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Keywords: haemodynamics
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Clin Sci (Lond) (2015) 128 (1): 57–67.
Published: 29 August 2014
...Yvette C. Luiking; Martijn Poeze; Nicolaas E. Deutz Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (10): 589–602.
Published: 18 July 2014
...Tzu-Pin Weng; Tieh-Cheng Fu; Chao-Hung Wang; Chih-Chin Hsu; Jong-Shyan Wang Lymphocytopenia is associated with an adverse prognosis in heart failure (HF). The present study investigated whether lymphocytopenia results from activated lymphocyte autophagy/apoptosis, which reflects haemodynamic...
Clin Sci (Lond) (2013) 125 (12): 543–553.
Published: 02 August 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 acute aerobic exercise autonomic nervous system blood pressure haemodynamics post-exercise hypotension (PEH) swimming • Current evidence suggests that all forms of regular aerobic exercise are equally effective at lowering...
Clin Sci (Lond) (2012) 122 (12): 581–590.
Published: 05 March 2012
... (mean arterial pressure), SV (stroke volume) and HR. Saline had no haemodynamic effects. β-FXIIa infusion increased its plasma concentration 3-fold in both groups. In adrenally intact rats, β-FXIIa infusion increased MAP by 6% (5±2 mmHg) and TPR by 45% (0.50±0.12 mmHg/ml per min), despite falls in SV...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (9): 429–437.
Published: 16 January 2012
... in urine volume (HD 2-fold increment, P <0.05) and urine sodium (2.7-fold increment, P <0.01), potassium (1.7-fold increment, P <0.05) and creatinine (1.4-fold increment, P <0.05) excretion and creatinine clearance (60% increment, P <0.05). In conclusion, AM5 has significant haemodynamic...
Clin Sci (Lond) (2011) 120 (5): 207–217.
Published: 19 November 2010
... to acute LAP changes. Direct LAP, impedance and natriuretic peptide measurements all show promise as early indicators of worsening HF. A LAP provides an estimate of LAP that may be clinically useful. haemodynamics heart failure implantable monitor intrathoracic impedance left atrial pressure...
Clin Sci (Lond) (2011) 120 (4): 161–167.
Published: 02 November 2010
... addressed cardiac baroreflex function in humans under acute psychological stress. The new finding is that BRS is higher during acute psychological stress in healthy subjects under β-adrenergic blockade. adrenergic β-antagonist autonomic nervous system baroreflex haemodynamics psychological stress...
Clin Sci (Lond) (2008) 114 (10): 635–642.
Published: 14 April 2008
... in haemodynamics, hormonal profile and renal function than achieved by captopril alone. These results indicate that dual treatment with these two agents is beneficial. Ucn2 (urocortin 2) is a recently identified member of the CRF (corticotropin-releasing factor) peptide family that binds selectively to the G...
Clin Sci (Lond) (2007) 113 (11): 449–457.
Published: 01 November 2007
...Julian M. Stewart; Indu Taneja; Marvin S. Medow Altered peripheral haemodynamics, decreased cardiac output, decreased blood volume and increased AngII (angiotensin II) have been reported in POTS (postural tachycardia syndrome). Recent findings indicate that BMI (body mass index) may be reduced...
Clin Sci (Lond) (2007) 113 (10): 401–407.
Published: 12 October 2007
...@amc.uva.nl ). 19 2 2007 11 4 2007 12 6 2007 12 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 blood pressure haemodynamics initial orthostatic hypotension (IOH) lower body muscle tensing posture pre-syncope syncope TLOC (transient loss...
Clin Sci (Lond) (2007) 112 (9): 485–491.
Published: 02 April 2007
...Christopher J. Charles; Miriam T. Rademaker; A. Mark Richards In addition to haemodynamic actions, Ucn1 (urocortin 1) has been reported to affect a number of hormonal systems; however, it remains unclear whether Ucn1 modulates circulating hormones under physiological conditions. Accordingly...
Clin Sci (Lond) (2007) 112 (5): 315–324.
Published: 01 February 2007
.... (intravenous) bolus at 0.3 μg·kg −1 of body weight·min −1 , followed by an infusion at a rate of 0.015 μg·kg −1 of body weight·min −1 for 60 min. The animals in the control group ( n =10) received a saline solution instead of BNP. Haemodynamic and clinical chemistry parameters as well as the amount...
Clin Sci (Lond) (2006) 110 (3): 329–336.
Published: 10 February 2006
.... In the present study, we studied the acute effects of the imidazoline-receptor agonist moxonidine on haemodynamics, NA (noradrenaline) kinetics and myocardial metabolism. Fifteen patients with CHF (chronic heart failure) were randomized to a single dose of 0.6 mg of sustained-release moxonidine or matching...
Clin Sci (Lond) (2006) 110 (3): 343–352.
