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Keywords: hypertension
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Articles
Clin Sci (Lond) (2024) 138 (10): 573–597.
Published: 22 May 2024
..., striatin-based STRIPAKs are required for cardiomyocyte and cardiac hypertrophy in AngII-induced hypertension. With heterozygous global STRN knockout, there was no significant effect on interstitial or perivascular fibrosis induced by AngII compared with wild-type littermates, but there was greater...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (23): 1771–1785.
Published: 14 December 2023
... immunomodulatory properties, including promoting the expansion of proinflammatory T lymphocytes and the proliferation and survival of B cells. In the present study, we hypothesized that leptin antagonism would improve B- and T-cell dysfunction and attenuate hypertension in an experimental model of SLE, the NZBWF1...
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Clin Sci (Lond) (2023) 137 (8): 597–601.
Published: 19 April 2023
...Andreia Zago Chignalia Hypertension is associated with the activation of the immune and lymphatic systems as well as lymphangiogenesis. The changes in the lymphatic system are considered an adaptive response to mitigate the deleterious effects of immune and inflammatory cells on the cardiovascular...
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Clin Sci (Lond) (2023) 137 (3): 239–250.
Published: 07 February 2023
...Jun Yu Chen; Khai Syuen Chew; Sheon Mary; Philipp Boder; Domenico Bagordo; Gian Paolo Rossi; Rhian M. Touyz; Christian Delles; Giacomo Rossitto Increasing evidence suggests excess skin Na + accumulation in hypertension; however, the role of skin-specific mechanisms of local Na + /water regulation...
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Clin Sci (Lond) (2022) 136 (23): 1759–1772.
Published: 02 December 2022
...Bethany L. Goodlett; Dakshnapriya Balasubbramanian; Shobana Navaneethabalakrishnan; Sydney E. Love; Emily M. Luera; Sunitha Konatham; Valorie L. Chiasson; Sophie Wedgeworth; Joseph M. Rutkowski; Brett M. Mitchell Background: Hypertension (HTN) is associated with renal proinflammatory immune cell...
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Clin Sci (Lond) (2022) 136 (22): 1661–1681.
Published: 21 November 2022
.... with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hypertension) is associated with additional features including increased fibrosis and can lead to heart failure. RAF kinases (ARAF/BRAF/RAF1) integrate signals into the extracellular signal-regulated...
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Clin Sci (Lond) (2022) 136 (16): 1205–1227.
Published: 18 August 2022
...Pedro Alves Soares Vaz de Castro; Pedro A. Jose; Ana Cristina Simões e Silva Systemic arterial hypertension is one of the leading causes of morbidity and mortality in the general population, being a risk factor for many cardiovascular diseases. Although its pathogenesis is complex and still poorly...
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Clin Sci (Lond) (2022) 136 (11): 879–894.
Published: 06 June 2022
...Shobana Navaneethabalakrishnan; Brooke K. Wilcox; Bethany L. Goodlett; Malea M. Murphy; Brett M. Mitchell Hypertension (HTN) is associated with gonadal dysfunction and impaired reproductive health in both men and women. An imbalance in the systemic and renal proinflammatory (M1)/anti-inflammatory...
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Clin Sci (Lond) (2022) 136 (8): 599–620.
Published: 22 April 2022
...Theodore W. Kurtz; Michal Pravenec; Stephen E. DiCarlo High-salt diets are a major cause of hypertension and cardiovascular (CV) disease. Many governments are interested in using food salt reduction programs to reduce the risk for salt-induced increases in blood pressure and CV events...
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Clin Sci (Lond) (2021) CS20210937.
Published: 17 December 2021
...Geoffrey Culshaw; David Binnie; Neeraj Dhaun; Patrick Hadoke; Matthew Bailey; David J Webb Hypertension is a major risk factor for cardiovascular disease. In a significant minority of people, it develops when salt intake is increased (salt-sensitivity). It is not clear whether this represents...
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Clin Sci (Lond) (2021) 135 (17): 2165–2196.
