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Keywords: hypertension
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (8): 597–601.
Published: 19 April 2023
...Andreia Zago Chignalia Hypertension is associated with the activation of the immune and lymphatic systems as well as lymphangiogenesis. The changes in the lymphatic system are considered an adaptive response to mitigate the deleterious effects of immune and inflammatory cells on the cardiovascular...
Articles
Jun Yu Chen, Khai Syuen Chew, Sheon Mary, Philipp Boder, Domenico Bagordo, Gian Paolo Rossi, Rhian M. Touyz, Christian Delles, Giacomo Rossitto
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (3): 239–250.
Published: 07 February 2023
...Jun Yu Chen; Khai Syuen Chew; Sheon Mary; Philipp Boder; Domenico Bagordo; Gian Paolo Rossi; Rhian M. Touyz; Christian Delles; Giacomo Rossitto Increasing evidence suggests excess skin Na + accumulation in hypertension; however, the role of skin-specific mechanisms of local Na + /water regulation...
Includes: Supplementary data
Articles
Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (23): 1759–1772.
Published: 02 December 2022
...Bethany L. Goodlett; Dakshnapriya Balasubbramanian; Shobana Navaneethabalakrishnan; Sydney E. Love; Emily M. Luera; Sunitha Konatham; Valorie L. Chiasson; Sophie Wedgeworth; Joseph M. Rutkowski; Brett M. Mitchell Background: Hypertension (HTN) is associated with renal proinflammatory immune cell...
Includes: Supplementary data
Articles
Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1661–1681.
Published: 21 November 2022
.... with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hypertension) is associated with additional features including increased fibrosis and can lead to heart failure. RAF kinases (ARAF/BRAF/RAF1) integrate signals into the extracellular signal-regulated...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (16): 1205–1227.
Published: 18 August 2022
...Pedro Alves Soares Vaz de Castro; Pedro A. Jose; Ana Cristina Simões e Silva Systemic arterial hypertension is one of the leading causes of morbidity and mortality in the general population, being a risk factor for many cardiovascular diseases. Although its pathogenesis is complex and still poorly...
Articles
Shobana Navaneethabalakrishnan, Brooke K. Wilcox, Bethany L. Goodlett, Malea M. Murphy, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (11): 879–894.
Published: 06 June 2022
...Shobana Navaneethabalakrishnan; Brooke K. Wilcox; Bethany L. Goodlett; Malea M. Murphy; Brett M. Mitchell Hypertension (HTN) is associated with gonadal dysfunction and impaired reproductive health in both men and women. An imbalance in the systemic and renal proinflammatory (M1)/anti-inflammatory...
Includes: Supplementary data
Articles
Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (11): 803–817.
Published: 30 May 2022
... channel in the neuronal development, but its potential roles in vascular Ca V 1.2 channels and vasoconstriction remain undefined. Here, we detect Rbfox1 is expressed in rat vascular smooth muscles. Moreover, the protein level of Rbfox1 is dramatically decreased in the hypertensive small arteries from...
Includes: Supplementary data
Articles
In Collection
Cardiovascular-Oncology
Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (9): 675–694.
Published: 10 May 2022
... Visser; A.H. Jan Danser; Jorie Versmissen Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a ‘preeclampsia-like’ syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with aspirin is known...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 599–620.
Published: 22 April 2022
...Theodore W. Kurtz; Michal Pravenec; Stephen E. DiCarlo High-salt diets are a major cause of hypertension and cardiovascular (CV) disease. Many governments are interested in using food salt reduction programs to reduce the risk for salt-induced increases in blood pressure and CV events...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) CS20210937.
Published: 17 December 2021
...Geoffrey Culshaw; David Binnie; Neeraj Dhaun; Patrick Hadoke; Matthew Bailey; David J Webb Hypertension is a major risk factor for cardiovascular disease. In a significant minority of people, it develops when salt intake is increased (salt-sensitivity). It is not clear whether this represents...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (22): 2575–2588.
Published: 26 November 2021
...Cuimei Hu; Yu Tao; Yi Deng; Qi Cai; Hongmei Ren; Cheng Yu; Shuo Zheng; Jian Yang; Chunyu Zeng Maternal exposure to fine particulate matter (PM 2.5 ) causes hypertension in offspring. However, paternal contribution of PM 2.5 exposure to hypertension in offspring remains unknown. In the present study...