Published: 10 February 2006
... Society 2006 head-up tilting haemodynamics orthostatic tolerance posturally related syncope water Syncope is a common medical problem, responsible for 0.77% of hospital admissions in the United States [ 1 ] and between 0.9–1.2% of hospital admissions in Europe [ 2 ]. It does not have...
Clin Sci (Lond) (2005) 108 (6): 531–538.
Published: 24 May 2005
... significantly alters aortic root haemodynamics. This phenomenon is associated with impaired NO-dependent vasodilation in vessel segments known to be prone to atherosclerosis. 1 These authors contributed equally to this work. Correspondence: Dr Li-ming Gan, Department of Physiology, Institute...
Clin Sci (Lond) (2005) 108 (2): 113–119.
Published: 21 January 2005
... =0.57). In conclusion, EPRO did not significantly inhibit sympathetic reactivity compared with placebo; however, it blunted the haemodynamic responses elicited by the sympatho-adrenal stimulation which only tended to be attenuated by this drug. Correspondence: Dr Marina Christensen (email macn...
Clin Sci (Lond) (2004) 107 (6): 571–581.
Published: 24 November 2004
..., Institute of Physiology and Pharmacology, Göteborg, Sweden (email li-ming.gan@hjl.gu.se ). 15 6 2004 13 7 2004 6 8 2004 6 8 2004 The Biochemical Society 2004 endothelial function haemodynamics oxygen radical nitric oxide ultrasound Epidemiological data suggest...
Clin Sci (Lond) (2004) 107 (5): 467–475.
Published: 26 October 2004
.... In anaesthetized open-chest rats the haemodynamic and inotropic effects of ET A receptor stimulation were studied by monitoring responses evoked by ET-1 (1 nmol/kg of body weight) after ET B receptor blockade with BQ 788 (0.5 μmol/kg of body weight); these responses were compared with saline controls (after ET B...
Clin Sci (Lond) (2004) 106 (5): 547–548.
Published: 01 May 2004
...Keith N. FRAYN; Jean-Luc ARDILOUZE; Barbara A. FIELDING; Fredrik KARPE Correspondence: Professor Keith Frayn (e-mail keith.frayn@oxlip.ox.ac.uk ). 10 12 2003 19 12 2003 19 12 2003 © 2004 The Biochemical Society 2004 blood flow glucose haemodynamics insulin...
Clin Sci (Lond) (2003) 105 (6): 715–721.
Published: 01 December 2003
...Andreas FUGMANN; Jonas MILLGÅRD; Mahziar SARABI; Christian BERNE; Lars LIND The aim of the present study was to evaluate the haemodynamic changes during hyperinsulinaemia, hyperglycaemia or hypertriglyceridaemia in relation to those following a mixed meal. Ten subjects were subjected...
Clin Sci (Lond) (2003) 105 (4): 431–435.
Published: 01 October 2003
... min after ghrelin administration. These haemodynamic and hormonal changes were still apparent 60 min after ghrelin injection. In conclusion, subcutaneous administration of ghrelin dose-dependently induced relatively specific GH release and enhanced cardiac performance in humans. Correspondence...
Clin Sci (Lond) (2003) 104 (4): 429–436.
Published: 20 March 2003
... (all P <0.05) were higher in the MI group compared with normal control sheep. There were no differences in haemodynamics, body mass or renin–aldosterone levels between groups. This study provides evidence that natriuretic peptides play a pivotal role in preserving volume/electrolyte balance...
Clin Sci (Lond) (2003) 104 (4): 349–356.
Published: 06 March 2003
... 77555-0833, U.S.A. (e-mail dltraber@utmb.edu ). 26 9 2002 25 10 2002 3 1 2003 The Biochemical Society and the Medical Research Society © 2003 2003 anticoagulant haemodynamics infection/inflammation Pseudomonas aeruginosa septic shock thrombosis 349Clinical Science...
Clin Sci (Lond) (2002) 103 (6): 535–542.
Published: 30 October 2002
... is greatly elevated in patients with congestive heart failure, but the clinical relevance of this finding is unclear. Central haemodynamic effects, cardiac conduction system electrophysiology and coronary sinus blood flow were therefore studied in two sets of experiments, each carried out on seven healthy...
Clin Sci (Lond) (2001) 101 (6): 749–757.
Published: 21 November 2001
... haemodynamics reflected waves wave intensity. 749Clinical Science (2001) 101, 749 757 (Printed in Great Britain) Arterial waves in humans during peripheral vascular surgery Ashraf W. KHIR*, Michael Y. HENEIN , Tat KOH , Saroj K. DAS , Kim H. PARKER* and Derek G. GIBSON *Physiological Flow Study Group...
Clin Sci (Lond) (2001) 101 (3): 285–294.
