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Keywords: glutathione
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Articles
Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
...Percíllia V.S. Oliveira; Francisco R.M. Laurindo Thiol groups are crucially involved in signaling/homeostasis through oxidation, reduction, and disulphide exchange. The overall thiol pool is the resultant of several individual pools of small compounds (e.g. cysteine), peptides (e.g. glutathione...
Articles
Clin Sci (Lond) (2015) 129 (7): 561–574.
Published: 03 July 2015
... transitions glutathione hyperglycaemia redox balance • In chronic diseases such as diabetes, mitochondria function under oxidizing conditions, thus chiefly contributing to cardiac dysfunction development. Our study adds to this scenario that lower and slower energetic output and higher ROS...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (1): 19–29.
Published: 15 August 2013
... was undertaken to investigate the mechanism by which glycine, supplemented to the diet of SF (sucrose-fed) rats, modulates glutathione biosynthesis and protects against oxidative stress and altered endothelium-dependent relaxation in isolated aorta. Glycine reduced O 2 •− (superoxide anion radical) release...
Articles
Clin Sci (Lond) (2012) 122 (12): 591–597.
Published: 05 March 2012
.... In addition to glutamine, glutathione may be a limiting factor in ICU patients with MOF (multiple organ failure). To study the prevalence of glutamine and glutathione depletion an observational study was performed. The results were analysed in relation to mortality and the conventional predictors of mortality...
Articles
Clin Sci (Lond) (2009) 117 (9): 339–344.
Published: 01 September 2009
...Bo Westman; Anders Thörne; Olav Rooyackers; Katarina Fredriksson; Jan Wernerman; Folke Hammarqvist Glutathione is a major antioxidant, and, in the present study, we investigated whether a clinical model of short warm ischaemia and reperfusion of the human liver during surgery would influence...
Articles
Clin Sci (Lond) (2009) 117 (9): 313–319.
Published: 01 September 2009
...Urban B. Fläring; Christina Hebert; Jan Wernerman; Folke Hammarqvist; Olav E. Rooyackers Patients with septic shock have high plasma glutathione concentrations, whereas intracellular concentrations in erythrocytes and muscle are low. In the present study, we investigated the temporal pattern...
Articles
Clin Sci (Lond) (2007) 113 (7): 313–318.
Published: 03 September 2007
...Bo Westman; Lars Weidenhielm; Olav Rooyackers; Katarina Fredriksson; Jan Wernerman; Folke Hammarqvist The temporal pattern of metabolic alterations in muscle tissue during total ischaemia and reperfusion are not well-characterized in humans with respect to glutathione, amino acids and energy-rich...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2004) 106 (3): 235–237.
Published: 01 March 2004
... for disease progression from stable steatosis to steatohepatitis. Correspondence: Dr Isabelle Leclercq ( isabelle_leclercq@wmi.usyd.edu.au ). 7 11 2003 7 11 2003 7 11 2003 © 2004 The Biochemical Society 2004 antioxidant pathway glutathione non-alcoholic fatty liver disease...
Articles
Clin Sci (Lond) (2003) 104 (3): 275–282.
Published: 14 February 2003
...U.B. FLÄRING; O.E. ROOYACKERS; J. WERNERMAN; F. HAMMARQVIST Glutathione is quantitatively the most important endogenous scavenger system. Glutathione depletion in skeletal muscle is pronounced following major trauma and sepsis in intensive care unit patients. Also, following elective surgery...
Articles
Clin Sci (Lond) (2002) 103 (1): 53–57.
Published: 11 June 2002
...) were incubated with serum from 18 pre-eclamptic, 18 healthy pregnant and 18 healthy non-pregnant women for 24h. The levels of reduced glutathione (GSH) and lipid peroxides (LPOs) were measured in endothelial cell lysates. Measurement of malondialdehyde in combination with 4-hydroxyalkenals has been...
Articles
Clin Sci (Lond) (2002) 102 (5): 569–577.
Published: 22 April 2002
... 569Clinical Science (2002) 102, 569 577 (Printed in Great Britain) The effect of rate of weight loss on erythrocyte glutathione concentration and synthesis in healthy obese men Peter FABER Alexandra M. JOHNSTONE , Eileen R. GIBNEY , Marinos ELIA§, R. James STUBBS , Gary G. DUTHIE , A. Graham CALDER...
Articles
Clin Sci (Lond) (2000) 99 (4): 315–320.
Published: 01 September 2000
... of glutathione, one of the antioxidant systems that plays a critical role in defence against oxidative stress. On the other hand, α-tocopherol may be decreased in liver diseases, and treatment with this vitamin reduces liver injury in CCl 4 -treated rats. Since there is a close relationship among the different...
Articles
Clin Sci (Lond) (1996) 91 (2): 121–130.
