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Keywords: heart failure
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Clin Sci (Lond) (2021) 135 (23): 2625–2641.
Published: 08 December 2021
...Patrizia Dardi; Laís Rossi Perazza; Gisele Kruger Couto; Gianne Paul Campos; Luciano dos Santos Aggum Capettini; Luciana Venturini Rossoni Arterial endothelial dysfunction has been extensively studied in heart failure (HF). However, little is known about the adjustments shown by the venous system...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
..., heart failure with preserved ejection fraction (HFpEF). In addition, emerging evidence indicates that obesity increases the risk of both hypertension and heart failure in pregnancy. This review will summarize clinical and experimental data on the female-specific prevalence and mechanisms of hypertension...
Clin Sci (Lond) (2021) 135 (7): 991–1007.
Published: 16 April 2021
... CHIP, inflammation and atherosclerotic disease has recently become better defined. However, there is a paucity of information about the role of CHIP in the development and progression of heart failure, particularly heart failure with preserved ejection fraction (HFpEF). While systemic inflammation...
Clin Sci (Lond) (2021) 135 (5): 703–724.
Published: 09 March 2021
... ). Correspondence: Mandar A. Aras ( mandar.aras@ucsf.edu ) 28 12 2020 22 02 2021 24 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 autoimmunity cardiovascular disease heart failure immunomodulation Adaptive immune...
Clin Sci (Lond) (2021) 135 (5): 683–686.
Published: 02 March 2021
...Carlos M. Ferrario We comment on the publication of a paper in which Brazilian investigators evaluate the anticontractile response of perivascular adipose tissue (PVAT) in experimental heart failure (HF) induced in rats by occlusion of a coronary artery. Correspondence: Carlos M. Ferrario...
Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
... systolic dysfunction (LVSD) and heart failure as well as arterial and venous thromboembolism, QTc interval prolongation and arrhythmia. The mechanisms behind the development of VEGFI-associated LVSD and heart failure likely involve the combination of a number of myocardial insults. These include direct...
Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
... ACE2 COVID-19 Heart Failure Hypertension Kidney Diseases SARS-CoV-2 Since its discovery in late 2000, angiotensin-converting enzyme 2 (ACE2) has garnered widespread attention for its multiple physiological roles: a negative regulator of renin–angiotensin system (RAS), a mediator of amino...
Clin Sci (Lond) (2020) 134 (23): 3195–3211.
Published: 09 December 2020
... diseases. Although heart failure (HF)-induced endothelial dysfunction is associated with renin–angiotensin system (RAS) activation, no data have correlated this syndrome with PVAT dysfunction. Thus, the aim of the present study was to investigate whether the hyperactivation of the RAS in PVAT participates...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (23): 3119–3121.
Published: 03 December 2020
... 2020 12 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 diabetes glucose heart failure Incretin Glucagon-like peptide-1 (GLP-1) is a 36 amino acid peptide hormone secreted by L-cells in the proximal intestine...
Clin Sci (Lond) (2020) 134 (20): 2755–2769.
Published: 30 October 2020
...Beverly Giam; Haru Nomura; Sanjaya Kuruppu; Po-Yin Chu; Sumia Essid; Helen Kiriazis; Xiao-Jun Du; David M. Kaye; Niwanthi W. Rajapakse Heart failure (HF) is associated with impaired L-arginine transport. In the present study, we tested the hypothesis that augmented L-arginine transport prevents...
Clin Sci (Lond) (2020) 134 (19): 2595–2622.
Published: 14 October 2020
... pathological hypertrophy [ 65 ], suggesting that augmentation of the PI3Kα signalling pathway may improve the functionality of a diseased heart and may potentially be used for the treatment of heart failure. Activation of PI3Kα has been shown to improve the function of failing hearts, through exercise-induced...
Clin Sci (Lond) (2020) 134 (19): 2623–2643.
Published: 14 October 2020
... in humans with systolic heart failure. NRG-4 has recently emerged as an adipokine with similar potential to regulate cardiovascular responses to inflammation and injury. Beyond systolic heart failure, NRGs appear to have beneficial effects in diastolic heart failure, prevention of atherosclerosis...
Clin Sci (Lond) (2020) 134 (9): 1081–1094.
Published: 07 May 2020
... disturbances in glucose homeostasis and heart failure (HF) progression is bidirectional. However, the mechanisms by which HF intrinsically impairs glucose homeostasis remain unknown. The present study tested the hypothesis that the bioavailability of intact glucagon-like peptide-1 (GLP-1) is affected in HF...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (7): 827–851.