Published: 15 August 2001
.... Haemodynamics, lung weight gain (LWG), capillary filtration coefficient ( K fc ), tissue pathology, the concentrations of cytokines in the perfusate, and mRNAs for the various cytokines in the lung tissues were measured. I/R induced a permeability type of pulmonary oedema, as reflected by increases in LWG and K...
Clin Sci (Lond) (2000) 99 (5): 413–419.
Published: 27 October 2000
... in an isolated rat lung model, lungs were reperfused for 60 min in a closed circulating system with one of the following solutions: (1) NS (0.9% normal saline), (2) NS+Dex (dexamethasone), (3) NS+Penta (pentastarch), or (4) NS+Penta+Dex. Haemodynamic changes, lung weight gain (LWG), capillary filtration...
Clin Sci (Lond) (2000) 98 (6): 703–711.
Published: 10 May 2000
... pressures ( P < 0.05), plasma brain natriuretic peptide levels ( P < 0.05) and adrenaline levels ( P < 0.05). Rises seen in plasma endothelin levels in sham controls were blunted in the coil group ( P < 0.001). Haemodynamic changes were less marked in the balloon group. In conclusion...
Clin Sci (Lond) (2000) 98 (6): 661–665.
Published: 08 May 2000
... mechanisms must be operating in these women. Haemodynamic changes have been demonstrated in the pelvic vessels and aorta in this syndrome, but there have been no studies of the cerebral circulation. Since insulin resistance is a central feature of PCOS, it is of interest that cerebral blood flow may...
Clin Sci (Lond) (1998) 95 (3): 303–309.
Published: 01 September 1998
... accordingly. Correspondence : Dr Sven-Olof Granstam. 5 1 1998 18 3 1998 14 4 1998 The Biochemical Society and the Medical Research Society © 1998 1998 acetylcholine blood flow carvedilol haemodynamics hypertension spontaneously hypertensive rat 303Clinical Science...
Clin Sci (Lond) (1998) 95 (3): 287–294.
Published: 01 September 1998
... = 0.02). Minimal resistance was significantly lower in obstructed than in non-obstructed subjects. Both basal and minimal resistance progressively decreased, although insignificantly, with worsening bronchial obstruction. P a c o 2 did not correlate with any haemodynamic parameter. Borg index correlated...
Clin Sci (Lond) (1998) 94 (6): 645–650.
Published: 01 June 1998
... hypertension, the reduction of portal pressure was enhanced when nitrovasodilators were combined with propranolol or vasopressin. The present study was undertaken to evaluate the effect of long-term administration of octreotide and isosorbide dinitrate on haemodynamics in rats with portal vein stenosis. 2...
Clin Sci (Lond) (1998) 94 (5): 493–498.
Published: 01 May 1998
... contribute to nocturnal postural hypotension in the elderly. We therefore studied haemodynamic responses to head-up tilt in healthy elderly and young subjects, with and without passive heating induced by covering with blankets. 2. Nine young (28.7 ± 1.5 years; mean ± S.E.M.) and nine elderly (71.9 ± 1.8...
Clin Sci (Lond) (1997) 93 (6): 549–556.
Published: 01 December 1997
...G. Van Roey; P. Lijnen; R. Verbesselt; A. Verbruggen; J. Fevery 1. The haemodynamic effects of different narcotic agents have been tested in healthy rats and in rats with cirrhosis. 2. Pentobarbital suppresses the sympathetic nervous system. Susceptibility to ketamine is unpredictable, leading...
Clin Sci (Lond) (1997) 92 (2): 159–165.
Published: 01 February 1997
... examined the effects of brain natriuretic peptide (BNP), none have directly compared the bioactivity of similar doses of ANP and BNP under standard conditions of impaired cardiac function. We compared the hormonal, haemodynamic and renal effects of 3 h infusions of ANP, BNP and a vehicle control in eight...
Clin Sci (Lond) (1996) 91 (3): 283–291.
Published: 01 September 1996
... and brain natriuretic peptide, together with the effects on other vasoactive hormones, haemodynamics and renal indices, to a neutral endopeptidase inhibitor, SCH32615, and a vehicle control in eight conscious sheep before and during pacing-induced heart failure. 2. In normal animals, SCH32615 significantly...
Clin Sci (Lond) (1996) 91 (1): 51–58.
Published: 01 July 1996
...M. S. Thorniley; A. Lahiri; B. Glenville; C. Shurey; G. Baker; U. Ravel; J. Crawley; C. J. Green 1. The non-invasive method of near-infrared spectroscopy was used to measure myocardial oxygenation and haemodynamics in response to left anterior descending coronary artery occlusion in a porcine model...
Clin Sci (Lond) (1995) 88 (5): 501–508.