Published: 01 August 1996
...Robert F. Grimble © 1996 The Biochemical Society and the Medical Research Society 1996 amino acids antioxidants cytokines fats glutathione inflammation interleukin nutrition tumour necrosis factor vitamin E Clinical Science (1996) 91, 121-130 (Printed i n Great Britain...
Articles
Clin Sci (Lond) (1996) 90 (6): 517–523.
Published: 01 June 1996
...Takeshi Ishizaki; Youichi Kishi; Fumihiko Sasaki; Shingo Ameshima; Tsuguhiko Nakai; Susumu Miyabo 1. We hypothesized that probucol, an oral hypocholesterolaemic agent, can suppress the oxidant stress induced by acute tobacco smoke inhalation in rats. We determined lung tissue glutathione (reduced...
Articles
Clin Sci (Lond) (1994) 87 (1): 21–29.
Published: 01 July 1994
... (21). The reduced glutathione concentrations in blood samples from the insulin-dependent and non-insulin-dependent diabetic patient groups were not different from the control group values ( P >0.05). 3. The activities of glyoxalase enzymes in erythrocytes were increased: glyoxalase I activity [mean...
Articles
Clin Sci (Lond) (1992) 82 (6): 709–716.
Published: 01 June 1992
...M. Salleh; M. Ardawi 1. The hepatic metabolism of glutamine, alanine, ammonia, urea, glutathione and glucose was studied in rats made septic by caecal ligation and puncture and was compared with that in rats that had undergone sham operation (laparotomy). 2. Sepsis resulted in increases...
Articles
Clin Sci (Lond) (1991) 80 (6): 559–564.
Published: 01 June 1991
...M. J. Jackson; M. H. Brooke; K. Kaiser; R. H. T. Edwards 1. The release of glutathione has been studied in comparison with the release of creatine kinase from isolated rat soleus muscles subjected to certain forms of experimental damage. 2. Excessive electrically stimulated contractile activity...
Articles
Clin Sci (Lond) (1987) 73 (2): 235–237.
Published: 01 August 1987
...Teresa Sir; Carlos Wolff; Juan Ramon Soto; Gilberto Perez; Rodolfo Armas Merino 1. Sulphobromophthalein (BSP) retention and liver glutathione levels were studied in uncomplicated hyperthyroid patients. 2. BSP retention was increased in 52.5% of the subjects at admission ( n = 40) and in 28...
Articles
Clin Sci (Lond) (1985) 69 (4): 383–393.
Published: 01 October 1985
... endoperoxides but not arachidonic acid into prostacyclin, and most probably is due to high concentrations of peroxides: it can be accelerated by H 2 O 2 or by interrupting the glutathione cycle, while it is delayed by reduced glutathione. 2. Incubation of exhausted rings in human plasma or in a plasma filtrate...
Articles
Clin Sci (Lond) (1984) 66 (3): 283–290.
Published: 01 March 1984
...Luis A. Videla; Hernán Iturriaga; María E. Pino; Daniel Bunout; Alfonso Valenzuela; Guillermo Ugarte 1. The relationship between the content of hepatic reduced glutathione (GSH) and the length of abstinence was investigated in 45 chronic alcoholic patients. 2. Hepatic GSH levels were significantly...
Articles
Clin Sci (Lond) (1982) 62 (3): 279–283.
Published: 01 March 1982
...E. C. P. Shi; R. Fisher; Maeve McEvoy; Rebecca Vantol; Margaret Rose; J. M. Ham 1. Hepatic total glutathione (reduced plus oxidized) and oxidized glutathione levels were measured in operative wedge liver biopsy specimens obtained from 70 patients. 2. The effects on hepatic reduced glutathione (GSH...
Articles
Clin Sci (Lond) (1980) 58 (3): 211–219.
Published: 01 March 1980
... decrease in the activity of glutathione reductase in patients with secondary iron overload due to multiple transfusion therapy for thalassaemia major. 3. The activities of superoxide dismutase, catalase and glutathione peroxidase were similar in both patient groups. 4. Subcellular fractionation studies...
Articles
Clin Sci Mol Med (1977) 52 (4): 429–442.
Published: 01 April 1977
.... NAD(P)H/nitroblue tetrazolium reductase activity was partially inhibited by superoxide dismutase. 5. NADPH and NADH oxidase activities, measured by the production of oxidized nucleotide, were localized with the azurophil granules. 6. Superoxide dismutase, catalase, glutathione reductase...
Articles
Clin Sci Mol Med (1975) 49 (5): 495–502.
Published: 01 November 1975
... into the liver and excretion into the bile. Impaired hepatic uptake of bromosulphthalein could also be demonstrated in man at doses of the drug within the therapeutic range. 3. In patients studied a smaller proportion of bromosulphthalein was retained in the plasma as the glutathione conjugate after an overdose...