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Keywords: heart
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Clin Sci (Lond) (2021) 135 (17): 2143–2163.
Published: 17 September 2021
... (IS) compared with SHR. The proarrhythmic phenotype in SHR-CRP was associated with altered heart and plasma eicosanoids, myocardial composition of fatty acids (FAs) in phospholipids, and autonomic nervous system imbalance before ischemia. To explain unexpected IS-limiting effect in SHR-CRP, we performed...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (9): 1103–1126.
Published: 11 May 2021
... exhibiting myocardial remodeling and heart failure at human equivalent ∼25 years. Term control and MNR baboon offspring were necropsied following cesarean-section, and left ventricle (LV) samples were collected. MNR adversely impacted fetal cardiac LV mitochondria in a sex-dependent fashion. Increased...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (22): 3023–3046.
Published: 24 November 2020
... ( sbourque@ualberta.ca ) 28 09 2020 07 11 2020 10 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Cardiovascular Developmental programming Heart Kidney Vasculature Three and half decades have passed since...
Clin Sci (Lond) (2019) 133 (24): 2431–2447.
Published: 16 December 2019
... in obese insulin-resistant rats. We hypothesized that Mdivi1 and M1 protect heart against obese insulin-resistant condition, but also there will be greater improvement using Mdivi1 and M1 as a combined treatment. Wistar rats ( n =56, male) were randomly assigned to a high-fat diet (HFD) and normal diet (ND...
Clin Sci (Lond) (2019) 133 (3): 497–513.
Published: 12 February 2019
..., and arrhythmia score was determined based on the criteria of Curtis and Walker [ 10 , 26 ]. The right carotid artery was identified and a P–V catheter (Scisense, Ontario, Canada) was inserted and advanced into the left ventricle to determine LV function during the cardiac I/R injury. Heart rate (HR), left...
Clin Sci (Lond) (2018) 132 (15): 1669–1683.
Published: 14 August 2018
.... Then, the heart was removed to determine infarct size, mitochondrial function, mitochondrial dynamics, and apoptosis. Our results showed that Mdivi-1 given prior to ischemia, exerted the highest level of cardioprotection quantitated through the attenuated incidence of arrhythmia, reduced infarct size, improved...
Clin Sci (Lond) (2017) 131 (9): 865–881.
Published: 19 April 2017
... of the mitochondrial permeability transition pore (MPTP) to opening, and infarct size (IS) in hearts of spontaneously hypertensive rats (SHR) and the conplastic SHR-mt BN strain, characterized by the selective replacement of the mitochondrial genome of SHR with that of the more ischaemia-resistant brown Norway (BN...
Clin Sci (Lond) (2016) 130 (10): 747–759.
Published: 01 April 2016
...Glenna C.L. Bett Disruption of cardiac electrical activity resulting in palpitations and syncope is often an early symptom of pregnancy. Pregnancy is a time of dramatic and dynamic physiological and hormonal changes during which numerous demands are placed on the heart. These changes result...
Clin Sci (Lond) (2011) 121 (9): 405–413.
Published: 12 July 2011
... and subchronic models respectively. Mice received either CsA (1 mg/kg of body weight, intraperitoneal on alternate days) or saline until follow-up. Heart function was evaluated by echocardiography. Mitochondrial measurements included oxygen consumption, membrane potential and externally added calcium-induced...
Clin Sci (Lond) (2009) 116 (9): 697–712.
Published: 02 April 2009
... in yeast, the discovery of human orthologues and the definition of signalling pathways regulating autophagy have accelerated our molecular understanding and interest in this fundamental process. A growing body of evidence indicates that autophagy is associated with heart disease, cancer and a number...
Clin Sci (Lond) (2005) 109 (3): 277–286.
Published: 24 August 2005
... formation was measured by ELISA. Rats fed an iron-deficient diet exhibited increased heart weight and size compared with the control group. Heart width, length and ventricular free wall thickness were similar between the two groups. However, the left ventricular dimension and chamber volume were...
Clin Sci (Lond) (2004) 107 (5): 467–475.
Published: 26 October 2004
... endothelin A receptor haemodynamics heart The effects of the most potent endogenous vasoconstrictor ET (endothelin)-1 [ 1 ] are mediated via ET A [ 2 ] and ET B [ 3 ] receptors. Since ET-1 is implicated in the development of diseases, such as heart failure [ 4 ] or coronary heart disease [ 5...
