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Keywords: hyperglycaemia
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Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
... that these mechanisms provide for suppression of inappropriate inflammation in obesity and vascular disease. cardiovascular disease hyperglycaemia inflammation obesity Cardiovascular diseases are the leading cause of morbidity and mortality in people with type 2 diabetes mellitus (T2DM). It is now...
Clin Sci (Lond) (2017) 131 (10): 897–915.
Published: 04 May 2017
... fibrosis cardiomyocyte hypertrophy diabetic cardiomyopathy diastolic dysfunction hyperglycaemia The global incidence of diabetes is predicted to reach 642 million adults by 2040, affecting both human health and world economies. Cardiovascular disease is the leading cause of death in patients...
Clin Sci (Lond) (2015) 129 (7): 561–574.
Published: 03 July 2015
...Carlo G. Tocchetti; Brian A. Stanley; Vidhya Sivakumaran; Djahida Bedja; Brian O'Rourke; Nazareno Paolocci; Sonia Cortassa; Miguel A. Aon In Type I diabetic (T1DM) patients, both peaks of hyperglycaemia and increased sympathetic tone probably contribute to impair systolic and diastolic function...
Includes: Supplementary data
Clin Sci (Lond) (2013) 125 (8): 361–382.
Published: 14 June 2013
... signalling in cells from different organs afflicted by the diabetic milieu. In the present review, we provide an overview of the current knowledge related to the understanding of the role of Nox in the processes that control cell injury induced by hyperglycaemia and other predominant factors enhanced...
Clin Sci (Lond) (2013) 124 (11): 675–686.
Published: 15 February 2013
...Kostas Tsintzas; Luke Norton; Kamal Chokkalingam; Nusrat Nizamani; Scott Cooper; Francis Stephens; Rudolf Billeter; Andrew Bennett Physiological hyperglycaemia and hyperinsulinaemia are strong modulators of gene expression, which underpins some of their well-known effects on insulin action...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (5): 203–214.
Published: 28 October 2011
... 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative stress Toll-like receptor Type 2 diabetes Diabetes affects more than 348 million people worldwide and around 36 million in the U.S.A. [ 1 , 2 ]. The prevalence of diabetes is increasing...
Clin Sci (Lond) (2010) 118 (8): 527–535.
Published: 02 February 2010
... 2009 13 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 coronary artery disease diagnosis hyperglycaemia myocardial infarction prognosis Abnormalities of glucose metabolism have powerful association with adverse prognosis for patients with coronary...
Clin Sci (Lond) (2009) 116 (10): 741–760.
Published: 15 April 2009
... ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. diabetic cardiomyopathy heart failure hyperglycaemia Type 2 diabetes The link between HF (heart...
Clin Sci (Lond) (2007) 113 (5): 219–232.
Published: 01 August 2007
...) hormones. Several animal studies have shown that prenatal glucocorticoid excess, either from endogenous overproduction with maternal stress or through exogenous administration to the mother or fetus, reduces birth weight and causes lifelong hypertension, hyperglycaemia and behavioural abnormality...
Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
...Xiao C. Li; Jia L. Zhuo Pancreatic bi-hormones insulin and glucagon are the Yin and Yang in the regulation of glucose metabolism and homoeostasis. Insulin is synthesized primarily by pancreatic β-cells and is released in response to an increase in blood glucose levels (hyperglycaemia). By contrast...
Clin Sci (Lond) (2007) 112 (9): 493–498.
Published: 02 April 2007
...Donald R. Dengel; Aaron S. Kelly; Julia Steinberger; Alan R. Sinaiko The aim of the present study was to investigate the impact of acute hyperglycaemia on endothelial function in both normal-weight and overweight children. A total of 16 overweight [BMI (body mass index) ≥85th percentile] and 15...
Clin Sci (Lond) (2006) 111 (2): 119–126.
Published: 13 July 2006
... glucose tolerance and/or glycaemic control. In the healthy control group, hyperglycaemia (blood glucose concentration >10 mmol/l) was hardly present (2±1% or 0.4±0.2/24 h). However, in the patients with Type II diabetes, hyperglycaemia was experienced for as much as 55±7% of the time (13±2 h over 24 h...
Clin Sci (Lond) (2006) 111 (1): 53–59.
Published: 14 June 2006
... 2006 cardiomyopathy congestive heart failure hyperglycaemia hypertension systole Type II diabetes ventricular function There is a close association between the incidence of congestive heart failure and Type II diabetes [ 1 ]. The Type II diabetic patient is far more susceptible...
Clin Sci (Lond) (2005) 109 (2): 143–159.
Published: 25 July 2005
... is impaired from the onset of the disease and is strongly related to adverse outcomes. It is not clear whether impaired endothelial function is caused by hyperglycaemia or by other factors. Impaired endothelial function is closely associated with and may contribute to insulin resistance regardless...
Clin Sci (Lond) (2004) 106 (5): 527–533.
Published: 01 May 2004
...David M. WOOD; Amanda L. BRENNAN; Barbara J. PHILIPS; Emma H. BAKER Glucose is not detectable in airways secretions of normoglycaemic volunteers, but is present at 1–9 mmol·l -1 in airways secretions from people with hyperglycaemia. These observations suggest the existence of a blood glucose...
Clin Sci (Lond) (1997) 93 (6): 573–580.
Published: 01 December 1997
...W. F. Lam; E. S. M. Muller; J. H. M. Souverijn; C. B. H. W. Lamers; A. A. M. Masclee 1. We have investigated the effect of acute hyperglycaemia on pancreatico-biliary secretion in healthy subjects. Duodenal outputs of trypsin, lipase, amylase, bicarbonate and bilirubin were measured for 90 min...
Clin Sci (Lond) (1996) 91 (5): 583–589.
Published: 01 November 1996
... in these attacks. We studied the effect of hyperglycaemia and of the potassium channel opener pinacidil on insulin release and muscle strength in patients with hypokalaemic periodic paralysis. 2. Insulin release was assessed on two occasions in four patients with hypokalaemic periodic paralysis and in eight...
Clin Sci (Lond) (1988) 75 (1): 71–77.
Published: 01 July 1988
...Clive N. May; Ian W. Ham; Kirsten E. Heslop; Frances A. Stone; Christopher J. Mathias 1. In conscious rabbits, intravenous morphine (3 mg/kg) caused hypertension, bradycardia, hyperglycaemia and sedation. These changes were accompanied by large increases in plasma adrenaline and smaller increases...