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Clin Sci (Lond) (2015) 128 (1): 57–67.
Published: 29 August 2014
...Yvette C. Luiking; Martijn Poeze; Nicolaas E. Deutz Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (10): 589–602.
Published: 18 July 2014
...Tzu-Pin Weng; Tieh-Cheng Fu; Chao-Hung Wang; Chih-Chin Hsu; Jong-Shyan Wang Lymphocytopenia is associated with an adverse prognosis in heart failure (HF). The present study investigated whether lymphocytopenia results from activated lymphocyte autophagy/apoptosis, which reflects haemodynamic...
Clin Sci (Lond) (2013) 125 (12): 543–553.
Published: 02 August 2013
... endurance-trained and UT (untrained) individuals. Furthermore, we sought to characterize the haemodynamic, autonomic and thermoregulatory responses in the post-exercise period. We hypothesized that swimming would fail to elicit a PEH BP response of the same magnitude as land-based cycling, irrespective...
Clin Sci (Lond) (2012) 122 (12): 581–590.
Published: 05 March 2012
... (mean arterial pressure), SV (stroke volume) and HR. Saline had no haemodynamic effects. β-FXIIa infusion increased its plasma concentration 3-fold in both groups. In adrenally intact rats, β-FXIIa infusion increased MAP by 6% (5±2 mmHg) and TPR by 45% (0.50±0.12 mmHg/ml per min), despite falls in SV...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (9): 429–437.
Published: 16 January 2012
... in urine volume (HD 2-fold increment, P <0.05) and urine sodium (2.7-fold increment, P <0.01), potassium (1.7-fold increment, P <0.05) and creatinine (1.4-fold increment, P <0.05) excretion and creatinine clearance (60% increment, P <0.05). In conclusion, AM5 has significant haemodynamic...
Miriam T. Rademaker, Christopher J. Charles, Iain C. Melton, A. Mark Richards, Christopher M. Frampton, Jeff Siou, Fujian Qu, Neal L. Eigler, Dan Gutfinger, Richard W. Troughton
Clin Sci (Lond) (2011) 120 (5): 207–217.
Published: 19 November 2010
... ). haemodynamics heart failure implantable monitor intrathoracic impedance left atrial pressure natriuretic peptide 22 7 2010 15 9 2010 17 9 2010 17 9 2010 © 2011 The Authors 2011 This is an open-access article distributed under the terms of the Creative Commons Attribution...
Jasper Truijen, Shyrin C.A.T. Davis, Wim J. Stok, Yu-Sok Kim, David J. van Westerloo, Marcel Levi, Tom van der Poll, Berend E. Westerhof, John M. Karemaker, Johannes J. van Lieshout
Clin Sci (Lond) (2011) 120 (4): 161–167.
Published: 02 November 2010
...-antagonist autonomic nervous system baroreflex haemodynamics psychological stress Physiological adaptation to a potentially threatening situation involves a ‘fight-or-flight’ or stress response assumed to protect the individual [ 1 ]. Besides mental changes, the autonomic nervous system is also...
Clin Sci (Lond) (2008) 114 (10): 635–642.
Published: 14 April 2008
... in haemodynamics, hormonal profile and renal function than achieved by captopril alone. These results indicate that dual treatment with these two agents is beneficial. Compared with time-matched controls, separate Ucn2 and captopril administration significantly increased CO (Ucn2>captopril; both P...
Clin Sci (Lond) (2007) 113 (11): 449–457.
Published: 01 November 2007
...Julian M. Stewart; Indu Taneja; Marvin S. Medow Altered peripheral haemodynamics, decreased cardiac output, decreased blood volume and increased AngII (angiotensin II) have been reported in POTS (postural tachycardia syndrome). Recent findings indicate that BMI (body mass index) may be reduced...
C. T. Paul Krediet, Ingeborg K. Go-Schön, Yu-Sok Kim, Mark Linzer, Johannes J. Van Lieshout, Wouter Wieling
Clin Sci (Lond) (2007) 113 (10): 401–407.
Published: 12 October 2007
... and pulse wave analysis to assess haemodynamic changes. We studied 13 patients who were referred to our syncope unit for the evaluation of TLOC [nine men; height, 180 (152–204) cm; body weight, 77 (55–97) kg; age, 27 (15–59) years, with 4.5 (0–100) episodes of syncope in their lifetimes; values...
Clin Sci (Lond) (2007) 112 (9): 485–491.