Articles
Ellen E. Gillis, Kasey Belanger, Mahmoud Abdelbary, Riyaz Mohamed, Jingping Sun, Michael W. Brands, Jennifer C. Sullivan
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (19): 2329–2339.
Published: 13 October 2021
...Ellen E. Gillis; Kasey Belanger; Mahmoud Abdelbary; Riyaz Mohamed; Jingping Sun; Michael W. Brands; Jennifer C. Sullivan Over the past decade there has been increasing support for a role of the immune system in the development of hypertension. Our lab has previously reported that female...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2165–2196.
Published: 17 September 2021
...Erika I. Boesen; Rahul M. Kakalij Hypertension is a major risk factor for cardiovascular disease, chronic kidney disease (CKD), and mortality. Troublingly, hypertension is highly prevalent in patients with autoimmune renal disease and hastens renal functional decline. Although progress has been...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1791–1804.
Published: 02 August 2021
... utilized the spontaneously hypertensive rats (SHR) as an experimental model of essential hypertension to increase our understanding of the mechanisms regulating blood pressure in males and females. Previous work by our group and others have implicated that differential regulation of adrenergic receptors...
Articles
In Collection
Cardiovascular-Oncology
Daniel N. Meijles, Joshua J. Cull, Susanna T.E. Cooper, Thomais Markou, Michelle A. Hardyman, Stephen J. Fuller, Hajed O. Alharbi, Zoe H.R. Haines, Viridiana Alcantara-Alonso, Peter E. Glennon, Mary N. Sheppard, Peter H. Sugden, Angela Clerk
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1631–1647.
Published: 23 July 2021
... remodelling. Thus, dabrafenib may affect the heart in the context of, for example, hypertension. In experiments with cardiomyocytes, cardiac fibroblasts and perfused rat hearts, dabrafenib inhibited ERK1/2 signalling. We assessed the effects of dabrafenib (3 mg/kg/d) on male C57BL/6J mouse hearts in vivo...
Includes: Supplementary data
Articles
In Collection
Cardiovascular-Oncology
Daan C.H. van Dorst, Leni van Doorn, Katrina M. Mirabito Colafella, Olivier C. Manintveld, H. Carlijne Hassing, A.H. Jan Danser, Ron H.J. Mathijssen, Jorie Versmissen
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1649–1668.
Published: 20 July 2021
..., including hypertension, congestive heart failure, myocarditis and acceleration of atherosclerosis. Currently, VEGFI and ICI combination therapy is recommended for the treatment of advanced renal cell carcinoma (RCC) and has shown promising treatment efficacy in other tumour types as well. Consequently...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1627–1630.
Published: 09 July 2021
...Keiichi Torimoto; Satoru Eguchi This commentary highlights the study entitled ‘Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor’ presented by Fu et al. published in Clinical Science ( Clin...
Articles
In Collection
Cardiovascular-Oncology
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1609–1625.
Published: 09 July 2021
... being attributed to neoplasms. The two share multiple common risk factors such as obesity, poor physical exercise, older age, smoking and there exists rare monogenic hypertension syndromes. Hypertension is the most important risk factor for cardiovascular disease and affects more than a billion people...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
... is also discrepant in women between their premenopausal, pregnancy and postmenopausal phases of life. Emerging data indicate that at all reproductive statuses and ages, the presentation of a cardiovascular event in obese women is strongly associated with hypertension and its subsequent chronic risk factor...
Articles
Kana N. Miyata, Chao-Sheng Lo, Shuiling Zhao, Min-Chun Liao, Yuchao Pang, Shiao-Ying Chang, Junzheng Peng, Matthias Kretzler, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S.D. Chan
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 943–961.
Published: 14 April 2021
... microcapillaries at the first time point of inulin clearance. Angiotensin II Hypertension Intrarenal RAS SGLT2 Transgenic mice tubulointerstitial fibrosis Recent large clinical trials have reported that sodium/glucose co-transporter 2 (SGLT2) inhibitors (SGLT2i) have renoprotective effects...