Published: 17 September 2021
...Erika I. Boesen; Rahul M. Kakalij Hypertension is a major risk factor for cardiovascular disease, chronic kidney disease (CKD), and mortality. Troublingly, hypertension is highly prevalent in patients with autoimmune renal disease and hastens renal functional decline. Although progress has been...
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Clin Sci (Lond) (2021) 135 (15): 1791–1804.
Published: 02 August 2021
... utilized the spontaneously hypertensive rats (SHR) as an experimental model of essential hypertension to increase our understanding of the mechanisms regulating blood pressure in males and females. Previous work by our group and others have implicated that differential regulation of adrenergic receptors...
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Clin Sci (Lond) (2021) 135 (13): 1627–1630.
Published: 09 July 2021
...Keiichi Torimoto; Satoru Eguchi This commentary highlights the study entitled ‘Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor’ presented by Fu et al. published in Clinical Science ( Clin...
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Clin Sci (Lond) (2021) 135 (13): 1609–1625.
Published: 09 July 2021
... being attributed to neoplasms. The two share multiple common risk factors such as obesity, poor physical exercise, older age, smoking and there exists rare monogenic hypertension syndromes. Hypertension is the most important risk factor for cardiovascular disease and affects more than a billion people...
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Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
... is also discrepant in women between their premenopausal, pregnancy and postmenopausal phases of life. Emerging data indicate that at all reproductive statuses and ages, the presentation of a cardiovascular event in obese women is strongly associated with hypertension and its subsequent chronic risk factor...
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Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
...Olga Schweigert; Julia Adler; Natalie Längst; Dylan Aïssi; Jorge Duque Escobar; Teng Tong; Christian Müller; David-Alexandre Trégouët; Robert Lukowski; Tanja Zeller Hypertension is a complex and multifactorial disorder caused by lifestyle and environmental factors, inflammation and disease-related...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (7): 907–910.
Published: 09 April 2021
...Carlos M. Ferrario; Leanne Groban; Hao Wang; Sarfaraz Ahmad © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 angiotensinogen blood brain barrier hypertension neural Dear Editor AGT angiotensinogen ASO antisense...
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Clin Sci (Lond) (2021) 135 (6): 775–791.
Published: 17 March 2021
... of blood pressure (BP) in hypertensive rats and increases vasopressin release. Blocking brain angiotensin III formation by the APA inhibitor prodrug RB150/firibastat normalizes arterial BP in hypertensive deoxycorticosterone acetate (DOCA)-salt rats without inducing angiotensin II accumulation. We...
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Clin Sci (Lond) (2021) 135 (1): 127–142.
Published: 08 January 2021
... by Portland Press Limited on behalf of the Biochemical Society 2021 Cardiometabolic Disease Diabetes Epigenetics Hypertension Renin Angiotensin System Cardiometabolic disease (CMD) refers to coexisting conditions of insulin resistance, dyslipidemia, obesity, elevated blood pressure (BP...
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Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
.... However, these drugs are associated with cardiovascular toxicities which can impact optimal cancer treatment in the short-term and may lead to increased morbidity and mortality in the longer term. Vascular endothelial growth factor inhibitors (VEGFIs) are associated with hypertension, left ventricular...
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Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ACE2 COVID-19 Heart Failure Hypertension Kidney Diseases SARS-CoV-2...
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Clin Sci (Lond) (2020) 134 (18): 2503–2520.
Published: 29 September 2020
... hypertension and thromboembolism. Molecular processes underlying VEGFi-induced vascular toxicities still remain unclear but inhibition of endothelial NO synthase (eNOS), reduced nitric oxide (NO) production, oxidative stress, activation of the endothelin system, and rarefaction have been implicated. However...
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Clin Sci (Lond) (2020) 134 (13): 1763–1774.
Published: 10 July 2020
... homeostasis hypertension nephrology renin-angiotensin system vasculature Renin-expressing cells are fundamental for the maintenance of extracellular fluid volume, and blood pressure homeostasis. Through evolution, these cells have acquired additional roles in kidney vascular development...