Published: 02 April 2007
...Christopher J. Charles; Miriam T. Rademaker; A. Mark Richards In addition to haemodynamic actions, Ucn1 (urocortin 1) has been reported to affect a number of hormonal systems; however, it remains unclear whether Ucn1 modulates circulating hormones under physiological conditions. Accordingly...
Dorothee H. L. Bail, Volker Steger, Uli Heinzelmann, Sandra Schiller, Anita I. Geim, Benjamin Brüllmann, Gerhard Ziemer
Clin Sci (Lond) (2007) 112 (5): 315–324.
Published: 01 February 2007
.... (intravenous) bolus at 0.3 μg·kg −1 of body weight·min −1 , followed by an infusion at a rate of 0.015 μg·kg −1 of body weight·min −1 for 60 min. The animals in the control group ( n =10) received a saline solution instead of BNP. Haemodynamic and clinical chemistry parameters as well as the amount...
Clin Sci (Lond) (2006) 110 (3): 343–352.
Published: 10 February 2006
...±3.9 mmHg respectively; P <0.01). head-up tilting haemodynamics orthostatic tolerance posturally related syncope water Syncope is a common medical problem, responsible for 0.77% of hospital admissions in the United States [ 1 ] and between 0.9–1.2% of hospital admissions in Europe...
Reza Mobini, Michael Fu, Per-Anders Jansson, Claes-Håkan Bergh, Margareta Scharin Täng, Finn Waagstein, Bert Andersson
Clin Sci (Lond) (2006) 110 (3): 329–336.
Published: 10 February 2006
.... In the present study, we studied the acute effects of the imidazoline-receptor agonist moxonidine on haemodynamics, NA (noradrenaline) kinetics and myocardial metabolism. Fifteen patients with CHF (chronic heart failure) were randomized to a single dose of 0.6 mg of sustained-release moxonidine or matching...
Clin Sci (Lond) (2005) 108 (6): 531–538.
Published: 24 May 2005
... significantly alters aortic root haemodynamics. This phenomenon is associated with impaired NO-dependent vasodilation in vessel segments known to be prone to atherosclerosis. Correspondence: Dr Li-ming Gan, Department of Physiology, Institute of Physiology and Pharmacology, The Sahlgrenska Academy, Göteburg...
Clin Sci (Lond) (2005) 108 (2): 113–119.
Published: 21 January 2005
... =0.57). In conclusion, EPRO did not significantly inhibit sympathetic reactivity compared with placebo; however, it blunted the haemodynamic responses elicited by the sympatho-adrenal stimulation which only tended to be attenuated by this drug. Correspondence: Dr Marina Christensen (email macn...
Ulrika HÄGG, Irene ANDERSSON, Andrew S. NAYLOR, Julia GRÖNROS, Ingibjörg H. JONSDOTTIR, Göran BERGSTRÖM, Li-ming GAN
Clin Sci (Lond) (2004) 107 (6): 571–581.
Published: 24 November 2004
... cage system. Adult SHR of 9 weeks of age were used in the study, since animals of this age are considered to have established hypertension. Using this voluntary exercise model, effects of exercise on central haemodynamics in adult SHR have been studied extensively [ 13 , 14 ]. It has also been shown...
Clin Sci (Lond) (2004) 107 (5): 467–475.
Published: 26 October 2004
.... In anaesthetized open-chest rats the haemodynamic and inotropic effects of ET A receptor stimulation were studied by monitoring responses evoked by ET-1 (1 nmol/kg of body weight) after ET B receptor blockade with BQ 788 (0.5 μmol/kg of body weight); these responses were compared with saline controls (after ET B...
Clin Sci (Lond) (2004) 106 (5): 547–548.
Published: 01 May 2004
... Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, U.K. We read with interest the paper by Fugmann et al. , in a previous issue of Clinical Science, showing the close link between metabolic changes, mimicking those of the postprandial state, and haemodynamic...
Clin Sci (Lond) (2003) 105 (6): 715–721.
Published: 01 December 2003
...Andreas FUGMANN; Jonas MILLGÅRD; Mahziar SARABI; Christian BERNE; Lars LIND The aim of the present study was to evaluate the haemodynamic changes during hyperinsulinaemia, hyperglycaemia or hypertriglyceridaemia in relation to those following a mixed meal. Ten subjects were subjected...