Includes: Supplementary data
Articles
Olga Schweigert, Julia Adler, Natalie Längst, Dylan Aïssi, Jorge Duque Escobar, Teng Tong, Christian Müller, David-Alexandre Trégouët, Robert Lukowski, Tanja Zeller
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
...Olga Schweigert; Julia Adler; Natalie Längst; Dylan Aïssi; Jorge Duque Escobar; Teng Tong; Christian Müller; David-Alexandre Trégouët; Robert Lukowski; Tanja Zeller Hypertension is a complex and multifactorial disorder caused by lifestyle and environmental factors, inflammation and disease-related...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 907–910.
Published: 09 April 2021
...Carlos M. Ferrario; Leanne Groban; Hao Wang; Sarfaraz Ahmad We read with great interest the article by Uijl et al. [ 1 ] who reported that liver-directed small interfering RNA (siRNA) targeted to angiotensinogen (AGT) does not reverse the hypertension induced in male Sprague–Dawley rats...
Articles
Ziwei Fu, Fei Wang, Xiyang Liu, Jiajia Hu, Jiahui Su, Xiaohan Lu, Aihua Lu, Jae Min Cho, J. David Symons, Chang-Jiang Zou, Tianxin Yang
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (6): 793–810.
Published: 23 March 2021
... was sensitive to Los. Besides, sPRR-His elevated blood pressure in obese C57/BL6 mice, an effect that was reversed by concurrent treatment with Los but not Cap. Collectively, we provide solid evidence that the AT1R mediates the functions of sPRR during obesity-related hypertension. Inhibiting sPRR signaling...
Includes: Supplementary data
Articles
Reda Hmazzou, Yannick Marc, Adrien Flahault, Romain Gerbier, Nadia De Mota, Catherine Llorens-Cortes
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (6): 775–791.
Published: 17 March 2021
... of blood pressure (BP) in hypertensive rats and increases vasopressin release. Blocking brain angiotensin III formation by the APA inhibitor prodrug RB150/firibastat normalizes arterial BP in hypertensive deoxycorticosterone acetate (DOCA)-salt rats without inducing angiotensin II accumulation. We...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 127–142.
Published: 08 January 2021
... by Portland Press Limited on behalf of the Biochemical Society 2021 Cardiometabolic Disease Diabetes Epigenetics Hypertension Renin Angiotensin System Cardiometabolic disease (CMD) refers to coexisting conditions of insulin resistance, dyslipidemia, obesity, elevated blood pressure (BP...
Articles
In Collection
Cardiovascular-Oncology
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
.... However, these drugs are associated with cardiovascular toxicities which can impact optimal cancer treatment in the short-term and may lead to increased morbidity and mortality in the longer term. Vascular endothelial growth factor inhibitors (VEGFIs) are associated with hypertension, left ventricular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
... on SARS-CoV-2 infections indicate that individuals with pre-existing conditions such as obesity, diabetes, hypertension (HTN), lung and kidney disease, are at greater risk of severe manifestations of COVID-19. Since these pre-existing conditions are associated with abnormal RAS signaling, it is worth...
Articles
Shobana Navaneethabalakrishnan, Bethany L. Goodlett, Alexandra H. Lopez, Joseph M. Rutkowski, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (24): 3237–3257.
Published: 21 December 2020
...Shobana Navaneethabalakrishnan; Bethany L. Goodlett; Alexandra H. Lopez; Joseph M. Rutkowski; Brett M. Mitchell Hypertension is one of the most prevalent diseases that leads to end organ damage especially affecting the heart, kidney, brain, and eyes. Numerous studies have evaluated the association...
Articles
In Collection
Cardiovascular-Oncology
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2503–2520.
Published: 29 September 2020
... hypertension and thromboembolism. Molecular processes underlying VEGFi-induced vascular toxicities still remain unclear but inhibition of endothelial NO synthase (eNOS), reduced nitric oxide (NO) production, oxidative stress, activation of the endothelin system, and rarefaction have been implicated. However...
Articles
Yan Zhang, Shaoxiong Wang, Hefei Huang, Andi Zeng, Yu Han, Cindy Zeng, Shuo Zheng, Hongmei Ren, Yajing Wang, Yu Huang, Pedro A. Jose, Xin-Liang Ma, Chunyu Zeng, Ken Chen
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2453–2467.
