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Keywords: heart failure
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Clin Sci (Lond) (2023) 137 (16): 1225–1247.
Published: 22 August 2023
...Charles Duncan Smart; Meena S. Madhur Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of new heart failure diagnoses and continues to increase in prevalence in the United States. Importantly, HFpEF is a highly morbid, heterogeneous syndrome lacking effective...
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Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
..., heart failure with preserved ejection fraction (HFpEF). In addition, emerging evidence indicates that obesity increases the risk of both hypertension and heart failure in pregnancy. This review will summarize clinical and experimental data on the female-specific prevalence and mechanisms of hypertension...
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Clin Sci (Lond) (2021) 135 (5): 703–724.
Published: 09 March 2021
... and mechanisms of these and additional cardiovascular toxicities, to be discussed here in further detail. autoimmunity cardiovascular disease heart failure immunomodulation Given that ICIs use will only become increasingly widespread in coming years, it is crucial for all medical care...
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Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
... systolic dysfunction (LVSD) and heart failure as well as arterial and venous thromboembolism, QTc interval prolongation and arrhythmia. The mechanisms behind the development of VEGFI-associated LVSD and heart failure likely involve the combination of a number of myocardial insults. These include direct...
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Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ACE2 COVID-19 Heart Failure Hypertension Kidney Diseases SARS-CoV-2...
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Clin Sci (Lond) (2020) 134 (19): 2595–2622.
Published: 14 October 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiac arrhythmia cardio-oncology cardiotoxicity chemotherapy heart failure PI3Kα The phosphoinositide 3-kinases (PI3Ks) are a family of intracellular lipid kinases that phosphorylate the 3...
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Clin Sci (Lond) (2020) 134 (19): 2623–2643.
Published: 14 October 2020
... in humans with systolic heart failure. NRG-4 has recently emerged as an adipokine with similar potential to regulate cardiovascular responses to inflammation and injury. Beyond systolic heart failure, NRGs appear to have beneficial effects in diastolic heart failure, prevention of atherosclerosis...
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Clin Sci (Lond) (2020) 134 (7): 827–851.
Published: 09 April 2020
... are at a high risk of cardiovascular complications ranging from microvascular dysfunction to cardiometabolic syndromes including heart failure. Despite significant advances in the standards of care for obese and diabetic patients, current therapeutic approaches are not always successful in averting...
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Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics...
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Clin Sci (Lond) (2017) 131 (18): 2319–2345.
Published: 25 August 2017
... in the left ventricle (LV) in response to internal or external cardiovascular damage or influence by pathogenic risk factors, and is a precursor of clinical heart failure (HF). Pathological remodelling is associated with fibrosis, inflammation and cellular dysfunction (e.g. abnormal cardiomyocyte/non...
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Clin Sci (Lond) (2017) 131 (16): 2063–2078.
Published: 24 July 2017
... Society 2017 Taken together, the mitochondrial SIRT3 and SIRT5 act as antioxidants whereas SIRT4 promotes the generation of mitochondrial ROS. Defects in BCAAs catabolism are critically associated with heart failure and ischemic injury [ 44 , 45 ]. All the mitochondrial Sirtuins are reported...
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Clin Sci (Lond) (2017) 131 (16): 2079–2094.
Published: 24 July 2017
... concomitantly with changes in cardiac function. In heart failure, FA oxidation is decreased, correlating with systolic dysfunction and hypertrophy. In contrast, in type 2 diabetes, FA oxidation and triglyceride storage are increased, and correlate with diastolic dysfunction and insulin resistance. Therefore...
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Clin Sci (Lond) (2017) 131 (13): 1375–1392.
Published: 23 June 2017
... Limited on behalf of the Biochemical Society 2017 arrhythmogenic right ventricular (ARVC) cardiomyocyte cardiomyopathy dilated cardiomyopathy (DCM) heart failure hypertrophic cardiomyopathy (HCM) hypertrophy primary cardiomyopathy restrictive cardiomyopathy (RCM) Cardiomyopathy...
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Clin Sci (Lond) (2017) 131 (6): 439–448.
Published: 06 March 2017
...Michael D. Fridman; Seema Mital In 2015, President Obama launched the Precision Medicine Initiative (PMI), which introduced new funding to a method of research with the potential to study rare and complex diseases. Paediatric heart failure, a heterogeneous syndrome affecting approximately 1...
