...; TRAF, TNF receptor-associated factor. cardiovascular disease hyperglycaemia inflammation obesity Cardiovascular diseases are the leading cause of morbidity and mortality in people with type 2 diabetes mellitus (T2DM). It is now clear that obesity, T2DM and cardiovascular diseases...

... for heart failure in diabetic subjects that is not observed in patients with normal fasting glucose levels [ 40 , 41 ], suggesting that exposure to hyperglycaemia and other metabolic changes is necessary to induce this morphological change [ 42 ]. Although ventricular hypertrophy is an established...

...Carlo G. Tocchetti; Brian A. Stanley; Vidhya Sivakumaran; Djahida Bedja; Brian O'Rourke; Nazareno Paolocci; Sonia Cortassa; Miguel A. Aon In Type I diabetic (T1DM) patients, both peaks of hyperglycaemia and increased sympathetic tone probably contribute to impair systolic and diastolic function...

... signalling in cells from different organs afflicted by the diabetic milieu. In the present review, we provide an overview of the current knowledge related to the understanding of the role of Nox in the processes that control cell injury induced by hyperglycaemia and other predominant factors enhanced...

...Kostas Tsintzas; Luke Norton; Kamal Chokkalingam; Nusrat Nizamani; Scott Cooper; Francis Stephens; Rudolf Billeter; Andrew Bennett Physiological hyperglycaemia and hyperinsulinaemia are strong modulators of gene expression, which underpins some of their well-known effects on insulin action...

...), and oxidative (p47 phox and ROS) and inflammatory effects (NF-κB) of high-fat and high-carbohydrate meals [ 66 – 68 ]. 12 7 2011 1 9 2011 8 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative...

... system and insulin. Correspondence: Professor Iain B. Squire (email is11@le.ac.uk ). 10 6 2009 28 9 2009 13 10 2009 13 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 coronary artery disease diagnosis hyperglycaemia myocardial...

... hyperglycaemia Type 2 diabetes The link between HF (heart failure) and diabetes is well documented, but the existence of diabetic cardiomyopathy as a distinct clinical entity continues to be the subject of debate. In 1881, Leyden commented that HF was a “frequent and noteworthy complication of diabetes...

...) hormones. Several animal studies have shown that prenatal glucocorticoid excess, either from endogenous overproduction with maternal stress or through exogenous administration to the mother or fetus, reduces birth weight and causes lifelong hypertension, hyperglycaemia and behavioural abnormality...

...Xiao C. Li; Jia L. Zhuo Pancreatic bi-hormones insulin and glucagon are the Yin and Yang in the regulation of glucose metabolism and homoeostasis. Insulin is synthesized primarily by pancreatic β-cells and is released in response to an increase in blood glucose levels (hyperglycaemia). By contrast...

...Donald R. Dengel; Aaron S. Kelly; Julia Steinberger; Alan R. Sinaiko The aim of the present study was to investigate the impact of acute hyperglycaemia on endothelial function in both normal-weight and overweight children. A total of 16 overweight [BMI (body mass index) ≥85th percentile] and 15...

... glucose tolerance and/or glycaemic control. In the healthy control group, hyperglycaemia (blood glucose concentration >10 mmol/l) was hardly present (2±1% or 0.4±0.2/24 h). However, in the patients with Type II diabetes, hyperglycaemia was experienced for as much as 55±7% of the time (13±2 h over 24 h...

... 2006 cardiomyopathy congestive heart failure hyperglycaemia hypertension systole Type II diabetes ventricular function There is a close association between the incidence of congestive heart failure and Type II diabetes [ 1 ]. The Type II diabetic patient is far more susceptible...

... is impaired from the onset of the disease and is strongly related to adverse outcomes. It is not clear whether impaired endothelial function is caused by hyperglycaemia or by other factors. Impaired endothelial function is closely associated with and may contribute to insulin resistance regardless...

...David M. WOOD; Amanda L. BRENNAN; Barbara J. PHILIPS; Emma H. BAKER Glucose is not detectable in airways secretions of normoglycaemic volunteers, but is present at 1–9 mmol·l -1 in airways secretions from people with hyperglycaemia. These observations suggest the existence of a blood glucose...

...W. F. Lam; E. S. M. Muller; J. H. M. Souverijn; C. B. H. W. Lamers; A. A. M. Masclee 1. We have investigated the effect of acute hyperglycaemia on pancreatico-biliary secretion in healthy subjects. Duodenal outputs of trypsin, lipase, amylase, bicarbonate and bilirubin were measured for 90 min...

... in these attacks. We studied the effect of hyperglycaemia and of the potassium channel opener pinacidil on insulin release and muscle strength in patients with hypokalaemic periodic paralysis. 2. Insulin release was assessed on two occasions in four patients with hypokalaemic periodic paralysis and in eight...

...Clive N. May; Ian W. Ham; Kirsten E. Heslop; Frances A. Stone; Christopher J. Mathias 1. In conscious rabbits, intravenous morphine (3 mg/kg) caused hypertension, bradycardia, hyperglycaemia and sedation. These changes were accompanied by large increases in plasma adrenaline and smaller increases...