Mitsunobu ENOMOTO, Noritoshi NAGAYA, Masaaki UEMATSU, Hiroyuki OKUMURA, Eiichiroh NAKAGAWA, Fumiaki ONO, Hiroshi HOSODA, Hideo OYA, Masayasu KOJIMA, Katsuo KANMATSUSE, Kenji KANGAWA
Clin Sci (Lond) (2003) 105 (4): 431–435.
Published: 01 October 2003
... min after ghrelin administration. These haemodynamic and hormonal changes were still apparent 60 min after ghrelin injection. In conclusion, subcutaneous administration of ghrelin dose-dependently induced relatively specific GH release and enhanced cardiac performance in humans. Correspondence...
Clin Sci (Lond) (2003) 104 (4): 429–436.
Published: 20 March 2003
... (all P <0.05) were higher in the MI group compared with normal control sheep. There were no differences in haemodynamics, body mass or renin–aldosterone levels between groups. This study provides evidence that natriuretic peptides play a pivotal role in preserving volume/electrolyte balance...
Kazunori MURAKAMI, Perenlei ENKHBAATAR, Katsumi SHIMODA, Akio MIZUTANI, Robert A. COX, Frank C. SCHMALSTIEG, Jeffrey M. JODOIN, Hal K. HAWKINS, Lillian D. TRABER, Daniel L. TRABER
Clin Sci (Lond) (2003) 104 (4): 349–356.
Published: 06 March 2003
... . In conclusion, high-dose heparin did not prevent lung dysfunction in this model, in which acute lung injury was induced by combined smoke and septic challenge. anticoagulant haemodynamics infection/inflammation Pseudomonas aeruginosa septic shock thrombosis Correspondence: Professor Daniel L...
Clin Sci (Lond) (2002) 103 (6): 535–542.
Published: 30 October 2002
... is greatly elevated in patients with congestive heart failure, but the clinical relevance of this finding is unclear. Central haemodynamic effects, cardiac conduction system electrophysiology and coronary sinus blood flow were therefore studied in two sets of experiments, each carried out on seven healthy...
Clin Sci (Lond) (2001) 101 (6): 749–757.
Published: 21 November 2001
... haemodynamics reflected waves wave intensity. 749Clinical Science (2001) 101, 749 757 (Printed in Great Britain) Arterial waves in humans during peripheral vascular surgery Ashraf W. KHIR*, Michael Y. HENEIN , Tat KOH , Saroj K. DAS , Kim H. PARKER* and Derek G. GIBSON *Physiological Flow Study Group...
Clin Sci (Lond) (2001) 101 (3): 285–294.
Published: 15 August 2001
.... Haemodynamics, lung weight gain (LWG), capillary filtration coefficient ( K fc ), tissue pathology, the concentrations of cytokines in the perfusate, and mRNAs for the various cytokines in the lung tissues were measured. I/R induced a permeability type of pulmonary oedema, as reflected by increases in LWG and K...
Clin Sci (Lond) (2000) 99 (5): 413–419.
Published: 27 October 2000
... in an isolated rat lung model, lungs were reperfused for 60 min in a closed circulating system with one of the following solutions: (1) NS (0.9% normal saline), (2) NS+Dex (dexamethasone), (3) NS+Penta (pentastarch), or (4) NS+Penta+Dex. Haemodynamic changes, lung weight gain (LWG), capillary filtration...
Clin Sci (Lond) (2000) 98 (6): 703–711.
Published: 10 May 2000
... pressures ( P < 0.05), plasma brain natriuretic peptide levels ( P < 0.05) and adrenaline levels ( P < 0.05). Rises seen in plasma endothelin levels in sham controls were blunted in the coil group ( P < 0.001). Haemodynamic changes were less marked in the balloon group. In conclusion...
Clin Sci (Lond) (2000) 98 (6): 661–665.
Published: 08 May 2000
... mechanisms must be operating in these women. Haemodynamic changes have been demonstrated in the pelvic vessels and aorta in this syndrome, but there have been no studies of the cerebral circulation. Since insulin resistance is a central feature of PCOS, it is of interest that cerebral blood flow may...
Clin Sci (Lond) (1998) 95 (3): 303–309.
Published: 01 September 1998
... accordingly. Correspondence : Dr Sven-Olof Granstam. 5 1 1998 18 3 1998 14 4 1998 The Biochemical Society and the Medical Research Society © 1998 1998 acetylcholine blood flow carvedilol haemodynamics hypertension spontaneously hypertensive rat 303Clinical Science...
