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Keywords: hypertension
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Articles
Clin Sci (Lond) (2022) 136 (11): 879–894.
Published: 06 June 2022
...Shobana Navaneethabalakrishnan; Brooke K. Wilcox; Bethany L. Goodlett; Malea M. Murphy; Brett M. Mitchell Hypertension (HTN) is associated with gonadal dysfunction and impaired reproductive health in both men and women. An imbalance in the systemic and renal proinflammatory (M1)/anti-inflammatory...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (11): 803–817.
Published: 30 May 2022
... channel in the neuronal development, but its potential roles in vascular Ca V 1.2 channels and vasoconstriction remain undefined. Here, we detect Rbfox1 is expressed in rat vascular smooth muscles. Moreover, the protein level of Rbfox1 is dramatically decreased in the hypertensive small arteries from...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (9): 675–694.
Published: 10 May 2022
... Visser; A.H. Jan Danser; Jorie Versmissen Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a ‘preeclampsia-like’ syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with aspirin is known...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (8): 599–620.
Published: 22 April 2022
...Theodore W. Kurtz; Michal Pravenec; Stephen E. DiCarlo High-salt diets are a major cause of hypertension and cardiovascular (CV) disease. Many governments are interested in using food salt reduction programs to reduce the risk for salt-induced increases in blood pressure and CV events...
Articles
Clin Sci (Lond) (2021) CS20210937.
Published: 17 December 2021
...Geoffrey Culshaw; David Binnie; Neeraj Dhaun; Patrick Hadoke; Matthew Bailey; David J Webb Hypertension is a major risk factor for cardiovascular disease. In a significant minority of people, it develops when salt intake is increased (salt-sensitivity). It is not clear whether this represents...
Articles
Clin Sci (Lond) (2021) 135 (22): 2575–2588.
Published: 26 November 2021
...Cuimei Hu; Yu Tao; Yi Deng; Qi Cai; Hongmei Ren; Cheng Yu; Shuo Zheng; Jian Yang; Chunyu Zeng Maternal exposure to fine particulate matter (PM 2.5 ) causes hypertension in offspring. However, paternal contribution of PM 2.5 exposure to hypertension in offspring remains unknown. In the present study...
Articles
Clin Sci (Lond) (2021) 135 (19): 2329–2339.
Published: 13 October 2021
...Ellen E. Gillis; Kasey Belanger; Mahmoud Abdelbary; Riyaz Mohamed; Jingping Sun; Michael W. Brands; Jennifer C. Sullivan Over the past decade there has been increasing support for a role of the immune system in the development of hypertension. Our lab has previously reported that female...
Articles
Clin Sci (Lond) (2021) 135 (17): 2165–2196.
Published: 17 September 2021
...Erika I. Boesen; Rahul M. Kakalij Hypertension is a major risk factor for cardiovascular disease, chronic kidney disease (CKD), and mortality. Troublingly, hypertension is highly prevalent in patients with autoimmune renal disease and hastens renal functional decline. Although progress has been...
Articles
Clin Sci (Lond) (2021) 135 (15): 1791–1804.
Published: 02 August 2021
... utilized the spontaneously hypertensive rats (SHR) as an experimental model of essential hypertension to increase our understanding of the mechanisms regulating blood pressure in males and females. Previous work by our group and others have implicated that differential regulation of adrenergic receptors...
Articles
Clin Sci (Lond) (2021) 135 (14): 1631–1647.
Published: 23 July 2021
... remodelling. Thus, dabrafenib may affect the heart in the context of, for example, hypertension. In experiments with cardiomyocytes, cardiac fibroblasts and perfused rat hearts, dabrafenib inhibited ERK1/2 signalling. We assessed the effects of dabrafenib (3 mg/kg/d) on male C57BL/6J mouse hearts in vivo...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (14): 1649–1668.
Published: 20 July 2021
..., including hypertension, congestive heart failure, myocarditis and acceleration of atherosclerosis. Currently, VEGFI and ICI combination therapy is recommended for the treatment of advanced renal cell carcinoma (RCC) and has shown promising treatment efficacy in other tumour types as well. Consequently...
Articles
Clin Sci (Lond) (2021) 135 (13): 1627–1630.
Published: 09 July 2021
...Keiichi Torimoto; Satoru Eguchi This commentary highlights the study entitled ‘Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor’ presented by Fu et al. published in Clinical Science ( Clin...