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Clin Sci (Lond) (2017) 131 (5): 395–409.
Published: 17 February 2017
... amyloidosis), tools available to clinicians to improve diagnostic accuracy, available and newly developing therapeutics, as well as a brief biochemical and biophysical background of TTR amyloidogenesis. ATTR amyloidosis cardiac amyloidosis cardiomyopathy heart failure polyneuropathy transthyretin...
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Clin Sci (Lond) (2017) 131 (2): 113–121.
Published: 14 December 2016
...Paaladinesh Thavendiranathan; Mark T. Nolan Heart disease and cancer are the two leading causes of mortality globally. Cardiovascular complications of cancer therapy significantly contribute to the global burden of cardiovascular disease. Heart failure (HF) in particular is a relatively common...
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Clin Sci (Lond) (2016) 130 (24): 2239–2244.
Published: 04 November 2016
...Mark J. Haykowsky; Rhys Beaudry; R. Matthew Brothers; Michael D. Nelson; Satyam Sarma; Andre La Gerche Breast cancer (BC) survival rates have improved during the past two decades and as a result older BC survivors are at increased risk of developing heart failure (HF). Although the HF phenotype...
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Clin Sci (Lond) (2016) 130 (23): 2139–2149.
Published: 20 October 2016
... patients presented lower cardiomyocyte density ( P <0.001) and ejection fraction ( P <0.05), and higher troponin T levels ( P <0.05), prevalence of heart failure (HF; P <0.05) and NT-proBNP levels ( P <0.05) than those from group 1. miRNA expression profile analysed in 5 patients randomly...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (8): 551–563.
Published: 08 March 2016
.... These differences can be found in all domains of cardiovascular health and disease, including heart rhythm, heart failure, coronary disease and valvular disease. Further understanding of gender differences in the heart is crucial for advancing our ability to maintain a healthy population and identify and treat...
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Clin Sci (Lond) (2016) 130 (7): 463–478.
Published: 17 February 2016
... has revealed the participation of CXCR3 and its ligands in multiple cardiovascular diseases (CVDs) of different aetiologies including atherosclerosis, hypertension, cardiac hypertrophy and heart failure, as well as in heart transplant rejection and transplant coronary artery disease (CAD). CXCR3...
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Clin Sci (Lond) (2015) 129 (10): 851–862.
Published: 28 August 2015
... states, and in particular has recently become regarded as one of the best diagnostic biomarkers available for acute kidney injury. Nevertheless, the precise physiological effects of NGAL on the heart and the significance of their alterations during the development of heart failure are only now beginning...
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Clin Sci (Lond) (2014) 127 (2): 65–76.
Published: 17 March 2014
... exchange. This pathological process may also contribute to PH (pulmonary hypertension) due to LHD. Few clinical trials have specifically evaluated lung structural remodelling and the effect of related therapies in LHD. Currently approved treatment for chronic HF (heart failure) may have direct beneficial...
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Clin Sci (Lond) (2014) 127 (1): 1–13.
Published: 10 March 2014
... peptide cardiac hypertrophy gene variant heart failure NT-proANP levels hypertension metabolic syndrome vascular damage Studies performed in the SHRsp (stroke-prone spontaneously hypertensive rat) animal model, a spontaneous model of hypertension with a higher predisposition to vascular...
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Clin Sci (Lond) (2013) 125 (7): 319–327.
Published: 07 June 2013
... for the treatment of heart disease. Ischaemic heart disease and resultant heart failure are the leading causes of death worldwide [ 1 ]. The ongoing loss of cardiomyocytes during and after ischaemic injury and replacement fibrosis are the major reasons for cardiac dysfunction [ 2 ]. As adult human hearts have...
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Clin Sci (Lond) (2013) 124 (6): 391–401.
Published: 27 November 2012
.... The concentration of isoflurane was kept between 1.0 and 1.5%, so that the animals tolerated the study but could react to a leg pinch with a withdrawal response. animal model echocardiography faecal peritonitis gene transcript heart failure sepsis • Myocardial function is depressed in sepsis...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 123 (12): 659–668.
Published: 10 August 2012
.... Local paracrine effects in the gut through GC-C stimulation may have tumour-suppressing actions through the regulation of cell proliferation and metabolism. Although most information on this system has been derived from knockout models, recent human studies have indicated possible roles in heart failure...
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