Published: 01 May 1995
... takes place at the level of the microcirculation, the hallmark of an adequate circulation is the ability to maintain microvascular haemodynamics which allow optimum provision of substrate for metabolic needs and prevent accumulation of unwanted or toxic metabolites, while simultaneously preserving...
Clin Sci (Lond) (1995) 88 (2): 165–172.
Published: 01 February 1995
...Hans Berglund; Anders Edlund; Elvar Theodorsson; Hans Vallin 1. To examine the effects of rate and pressure on release of vasoactive hormones, 10 healthy subjects were examined. 2. A standardized pacing protocol was used to achieve different haemodynamic responses at two predetermined heart rates...
Clin Sci (Lond) (1995) 88 (2): 173–178.
Published: 01 February 1995
... filling pressures. 19 8 1994 19 9 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 congestive heart failure continuous positive airway pressure haemodynamics Clinical Science (1995) 88, 173-178 (Printed in Great Britain) I73 Haemodynamic effects...
Clin Sci (Lond) (1995) 88 (1): 87–93.
Published: 01 January 1995
... pressure cardiopulmonary receptors haemodynamics head-down tilt heart rate spectral analysis transfer function analysis Clinical Science (1995) 88, 87-93 (Printed in Great Britain) 87 Effect of headdown tilt on cardiovascular control in healthy subjects: a spectral analytic approach F. WEISE, G. M...
Clin Sci (Lond) (1994) 87 (3): 275–287.
Published: 01 September 1994
...Paolo Palatini © 1994 The Biochemical Society and the Medical Research Society 1994 blood pressure cardiac performance echocardiography exercise haemodynamics hypertension left ventricle sport Clinical Science (1994) 87, 275-287 (Printed i n G r e a t Britain) Editorial Review...
Clin Sci (Lond) (1994) 87 (3): 303–310.
Published: 01 September 1994
... the effects of an intravenous infusion of L-arginine (30 g, 30 min) compared with placebo on blood pressure, heart rate and peripheral haemodynamics in ten healthy male subjects. Cyclic GMP, NO − 2 and NO − 3 were determined in plasma and urine to assess NO production in vivo by a new, highly specific...
Clin Sci (Lond) (1994) 86 (5): 497–503.
Published: 01 May 1994
.... However, the possibility that 1-desamino-8-d-vasopressin influences liver blood flow, which is a major determinant of tissue-type plasminogen activator clearance, cannot be ruled out. 2. The influence of 1-desamino-8-d-vasopressin on haemodynamics, liver blood flow and fibrinolytic parameters...
Clin Sci (Lond) (1994) 86 (1): 27–34.
Published: 01 January 1994
... resistance were also similar in the two groups. 3. In conclusion, after long-lasting strenuous leg exercise central and peripheral haemodynamics vary to the same degree in hypertensive and normotensive trained subjects. Peripheral haemodynamics (similar in the leg and the arm in both groups) closely reflect...
Clin Sci (Lond) (1993) 85 (4): 401–409.
Published: 01 October 1993
... 1993 The Biochemical Society and the Medical Research Society 1993 catecholamines haemodynamics hypertension neuropeptide Y psychological stress vascular resistance Clinical Science (1993) 85, 40149 (Printed in Great Britain) Cardiovascular and sympathdrenal responses to mental stress...
Clin Sci (Lond) (1992) 83 (1): 41–45.
Published: 01 July 1992
...M. Dagenais; G. Pomier-Layrargues; B. Rocheleau; L. Giroux; P.-M. Huet 1. The systemic and splanchnic haemodynamic effects of pentifylline (40 mg/kg body weight intravenously) were assessed in rats with portal hypertension associated either with CCl 4 -induced cirrhosis ( n = 13) or portal vein...
Clin Sci (Lond) (1992) 82 (4): 363–368.
Published: 01 April 1992
... in congestive heart failure. Compared with the infusion of arginine vasopressin alone, atrial natriuretic factor co-infusion enhanced both the urine flow rate and the sodium excretion rate (both P < 0.05) without significant haemodynamic and hormonal effects. 3. Systematic blood pressure was elevated...
Clin Sci (Lond) (1989) 77 (1): 29–34.
Published: 01 July 1989
... by the baroreceptor reflex directly or indirectly by systemic changes in the sympathetic nervous system or arginine vasopressin secretion. © 1989 The Biochemical Society and the Medical Research Society 1989 arginine vasopressin atrial natriuretic factor baroreceptor reflex haemodynamics sympathetic...
Clin Sci (Lond) (1988) 75 (5): 469–475.
Published: 01 November 1988
...Peter C. Chang; Eugene Kriek; Jacques A. Van Der Krogt; Gerard-Jan Blauw; Peter Van Brummelen 1. To define the role of circulating noradrenaline in cardiovascular regulation, threshold concentrations for haemodynamic effects were determined in arterial and venous plasma of eight healthy volunteers...