Articles
Clin Sci (Lond) (2021) 135 (13): 1609–1625.
Published: 09 July 2021
... being attributed to neoplasms. The two share multiple common risk factors such as obesity, poor physical exercise, older age, smoking and there exists rare monogenic hypertension syndromes. Hypertension is the most important risk factor for cardiovascular disease and affects more than a billion people...
Articles
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
... is also discrepant in women between their premenopausal, pregnancy and postmenopausal phases of life. Emerging data indicate that at all reproductive statuses and ages, the presentation of a cardiovascular event in obese women is strongly associated with hypertension and its subsequent chronic risk factor...
Articles
Clin Sci (Lond) (2021) 135 (7): 943–961.
Published: 14 April 2021
... and processed for histology. Non-Tg littermates (WT) served as controls. 28 01 2021 01 04 2021 06 04 2021 06 04 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Angiotensin II Hypertension Intrarenal RAS SGLT2...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
...Olga Schweigert; Julia Adler; Natalie Längst; Dylan Aïssi; Jorge Duque Escobar; Teng Tong; Christian Müller; David-Alexandre Trégouët; Robert Lukowski; Tanja Zeller Hypertension is a complex and multifactorial disorder caused by lifestyle and environmental factors, inflammation and disease-related...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (7): 907–910.
Published: 09 April 2021
... angiotensinogen blood brain barrier hypertension neural Dear Editor We read with great interest the article by Uijl et al. [ 1 ] who reported that liver-directed small interfering RNA (siRNA) targeted to angiotensinogen (AGT) does not reverse the hypertension induced in male Sprague–Dawley rats...
Articles
Clin Sci (Lond) (2021) 135 (6): 793–810.
Published: 23 March 2021
... was sensitive to Los. Besides, sPRR-His elevated blood pressure in obese C57/BL6 mice, an effect that was reversed by concurrent treatment with Los but not Cap. Collectively, we provide solid evidence that the AT1R mediates the functions of sPRR during obesity-related hypertension. Inhibiting sPRR signaling...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (6): 775–791.
Published: 17 March 2021
... of blood pressure (BP) in hypertensive rats and increases vasopressin release. Blocking brain angiotensin III formation by the APA inhibitor prodrug RB150/firibastat normalizes arterial BP in hypertensive deoxycorticosterone acetate (DOCA)-salt rats without inducing angiotensin II accumulation. We...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (1): 127–142.
Published: 08 January 2021
... of central RAS components can lead to instability in metabolic and cardiovascular homeostasis precipitating the occurrence of CMD. Several studies pointed to a role for the brain RAS in CMD [ 30 , 76 ]. In addition to its well-featured association with neurogenic hypertension [ 61 , 62 , 77 , 78...
Articles
Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
.... However, these drugs are associated with cardiovascular toxicities which can impact optimal cancer treatment in the short-term and may lead to increased morbidity and mortality in the longer term. Vascular endothelial growth factor inhibitors (VEGFIs) are associated with hypertension, left ventricular...
Articles
Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ACE2 COVID-19 Heart Failure Hypertension Kidney Diseases SARS-CoV-2...
Articles
Clin Sci (Lond) (2020) 134 (24): 3237–3257.
Published: 21 December 2020
...Shobana Navaneethabalakrishnan; Bethany L. Goodlett; Alexandra H. Lopez; Joseph M. Rutkowski; Brett M. Mitchell Hypertension is one of the most prevalent diseases that leads to end organ damage especially affecting the heart, kidney, brain, and eyes. Numerous studies have evaluated the association...
Articles
Clin Sci (Lond) (2020) 134 (18): 2503–2520.
Published: 29 September 2020
... hypertension and thromboembolism. Molecular processes underlying VEGFi-induced vascular toxicities still remain unclear but inhibition of endothelial NO synthase (eNOS), reduced nitric oxide (NO) production, oxidative stress, activation of the endothelin system, and rarefaction have been implicated. However...
Articles
Clin Sci (Lond) (2020) 134 (18): 2453–2467.
Published: 25 September 2020
...Yan Zhang; Shaoxiong Wang; Hefei Huang; Andi Zeng; Yu Han; Cindy Zeng; Shuo Zheng; Hongmei Ren; Yajing Wang; Yu Huang; Pedro A. Jose; Xin-Liang Ma; Chunyu Zeng; Ken Chen Hypertensive patients have impaired sodium excretion. However, the mechanisms are incompletely understood. Despite...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (13): 1805–1819.
