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Macarena Orejudo, Ana B. García-Redondo, Raúl R. Rodrigues-Diez, Raquel Rodrigues-Díez, Laura Santos-Sanchez, Antonio Tejera-Muñoz, Jesús Egido, Rafael Selgas, Mercedes Salaices, Ana M. Briones, Marta Ruiz-Ortega
Clin Sci (Lond) (2020) 134 (5): 513–527.
Published: 09 March 2020
... smooth muscle cell (VSMC) hypertrophy and phenotype changes, in the absence of extracellular matrix (ECM) proteins accumulation. Accordingly, treatment with an IL-17A neutralizing antibody diminished SMA remodeling in a model of angiotensin II (Ang II) infusion. Moreover, in vitro studies in VSMCs...
Clin Sci (Lond) (2017) 131 (13): 1375–1392.
Published: 23 June 2017
... Limited on behalf of the Biochemical Society 2017 arrhythmogenic right ventricular (ARVC) cardiomyocyte cardiomyopathy dilated cardiomyopathy (DCM) heart failure hypertrophic cardiomyopathy (HCM) hypertrophy primary cardiomyopathy restrictive cardiomyopathy (RCM) Cardiomyopathy...
Clin Sci (Lond) (2016) 130 (10): 747–759.
Published: 01 April 2016
... variability between patients and the dynamic nature of pregnancy hampers interpretation of smaller studies, but some facts are consistent. Gestational cardiac hypertrophy and a physical shift of the heart contribute to changes in the ECG. There are also electrical changes such as an increased heart rate...
Zhi Zeng, Liang Shen, Xixian Li, Tao Luo, Xuan Wei, Jingwen Zhang, Shiping Cao, Xiaobo Huang, Yasushi Fukushima, Jianping Bin, Masafumi Kitakaze, Dingli Xu, Yulin Liao
Clin Sci (Lond) (2014) 127 (7): 435–448.
Published: 17 June 2014
... apoptosis through lowering of mitochondrial permeability in cardiomyocytes, finally achieving the goal of improving heart failure. apoptosis calcineurin fibrosis histamine H 2 receptor hypertrophy The shRNA cassettes of Ppp3ca (calcineurin-α, NM_017041.1) were cloned into the lentivirus...
Includes: Supplementary data
Clin Sci (Lond) (2010) 119 (11): 453–463.
Published: 17 August 2010
... (renin–angiotensin–aldosterone system) to exert its effects. In numerous genetically modified animal models, non-specific or organ-targeted ET-1 overexpression causes intense organ damage, especially hypertrophy and fibrosis, in the absence of haemodynamic changes, confirming a local activity of the ET...
Xiaojian Wang, Xu Yang, Kai Sun, Jingzhou Chen, Xiaodong Song, Hu Wang, Zhe Liu, Changxin Wang, Channa Zhang, Rutai Hui
Clin Sci (Lond) (2010) 118 (2): 137–145.
Published: 19 October 2009
... in the process of hypertrophy. In the present study, we have investigated the relationship between GDF15 gene variants and left ventricular hypertrophy in human essential hypertension. A community-based hypertensive population sample of 1527 individuals (506 men and 1021 women) was genotyped for three GDF15...
Includes: Supplementary data
Clin Sci (Lond) (2008) 115 (7): 203–218.
Published: 03 September 2008
..., but the role of individual signalling proteins in the pathogenesis of various cardiovascular diseases is still being elucidated. In the present review, the role of the MAPKs ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase) and p38 MAPK in cardiac hypertrophy, cardiac remodelling after...
Maurício M. Lopes, Gustavo C. A. Ribeiro, Thais F. Tornatore, Carolina F. M. Z. Clemente, Vicente P. A. Teixeira, Kleber G. Franchini
Clin Sci (Lond) (2007) 113 (4): 195–204.
Published: 13 July 2007
... Cardiac diseases often result in adverse remodelling of the left ventricle and progression to heart failure. Complex alterations of the architecture of the myocardium, including hypertrophy and loss of cardiac myocytes as well as interstitial fibrosis, lead to contractile and relaxing dysfunctions...
Philippa J. Talmud, David M. Flavell, Khaled Alfakih, Jackie A. Cooper, Anthony J. Balmforth, Mohan Sivananthan, Hugh E. Montgomery, Alistair S. Hall, Steve E. Humphries
Clin Sci (Lond) (2007) 112 (12): 617–624.
Published: 14 May 2007
...Philippa J. Talmud; David M. Flavell; Khaled Alfakih; Jackie A. Cooper; Anthony J. Balmforth; Mohan Sivananthan; Hugh E. Montgomery; Alistair S. Hall; Steve E. Humphries LVH [LV (left ventricular) hypertrophy] is an independent risk factor for CHD (coronary heart disease). During LVH, the preferred...
Clin Sci (Lond) (2002) 103 (s2002): 276S–279S.
Published: 01 September 2002
... on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr Bernhard R. Brehm (e-mail email@example.com ). © 2002 The Biochemical Society and the Medical Research Society 2002 endothelin-1 hypertrophy protein kinase C ...