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Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Published: 16 June 2020
... in a dysfunctional endothelium with diminished perfusion, shunting and tissue hypoxia. Endothelial cell apoptosis, hypertension, multiple metabolic, endocrine and immune disturbances of the uremic milieu and specifically, a dysregulated angiogenesis, all contribute to the multifactorial pathogenesis. By setting...
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Clin Sci (Lond) (2020) 134 (7): 747–750.
Published: 07 April 2020
... 28 03 2020 31 03 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Angiotensin ACE2 receptor coronavirus hypertension cardiovascular COVID-19 Angiotensin converting enzyme 2 (ACE2) is a key element in the protective...
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Clin Sci (Lond) (2020) 134 (6): 641–656.
Published: 27 March 2020
... of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin–angiotensin–aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation...
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Clin Sci (Lond) (2020) 134 (5): 513–527.
Published: 09 March 2020
...Macarena Orejudo; Ana B. García-Redondo; Raúl R. Rodrigues-Diez; Raquel Rodrigues-Díez; Laura Santos-Sanchez; Antonio Tejera-Muñoz; Jesús Egido; Rafael Selgas; Mercedes Salaices; Ana M. Briones; Marta Ruiz-Ortega An important link exists between hypertension and inflammation. Hypertensive patients...
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Clin Sci (Lond) (2020) 134 (2): 303–313.
Published: 30 January 2020
...) will increase the inflammatory state through activation of TLR3, contributing to vascular dysfunction and increased BP. Therefore, inhibition of TLR3 could be a therapeutic target for the treatment of hypertension with potential improvement in vascular reactivity and consequently, a decrease in BP...
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Clin Sci (Lond) (2019) 133 (9): 1097–1113.
Published: 09 May 2019
... receptor antagonist losartan in the PVN lowered blood pressure to a greater extent in prenatal cold-exposed that control offspring. The present study provides evidence for overactive peripheral and central sympathetic nervous systems in the pathogenesis of prenatal cold-induced hypertension. Central AT 1...
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Clin Sci (Lond) (2019) 133 (7): 853–857.
Published: 04 April 2019
...Roberta Imperatore; Luigia Cristino Emerging evidence attributes to orexins/hypocretins (ORs) a protective function in the regulation of cardiovascular responses, heart rate, and hypertension. However, little is known about any direct effect of orexins in the heart function. This is of special...
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Clin Sci (Lond) (2018) 132 (17): 1953–1962.
Published: 14 September 2018
... protein to total expression in relative optical density units. fetal programming hypertension mitogen-activated protein kinases sex differences Data are expressed as the mean ± S.E.M. Unpaired Student’s t tests were used to determine significance between two groups for data derived from...
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Clin Sci (Lond) (2018) 132 (16): 1837–1853.
Published: 30 August 2018
... of its target myosin phosphatase target subunit 1 (MYPT1), but its relationship with Rho-kinase activity in the myocardium and in vasculature in hypertension has not been evaluated. The aim was to determine the degree of association between Rho-kinase cascade activation in circulating leukocytes...
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Clin Sci (Lond) (2018) 132 (13): 1383–1401.
Published: 09 July 2018
...Xiao C. Li; Dongmin Zhu; Xiaowen Zheng; Jiangfeng Zhang; Jia L. Zhuo The renin–angiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived...
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Clin Sci (Lond) (2018) 132 (12): 1345–1363.
Published: 28 June 2018
...), p-ERK, p-β-catenin, and p-Akt were dramatically increased in prorenin overexpressing rats. These results indicate that prorenin, without being converted into renin, causes hypertension, renal and cardiac fibrosis via the induction of inflammation, oxidative stress and the ERK, β-catenin, and Akt...
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Clin Sci (Lond) (2018) 132 (12): 1215–1242.
Published: 21 June 2018
... 08 05 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 antidigoxin antibody glomerular filtration rate endogenous digitalis-like factor hypertension preeclampsia pulmonary edema Endogenous digitalis-like factor(s...
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Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke The RAS is of profound physiological...