... and these changes were associated with induction of HO (haem oxygenase)-1. The present study determines whether the inhibition of HO negates the renoprotective effect of sEH inhibition in diabetic SHR (spontaneously hypertensive rats). After 6 weeks of induction of diabetes with streptozotocin, SHR were divided...

...Pai-Huei Peng; Mei-Lan Ko; Chau-Fong Chen; Shu-Hui Juan RGC (retinal ganglion cell) death following ischaemic insult is the major cause of a number of vision-threatening diseases, including glaucoma. The aim of the present study was to evaluate the role of HO-1 (haem oxygenase-1) in the retina...

...Ismail H. Mallick; Marc C. Winslet; Alexander M. Seifalian IR (ischaemia/reperfusion) injury of the intestine occurs commonly during abdominal surgery. We have previously shown that PDTC (pyrrolidine dithiocarbamate), an HO-1 (haem oxygenase-1) donor, improves intestinal microvascular perfusion...

... and the Medical Research Society © 2001 2001 ARDS ferritin haem oxygenase iron-regulatory proteins iron signalling reactive oxygen species sepsis transferrin 169Clinical Science (2001) 100, 169 182 (Printed in Great Britain) + R E V I E W Iron signalling regulated directly and through oxygen...