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Keywords: hypercholesterolaemia
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Clin Sci (Lond) (2017) 131 (18): 2397–2408.
Published: 08 September 2017
... Hypercholesterolaemia provokes reactive oxygen species (ROS) increase and is a major risk factor for cardiovascular disease (CVD) development. We previously showed that circulating miR-33a/b expression levels were up-regulated in children with familial hypercholesterolaemia (FH). miR-33a/b control cholesterol...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (14): 1561–1578.
Published: 30 June 2017
... vascular risk factors–diabetes, hypercholesterolaemia, hypertension and smoking–are implicated as risk factors for VaD. The associations between cholesterol and small vessel disease (SVD), stroke, cognitive impairment and subsequent dementia are complex and as yet not fully understood. Similarly...
Clin Sci (Lond) (2015) 129 (12): 1151–1161.
Published: 30 October 2015
...Xina Xie; Xuhong Song; Song Yuan; Haitao Cai; Yequn Chen; Xiaolan Chang; Bin Liang; Dongyang Huang Hypercholesterolaemia and inflammation are correlated with atherogenesis. Orphan nuclear receptor NR4A1, as a key regulator of inflammation, is closely associated with lipid levels in vivo . However...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (11): 963–972.
Published: 10 September 2015
...Francesco Martino; Fabrizio Carlomosti; Daniele Avitabile; Luca Persico; Mario Picozza; Francesco Barillà; Marcello Arca; Anna Montali; Eliana Martino; Cristina Zanoni; Sandro Parrotto; Alessandra Magenta Hypercholesterolaemia is one of the major causes of CVD (cardiovascular disease...
Clin Sci (Lond) (2007) 113 (11): 427–434.
Published: 01 November 2007
...Christopher C. T. Smith; Lee Stanyer; D. John Betteridge; Michael B. Cooper Cerebrovascular accumulation of Aβ (β-amyloid) occurs in aging and AD (Alzheimer's disease). Hypercholesterolaemia, which is associated with raised plasma LDL (low-density lipoprotein), may predispose to AD. Soluble Aβ...
Clin Sci (Lond) (2004) 107 (3): 273–280.
Published: 24 August 2004
...Jun Zhu CHEN; Fu Rong ZHANG; Qian Min TAO; Xing Xiang WANG; Jian Hua ZHU; Jun Hui ZHU Hypercholesterolaemia contributes to atherosclerosis and coronary artery diseases by inducing endothelial cell injury and dysfunction. Recent studies have provided increasing evidence that EPCs (endothelial...
Clin Sci (Lond) (2004) 106 (2): 215–217.
Published: 01 February 2004
..., 3.4–4.9 mmol/l) hypercholesterolaemia participating in a randomized double-blinded, 8-week trial comparing pravastatin (40 mg), simvastatin (20 and 80 mg) and placebo. sICAM-1 levels (means±S.D.) increased slightly from 12.2±4.2 to 13.6±4.2 ng/ml with statin therapy, whereas, among placebo-assigned...
Clin Sci (Lond) (2003) 104 (6): 627–632.
Published: 01 June 2003
... of simvastatin on these parameters. In patients with heterozygous familial hypercholesterolaemia, without atherosclerotic events, flow-mediated vasodilatation (FMD) of the brachial artery was measured after a wash-out period for lipid-lowering drugs (baseline) and after 6 weeks of treatment with simvastatin 80...
Clin Sci (Lond) (2003) 104 (4): 357–365.
Published: 06 March 2003
...Natalia de las HERAS; Eva CEDIEL; M. Pilar OUBIÑA; Paloma ARAGONCILLO; David SANZ-ROSA; Vicente LAHERA; Victoria CACHOFEIRO We compared the impact of hypercholesterolaemia and mixed dyslipidaemia on vascular function, vascular structure and fibrinolytic balance in rabbits. To this end, vascular...
Clin Sci (Lond) (2001) 100 (2): 191–198.
Published: 02 January 2001
.... The susceptibility of LDL to oxidation has been found to be greater in patients with coronary heart disease. Familial hypercholesterolaemia (FH) is a powerful clinical model in which to study the predictive role of LDL in atherogenesis. LDL-apheresis is a treatment that is able to decrease lipid levels in plasma...
Clin Sci (Lond) (1999) 96 (2): 199–207.
Published: 01 February 1999
... 1999 1999 L-arginine hypercholesterolaemia pharmacokinetics 199Clinical Science (1999) 96, 199 207 (Printed in Great Britain) Pharmacokinetics of L-arginine during chronic administration to patients with hypercholesterolaemia Oranee TANGPHAO*, Stephan CHALON , Heitor MORENO JR Brian B...
