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Keywords: hypertension
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Articles

Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease

Erin B. Taylor, William J Kalusche, Clinton T Case
Journal: Clinical Science
Clin Sci (Lond) (2023) CS20230924.
https://doi.org/10.1042/CS20230924
Published: 29 November 2023
... properties, including promoting the expansion of proinflammatory T lymphocytes and the proliferation and survival of B cells. In the present study, we hypothesized that leptin antagonism would improve B and T cell dysfunction and attenuate hypertension in an experimental model of SLE, the NZBWF1 mouse...
View article titled, Leptin antagonism attenuates <span class="search-highlight">hypertension</span> and renal injury in an experimental model of autoimmune disease
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Articles

Novel avenues to control blood pressure: targeting the renal lymphatic system

Andreia Zago Chignalia
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 597–601.
https://doi.org/10.1042/CS20220775
Published: 19 April 2023
...Andreia Zago Chignalia Hypertension is associated with the activation of the immune and lymphatic systems as well as lymphangiogenesis. The changes in the lymphatic system are considered an adaptive response to mitigate the deleterious effects of immune and inflammatory cells on the cardiovascular...
View article titled, Novel avenues to control blood pressure: targeting the renal lymphatic system
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Articles

Skin-specific mechanisms of body fluid regulation in hypertension

Jun Yu Chen, Khai Syuen Chew, Sheon Mary, Philipp Boder, Domenico Bagordo, Gian Paolo Rossi, Rhian M. Touyz, Christian Delles, Giacomo Rossitto
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (3): 239–250.
https://doi.org/10.1042/CS20220609
Published: 07 February 2023
...Jun Yu Chen; Khai Syuen Chew; Sheon Mary; Philipp Boder; Domenico Bagordo; Gian Paolo Rossi; Rhian M. Touyz; Christian Delles; Giacomo Rossitto Increasing evidence suggests excess skin Na + accumulation in hypertension; however, the role of skin-specific mechanisms of local Na + /water regulation...
View article titled, Skin-specific mechanisms of body fluid regulation in <span class="search-highlight">hypertension</span>
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Includes: Supplementary data
Articles

Genetically inducing renal lymphangiogenesis attenuates hypertension in mice

Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (23): 1759–1772.
https://doi.org/10.1042/CS20220547
Published: 02 December 2022
...Bethany L. Goodlett; Dakshnapriya Balasubbramanian; Shobana Navaneethabalakrishnan; Sydney E. Love; Emily M. Luera; Sunitha Konatham; Valorie L. Chiasson; Sophie Wedgeworth; Joseph M. Rutkowski; Brett M. Mitchell Background: Hypertension (HTN) is associated with renal proinflammatory immune cell...
View article titled, Genetically inducing renal lymphangiogenesis attenuates <span class="search-highlight">hypertension</span> in mice
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Includes: Supplementary data
Articles

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1661–1681.
https://doi.org/10.1042/CS20220607
Published: 21 November 2022
.... with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hypertension) is associated with additional features including increased fibrosis and can lead to heart failure. RAF kinases (ARAF/BRAF/RAF1) integrate signals into the extracellular signal-regulated...
View article titled, Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice
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Includes: Supplementary data
Articles

Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure

Pedro Alves Soares Vaz de Castro, Pedro A. Jose, Ana Cristina Simões e Silva
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (16): 1205–1227.
https://doi.org/10.1042/CS20220338
Published: 18 August 2022
...Pedro Alves Soares Vaz de Castro; Pedro A. Jose; Ana Cristina Simões e Silva Systemic arterial hypertension is one of the leading causes of morbidity and mortality in the general population, being a risk factor for many cardiovascular diseases. Although its pathogenesis is complex and still poorly...
View article titled, Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure
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Articles

Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction

Shobana Navaneethabalakrishnan, Brooke K. Wilcox, Bethany L. Goodlett, Malea M. Murphy, Brett M. Mitchell
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 879–894.
https://doi.org/10.1042/CS20220117
Published: 06 June 2022
...Shobana Navaneethabalakrishnan; Brooke K. Wilcox; Bethany L. Goodlett; Malea M. Murphy; Brett M. Mitchell Hypertension (HTN) is associated with gonadal dysfunction and impaired reproductive health in both men and women. An imbalance in the systemic and renal proinflammatory (M1)/anti-inflammatory...
View article titled, <span class="search-highlight">Hypertension</span> induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction
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Includes: Supplementary data
Articles

Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension

Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 803–817.
https://doi.org/10.1042/CS20220226
Published: 30 May 2022
... channel in the neuronal development, but its potential roles in vascular Ca V 1.2 channels and vasoconstriction remain undefined. Here, we detect Rbfox1 is expressed in rat vascular smooth muscles. Moreover, the protein level of Rbfox1 is dramatically decreased in the hypertensive small arteries from...
View article titled, Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in <span class="search-highlight">hypertension</span>
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Includes: Supplementary data
Articles

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

In Collection
Cardiovascular-Oncology
Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (9): 675–694.
https://doi.org/10.1042/CS20220182
Published: 10 May 2022
... Visser; A.H. Jan Danser; Jorie Versmissen Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a ‘preeclampsia-like’ syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with aspirin is known...
View article titled, Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced <span class="search-highlight">hypertension</span> and kidney damage
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Includes: Supplementary data
Articles

Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension

Theodore W. Kurtz, Michal Pravenec, Stephen E. DiCarlo
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (8): 599–620.
https://doi.org/10.1042/CS20210566
Published: 22 April 2022
...Theodore W. Kurtz; Michal Pravenec; Stephen E. DiCarlo High-salt diets are a major cause of hypertension and cardiovascular (CV) disease. Many governments are interested in using food salt reduction programs to reduce the risk for salt-induced increases in blood pressure and CV events...
View article titled, Mechanism-based strategies to prevent salt sensitivity and salt-induced <span class="search-highlight">hypertension</span>
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Articles

The acute pressure natriuresis response is suppressed by selective ET A receptor blockade

Geoffrey Culshaw, David Binnie, Neeraj Dhaun, Patrick Hadoke, Matthew Bailey, David J Webb
Journal: Clinical Science
Clin Sci (Lond) (2021) CS20210937.
https://doi.org/10.1042/CS20210937
Published: 17 December 2021
...Geoffrey Culshaw; David Binnie; Neeraj Dhaun; Patrick Hadoke; Matthew Bailey; David J Webb Hypertension is a major risk factor for cardiovascular disease. In a significant minority of people, it develops when salt intake is increased (salt-sensitivity). It is not clear whether this represents...
View article titled, The acute pressure natriuresis response is suppressed by selective ET A receptor blockade
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Articles

Paternal long-term PM 2.5 exposure causes hypertension via increased renal AT 1 R expression and function in male offspring

Cuimei Hu, Yu Tao, Yi Deng, Qi Cai, Hongmei Ren, Cheng Yu, Shuo Zheng, Jian Yang, Chunyu Zeng
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (22): 2575–2588.
https://doi.org/10.1042/CS20210802
Published: 26 November 2021
...Cuimei Hu; Yu Tao; Yi Deng; Qi Cai; Hongmei Ren; Cheng Yu; Shuo Zheng; Jian Yang; Chunyu Zeng Maternal exposure to fine particulate matter (PM 2.5 ) causes hypertension in offspring. However, paternal contribution of PM 2.5 exposure to hypertension in offspring remains unknown. In the present study...
View article titled, Paternal long-term PM 2.5 exposure causes <span class="search-highlight">hypertension</span> via increased renal AT 1 R expression and function in male offspring
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Articles

Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats

Ellen E. Gillis, Kasey Belanger, Mahmoud Abdelbary, Riyaz Mohamed, Jingping Sun, Michael W. Brands, Jennifer C. Sullivan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (19): 2329–2339.
https://doi.org/10.1042/CS20210469
Published: 13 October 2021
...Ellen E. Gillis; Kasey Belanger; Mahmoud Abdelbary; Riyaz Mohamed; Jingping Sun; Michael W. Brands; Jennifer C. Sullivan Over the past decade there has been increasing support for a role of the immune system in the development of hypertension. Our lab has previously reported that female...
View article titled, Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously <span class="search-highlight">hypertensive</span> rats
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Articles