Clin Sci (Lond) (2004) 106 (3): 337–343.
Published: 01 March 2004
...Leila M. M. PEREIRA; Daniele G. BEZERRA; Denise L. MACHADO; Carlos A. MANDARIM-DE-LACERDA Stereological structural alterations of the heart and kidney were studied in four groups ( n =5) of spontaneously hypertensive rats (SHRs) treated for 30 days: (i) control, (ii) N G -nitro- L -arginine methyl...
Clin Sci (Lond) (2003) 104 (4): 429–436.
Published: 20 March 2003
...Christopher J. CHARLES; John M. ELLIOTT; M. Gary NICHOLLS; Miriam T. RADEMAKER; A. Mark RICHARDS The impaired ability to excrete sodium is a key feature of established congestive heart failure and is also apparent in asymptomatic left ventricular (LV) impairment. However, few studies have examined...
Clin Sci (Lond) (2002) 103 (s2002): 357S–362S.
Published: 01 September 2002
... as a therapeutic strategy. The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr A. Davenport (e-mail apd10@medschl.cam.ac.uk ). © 2002 The Biochemical Society and the Medical Research Society 2002 adenovirus aorta heart lung...
Clin Sci (Lond) (2002) 103 (s2002): 152S–157S.
Published: 01 September 2002
...Motoyuki IEMITSU; Takashi MIYAUCHI; Seiji MAEDA; Takumi TANABE; Yoko IRUKAYAMA-TOMOBE; Katsutoshi GOTO; Mitsuo MATSUDA; Iwao YAMAGUCHI Endothelin-1 (ET-1) is produced by endothelial cells and cardiac myocytes. ET-1 has potent positive inotropic and chronotropic effects on heart and induces...
Clin Sci (Lond) (2002) 102 (2): 241–246.
Published: 10 January 2002
...) were seen in women only ( P < 0.05 compared with men). Blood pressure and heart rate were not altered in either sex. Whole-body insulin-mediated glucose uptake and forearm glucose uptake did not differ between the sexes, and the ability of insulin to enhance endothelium-dependent vasodilatation (+19...
Clin Sci (Lond) (2001) 100 (5): 529–537.
Published: 09 April 2001
... or diastolic blood pressure throughout the exercise period, but heart rate drifted upwards from 141±2 beats/min after 30 min to 154±3 beats/min after 150 min ( P < 0.05). There was a small decline (8%; P < 0.05) in end-diastolic volume at 150 min. No changes were observed in left ventricular ejection...
Clin Sci (Lond) (2000) 99 (6): 547–554.
Published: 23 November 2000
...-mail J.Lee@shef.ac.uk ). 8 3 2000 5 7 2000 15 8 2000 The Biochemical Society and the Medical Research Society © 2000 2000 arrhythmias heart inotropic agents intracellular Ca2+ myofilaments sarcoplasmic reticulum 547Clinical Science (2000) 99, 547 554 (Printed in Great...
Clin Sci (Lond) (2000) 98 (6): 703–711.
Published: 10 May 2000
...Christopher J. CHARLES; John M. ELLIOTT; M. Gary NICHOLLS; Miriam T. RADEMAKER; Mark RICHARDS There are few stable and reproducible large-animal models of chronic heart failure produced by ischaemic damage to the myocardium. Here we characterize a novel method of inducing myocardial damage...
Clin Sci (Lond) (1998) 95 (1): 3–17.
Published: 01 July 1998
... correlated to the concomitant reduction in ejection fraction. The regulatory and pathophysiological changes in the activity and concentration of Na + ,K + -pumps are important for the contractile function of skeletal muscle and heart as well as for K + homoeostasis and the response to digitalization...
Clin Sci (Lond) (1997) 93 (5): 401–411.
Published: 01 November 1997
..., characterized by fibrinoid necrosis. This condition was absent in drug-treated animals, which presented minor signs of ischaemic lesion. Heart hypertrophy, when heart weight was expressed as a percentage of body weight, was similar in saline-, delapril- or indapamide-treated rats. At variance...
Clin Sci (Lond) (1995) 89 (2): 145–154.