Published: 09 April 2020
... are at a high risk of cardiovascular complications ranging from microvascular dysfunction to cardiometabolic syndromes including heart failure. Despite significant advances in the standards of care for obese and diabetic patients, current therapeutic approaches are not always successful in averting...
Clin Sci (Lond) (2019) 133 (8): 939–951.
Published: 29 April 2019
...) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day; p.o., 9...
Clin Sci (Lond) (2019) 133 (3): 393–405.
Published: 05 February 2019
...David C. Andrade; Camilo Toledo; Hugo S. Díaz; Claudia Lucero; Alexis Arce-Álvarez; Luiz M. Oliveira; Ana C. Takakura; Thiago S. Moreira; Harold D. Schultz; Noah J. Marcus; Julio Alcayaga; Rodrigo Del Rio Activation of the sympathetic nervous system is a hallmark of heart failure (HF...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (3): 381–397.
Published: 08 February 2018
... regulator of fatty acid oxidation) is positively modulated in the heart by the cardioprotective kinase, phosphoinositide 3-kinase (PI3K(p110α)). Disturbances in cardiac metabolism are a feature of heart failure (HF) patients and targeting metabolic defects is considered a potential therapeutic approach...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease. cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics The human gut harbors more than 100 trillion microbial cells, and majority of them being...
Clin Sci (Lond) (2017) 131 (18): 2319–2345.
Published: 25 August 2017
... in the left ventricle (LV) in response to internal or external cardiovascular damage or influence by pathogenic risk factors, and is a precursor of clinical heart failure (HF). Pathological remodelling is associated with fibrosis, inflammation and cellular dysfunction (e.g. abnormal cardiomyocyte/non...
Clin Sci (Lond) (2017) 131 (16): 2063–2078.
Published: 24 July 2017
.... Mitochondrial damage contributes to the development of CMDs, including heart failure, atherosclerosis, diabetes, and hypertension [ 5 – 8 ]. Thus, mitochondria have been considered as promising drug targets for improving the outcomes of CMDs [ 4 , 5 ]. The Sirtuins are a family of NAD + -dependent...
Clin Sci (Lond) (2017) 131 (16): 2079–2094.
Published: 24 July 2017
... concomitantly with changes in cardiac function. In heart failure, FA oxidation is decreased, correlating with systolic dysfunction and hypertrophy. In contrast, in type 2 diabetes, FA oxidation and triglyceride storage are increased, and correlate with diastolic dysfunction and insulin resistance. Therefore...
Clin Sci (Lond) (2017) 131 (13): 1375–1392.
Published: 23 June 2017
..., and plays a critical role in development as JPH2 knockout mice are embryonic lethal, likely due to impaired contractility [ 41 ]. However, JPH2 ablation in adult mice profoundly affects Ca 2+ release channel inactivation, impaired cardiac contractility with the development of heart failure [ 42...
Clin Sci (Lond) (2017) 131 (12): 1317–1327.
Published: 07 June 2017
...Yen-Yu Lu; Chen-Chuan Cheng; Chin-Feng Tsai; Yung-Kuo Lin; Ting-I Lee; Yao-Chang Chen; Shih-Ann Chen; Yi-Jen Chen Ventricular arrhythmias commonly arise from the right (RVOT) and left ventricular outflow tracts (LVOT) in patients without structural heart disease. Heart failure (HF) significantly...
Clin Sci (Lond) (2017) 131 (7): 553–566.
Published: 17 March 2017
...Yasbanoo Moayedi; Heather J. Ross The purpose of this review is to provide an overview of diagnosis, prognosis and management of heart failure (HF) with reduced ejection fraction (HFrEF). Specifically, this review is divided into three sections. The first section will address biomarkers...
Clin Sci (Lond) (2017) 131 (6): 439–448.
Published: 06 March 2017
...Michael D. Fridman; Seema Mital In 2015, President Obama launched the Precision Medicine Initiative (PMI), which introduced new funding to a method of research with the potential to study rare and complex diseases. Paediatric heart failure, a heterogeneous syndrome affecting approximately 1...
Clin Sci (Lond) (2017) 131 (5): 395–409.
Published: 17 February 2017
... of ATTR in the heart, and is one of the major reasons why clinicians must be cautious in managing patients of African American descent who present with early signs of heart failure. Regardless of the subtype of ATTR amyloidosis, all affected patient populations are at significant risk of disease...
Clin Sci (Lond) (2017) 131 (2): 113–121.
