...James T. Pearson Epigenome changes in chronic states of cardiovascular stress including diabetes, pressure overload and cardiomyopathies frequently involve changes in open chromatin and post-translation modifications of histone lysine residues at specific amino acid positions by acetylation...

...) the balance of energy supply–demand promoting, e.g. over-nutrition or calorie restriction. These interventions have an impact on the fluxome and the levels of metabolites, second messengers, that in turn modify the epigenome via chromatin by, e.g. methylation, acetylation, of the DNA and/or histones. NAD...

... that received prasugrel or placebo 2 h before infusion of a bolus of LPS (2 ng/kg of body weight), whereas four subjects were assigned to a control group receiving prasugrel or placebo without LPS. hcDNA (histone-complexed DNA), coagulation and platelet-specific parameters were measured by enzyme immunoassay...