Published: 01 August 1995
... nervous activity in healthy, lean subjects. 2. In nine male subjects, noradrenaline spillover was measured from the heart, kidney and liver using isotope dilution, both while fasting and after consumption of a high-energy liquid meal of composition 53% carbohydrate, 32% fat and 15% protein (energy value...
Clin Sci (Lond) (1995) 88 (3): 257–262.
Published: 01 March 1995
... current between heart muscle cells. 3. In this article, some of the contributions to this field by the author and his collaborators are summarized. Studies using confocal microscopy and digital imaging techniques to characterize the three-dimensional organization of electrical contacts between myocytes...
Clin Sci (Lond) (1991) 81 (5): 611–619.
Published: 01 November 1991
... in the whole body. k s was selectively depressed in skeletal muscles, mainly owing to a reduced k RNA , and was not modified in heart, liver and skin. The contribution of skin to whole-body protein synthesis increased by 39%. 3. During the phase of protein sparing (5 days of fasting), k d in the whole body...
Clin Sci (Lond) (1988) 74 (3): 269–274.
Published: 01 March 1988
...A. M. Dart; R. A. Riemersma 1. Reperfusion of the globally ischaemic isolated rat heart is associated with an enhanced overflow of endogenous noradrenaline (NA) after ischaemic periods of 20, 40 or 60 min but not of 10 min. 2. Reperfusion NA overflow, after 40 min of ischaemia, is suppressed...
Clin Sci (Lond) (1987) 72 (3): 271–275.
Published: 01 March 1987
... to the heart or is a generalized phenomenon in this hypertensive model. 2. The ventricles, kidney and liver of newborn SHR, Wistar and Wistar-Kyoto (WKY) rats were analysed for their protein and DNA content. 3. Total organ weight and the organ/body weight ratio of the heart and kidney but not of the liver were...
Clin Sci (Lond) (1986) 71 (4): 449–451.
Published: 01 October 1986
... to the sinoatrial node was occluded for periods of 1–3 min during this intermittent vagal stimulation. 3. Vagal action on heart rate was potentiated during ischaemia of the sino-atrial node. 21 1 1986 19 6 1986 © 1986 The Biochemical Society and the Medical Research Society 1986 bradycardia...
Clin Sci (Lond) (1986) 70 (1): 7–12.
Published: 01 January 1986
... in myocardial metabolism. Glutamic acid may be useful in treatment of circulatory and metabolic disturbances in cardiac failure. Key words: cardiac function, exogenous glutamic acid, heart, myocardial metabolism, postoperative cardiac failure. Introduction Recent studies in different experimental models...
Clin Sci (Lond) (1984) 67 (5): 535–540.
Published: 01 November 1984
... 1984 17 5 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 calcium-binding proteins heart hypertension Na + , K + -ATPase ouabain Clinical Science (1984) 61, 535-540 535 Calmodulin reduces ouabain-sensitive AT Pase of cardiac sarcolemmal membranes: high...
Clin Sci (Lond) (1983) 65 (6): 579–588.
Published: 01 December 1983
... on the early electrical changes in the intact heart. 28 4 1983 21 6 1983 © 1983 The Biochemical Society and the Medical Research Society 1983 electrophysiology heart myocardial ischaemia Clinical Science (1983) 65, 579-588 579 Study of the electrophysiological effects of early...
Clin Sci (Lond) (1982) 63 (s8): 383s–385s.
Published: 01 October 1982
... higher, heart rates were slightly higher, and heart weight/body weight ratios were higher in SHR. 3. Vascular dimensions were determined in a small sample of those rats, and the data there also indicate hypertrophy to some degree: the ratio of wall thickness/lumen radius was higher in SHR, tangential...
Clin Sci (Lond) (1982) 62 (3): 337–339.
Published: 01 March 1982
...F. Y. Leung; A. R. Henderson 1. Cytoplasmic aspartate aminotransferase was isolated and purified from human heart with a final specific activity of 236 units/mg of protein. 2. Three distinct peaks of aspartate aminotransferase activity were detected by isoelectric focusing with isoelectric points...
Clin Sci (Lond) (1981) 61 (s7): 45s–48s.