Autoimmune-mediated renal disease and hypertension

Erika I. Boesen, Rahul M. Kakalij
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2165–2196.
https://doi.org/10.1042/CS20200955
Published: 17 September 2021
...Erika I. Boesen; Rahul M. Kakalij Hypertension is a major risk factor for cardiovascular disease, chronic kidney disease (CKD), and mortality. Troublingly, hypertension is highly prevalent in patients with autoimmune renal disease and hastens renal functional decline. Although progress has been...
View article titled, Autoimmune-mediated renal disease and <span class="search-highlight">hypertension</span>
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Articles

Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)

Ahmed A. Elmarakby, Jennifer C. Sullivan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1791–1804.
https://doi.org/10.1042/CS20201017
Published: 02 August 2021
... utilized the spontaneously hypertensive rats (SHR) as an experimental model of essential hypertension to increase our understanding of the mechanisms regulating blood pressure in males and females. Previous work by our group and others have implicated that differential regulation of adrenergic receptors...
View article titled, Sex differences in <span class="search-highlight">hypertension</span>: lessons from spontaneously <span class="search-highlight">hypertensive</span> rats (SHR)
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Articles

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

In Collection
Cardiovascular-Oncology
Daniel N. Meijles, Joshua J. Cull, Susanna T.E. Cooper, Thomais Markou, Michelle A. Hardyman, Stephen J. Fuller, Hajed O. Alharbi, Zoe H.R. Haines, Viridiana Alcantara-Alonso, Peter E. Glennon, Mary N. Sheppard, Peter H. Sugden, Angela Clerk
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1631–1647.
https://doi.org/10.1042/CS20210192
Published: 23 July 2021
... remodelling. Thus, dabrafenib may affect the heart in the context of, for example, hypertension. In experiments with cardiomyocytes, cardiac fibroblasts and perfused rat hearts, dabrafenib inhibited ERK1/2 signalling. We assessed the effects of dabrafenib (3 mg/kg/d) on male C57BL/6J mouse hearts in vivo...
View article titled, The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of <span class="search-highlight">hypertension</span>
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Includes: Supplementary data
Articles

Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?

In Collection
Cardiovascular-Oncology
Daan C.H. van Dorst, Leni van Doorn, Katrina M. Mirabito Colafella, Olivier C. Manintveld, H. Carlijne Hassing, A.H. Jan Danser, Ron H.J. Mathijssen, Jorie Versmissen
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1649–1668.
https://doi.org/10.1042/CS20200300
Published: 20 July 2021
..., including hypertension, congestive heart failure, myocarditis and acceleration of atherosclerosis. Currently, VEGFI and ICI combination therapy is recommended for the treatment of advanced renal cell carcinoma (RCC) and has shown promising treatment efficacy in other tumour types as well. Consequently...
View article titled, Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?
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Articles

Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?

Keiichi Torimoto, Satoru Eguchi
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1627–1630.
https://doi.org/10.1042/CS20210227
Published: 09 July 2021
...Keiichi Torimoto; Satoru Eguchi This commentary highlights the study entitled ‘Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor’ presented by Fu et al. published in Clinical Science ( Clin...
View article titled, Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?
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Articles

Unravelling the tangled web of hypertension and cancer

In Collection
Cardiovascular-Oncology
Aristeidis Sionakidis, Linsay McCallum, Sandosh Padmanabhan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1609–1625.
https://doi.org/10.1042/CS20200307
Published: 09 July 2021
... being attributed to neoplasms. The two share multiple common risk factors such as obesity, poor physical exercise, older age, smoking and there exists rare monogenic hypertension syndromes. Hypertension is the most important risk factor for cardiovascular disease and affects more than a billion people...
View article titled, Unravelling the tangled web of <span class="search-highlight">hypertension</span> and cancer
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Articles

Obesity-associated cardiovascular risk in women: hypertension and heart failure

Jessica L. Faulkner
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
https://doi.org/10.1042/CS20210384
Published: 23 June 2021
... is also discrepant in women between their premenopausal, pregnancy and postmenopausal phases of life. Emerging data indicate that at all reproductive statuses and ages, the presentation of a cardiovascular event in obese women is strongly associated with hypertension and its subsequent chronic risk factor...
View article titled, Obesity-associated cardiovascular risk in women: <span class="search-highlight">hypertension</span> and heart failure
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Articles

Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice

Kana N. Miyata, Chao-Sheng Lo, Shuiling Zhao, Min-Chun Liao, Yuchao Pang, Shiao-Ying Chang, Junzheng Peng, Matthias Kretzler, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S.D. Chan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 943–961.
https://doi.org/10.1042/CS20210094
Published: 14 April 2021
... Angiotensin II Hypertension Intrarenal RAS SGLT2 Transgenic mice tubulointerstitial fibrosis Recent large clinical trials have reported that sodium/glucose co-transporter 2 (SGLT2) inhibitors (SGLT2i) have renoprotective effects in a glucose-independent manner in patients with type 2 diabetes [ 1...
View article titled, Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced <span class="search-highlight">hypertensive</span> renal injury in mice
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Includes: Supplementary data
Articles

CRIP1 expression in monocytes related to hypertension

Olga Schweigert, Julia Adler, Natalie Längst, Dylan Aïssi, Jorge Duque Escobar, Teng Tong, Christian Müller, David-Alexandre Trégouët, Robert Lukowski, Tanja Zeller
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 911–924.
https://doi.org/10.1042/CS20201372
Published: 12 April 2021
...Olga Schweigert; Julia Adler; Natalie Längst; Dylan Aïssi; Jorge Duque Escobar; Teng Tong; Christian Müller; David-Alexandre Trégouët; Robert Lukowski; Tanja Zeller Hypertension is a complex and multifactorial disorder caused by lifestyle and environmental factors, inflammation and disease-related...
View article titled, CRIP1 expression in monocytes related to <span class="search-highlight">hypertension</span>
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Includes: Supplementary data
Articles

Letter to the Editor: Brain renin–angiotensin system and liver-directed siRNA targeted to angiotensinogen

Carlos M. Ferrario, Leanne Groban, Hao Wang, Sarfaraz Ahmad
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 907–910.
https://doi.org/10.1042/CS20210163
Published: 09 April 2021
.... , Mirabito Colafella K.M. , van Veghel R. , Garrelds I.M. , Domenig O. et al . ( 2021 ) No evidence for brain renin-angiotensin system activation during DOCA-salt hypertension . Clin. Sci. (Lond.) 135 , 259 – 274 10.1042/CS20201239 33404046 2. Arnold A.C. , Sakima...
View article titled, Letter to the Editor: Brain renin–angiotensin system and liver-directed siRNA targeted to angiotensinogen
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Articles

Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor

Ziwei Fu, Fei Wang, Xiyang Liu, Jiajia Hu, Jiahui Su, Xiaohan Lu, Aihua Lu, Jae Min Cho, J. David Symons, Chang-Jiang Zou, Tianxin Yang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 793–810.
https://doi.org/10.1042/CS20201047
Published: 23 March 2021
... was sensitive to Los. Besides, sPRR-His elevated blood pressure in obese C57/BL6 mice, an effect that was reversed by concurrent treatment with Los but not Cap. Collectively, we provide solid evidence that the AT1R mediates the functions of sPRR during obesity-related hypertension. Inhibiting sPRR signaling...
View article titled, Soluble (pro)renin receptor induces endothelial dysfunction and <span class="search-highlight">hypertension</span> in mice with diet-induced obesity via activation of angiotensin II type 1 receptor
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Includes: Supplementary data
Articles

Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension

Reda Hmazzou, Yannick Marc, Adrien Flahault, Romain Gerbier, Nadia De Mota, Catherine Llorens-Cortes
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 775–791.
https://doi.org/10.1042/CS20201385
Published: 17 March 2021
... of blood pressure (BP) in hypertensive rats and increases vasopressin release. Blocking brain angiotensin III formation by the APA inhibitor prodrug RB150/firibastat normalizes arterial BP in hypertensive deoxycorticosterone acetate (DOCA)-salt rats without inducing angiotensin II accumulation. We...
View article titled, Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent <span class="search-highlight">hypertension</span>
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Includes: Supplementary data
Articles

Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases

Mona Elgazzaz, Eric Lazartigues
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 127–142.
https://doi.org/10.1042/CS20201287
Published: 08 January 2021
... Limited on behalf of the Biochemical Society 2021 Cardiometabolic Disease Diabetes Epigenetics Hypertension Renin Angiotensin System Cardiometabolic disease (CMD) refers to coexisting conditions of insulin resistance, dyslipidemia, obesity, elevated blood pressure (BP), and other...
View article titled, Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases
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Articles

Cardiotoxic effects of angiogenesis inhibitors

In Collection
Cardiovascular-Oncology
Stephen J.H. Dobbin, Mark C. Petrie, Rachel C. Myles, Rhian M. Touyz, Ninian N. Lang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 71–100.
https://doi.org/10.1042/CS20200305
Published: 06 January 2021
.... However, these drugs are associated with cardiovascular toxicities which can impact optimal cancer treatment in the short-term and may lead to increased morbidity and mortality in the longer term. Vascular endothelial growth factor inhibitors (VEGFIs) are associated with hypertension, left ventricular...
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Articles

Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases

In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Ravindra K. Sharma, Jing Li, Suraj Krishnan, Elaine M. Richards, Mohan K. Raizada, Rajesh Mohandas
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 1–17.
https://doi.org/10.1042/CS20200482
Published: 05 January 2021
... and a receptor for SARS-CoV-2 as well as the implications for Coronavirus disease 19 and its associated cardiovascular and renal complications. Recent studies on SARS-CoV-2 infections indicate that individuals with pre-existing conditions such as obesity, diabetes, hypertension (HTN), lung and kidney disease...
View article titled, Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases
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Articles

Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads

Shobana Navaneethabalakrishnan, Bethany L. Goodlett, Alexandra H. Lopez, Joseph M. Rutkowski, Brett M. Mitchell
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (24): 3237–3257.
https://doi.org/10.1042/CS20201023
Published: 21 December 2020
...Shobana Navaneethabalakrishnan; Bethany L. Goodlett; Alexandra H. Lopez; Joseph M. Rutkowski; Brett M. Mitchell Hypertension is one of the most prevalent diseases that leads to end organ damage especially affecting the heart, kidney, brain, and eyes. Numerous studies have evaluated the association...
View article titled, <span class="search-highlight">Hypertension</span> and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads
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Articles

Vascular toxicity associated with anti-angiogenic drugs

In Collection
Cardiovascular-Oncology
Karla B. Neves, Augusto C. Montezano, Ninian N. Lang, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2503–2520.
https://doi.org/10.1042/CS20200308
Published: 29 September 2020
... hypertension and thromboembolism. Molecular processes underlying VEGFi-induced vascular toxicities still remain unclear but inhibition of endothelial NO synthase (eNOS), reduced nitric oxide (NO) production, oxidative stress, activation of the endothelin system, and rarefaction have been implicated. However...
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Articles

GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension

Yan Zhang, Shaoxiong Wang, Hefei Huang, Andi Zeng, Yu Han, Cindy Zeng, Shuo Zheng, Hongmei Ren, Yajing Wang, Yu Huang, Pedro A. Jose, Xin-Liang Ma, Chunyu Zeng, Ken Chen
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2453–2467.
https://doi.org/10.1042/CS20200671
Published: 25 September 2020
...Yan Zhang; Shaoxiong Wang; Hefei Huang; Andi Zeng; Yu Han; Cindy Zeng; Shuo Zheng; Hongmei Ren; Yajing Wang; Yu Huang; Pedro A. Jose; Xin-Liang Ma; Chunyu Zeng; Ken Chen Hypertensive patients have impaired sodium excretion. However, the mechanisms are incompletely understood. Despite...
View article titled, GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in <span class="search-highlight">hypertension</span>
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Includes: Supplementary data
Articles

Clinically relevant high levels of human C-reactive protein induces endothelial dysfunction and hypertension by inhibiting the AMPK-eNOS axis