Published: 14 December 2016
...Paaladinesh Thavendiranathan; Mark T. Nolan Heart disease and cancer are the two leading causes of mortality globally. Cardiovascular complications of cancer therapy significantly contribute to the global burden of cardiovascular disease. Heart failure (HF) in particular is a relatively common...
Clin Sci (Lond) (2016) 130 (24): 2239–2244.
Published: 04 November 2016
...Mark J. Haykowsky; Rhys Beaudry; R. Matthew Brothers; Michael D. Nelson; Satyam Sarma; Andre La Gerche Breast cancer (BC) survival rates have improved during the past two decades and as a result older BC survivors are at increased risk of developing heart failure (HF). Although the HF phenotype...
Clin Sci (Lond) (2016) 130 (23): 2139–2149.
Published: 20 October 2016
... patients presented lower cardiomyocyte density ( P <0.001) and ejection fraction ( P <0.05), and higher troponin T levels ( P <0.05), prevalence of heart failure (HF; P <0.05) and NT-proBNP levels ( P <0.05) than those from group 1. miRNA expression profile analysed in 5 patients randomly...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (21): 1913–1928.
Published: 22 September 2016
... nervous system (CNS) to reset stress responses. acetylcholine autonomic nervous system heart failure stress vagus nerve Gradually accumulated evidence suggests that a non-neuronal cholinergic or non-neuronal acetylcholine (NNA) system plays a wide range of fundamental biological roles...
Clin Sci (Lond) (2016) 130 (8): 551–563.
Published: 08 March 2016
.... These differences can be found in all domains of cardiovascular health and disease, including heart rhythm, heart failure, coronary disease and valvular disease. Further understanding of gender differences in the heart is crucial for advancing our ability to maintain a healthy population and identify and treat...
Clin Sci (Lond) (2016) 130 (7): 463–478.
Published: 17 February 2016
... has revealed the participation of CXCR3 and its ligands in multiple cardiovascular diseases (CVDs) of different aetiologies including atherosclerosis, hypertension, cardiac hypertrophy and heart failure, as well as in heart transplant rejection and transplant coronary artery disease (CAD). CXCR3...
Clin Sci (Lond) (2016) 130 (2): 57–77.
Published: 04 December 2015
...Massimo Volpe; Marino Carnovali; Vittoria Mastromarino After its discovery in the early 1980s, the natriuretic peptide (NP) system has been extensively characterized and its potential influence in the development and progression of heart failure (HF) has been investigated. HF is a syndrome...
Clin Sci (Lond) (2015) 129 (10): 851–862.
Published: 28 August 2015
... states, and in particular has recently become regarded as one of the best diagnostic biomarkers available for acute kidney injury. Nevertheless, the precise physiological effects of NGAL on the heart and the significance of their alterations during the development of heart failure are only now beginning...
Clin Sci (Lond) (2015) 128 (10): 665–678.
Published: 20 February 2015
...Liang Shen; Ci Chen; Xuan Wei; Xixian Li; Guangjin Luo; Jingwen Zhang; Jianping Bin; Xiaobo Huang; Shiping Cao; Guofeng Li; Yulin Liao The Ankrd1 (ankyrin repeat domain 1) gene is known to be up-regulated in heart failure and acts as a co-activator of p53, modulating its transcriptional activity...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (10): 589–602.
Published: 18 July 2014
...Tzu-Pin Weng; Tieh-Cheng Fu; Chao-Hung Wang; Chih-Chin Hsu; Jong-Shyan Wang Lymphocytopenia is associated with an adverse prognosis in heart failure (HF). The present study investigated whether lymphocytopenia results from activated lymphocyte autophagy/apoptosis, which reflects haemodynamic...
Clin Sci (Lond) (2014) 127 (5): 331–340.
Published: 15 May 2014
...Nirmal Parajuli; Vaibhav B. Patel; Wang Wang; Ratnadeep Basu; Gavin Y. Oudit Oxidative stress plays a key pathogenic role in experimental and human heart failure. However, the source of ROS (reactive oxygen species) is a key determinant of the cardiac adaptation to pathological stressors...
Clin Sci (Lond) (2014) 127 (2): 65–76.
Published: 17 March 2014
... exchange. This pathological process may also contribute to PH (pulmonary hypertension) due to LHD. Few clinical trials have specifically evaluated lung structural remodelling and the effect of related therapies in LHD. Currently approved treatment for chronic HF (heart failure) may have direct beneficial...
