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Keywords: hepatocellular steatosisClose
Samuele Iesari, Isabelle Leclercq, Nicolas Joudiou, Mina Komuta, Aurélie Daumerie, Jérôme Ambroise, Alexandra Dili, Natacha Feza-Bingi, Daela Xhema, Caroline Bouzin, Bernard Gallez, Francesco Pisani, Eliano Bonaccorsi-Riani, Pierre Gianello
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (19): 2285–2305.
Published: 13 October 2021
... by the experimental compound. However, treated livers showed a mitigation in hepatocellular steatosis and ballooning, known markers of cellular stress after liver resection. RNAseq confirmed that roxadustat unexpectedly increases lipid breakdown and cellular respiration. Conclusions: Selective HIF stabilization did...
Includes: Supplementary data