Published: 25 September 2020
...Yan Zhang; Shaoxiong Wang; Hefei Huang; Andi Zeng; Yu Han; Cindy Zeng; Shuo Zheng; Hongmei Ren; Yajing Wang; Yu Huang; Pedro A. Jose; Xin-Liang Ma; Chunyu Zeng; Ken Chen Hypertensive patients have impaired sodium excretion. However, the mechanisms are incompletely understood. Despite...
Includes: Supplementary data
Articles
Lele Cheng, Liang Wang, Manyun Guo, Jinlong He, Yangyang Deng, Junhui Liu, Yuanyuan Wei, Chen Wang, Juan Zhou, Li Ma, Qing Song, Zuyi Yuan, Yue Wu
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1805–1819.
Published: 17 July 2020
...Lele Cheng; Liang Wang; Manyun Guo; Jinlong He; Yangyang Deng; Junhui Liu; Yuanyuan Wei; Chen Wang; Juan Zhou; Li Ma; Qing Song; Zuyi Yuan; Yue Wu Successful treatment of resistant hypertension accompanied by elevated human C-reactive protein (hCRP) remains a key challenge in reducing the burden...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1763–1774.
Published: 10 July 2020
... of renin cell number and structural integrity of the kidney. Ctcf homeostasis hypertension nephrology renin-angiotensin system vasculature Mouse genotypes from tail biopsies were determined using real-time PCR with specific probes designed by Transnetyx, Cordova, TN. As4.1 renin...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Published: 16 June 2020
... in a dysfunctional endothelium with diminished perfusion, shunting and tissue hypoxia. Endothelial cell apoptosis, hypertension, multiple metabolic, endocrine and immune disturbances of the uremic milieu and specifically, a dysregulated angiogenesis, all contribute to the multifactorial pathogenesis. By setting...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 747–750.
Published: 07 April 2020
... 28 03 2020 31 03 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Angiotensin ACE2 receptor coronavirus hypertension cardiovascular COVID-19 Angiotensin converting enzyme 2 (ACE2) is a key element in the protective...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (6): 641–656.
Published: 27 March 2020
... of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin–angiotensin–aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation...
Articles
Macarena Orejudo, Ana B. García-Redondo, Raúl R. Rodrigues-Diez, Raquel Rodrigues-Díez, Laura Santos-Sanchez, Antonio Tejera-Muñoz, Jesús Egido, Rafael Selgas, Mercedes Salaices, Ana M. Briones, Marta Ruiz-Ortega
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (5): 513–527.
Published: 09 March 2020
...Macarena Orejudo; Ana B. García-Redondo; Raúl R. Rodrigues-Diez; Raquel Rodrigues-Díez; Laura Santos-Sanchez; Antonio Tejera-Muñoz; Jesús Egido; Rafael Selgas; Mercedes Salaices; Ana M. Briones; Marta Ruiz-Ortega An important link exists between hypertension and inflammation. Hypertensive patients...
Articles
Laia Cañes, Ingrid Martí-Pàmies, Carme Ballester-Servera, Adela Herraiz-Martínez, Judith Alonso, María Galán, J. Francisco Nistal, Pedro Muniesa, Jesús Osada, Leif Hove-Madsen, Cristina Rodríguez, José Martínez-González
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (3): 359–377.
Published: 04 February 2020
...Laia Cañes; Ingrid Martí-Pàmies; Carme Ballester-Servera; Adela Herraiz-Martínez; Judith Alonso; María Galán; J. Francisco Nistal; Pedro Muniesa; Jesús Osada; Leif Hove-Madsen; Cristina Rodríguez; José Martínez-González Hypertensive cardiac hypertrophy (HCH) is a common cause of heart failure (HF...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 303–313.
Published: 30 January 2020
...) will increase the inflammatory state through activation of TLR3, contributing to vascular dysfunction and increased BP. Therefore, inhibition of TLR3 could be a therapeutic target for the treatment of hypertension with potential improvement in vascular reactivity and consequently, a decrease in BP...
Articles
Ken Chen, Dongdong Sun, Shuang Qu, Yue Chen, Jialiang Wang, Lin Zhou, Pedro A. Jose, Yongjian Yang, Chunyu Zeng
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1097–1113.
Published: 09 May 2019
... receptor antagonist losartan in the PVN lowered blood pressure to a greater extent in prenatal cold-exposed that control offspring. The present study provides evidence for overactive peripheral and central sympathetic nervous systems in the pathogenesis of prenatal cold-induced hypertension. Central AT 1...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (7): 853–857.
