... was measured at designated time points. ( C ) Western blotting analysis of hepatic PCNA protein expression at designated time points. ( D ) H&E staining of liver tissues from mice before and at 48 h after PH. ( E ) Representative micrographs showing Ki67-positive stained hepatocytes in hepatic tissues...

... by targeting extracellular signal-regulated kinase 1 (ERK1) signalling in hepatic stellate cells (HSC) and hepatocyte epithelial–mesenchymal transition (EMT). Our results revealed that enhanced miR-21 levels in cirrhotic patients were related to the severity and activity of liver cirrhosis. Ad-TuD-21...

... factor β) and CCL20 (CC chemokine ligand 20) accompanied the changes in Th17/Th22 cells. Livers of IL-17 −/− mice were protected from NASH development and characterized by an extensive infiltration of Th22 cells. In vitro , IL-17 exacerbated the JNK (c-Jun N-terminal kinase)-dependent mouse hepatocyte...

... with myriocin. Since myriocin is a known inhibitor of ERK (extracellular-signal-related kinase) phosphorylation, we assessed the possibility that myriocin may be acting to increase hepatic apoA-I production via this pathway. To address this, HepG2 cells and primary mouse hepatocytes were treated with 200 μM...

... our understanding of the governance of the concentration of plasma LDL and the maintenance of cholesterol homoeostasis in the hepatocyte. We believe that regulation of cholesterol homoeostasis within the hepatocyte is demonstrably more complex than envisioned by the LDL receptor paradigm...

... antigen-expressing hepatocytes, implicating a possible role for this cell type in hepatitis B viral clearance [ 31 ]. Interestingly, in patients, NKT cells appear to be important in the development of an adequate immune response following hepatitis B vaccination [ 32 ]. However, in hepatitis-B-infected...

...Marcel C. G. van de Poll; Sebastiaan J. P. Hanssen; Maaike Berbée; Nicolaas E. P. Deutz; Diethard Monbaliu; Wim A. Buurman; Cornelis H. C. Dejong Arginine is an important substrate in health and disease. It is a commonly held view that arginase-1 release from injured erythrocytes and hepatocytes...

... or cholestatic disorders. During liver injury, liver cells are exposed to increased levels of cytokines, bile acids and oxidative stress. This results in death of hepatocytes. In contrast, stellate cells become active and are resistant against cell death. Eventually, acute and chronic liver injury is followed...

...Michele A. MARKLEY; Agostino PIERRO; Simon EATON Glutamine has beneficial effects on enterocytes and the immune system in sepsis, but its effects on hepatic metabolism remain unknown. The aim of the present study was to determine the effects of glutamine on hepatocyte energy metabolism under...

...M.E. MENDOZA; M.J. MONTE; M.Y. EL-MIR; M.D. BADIA; J.J.G. MARIN Bile acids reach the nuclei of hepatocytes, where they may play an important role in controlling gene expression by binding to nuclear receptors. In previous studies, changes in the amounts of the different molecular species of bile...

... individuals would be reproducible in PBMCs isolated from patients with multiple organ failure (acute disease model) and gastrointestinal cancer (chronic disease model). The effects of interleukin-4 on the ability of PBMC supernatants to elicit an acute phase protein response from isolated human hepatocytes...

... hepatocyte mRNA receptors vasopressin 20 1 1995 24 2 1995 Clinical Science (1995) 88, 671674 (Printed in Great Britain) 67 I Down-regulation of vasopressin Vla receptor mRNA in diabetes mellitus in the rat Paddy A. PHILLIPS, John RISVANIS, Anne-Marie HUTCHINS, Louise M. BURRELL, Duncan...