 14 April 1999
... Society and the Medical Research Society © 1999 1999 diabetes dyspnoea hypoxia lung mechanics respiratory muscles 499Clinical Science (1999) 96, 499ñ506 (Printed in Great Britain) Dyspnoea, peripheral airway involvement and respiratory muscle effort in patients with Type I diabetes mellitus...
Clin Sci (Lond) (1999) 96 (2): 147–153.
Published: 01 February 1999
...Jacopo P. MORTOLA; Fabiola LEÓN-VELARDE; Lourdes AGUERO; Peter B. FRAPPELL In fetuses and newborn infants heart rate variability changes in conditions of acute and chronic hypoxia; we therefore asked whether heart rate variability of infants born at high altitude differed from that of low-altitude...
Clin Sci (Lond) (1998) 94 (4): 453–460.
Published: 01 April 1998
... explain some of the gas-exchange abnormalities observed in physiologically hyperfused lungs and in patients with one hyperfused lung. 18 11 1997 27 11 1997 © 1998 The Biochemical Society and the Medical Research Society 1998 blood gases catheters hypoxia microspheres sheep...
Clin Sci (Lond) (1997) 93 (4): 349–354.
Published: 01 October 1997
...Jacopo P. Mortola; Lina Naso 1. Hypoxia is known to decrease thermogenesis. We set out to determine whether this is accompanied by alterations in the brown adipose tissue, which is a major source of non-shivering thermogenesis. 2. Measurements were performed on 25- and 64-day-old rats, after 4 days...
Clin Sci (Lond) (1997) 92 (6): 593–598.
Published: 01 June 1997
...Andrew J. Pollard; Peter W. Barry; Nick P. Mason; David J. Collier; Rachel C. Pollard; Peter F. A. Pollard; Isla Martin; R. Scott Fraser; Martin R. Miller; James S. Milledge 1. Both hypoxia and hypocapnia can cause broncho-constriction in humans, and this could have a bearing on performance at high...
Clin Sci (Lond) (1997) 92 (5): 453–454.
Published: 01 May 1997
... Society and the Medical Research Society 1997 hypoxia myocardial infarction reperfusion therapy vascular endothelial growth factor Clinical Science (1997) 92,453-454 (Printed in Great Britain) 453 Rapid Communication Serum levels of vascular endothelial growth factor in patients with acute...
Clin Sci (Lond) (1996) 91 (2): 213–218.
Published: 01 August 1996
... of the RNA. 2. The normally low level of pancreatitis-associated protein mRNA in pancreas increased severalfold after 6 h of hypoxia, reaching peak levels (approximately 10-fold greater than normal) after 24 h hypoxia. After 3 days' hypoxia pancreatitis-associated protein mRNA levels were again undetectable...
Clin Sci (Lond) (1996) 90 (1): 81–85.
Published: 01 January 1996
... altitude. Although the key to protection against cerebral hypoxia cannot be established, it is possible that an increase in the usually short period of acclimatization could minimize brain damage in those low-landers who attempt the highest summits without supplementary oxygen. Clinical Science (1996) 90...
Clin Sci (Lond) (1995) 89 (3): 273–276.
Published: 01 September 1995
...Evelyn A. Millar; Robert M. Angus; Jane E. Nally; Robin Clayton; Neil C. Thomson 1. We have reported that the renin-angiotensin system is activated in acute asthma, and also by high-dose nebulized β 2 -agonists. The contribution of other possible stimuli such as hypoxia is unknown. The present...
Clin Sci (Lond) (1995) 88 (3): 345–350.
Published: 01 March 1995
... that at high altitude the contribution of the phasic volume-dependent vagal input to the inspiratory off-switch threshold is higher, and that the tonic vagal expiratory facilitation is lower, than at low altitude, presumably because of hypoxia. The larger V T and longer T E of the HA infant cannot be explained...
Clin Sci (Lond) (1993) 85 (2): 229–236.
Published: 01 August 1993
... analogue scaling as a means of improving the temporal resolution of this measurement. 2. Six normal naive subjects scaled breathlessness using a visual analogue scale, during steady-state exercise. Further changes in this sensation were induced by either sustained hypercapnia or acute hypoxia...
Clin Sci (Lond) (1993) 85 (1): 105–109.
Published: 01 July 1993
... ethics committee, and all patients (and their parents if under 17 years old) gave their informed and written consent to the study. Key words: congenital heart diswe, cyanosis, hypoxia. nuclear magnetic resonance spectroscopy, polycythaemia, skeletal muscle. Abbreviations: PCr, phosphocreatine; pHi...
Clin Sci (Lond) (1992) 83 (5): 633–636.
Published: 01 November 1992
...Thomas E. Schlaepfer; Peter Bärtsch; Hans U. Fisch 1. Prolonged (> 10h) exposure to hypoxia and high altitude (> 5000 m) invariably have detrimental effects on cognitive performance. Paradoxically, mild improvements in cognitive function in patients with chronic obstructive pulmonary disease...
Clin Sci (Lond) (1991) 81 (6): 751–758.
Published: 01 December 1991
...-' while the animals were breathing 10% oxygen. Hypoxaemia alone (arterial partial Key words: antidiuretic hormone, cardiac output, hypoxia, metabolism, oxygen consumption, regional blood flows. pressure of oxygen 4.67 kPa) decreased whole-body oxygen delivery by 30%. The fall in whole-body oxygen...
Clin Sci (Lond) (1991) 80 (2): 107–112.
Published: 01 February 1991
... to isocapnic hypoxia. 2. The subjects underwent hypoxic rebreathing manoeuvres after 3-day pretreatments with each of the drugs for 12 h and were at least 2 h postprandial. For each in-Minute ventilation, the maximum rate of isometric inspiratory pressure development at the mouth and the ratio of inspiratory...
Clin Sci (Lond) (1990) 78 (6): 541–545.
Published: 01 June 1990
... simuli is increased in obese subjects who maintain adequate alveolar ventilation while awake. 22 1 1990 30 1 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 control of breathing hypercapnia hypoxia obesity ventilation Clinical Science (1990) 78, 541...