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Keywords: hepatocellular carcinoma
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Clin Sci (Lond) (2022) 136 (5): 323–328.
Published: 02 March 2022
... pathologies. Specifically, the authors profiled circulating miRNAs in patients with hepatocellular carcinoma (HCC), liver cirrhosis (LC), and healthy controls and found that serum miR - 885 - 5p levels were significantly higher in samples of patients with HCC (6.5-fold increase) and LC (8.8-fold increase...
Clin Sci (Lond) (2021) 135 (7): 847–864.
Published: 06 April 2021
...Fang-Jing Zhong; Yi-Ming Li; Cong Xu; Bo Sun; Ji-Long Wang; Lian-Yue Yang Metastasis is the main cause of poor postoperative survival of hepatocellular carcinoma (HCC) patients. Cytoskeleton rearrangement is a key event in cancer metastasis. However, the significance of microtubule (MT), one...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (12): 1457–1472.
Published: 18 June 2020
...Yongjie Zhou; Qing Xu; Lv Tao; Yuwei Chen; Yuke Shu; Zhenru Wu; Changli Lu; Yujun Shi; Hong Bu The chromatin remodeling complex SWI/SNF regulates the accessibility of target genes to transcription factors and plays a critical role in the tumorigenesis of hepatocellular carcinoma (HCC). The SWI/SNF...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (19): 2019–2022.
Published: 11 October 2019
...Brittany Dewdney; Lionel Hebbard Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related deaths around the globe. For patients receiving liver tumour resection, the risk of reoccurrence and metastasis is high. Cancer metastasis can occur as a consequence of a physical...
Clin Sci (Lond) (2019) 133 (14): 1645–1662.
Published: 25 July 2019
...Yan-rong Zhao; Ji-long Wang; Cong Xu; Yi-ming Li; Bo Sun; Lian-yue Yang Heart development protein with EGF-like domains 1 (HEG1) plays critical roles in embryo development and angiogenesis, which are closely related to tumor progression. However, the role of HEG1 in hepatocellular carcinoma (HCC...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (13): 1487–1503.
Published: 15 July 2019
...Jiaze Yu; Minjie Yang; Bo Zhou; Jianjun Luo; Zihan Zhang; Wen Zhang; Zhiping Yan Accumulating evidences indicate that circular RNAs (circRNAs) play a vital role in diverse cancer biology. However, the contributions of circRNAs to hepatocellular carcinoma (HCC) and their underlying mechanism remain...
Clin Sci (Lond) (2019) 133 (2): 367–379.
Published: 30 January 2019
...Jing Chen; Di Wu; Yue Zhang; Yong Yang; Yunfei Duan; Yong An Long non-coding RNAs (lncRNAs) play important roles in a variety of tumours; however, their biological function and clinical significance in hepatocellular carcinoma (HCC) are still unclear. In the present study, the clinical significance...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (1): 27–36.
Published: 09 December 2016
... antineoplastic properties. For metabolic syndrome patients with hepatocellular carcinoma (HCC), metformin may provide antitumoral effects. We evaluated the impact of metformin on tumour growth and visceral fat composition using relevant preclinical models of metabolic syndrome. Studies were performed in three...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (13): 1125–1136.
Published: 23 May 2016
...Junjie Xiao; Qi Sun; Yihua Bei; Ling Zhang; Jasmina Dimitrova-Shumkovska; Dongchao Lv; Yuefeng Yang; Yan Cao; Yingying Zhao; Meiyi Song; Yang Song; Fei Wang; Changqing Yang Hepatocellular carcinoma (HCC) represents a leading cause of deaths worldwide. Novel therapeutic targets for HCC are needed...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (11): 775–791.
Published: 13 February 2014
...Anne-Christine Piguet; Syamantak Majumder; Uma Maheshwari; Reji Manjunathan; Uttara Saran; Suvro Chatterjee; Jean-François Dufour Progression of liver fibrosis to HCC (hepatocellular carcinoma) is a very complex process which involves several pathological phenomena, including hepatic stellate cell...
Includes: Supplementary data
Clin Sci (Lond) (2010) 118 (12): 691–705.
Published: 30 March 2010
... in the maintenance of liver homoeostasis as well as in the pathogenesis of a wide variety of conditions affecting the liver, including viral hepatitis, steatohepatitis, cirrhosis and hepatocellular carcinoma. Much of the current knowledge of NF-κB signalling in the liver relates to the canonical pathway, the IKK...
Clin Sci (Lond) (2008) 114 (1): 73–83.
Published: 30 November 2007
... ). 2 5 2007 5 7 2007 3 8 2007 3 8 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 cell cycle S -farnesylthiosalicylic acid (FTS) hepatocellular carcinoma liver mitogen-activated protein kinase (MAPK) partial hepatectomy Ras All operations...
Clin Sci (Lond) (2000) 99 (3): 207–214.
Published: 03 August 2000
... for thrombocytopenia in liver diseases. To address this issue, we measured serum TPO, using a sensitive sandwich ELISA, in 108 patients with chronic viral hepatitis, which included chronic hepatitis (CH) and liver cirrhosis (LC), and hepatocellular carcinoma (HCC), and in 29 normal controls. TPO mRNA in 78 liver...
Clin Sci (Lond) (1994) 86 (4): 447–451.
Published: 01 April 1994
..., such as hepatocellular carcinoma or liver cirrhosis caused by chronic viral hepatitis, and correlated with reduced albumin levels in these conditions, indicating that the liver is the site of phosphoinositol-specific phospholipase D synthesis and that phosphoinositol-specific phospholipase D may be used as an additional...
Clin Sci (Lond) (1991) 81 (2): 177–182.
Published: 01 August 1991
...W. L. Hutchinson; P. J. Johnson; M.-Q. Du; R. Williams 1. To assess the value of serum α- l -fucosidase (EC as a marker for hepatocellular carcinoma, the activity was measured in patients with hepatocellular carcinoma and in control subjects. 2. Mean serum α- l -fucosidase activity...
Clin Sci (Lond) (1990) 78 (6): 551–555.
Published: 01 June 1990
... with hepatocellular carcinoma or fulminant hepatic failure and in normal subjects. 2. Serum concentrations of thyroxine-binding globulin and α 1 -antitrypsin were significantly greater in patients with hepatocellular carcinoma than in normal subjects, and the percentage lentil-lectin reactivity of these two proteins...
Clin Sci (Lond) (1983) 64 (6): 643–648.
Published: 01 June 1983
...M. F. Bassendine; N. A. Wright; H. C. Thomas; S. Sherlock 1. The growth characteristics of a human hepatocellular carcinoma, derived from the PLC/PRF/5 cell-line (‘Alexander’), transplanted into sub-lethally irradiated athymic ( nu/nu ) mice have been examined. The xenograft re-expresses α...
Clin Sci Mol Med (1973) 45 (3): 387–396.
Published: 01 September 1973
...A. I. Vinik; W. Pooler 1. Responses to a 50 g oral glucose load and intravenous administration of 1 g of sodium tolbutamide have been compared in thirteen patients with hepatocellular carcinoma and ten control subjects. 2. The hepatoma patients have lower basal plasma glucose and immunoreactive...