Lele Cheng, Liang Wang, Manyun Guo, Jinlong He, Yangyang Deng, Junhui Liu, Yuanyuan Wei, Chen Wang, Juan Zhou, Li Ma, Qing Song, Zuyi Yuan, Yue Wu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1805–1819.
https://doi.org/10.1042/CS20200137
Published: 17 July 2020
...Lele Cheng; Liang Wang; Manyun Guo; Jinlong He; Yangyang Deng; Junhui Liu; Yuanyuan Wei; Chen Wang; Juan Zhou; Li Ma; Qing Song; Zuyi Yuan; Yue Wu Successful treatment of resistant hypertension accompanied by elevated human C-reactive protein (hCRP) remains a key challenge in reducing the burden...
View article titled, Clinically relevant high levels of human C-reactive protein induces endothelial dysfunction and <span class="search-highlight">hypertension</span> by inhibiting the AMPK-eNOS axis
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Includes: Supplementary data
Articles

Ctcf is required for renin expression and maintenance of the structural integrity of the kidney

Maria Florencia Martinez, Alexandre G. Martini, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1763–1774.
https://doi.org/10.1042/CS20200184
Published: 10 July 2020
... of renin cell number and structural integrity of the kidney. Ctcf homeostasis hypertension nephrology renin-angiotensin system vasculature 03 03 2020 23 06 2020 03 07 2020 03 07 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical...
View article titled, Ctcf is required for renin expression and maintenance of the structural integrity of the kidney
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Includes: Supplementary data
Articles

Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity

Uwe Querfeld, Robert H. Mak, Axel Radlach Pries
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
https://doi.org/10.1042/CS20200279
Published: 16 June 2020
... in a dysfunctional endothelium with diminished perfusion, shunting and tissue hypoxia. Endothelial cell apoptosis, hypertension, multiple metabolic, endocrine and immune disturbances of the uremic milieu and specifically, a dysregulated angiogenesis, all contribute to the multifactorial pathogenesis. By setting...
View article titled, Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity
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Articles

ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19

In Collection
Coronavirus
Rhian M. Touyz, Hongliang Li, Christian Delles
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 747–750.
https://doi.org/10.1042/CS20200363
Published: 07 April 2020
...). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Considering the important role of the RAS in the pathophysiology of hypertension and cardiovascular and renal diseases [ 28 ], it has been suggested that ACE inhibitors and Ang II-receptor blockers (ARBs) may increase...
View article titled, ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19
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Articles

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Lucas F. Almeida, Signe S. Tofteng, Kirsten Madsen, Boye L. Jensen
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (6): 641–656.
https://doi.org/10.1042/CS20190765
Published: 27 March 2020
... of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin–angiotensin–aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation...
View article titled, Role of the renin–angiotensin system in kidney development and programming of adult blood pressure
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Articles

Interleukin-17A induces vascular remodeling of small arteries and blood pressure elevation

Macarena Orejudo, Ana B. García-Redondo, Raúl R. Rodrigues-Diez, Raquel Rodrigues-Díez, Laura Santos-Sanchez, Antonio Tejera-Muñoz, Jesús Egido, Rafael Selgas, Mercedes Salaices, Ana M. Briones, Marta Ruiz-Ortega
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (5): 513–527.
https://doi.org/10.1042/CS20190682
Published: 09 March 2020
...Macarena Orejudo; Ana B. García-Redondo; Raúl R. Rodrigues-Diez; Raquel Rodrigues-Díez; Laura Santos-Sanchez; Antonio Tejera-Muñoz; Jesús Egido; Rafael Selgas; Mercedes Salaices; Ana M. Briones; Marta Ruiz-Ortega An important link exists between hypertension and inflammation. Hypertensive patients...
View article titled, Interleukin-17A induces vascular remodeling of small arteries and blood pressure elevation
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Articles

Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy

Laia Cañes, Ingrid Martí-Pàmies, Carme Ballester-Servera, Adela Herraiz-Martínez, Judith Alonso, María Galán, J. Francisco Nistal, Pedro Muniesa, Jesús Osada, Leif Hove-Madsen, Cristina Rodríguez, José Martínez-González
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (3): 359–377.
https://doi.org/10.1042/CS20191014
Published: 04 February 2020
...Laia Cañes; Ingrid Martí-Pàmies; Carme Ballester-Servera; Adela Herraiz-Martínez; Judith Alonso; María Galán; J. Francisco Nistal; Pedro Muniesa; Jesús Osada; Leif Hove-Madsen; Cristina Rodríguez; José Martínez-González Hypertensive cardiac hypertrophy (HCH) is a common cause of heart failure (HF...
View article titled, Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy
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Includes: Supplementary data
Articles