Clin Sci (Lond) (1998) 95 (3): 361–367.
Published: 01 September 1998
... improves basal or stimulated function of the nitric oxide (·NO) dilator system in patients with hypercholesterolaemia. 2. Seven subjects aged 47±3 (±S.E.M.) years with moderately elevated serum cholesterol concentrations (6.0±0.1 ;mmol/l) were given 4 weeks of placebo therapy followed by 500 i.u...
Clin Sci (Lond) (1995) 89 (5): 497–504.
Published: 01 November 1995
...Ming-Fong Chen; Hsiu-Ching Hsu; Yuan-Teh Lee 1. The effects of fish oil supplementation on atherosclerosis in different regions of the aorta in rabbits with diet-induced hypercholesterolaemia were studied. Control and experimental rabbits were fed a 1% cholesterol-enriched diet with or without 10...
Clin Sci (Lond) (1994) 87 (1): 53–59.
Published: 01 July 1994
...Michael D. Randall; Hiroshi Ujiie; Tudor M. Griffith 1. We have used an isolated, buffer-perfused, rabbit ear model of acute arterial occlusion to investigate the effects of exogenous l-arginine on the severe impairment of collateral perfusion associated with dietary-induced hypercholesterolaemia...
Clin Sci (Lond) (1991) 80 (2): 119–129.
Published: 01 February 1991
... be part of a general deleterious effect to the endothelium of hypercholesterolaemia. 2. This possibility has been investigated in vitro by measuring the response to acetylcholine, sodium nitroprusside, 5-hydroxytryptamine and noradrenaline in segments of aorta and of femoral, mesenteric and cerebral small...
Clin Sci (Lond) (1985) 68 (1): 83–88.
Published: 01 January 1985
...)-triglyceride and VLDL synthesis. Correspondence: Dr J. P. D. Reckless, Royal United Hospital, Combe Park, Bath BAl 3NG, U.K. Key words: ,acipimox, adipose tissue, cholesterol synthesis, hypercholesterolaemia, hypertriglyceri- daemia, jejunum, lipolysis. Abbreviations: LDL, low-density lipoprotein; VLDL, very...
Clin Sci (Lond) (1984) 67 (4): 439–444.
Published: 01 October 1984
... reductions in circulating cholesterol induced by HMG warrant further investigation into the use of this compound in the management of familial hypercholesterolaemia. 27 2 1984 29 3 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 cholestyramine 3-hydroxy-3...
Clin Sci (Lond) (1983) 65 (1): 95–98.
Published: 01 July 1983
... material during a 6 h incubation, after derepression of the lymphocytes for 72 h in lipoprotein-deficient medium. 3. No significant correlation existed between LDL receptor activity in vitro and plasma LDL cholesterol concentration in vivo (r =-0.08). Key words: hypercholesterolaemia, low-density...
Clin Sci (Lond) (1983) 64 (6): 637–642.
Published: 01 June 1983
...Gerald Brook; Giora Winterstein; Michael Aviram 1. Repeated plasma exchange was carried out on three young patients with severe familial hypercholesterolaemia. There was a 3 week interval between each exchange. After a single exchange, plasma cholesterol, apolipoprotein B and low density...
Clin Sci (Lond) (1979) 56 (4): 377–380.
Published: 01 April 1979
...Gillian M. Martin; P. Nestel 1. Possible defects in cholesterol metabolism were sought in children with familial hypercholesterolaemia. 2. In nine affected children (eight heterozygotes and one homozygote) and in five healthy children, cholesterol synthesis and bile acid synthesis were determined...
Clin Sci Mol Med (1976) 51 (s3): 37s–39s.
Published: 01 December 1976
... atherosclerosis genetic factor hypercholesterolaemia hypertension Clinlcal Science and Molecular Medicine (1916) 51, 319-39s. Importance of hypertension and genetic factors for atherogenesis in rats Y. YAMORI,*t R. HORIE,*S H . HANDA Y. NARA,*t M. OHTAKAIS AND M. FUKASE* *Japan Stroke Prevention Center...
Clin Sci Mol Med (1974) 47 (6): 547–557.
Published: 01 December 1974
... of cholesterol within the individual plasma lipoproteins, were consistent with an increased influx into plasma of non-esterified cholesterol within VLDL, and an increased efflux of cholesterol from plasma within LDL. Key words : bile acid, colestipol , hyperlipoproteinaemia, hypercholesterolaemia, lipoprotein...