Edoardo CASIGLIA, Lucia PAVAN, Luca MARCATO, Marco LEOPARDI, Alessandra PIZZIOL, Paolo SALVADOR, Renzo ZUIN, Achille C. PESSINA
Clin Sci (Lond) (1998) 95 (3): 287–294.
Published: 01 September 1998
... = 0.02). Minimal resistance was significantly lower in obstructed than in non-obstructed subjects. Both basal and minimal resistance progressively decreased, although insignificantly, with worsening bronchial obstruction. P a c o 2 did not correlate with any haemodynamic parameter. Borg index correlated...
Han-Chieh Lin, Yi-Tsau Huang, Yuh-Ren Cheng, Ming-Chih Hou, Fa-Yauh Lee, Full-Young Chang, Yang-Te Tsai, Shou-Dong Lee
Clin Sci (Lond) (1998) 94 (6): 645–650.
Published: 01 June 1998
... hypertension, the reduction of portal pressure was enhanced when nitrovasodilators were combined with propranolol or vasopressin. The present study was undertaken to evaluate the effect of long-term administration of octreotide and isosorbide dinitrate on haemodynamics in rats with portal vein stenosis. 2...
Clin Sci (Lond) (1998) 94 (5): 493–498.
Published: 01 May 1998
... contribute to nocturnal postural hypotension in the elderly. We therefore studied haemodynamic responses to head-up tilt in healthy elderly and young subjects, with and without passive heating induced by covering with blankets. 2. Nine young (28.7 ± 1.5 years; mean ± S.E.M.) and nine elderly (71.9 ± 1.8...
Clin Sci (Lond) (1997) 93 (6): 549–556.
Published: 01 December 1997
...G. Van Roey; P. Lijnen; R. Verbesselt; A. Verbruggen; J. Fevery 1. The haemodynamic effects of different narcotic agents have been tested in healthy rats and in rats with cirrhosis. 2. Pentobarbital suppresses the sympathetic nervous system. Susceptibility to ketamine is unpredictable, leading...
Miriam Tessa Rademaker, Christopher John Charles, Eric Arnold Espiner, Christopher Miles Frampton, Michael Gary Nicholls, Arthur Mark Richards
Clin Sci (Lond) (1997) 92 (2): 159–165.
Published: 01 February 1997
... examined the effects of brain natriuretic peptide (BNP), none have directly compared the bioactivity of similar doses of ANP and BNP under standard conditions of impaired cardiac function. We compared the hormonal, haemodynamic and renal effects of 3 h infusions of ANP, BNP and a vehicle control in eight...
Miriam Tessa Rademaker, Christopher John Charles, Eric Arnold Espiner, Michael Gary Nicholls, Arthur Mark Richards, Teddy Kosoglou
Clin Sci (Lond) (1996) 91 (3): 283–291.
Published: 01 September 1996
... and brain natriuretic peptide, together with the effects on other vasoactive hormones, haemodynamics and renal indices, to a neutral endopeptidase inhibitor, SCH32615, and a vehicle control in eight conscious sheep before and during pacing-induced heart failure. 2. In normal animals, SCH32615 significantly...
Clin Sci (Lond) (1996) 91 (1): 51–58.
Published: 01 July 1996
...M. S. Thorniley; A. Lahiri; B. Glenville; C. Shurey; G. Baker; U. Ravel; J. Crawley; C. J. Green 1. The non-invasive method of near-infrared spectroscopy was used to measure myocardial oxygenation and haemodynamics in response to left anterior descending coronary artery occlusion in a porcine model...
Clin Sci (Lond) (1995) 88 (5): 501–508.
Published: 01 May 1995
... takes place at the level of the microcirculation, the hallmark of an adequate circulation is the ability to maintain microvascular haemodynamics which allow optimum provision of substrate for metabolic needs and prevent accumulation of unwanted or toxic metabolites, while simultaneously preserving...
Clin Sci (Lond) (1995) 88 (2): 165–172.
Published: 01 February 1995
...Hans Berglund; Anders Edlund; Elvar Theodorsson; Hans Vallin 1. To examine the effects of rate and pressure on release of vasoactive hormones, 10 healthy subjects were examined. 2. A standardized pacing protocol was used to achieve different haemodynamic responses at two predetermined heart rates...
Clin Sci (Lond) (1995) 88 (2): 173–178.