Double-stranded RNA and Toll-like receptor activation: a novel mechanism for blood pressure regulation

Vanessa Dela Justina, Fernanda R. Giachini, Fernanda Priviero, R. Clinton Webb
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (2): 303–313.
https://doi.org/10.1042/CS20190913
Published: 30 January 2020
...) will increase the inflammatory state through activation of TLR3, contributing to vascular dysfunction and increased BP. Therefore, inhibition of TLR3 could be a therapeutic target for the treatment of hypertension with potential improvement in vascular reactivity and consequently, a decrease in BP...
View article titled, Double-stranded RNA and Toll-like receptor activation: a novel mechanism for blood pressure regulation
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Articles

Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system

Ken Chen, Dongdong Sun, Shuang Qu, Yue Chen, Jialiang Wang, Lin Zhou, Pedro A. Jose, Yongjian Yang, Chunyu Zeng
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1097–1113.
https://doi.org/10.1042/CS20190254
Published: 09 May 2019
... receptor antagonist losartan in the PVN lowered blood pressure to a greater extent in prenatal cold-exposed that control offspring. The present study provides evidence for overactive peripheral and central sympathetic nervous systems in the pathogenesis of prenatal cold-induced hypertension. Central AT 1...
View article titled, Prenatal cold exposure causes <span class="search-highlight">hypertension</span> in offspring by hyperactivity of the sympathetic nervous system
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Articles

Role of Orexin-B/Orexin 2 receptor in myocardial protection

Roberta Imperatore, Luigia Cristino
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (7): 853–857.
https://doi.org/10.1042/CS20181036
Published: 04 April 2019
...Roberta Imperatore; Luigia Cristino Emerging evidence attributes to orexins/hypocretins (ORs) a protective function in the regulation of cardiovascular responses, heart rate, and hypertension. However, little is known about any direct effect of orexins in the heart function. This is of special...
View article titled, Role of Orexin-B/Orexin 2 receptor in myocardial protection
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Articles

Sex-dependent expression of brain medullary MAP and PI3 kinases in adult sheep with antenatal betamethasone exposure

Alexa S. Hendricks, Hossam A. Shaltout, Brain M. Westwood, Mark C. Chappell, Debra I. Diz
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (17): 1953–1962.
https://doi.org/10.1042/CS20180417
Published: 14 September 2018
... protein to total expression in relative optical density units. fetal programming hypertension mitogen-activated protein kinases sex differences Data are expressed as the mean ± S.E.M. Unpaired Student’s t tests were used to determine significance between two groups for data derived from...
View article titled, Sex-dependent expression of brain medullary MAP and PI3 kinases in adult sheep with antenatal betamethasone exposure
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Articles

Rho kinase activation in circulating leukocytes is related to hypertensive myocardial remodeling

Maria P. Ocaranza, Camila Fierro, Jorge E. Jalil, Jackeline Moya, Leticia Gonzalez, Cristián Molina, Cristián Mancilla
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1837–1853.
https://doi.org/10.1042/CS20180312
Published: 30 August 2018
... of its target myosin phosphatase target subunit 1 (MYPT1), but its relationship with Rho-kinase activity in the myocardium and in vasculature in hypertension has not been evaluated. The aim was to determine the degree of association between Rho-kinase cascade activation in circulating leukocytes...
View article titled, Rho kinase activation in circulating leukocytes is related to <span class="search-highlight">hypertensive</span> myocardial remodeling
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Includes: Supplementary data
Articles

Mechanical stresses induce paracrine β-2 microglobulin from cardiomyocytes to activate cardiac fibroblasts through epidermal growth factor receptor

