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Keywords: host defence
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Clin Sci (Lond) (2016) 130 (7): 479–490.
Published: 17 February 2016
... oxidase (NOX2) is critical for antimicrobial host defence. Chronic granulomatous disease (CGD) is an inherited disorder of NOX2 characterized by severe life-threatening bacterial and fungal infections and by excessive inflammation, including Crohn's-like inflammatory bowel disease (IBD). NOX2 defends...
Clin Sci (Lond) (2011) 120 (11): 473–484.
Published: 15 February 2011
... compilation © 2011 Biochemical Society 2011 asthma atherosclerosis autoimmune disease host defence mast cell activation mast cell progenitor Paul Ehrlich first described MCs (mast cells) or ‘mastzellen’ in 1878 based on their unique staining characteristics and their large granule content...
Clin Sci (Lond) (2006) 111 (1): 1–20.
Published: 14 June 2006
...Mark T. Quinn; Mary Cloud B. Ammons; Frank R. DeLeo The NADPH oxidase was originally identified as a key component of human innate host defence. In phagocytes, this enzyme complex is activated to produce superoxide anion and other secondarily derived ROS (reactive oxygen species), which promote...
Clin Sci (Lond) (2005) 109 (2): 125–133.
Published: 25 July 2005
..., and these signals have important roles in the activation of host defence. TLRs may also respond to products of tissue damage, providing them with roles in infective and sterile inflammation. Their role as detectors of pathogens and pathogen-associated molecules provides molecular mechanisms to underpin...