Clin Sci (Lond) (2002) 103 (s2002): 148S–151S.
Published: 01 September 2002
... the influence of various agonists or physical stress that, in the long term, also lead to development of hypertrophy. Previously, we identified three different Cl - channel activities in neonatal rat cardiomyocytes: (i) Ca 2+ regulated, (ii) cAMP regulated (cystic fibrosis transmembrane conductance regulator Cl...
Clin Sci (Lond) (2002) 102 (4): 411–416.
Published: 04 March 2002
...Leong L. NG; Russell J. O'BRIEN; Bettina DEMME; Sonja JENNINGS Cardiotrophin-1 (CT-1) leads to a specific form of ventricular hypertrophy characterized by sarcomeres added in series, and has been reported to be elevated in heart failure. Previous competitive assays for CT-1 necessitate...
Clin Sci (Lond) (2001) 101 (1): 79–85.
Published: 12 June 2001
...Jenny A. DEAGUE; Catherine M. WILSON; Leeanne E. GRIGG; Stephen B. HARRAP Left ventricular hypertrophy is an independent cardiovascular risk factor. In hypertensives, the pattern of hypertrophy is influenced by central haemodynamic characteristics. Central haemodynamics may also determine...
Alison J. MACKAY, Carlene A. HAMILTON, Kenneth McARTHUR, Geoffrey BERG, Anne-Isabelle TROPEANO, Pierre BOUTOUYRIE, John L. REID, Anna F. DOMINICZAK
Clin Sci (Lond) (2001) 100 (5): 509–516.
Published: 03 April 2001
.... Correspondence : Dr A. J. Mackay (e-mail firstname.lastname@example.org ). 19 9 2000 14 12 2000 26 1 2001 The Biochemical Society and the Medical Research Society © 2001 2001 vasculature pathophysiology ultrasound atherosclerosis hypertension radial artery hypertrophy...
Clin Sci (Lond) (1999) 97 (3): 377–383.
Published: 06 August 1999
... hypertrophy left ventricle M-mode, population 377Clinical Science (1999) 97, 377 383 (Printed in Great Britain) Discrepancies between echocardiographic measurements of left ventricular mass in a healthy adult population Jenny A. DEAGUE Catherine M. WILSON , Leeanne E. GRIGG and Stephen B. HARRAP...
Clin Sci (Lond) (1997) 92 (2): 181–188.
Published: 01 February 1997
... myocytes in primary culture. Increased proto-oncogene expression has been implicated in the development of cardiac hypertrophy; we therefore wished to examine the effects of overexpression of the c- myc and c- fos proto-oncogenes induced by cell transfection on cell growth. 2. Neonatal rat ventricular...
Clin Sci (Lond) (1996) 90 (6): 447–452.
Published: 01 June 1996
... ventricular tachycardia. 6. Myocardium distant from infarction in patients with ischaemic heart disease has a normal pattern of connexin43 gap junction distribution, but has a 47% reduction in gap junction surface area per unit cell volume, and a 30% reduction per cell. 7. In hypertrophied myocardium from...
Martin Muntzel, Thierry Hannedouche, Roberte Niesor, Laure-Helène Nöel, Jean-Claude Souberbielle, Bernard Lacour, Tilman Drüeke
Clin Sci (Lond) (1992) 83 (5): 575–581.
Published: 01 November 1992
...Martin Muntzel; Thierry Hannedouche; Roberte Niesor; Laure-Helène Nöel; Jean-Claude Souberbielle; Bernard Lacour; Tilman Drüeke 1. To determine whether treatment with octreotide, a somatostatin analogue, may diminish or prevent long-term diabetic renal hypertrophy and nephropathy, uninephrectomized...
James J. Morton, Elisabeth C. Beattie, Sheila A. Griffin, Fiona MacPherson, Fiona Lyall, Domenico Russo
Clin Sci (Lond) (1990) 79 (5): 523–530.
Published: 01 November 1990
... and in the WIS 75.1 ± 7.8 mmHg ( P < 0.001). 6. These data indicate the presence of marked vascular and cardiac hypertrophy in the SHR at a very early period in its development. Blood pressure is elevated and there is no overactivity of the renin system. We conclude that, at this time...
Clin Sci (Lond) (1989) 77 (2): 205–211.
Published: 01 August 1989
... veins, portal pressure is a primary determinant of media thickness but not of lumen diameter. 11 1 1989 23 1 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 contractility hypertrophy mesenteric veins oesophageal varices Clinical Science (1 989...
Clin Sci Mol Med (1976) 51 (6): 551–555.
Published: 01 December 1976
... and the Medical Research Society 1976 deoxyribonucleic acid diabetes hyperplasia hypertrophy kidney ribonucleic acid Clinical Science and Molecular Medicine (1976) 51, 551-555. Renal hypertrophy in streptozotocin-diabetic rats K. SEYER-HANSEN Second University Clinic of Internal Medicine...