Published: 01 December 1981
...Marie-Gabrielle Pernollet; Marie-Aude Devynck; P. Meyer 1. Calcium handling by heart sarcolemmal vesicles from young spontaneously hypertensive rats (SHR) and normotensive Wistar—Kyoto (WKY) control rats were compared. 2. Calcium binding was significantly altered in SHR membranes...
Clin Sci (Lond) (1981) 61 (s7): 181s–183s.
Published: 01 December 1981
... cardiac sensory nerve endings, at doses devoid of systemic haemodynamic effects. 2. In conscious dogs with implanted catheters bradykinin (100 ng/kg) injected into a cannulated branch of the left coronary artery induced significant ( P < 0.01, n = 5) reflex increases in mean arterial pressure and heart...
Clin Sci (Lond) (1981) 61 (5): 585–590.
Published: 01 November 1981
... release and extraction. The estimated contribution of various organs to the noradrenaline concentrations in their venous effluent was: heart. 21%; kidney 47%; legs 68%. 5. This pattern of A—V difference proved a positive diagnostic feature for non-tumour patients since it was not found even...
Clin Sci (Lond) (1981) 60 (1): 33–40.
Published: 01 January 1981
...K. L. Evemy; P. Cummins; W. A. Littler 1. The effect of prolonged administration of β-adrenoreceptor-blocking agents was studied in growing rabbits. Equivalent doses of propranolol and timolol were given parenterally for 8 weeks. 2. Animals given propranolol had a significantly lower heart rate...
Clin Sci (Lond) (1980) 59 (s6): 169s–170s.
Published: 01 December 1980
...A. A. MacPhee; H. L. Blakesley; Karen A. Graci; E. D. Frohlich; F. E. Cole 1. Altered adrenergic responsiveness of hearts and blood vessels occurs in both experimental and clinical hypertension. 2. Since salt excess aggravates both types of hypertension, we investigated β-adrenoreceptor properties...
Clin Sci (Lond) (1980) 59 (s6): 415s–417s.
Published: 01 December 1980
... and the Medical Research Society 1980 cardiac adaptation heart ventricular weight ratio ClinicaZScience (1980) 5 9 , 4 1 5 ~ 4 1 7 ~ 415s Left/right ventricular weight ratio: an estimate of cardiac adaptation to hypertension M A R G A R E T A H A L L B A C K - N O R D L A N D E R Department...
Clin Sci (Lond) (1980) 59 (3): 207–209.
Published: 01 September 1980
... the last dose hearts were removed and subjected to aerobic perfusion, ischaemia and reperfusion. Rhythm disturbances were measured and compared with corresponding values in control hearts from the control untreated animals. 3. Three to 6 days after termination of drug administration a pronounced increase...
Clin Sci (Lond) (1980) 58 (6): 501–506.
Published: 01 June 1980
... in the relaxed dogs. 3. The increased tissue requirement for oxygen was met both by increased cardiac output and increased oxygen extraction from haemoglobin. 4. Oxygen utilization remained adequate in hypothermia, as shown by the absence of hypoxic acidosis. 5. Heart rate fell during cooling and stroke volume...
Clin Sci (Lond) (1979) 57 (s5): 39s–41s.
Published: 01 December 1979
... protein synthesis at this age. 4. Both β-adrenergic antagonists prevented the hypertrophy of aorta and mesenteric artery but not in heart. © 1979 The Biochemical Society and the Medical Research Society 1979 aorta, artery heart metoprolol propranolol vena cava Clinical Science (1979) 57.399...
Clin Sci Mol Med (1976) 51 (s3): 159s–162s.
Published: 01 December 1976
...C. E. Hall; S. Ayachi; O. Hall 1. Bilateral compression of adrenal glands combined with unilateral nephrectomy and followed by imposition of a high sodium chloride intake caused severe hypertension in all rats, accompanied by enlargement of the heart, kidneys and adrenal glands, atrophy...
Clin Sci Mol Med (1975) 49 (4): 337–341.
Published: 01 October 1975
...M. R. Moore; P. A. Meredith; A. Goldberg; K. E. Carr; P. G. Toner; T. D. V. Lawrie 1. There is no known cause for the increased mortality due to ischaemic heart disease in soft water areas. Since the lead concentration of soft water is elevated in houses with lead plumbing, studies have been...