Clin Sci (Lond) (2014) 127 (1): 1–13.
Published: 10 March 2014
... peptide cardiac hypertrophy gene variant heart failure NT-proANP levels hypertension metabolic syndrome vascular damage The natriuretic peptides family includes three well-characterized hormones: ANP (atrial natriuretic peptide), BNP (brain natriuretic peptide) and CNP (C-type natriuretic...
Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
...Irving H. Zucker; Liang Xiao; Karla K. V. Haack CHF (chronic heart failure) is a multifactorial disease process that is characterized by overactivation of the RAAS (renin–angiotensin–aldosterone system) and the sympathetic nervous system. Both of these systems are chronically activated in CHF...
Clin Sci (Lond) (2013) 125 (7): 319–327.
Published: 07 June 2013
... ]. Senescence and death of primitive cells and cardiomyocytes lead to premature cardiac aging and heart failure [ 27 ]. Disease conditions such as chronic heart failure [ 28 ] and diabetes [ 29 , 30 ] also lead to dysfunctional CS/PCs. On the other hand, it is possible that the microenvironment of an aging...
Clin Sci (Lond) (2013) 124 (6): 391–401.
Published: 27 November 2012
... animal model echocardiography faecal peritonitis gene transcript heart failure sepsis • Myocardial function is depressed in sepsis and is an important prognosticator in patients. • Using a long-term fluid-resuscitated rat model of faecal peritonitis, we demonstrate that significant...
Includes: Supplementary data
Clin Sci (Lond) (2013) 124 (2): 115–122.
Published: 26 September 2012
... and atherosclerosis in animals. In the present study, we sought to investigate the association of A-FABP with HF (heart failure) in Chinese subjects. Serum A-FABP levels were measured in 252 HF patients and 261 age-, gender- and BMI (body mass index)-matched non-HF subjects. Echocardiography was performed on each...
Clin Sci (Lond) (2013) 124 (2): 87–96.
Published: 26 September 2012
... 2012 31 7 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 angiotensin II type 2 receptor (AT 2 receptor) B 1 kinin receptor B 2 kinin receptor heart failure inflammation myocardial infarction renin–angiotensin system • CVD is the leading cause...
Clin Sci (Lond) (2012) 123 (12): 659–668.
Published: 10 August 2012
.... Local paracrine effects in the gut through GC-C stimulation may have tumour-suppressing actions through the regulation of cell proliferation and metabolism. Although most information on this system has been derived from knockout models, recent human studies have indicated possible roles in heart failure...
Clin Sci (Lond) (2012) 122 (9): 429–437.
Published: 16 January 2012
...Miriam T. Rademaker; Christopher J. Charles; M. Gary Nicholls; A. Mark Richards AM5 (adrenomedullin 5), a newly described member of the CGRP (calcitonin gene-related peptide) family, is reported to play a role in normal cardiovascular physiology. The effects of AM5 in HF (heart failure), however...
Clin Sci (Lond) (2012) 122 (4): 175–181.
Published: 14 October 2011
... assessed the reproducibility of cardiac power output and other more commonly reported cardiopulmonary exercise variables in patients with chronic heart failure. Metabolic, ventilatory and non-invasive (inert gas re-breathing) central haemodynamic measurements were undertaken at rest and near-maximal...
Clin Sci (Lond) (2011) 121 (6): 279–284.
Published: 27 May 2011
... on its relationship with invasive assessment by phenylephrine injection (Phe-slope). In the present study, we therefore compared these methodologies in a series of patients with HF (heart failure) in which both measures together with clinical and haemodynamic data were available. HRT parameters...
Clin Sci (Lond) (2011) 121 (1): 29–41.
Published: 18 March 2011
...Jan Benes; Ludmila Kazdova; Zdenek Drahota; Josef Houstek; Dasa Medrikova; Jan Kopecky; Nikola Kovarova; Marek Vrbacky; David Sedmera; Hynek Strnad; Michal Kolar; Jiri Petrak; Oldrich Benada; Petra Skaroupkova; Ludek Cervenka; Vojtech Melenovsky Advanced HF (heart failure) is associated...
Includes: Supplementary data
Clin Sci (Lond) (2011) 120 (10): 427–440.
Published: 28 January 2011
... with shorter leucocyte telomeres in patients with CHF (chronic heart failure) [ 48 ]. Most strikingly, childhood mistreatment, adverse life events, chronic and serious illness are associated with shorter telomeres later in life [ 49 ]. Smoking is typically marked by an increased oxidative stress...