Published: 01 February 1995
... filling pressures. 19 8 1994 19 9 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 congestive heart failure continuous positive airway pressure haemodynamics Clinical Science (1995) 88, 173-178 (Printed in Great Britain) I73 Haemodynamic effects...
Clin Sci (Lond) (1995) 88 (1): 87–93.
Published: 01 January 1995
... pressure cardiopulmonary receptors haemodynamics head-down tilt heart rate spectral analysis transfer function analysis Clinical Science (1995) 88, 87-93 (Printed in Great Britain) 87 Effect of headdown tilt on cardiovascular control in healthy subjects: a spectral analytic approach F. WEISE, G. M...
Clin Sci (Lond) (1994) 87 (3): 275–287.
Published: 01 September 1994
...Paolo Palatini Clinical Science (1994) 87, 275-287 (Printed i n G r e a t Britain) Editorial Review 275 Exercise haemodynamics in the normotensive and the hypertensive subject Paolo PALATlNl Clinica Medica I" , University of Padova, Padova. Italy INTRODUCTION Numerous studies have established...
Clin Sci (Lond) (1994) 87 (3): 303–310.
Published: 01 September 1994
... the effects of an intravenous infusion of L-arginine (30 g, 30 min) compared with placebo on blood pressure, heart rate and peripheral haemodynamics in ten healthy male subjects. Cyclic GMP, NO − 2 and NO − 3 were determined in plasma and urine to assess NO production in vivo by a new, highly specific...
Clin Sci (Lond) (1994) 86 (5): 497–503.
Published: 01 May 1994
.... However, the possibility that 1-desamino-8-d-vasopressin influences liver blood flow, which is a major determinant of tissue-type plasminogen activator clearance, cannot be ruled out. 2. The influence of 1-desamino-8-d-vasopressin on haemodynamics, liver blood flow and fibrinolytic parameters...
Edoardo Casiglia, Paolo Palatini, Stefano Bongiovi, Luca Mario, Giovanna Colangeli, Giuliana Ginocchio, Achille C. Pessina
Clin Sci (Lond) (1994) 86 (1): 27–34.
Published: 01 January 1994
... resistance were also similar in the two groups. 3. In conclusion, after long-lasting strenuous leg exercise central and peripheral haemodynamics vary to the same degree in hypertensive and normotensive trained subjects. Peripheral haemodynamics (similar in the leg and the arm in both groups) closely reflect...
Clin Sci (Lond) (1993) 85 (4): 401–409.
Published: 01 October 1993
... 1993 The Biochemical Society and the Medical Research Society 1993 catecholamines haemodynamics hypertension neuropeptide Y psychological stress vascular resistance Clinical Science (1993) 85, 40149 (Printed in Great Britain) Cardiovascular and sympathdrenal responses to mental stress...
Clin Sci (Lond) (1992) 83 (1): 41–45.
Published: 01 July 1992
...M. Dagenais; G. Pomier-Layrargues; B. Rocheleau; L. Giroux; P.-M. Huet 1. The systemic and splanchnic haemodynamic effects of pentifylline (40 mg/kg body weight intravenously) were assessed in rats with portal hypertension associated either with CCl 4 -induced cirrhosis ( n = 13) or portal vein...
Clin Sci (Lond) (1992) 82 (4): 363–368.
Published: 01 April 1992
... in congestive heart failure. Compared with the infusion of arginine vasopressin alone, atrial natriuretic factor co-infusion enhanced both the urine flow rate and the sodium excretion rate (both P < 0.05) without significant haemodynamic and hormonal effects. 3. Systematic blood pressure was elevated...
Clin Sci (Lond) (1989) 77 (1): 29–34.
Published: 01 July 1989
... reflex haemodynamics sympathetic nervous system volume expansion Clinical Science (1989) 77,29-34 29 Effects of the baroreceptor reflex system on atrial natriuretic factor secretion during volume expansion in dogs K. KOHARA, A. OTSUKA, H. MIKAMI, K. KATAHIRA, T. TSUNETOSHI AND T. OGIHARA Department...
Clin Sci (Lond) (1988) 75 (5): 469–475.
Published: 01 November 1988
...Peter C. Chang; Eugene Kriek; Jacques A. Van Der Krogt; Gerard-Jan Blauw; Peter Van Brummelen 1. To define the role of circulating noradrenaline in cardiovascular regulation, threshold concentrations for haemodynamic effects were determined in arterial and venous plasma of eight healthy volunteers...