Published: 04 April 2019
...Roberta Imperatore; Luigia Cristino Emerging evidence attributes to orexins/hypocretins (ORs) a protective function in the regulation of cardiovascular responses, heart rate, and hypertension. However, little is known about any direct effect of orexins in the heart function. This is of special...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (17): 1953–1962.
Published: 14 September 2018
... ), and in male sheep ( D ). Mean ± S.E.M. ( n =4 in all groups). fetal programming hypertension mitogen-activated protein kinases sex differences Administration of glucocorticoids (GCs) is a widely accepted therapy for women in jeopardy of preterm labor that facilitates the development...
Articles
Yang Li, Xiaoyi Zhang, Lu Li, Xiang Wang, Zhidan Chen, Xingxu Wang, Ying Wang, Le Kang, Yong Ye, Jianguo Jia, Guoping Zhang, Chunjie Yang, Jie Yuan, Jingmin Zhou, Junbo Ge, Hui Gong, Yunzeng Zou
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1855–1874.
Published: 30 August 2018
... that stretch induced a significantly high level of β-2 microglobulin (β2M), a non-glycosylated protein, which is related to inflammatory diseases but rarely known in cardiovascular diseases. The present data showed that serum β2M level was increased in patients with hypertension and further increased...
Includes: Supplementary data
Articles
Maria P. Ocaranza, Camila Fierro, Jorge E. Jalil, Jackeline Moya, Leticia Gonzalez, Cristián Molina, Cristián Mancilla
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1837–1853.
Published: 30 August 2018
... of its target myosin phosphatase target subunit 1 (MYPT1), but its relationship with Rho-kinase activity in the myocardium and in vasculature in hypertension has not been evaluated. The aim was to determine the degree of association between Rho-kinase cascade activation in circulating leukocytes...
Includes: Supplementary data
Articles
Alynne Carvalho-Galvão, Blessing Ogunlade, Jiaxi Xu, Cristiane R.A. Silva-Alves, Leônidas G. Mendes-Júnior, Drielle D. Guimarães, Josiane C. Cruz, Thyago M. Queiroz, Camille M. Balarini, Valdir A. Braga, Catalin M. Filipeanu, Eric Lazartigues, Maria do Socorro de França-Silva
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1513–1527.
Published: 23 July 2018
... on arterial pressure (AP), autonomic function, baroreflex sensitivity (BRS), and peripheral vascular reactivity. Spontaneously hypertensive (SH) and Wistar Kyoto (WKY) rats were treated with TRV027 for 14 days (20 ng/h) delivered to the lateral ventricle via osmotic minipumps. Mechanistic studies were...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (13): 1383–1401.
Published: 09 July 2018
...Xiao C. Li; Dongmin Zhu; Xiaowen Zheng; Jiangfeng Zhang; Jia L. Zhuo The renin–angiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1345–1363.
Published: 28 June 2018
...), p-ERK, p-β-catenin, and p-Akt were dramatically increased in prorenin overexpressing rats. These results indicate that prorenin, without being converted into renin, causes hypertension, renal and cardiac fibrosis via the induction of inflammation, oxidative stress and the ERK, β-catenin, and Akt...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1215–1242.
Published: 21 June 2018
... 08 05 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 antidigoxin antibody glomerular filtration rate endogenous digitalis-like factor hypertension preeclampsia pulmonary edema Endogenous digitalis-like factor(s...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1069–1073.
Published: 25 May 2018
... reticulum chaperone protein disulphide isomerase-A1 [ 15 ]. Akt cardiac hypertrophy cell signalling Fyn hypertension leflunomide Cardiac hypertrophy (CH) is a major independent cardiovascular risk factor and an underlying cause of heart failure and enhanced mortality [ 1 ]. While...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke Reinforcing the protective role of Ang-(1...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (8): 901–904.
Published: 30 April 2018
..., and hypertension. References 1 Tang W.H. and Hazen S.L. ( 2014 ) The contributory role of gut microbiota in cardiovascular disease . J. Clin. Invest. 124 , 4204 – 4211 10.1172/JCI72331 25271725 2 Santisteban M.M. , Qi Y. , Zubcevic J. , Kim S. , Yang T...
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