Published: 17 July 2020
...Lele Cheng; Liang Wang; Manyun Guo; Jinlong He; Yangyang Deng; Junhui Liu; Yuanyuan Wei; Chen Wang; Juan Zhou; Li Ma; Qing Song; Zuyi Yuan; Yue Wu Successful treatment of resistant hypertension accompanied by elevated human C-reactive protein (hCRP) remains a key challenge in reducing the burden...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (13): 1763–1774.
Published: 10 July 2020
... homeostasis hypertension nephrology renin-angiotensin system vasculature Renin-expressing cells are fundamental for the maintenance of extracellular fluid volume, and blood pressure homeostasis. Through evolution, these cells have acquired additional roles in kidney vascular development...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Published: 16 June 2020
... in a dysfunctional endothelium with diminished perfusion, shunting and tissue hypoxia. Endothelial cell apoptosis, hypertension, multiple metabolic, endocrine and immune disturbances of the uremic milieu and specifically, a dysregulated angiogenesis, all contribute to the multifactorial pathogenesis. By setting...
Articles
Clin Sci (Lond) (2020) 134 (7): 747–750.
Published: 07 April 2020
... as the N-terminal ectodomain and is found in very low concentrations in the circulation. The significance of circulating ACE2 is unclear, although levels may be increased in disease (diabetes, CKD, hypertension) [ 4 , 5 ]. ACE2 has multiple substrates including kinins, apelin, neurotensin, dynorphin...
Articles
Clin Sci (Lond) (2020) 134 (6): 641–656.
Published: 27 March 2020
... of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin–angiotensin–aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation...
Articles
Clin Sci (Lond) (2020) 134 (5): 513–527.
Published: 09 March 2020
...Macarena Orejudo; Ana B. García-Redondo; Raúl R. Rodrigues-Diez; Raquel Rodrigues-Díez; Laura Santos-Sanchez; Antonio Tejera-Muñoz; Jesús Egido; Rafael Selgas; Mercedes Salaices; Ana M. Briones; Marta Ruiz-Ortega An important link exists between hypertension and inflammation. Hypertensive patients...
Articles
Clin Sci (Lond) (2020) 134 (3): 359–377.
Published: 04 February 2020
...Laia Cañes; Ingrid Martí-Pàmies; Carme Ballester-Servera; Adela Herraiz-Martínez; Judith Alonso; María Galán; J. Francisco Nistal; Pedro Muniesa; Jesús Osada; Leif Hove-Madsen; Cristina Rodríguez; José Martínez-González Hypertensive cardiac hypertrophy (HCH) is a common cause of heart failure (HF...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 303–313.
Published: 30 January 2020
...) will increase the inflammatory state through activation of TLR3, contributing to vascular dysfunction and increased BP. Therefore, inhibition of TLR3 could be a therapeutic target for the treatment of hypertension with potential improvement in vascular reactivity and consequently, a decrease in BP...
Articles
Clin Sci (Lond) (2019) 133 (9): 1097–1113.
Published: 09 May 2019
... receptor antagonist losartan in the PVN lowered blood pressure to a greater extent in prenatal cold-exposed that control offspring. The present study provides evidence for overactive peripheral and central sympathetic nervous systems in the pathogenesis of prenatal cold-induced hypertension. Central AT 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (7): 853–857.
Published: 04 April 2019
...Roberta Imperatore; Luigia Cristino Emerging evidence attributes to orexins/hypocretins (ORs) a protective function in the regulation of cardiovascular responses, heart rate, and hypertension. However, little is known about any direct effect of orexins in the heart function. This is of special...
Articles
Clin Sci (Lond) (2018) 132 (17): 1953–1962.
Published: 14 September 2018
...: Debra I. Diz ( ddiz@wakehealth.edu ) 18 05 2018 04 07 2018 19 07 2018 19 07 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 fetal programming hypertension mitogen-activated protein kinases sex differences...
Articles
Clin Sci (Lond) (2018) 132 (16): 1837–1853.
Published: 30 August 2018
... of its target myosin phosphatase target subunit 1 (MYPT1), but its relationship with Rho-kinase activity in the myocardium and in vasculature in hypertension has not been evaluated. The aim was to determine the degree of association between Rho-kinase cascade activation in circulating leukocytes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (16): 1855–1874.