Yang Li, Xiaoyi Zhang, Lu Li, Xiang Wang, Zhidan Chen, Xingxu Wang, Ying Wang, Le Kang, Yong Ye, Jianguo Jia, Guoping Zhang, Chunjie Yang, Jie Yuan, Jingmin Zhou, Junbo Ge, Hui Gong, Yunzeng Zou
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1855–1874.
https://doi.org/10.1042/CS20180486
Published: 30 August 2018
... that stretch induced a significantly high level of β-2 microglobulin (β2M), a non-glycosylated protein, which is related to inflammatory diseases but rarely known in cardiovascular diseases. The present data showed that serum β2M level was increased in patients with hypertension and further increased...
View article titled, Mechanical stresses induce paracrine β-2 microglobulin from cardiomyocytes to activate cardiac fibroblasts through epidermal growth factor receptor
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Includes: Supplementary data
Articles

Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats

Alynne Carvalho-Galvão, Blessing Ogunlade, Jiaxi Xu, Cristiane R.A. Silva-Alves, Leônidas G. Mendes-Júnior, Drielle D. Guimarães, Josiane C. Cruz, Thyago M. Queiroz, Camille M. Balarini, Valdir A. Braga, Catalin M. Filipeanu, Eric Lazartigues, Maria do Socorro de França-Silva
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1513–1527.
https://doi.org/10.1042/CS20180222
Published: 23 July 2018
... on arterial pressure (AP), autonomic function, baroreflex sensitivity (BRS), and peripheral vascular reactivity. Spontaneously hypertensive (SH) and Wistar Kyoto (WKY) rats were treated with TRV027 for 14 days (20 ng/h) delivered to the lateral ventricle via osmotic minipumps. Mechanistic studies were...
View article titled, Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously <span class="search-highlight">hypertensive</span> rats
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Articles

Intratubular and intracellular renin–angiotensin system in the kidney: a unifying perspective in blood pressure control

Xiao C. Li, Dongmin Zhu, Xiaowen Zheng, Jiangfeng Zhang, Jia L. Zhuo
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (13): 1383–1401.
https://doi.org/10.1042/CS20180121
Published: 09 July 2018
...Xiao C. Li; Dongmin Zhu; Xiaowen Zheng; Jiangfeng Zhang; Jia L. Zhuo The renin–angiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived...
View article titled, Intratubular and intracellular renin–angiotensin system in the kidney: a unifying perspective in blood pressure control
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Articles

Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats

Guangyu Zhou, Jie Wu, Chunyan Gu, Bin Wang, E. Dale Abel, Alfred K. Cheung, Yufeng Huang
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1345–1363.
https://doi.org/10.1042/CS20171659
Published: 28 June 2018
...), p-ERK, p-β-catenin, and p-Akt were dramatically increased in prorenin overexpressing rats. These results indicate that prorenin, without being converted into renin, causes hypertension, renal and cardiac fibrosis via the induction of inflammation, oxidative stress and the ERK, β-catenin, and Akt...
View article titled, Prorenin independently causes <span class="search-highlight">hypertension</span> and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats
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Includes: Supplementary data
Articles

Role of endogenous digitalis-like factors in the clinical manifestations of severe preeclampsia: a systematic review

Vardaman M. Buckalew
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1215–1242.
https://doi.org/10.1042/CS20171499
Published: 21 June 2018
... 08 05 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 antidigoxin antibody glomerular filtration rate endogenous digitalis-like factor hypertension preeclampsia pulmonary edema Endogenous digitalis-like factor(s...
View article titled, Role of endogenous digitalis-like factors in the clinical manifestations of severe preeclampsia: a systematic review
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Articles

The depressor axis of the renin–angiotensin system and brain disorders: a translational approach

Mariela M. Gironacci, Augusto Vicario, Gustavo Cerezo, Mauro G. Silva
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
https://doi.org/10.1042/CS20180189
Published: 25 May 2018
... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke The RAS is of profound physiological...
View article titled, The depressor axis of the renin–angiotensin system and brain disorders: a translational approach
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Articles

Leflunomide counter akt s cardiac hypertrophy

Luciana A. Pescatore, Francisco R.M. Laurindo
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1069–1073.
https://doi.org/10.1042/CS20180228
Published: 25 May 2018
..., such growth factor-triggered Nox and Akt activation requires the endoplasmic reticulum chaperone protein disulphide isomerase-A1 [ 15 ]. Akt cardiac hypertrophy cell signalling Fyn hypertension leflunomide Cardiac hypertrophy (CH) is a major independent cardiovascular risk factor...
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