... human saphenous vein hydrogen peroxide nNOS • H 2 O 2 has been identified as the EDHF in human coronary arteries and, although NO and PGI 2 are more important for the HCA of healthy subjects, H 2 O 2 is gaining importance in disease states. nNOS is present in most vascular tissues...

... veins respectively. When responses to the constrictor plateaued, cumulative concentration–response curves (CRCs) to either the GTN or the HNO donor, AS (1 nM–10 μM) were constructed (0.5 log increments). Only one CRC was obtained in any one artery/vein. human radial artery human saphenous vein...

...Janet J. MAGUIRE; Julie C.-M. YU; Anthony P. DAVENPORT We have determined the ability of the endothelin (ET) A receptor antagonist, PD156707 (CI 1020), to inhibit intimal proliferation in human saphenous veins maintained in organ culture. After 28 days in culture, veins exposed to 1 µ M PD156707...