Published: 30 August 2018
... that stretch induced a significantly high level of β-2 microglobulin (β2M), a non-glycosylated protein, which is related to inflammatory diseases but rarely known in cardiovascular diseases. The present data showed that serum β2M level was increased in patients with hypertension and further increased...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (14): 1513–1527.
Published: 23 July 2018
... on arterial pressure (AP), autonomic function, baroreflex sensitivity (BRS), and peripheral vascular reactivity. Spontaneously hypertensive (SH) and Wistar Kyoto (WKY) rats were treated with TRV027 for 14 days (20 ng/h) delivered to the lateral ventricle via osmotic minipumps. Mechanistic studies were...
Articles
Clin Sci (Lond) (2018) 132 (13): 1383–1401.
Published: 09 July 2018
...Xiao C. Li; Dongmin Zhu; Xiaowen Zheng; Jiangfeng Zhang; Jia L. Zhuo The renin–angiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived...
Articles
Clin Sci (Lond) (2018) 132 (12): 1345–1363.
Published: 28 June 2018
...), p-ERK, p-β-catenin, and p-Akt were dramatically increased in prorenin overexpressing rats. These results indicate that prorenin, without being converted into renin, causes hypertension, renal and cardiac fibrosis via the induction of inflammation, oxidative stress and the ERK, β-catenin, and Akt...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (12): 1215–1242.
Published: 21 June 2018
... with natriuretic and vasoconstrictive properties [ 3 , 4 ] led to numerous studies in fetal, neonatal, and maternal tissues in health and various disease states including PE, the most serious hypertensive disorder of pregnancy. Despite its potential importance, little work has been done on the possible role...
Articles
Clin Sci (Lond) (2018) 132 (10): 1069–1073.
Published: 25 May 2018
..., such growth factor-triggered Nox and Akt activation requires the endoplasmic reticulum chaperone protein disulphide isomerase-A1 [ 15 ]. Akt cardiac hypertrophy cell signalling Fyn hypertension leflunomide Cardiac hypertrophy (CH) is a major independent cardiovascular risk factor...
Articles
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke Regarding ACE2, ACE2 is widespread...
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Clin Sci (Lond) (2018) 132 (8): 901–904.
Published: 30 April 2018
..., and hypertension. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 angiotensin II hypertension microbiota patients The gastrointestinal tract is the largest reservoir of commensal bacteria in the human body. Food intake through the oral route...
Articles
Clin Sci (Lond) (2018) 132 (6): 701–718.
Published: 30 March 2018
...Seungbum Kim; Ruby Goel; Ashok Kumar; Yanfei Qi; Gil Lobaton; Koji Hosaka; Mohammed Mohammed; Eileen M. Handberg; Elaine M. Richards; Carl J. Pepine; Mohan K. Raizada Recent evidence indicates a link between gut pathology and microbiome with hypertension (HTN) in animal models. However, whether...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (4): 461–474.
Published: 28 February 2018
...Anna K.J. Gradel; Max Salomonsson; Charlotte M. Sørensen; Niels-Henrik Holstein-Rathlou; Lars Jørn Jensen Abdominal obesity and/or a high intake of fructose may cause hypertension. K + channels, Na/K-ATPase, and voltage-gated Ca 2+ channels are crucial determinants of resistance artery tone...
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Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
...Alison H.M. Taylor; Alastair J. Rankin; Emily P. McQuarrie; E. Marie Freel; Natalie Z.M. Homer; Ruth Andrew; Alan G. Jardine; Patrick B. Mark Background: Hypertension is prevalent in chronic kidney disease (CKD). Studies suggest that reduction in dietary salt intake reduces blood pressure (BP). We...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (2): 173–183.
Published: 19 January 2018
...William C. Valinsky; Rhian M. Touyz; Alvin Shrier Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na + , K + , and Mg 2+ dysregulation. Owing to its steroidal structure, aldosterone is an active transcriptional modifier when bound to the mineralocorticoid receptor (MR...
Articles
Clin Sci (Lond) (2018) 132 (1): 127–130.
Published: 11 January 2018
...Rugina Neuman; A.H. Jan Danser Agonistic autoantibodies (AAs) directed against receptors of the sympathetic nervous system and the renin–angiotensin system have been suggested to contribute to cardiovascular and renal disease, in particular hypertension, preeclampsia, and graft failure in kidney...