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Clin Sci (Lond) (2020) 134 (23): 3119–3121.
Published: 03 December 2020
... in the development of diabetes mellitus and blood glucose control. After the seminal work of Paulescu and Banting and Best in the early 1920s that led to the discovery of insulin (Murray I. Paulesco and the isolation of insulin. J. Hist. Med. Allied Sci . (1971) 26 , 150–157; Raju T.N. The Nobel Chronicles. 1923...
Rui Curi, Renata de Siqueira Mendes, Luiz Aurélio de Campos Crispin, Giuseppe Danilo Norata, Sandra Coccuzzo Sampaio, Philip Newsholme
Clin Sci (Lond) (2017) 131 (12): 1329–1342.
Published: 07 June 2017
...Rui Curi; Renata de Siqueira Mendes; Luiz Aurélio de Campos Crispin; Giuseppe Danilo Norata; Sandra Coccuzzo Sampaio; Philip Newsholme In 1986 and 1987, Philip Newsholme et al. reported macrophages utilize glutamine, as well as glucose, at high rates. These authors measured key enzyme activities...
Cécile Faure, Keyne Charlot, Stéphane Henri, Marie-dominique Hardy-Dessources, Olivier Hue, Sophie Antoine-Jonville
Clin Sci (Lond) (2016) 130 (12): 1017–1025.
Published: 06 May 2016
...Cécile Faure; Keyne Charlot; Stéphane Henri; Marie-dominique Hardy-Dessources; Olivier Hue; Sophie Antoine-Jonville A high demand on thermoregulatory processes may challenge homoeostasis, particularly regarding glucose regulation. This has been understudied, although it might concern millions...
Luciano Ribeiro Filgueiras, Marianna Mainardi Koga, Paula G. Quaresma, Edson Kiyotaka Ishizuka, Marlise B.A. Montes, Patricia O. Prada, Mario J. Saad, Sonia Jancar, Francisco J. Rios
Clin Sci (Lond) (2016) 130 (8): 601–612.
Published: 08 March 2016
... the phenotype of ATMs (adipose tissue macrophages) and its effect on glucose and insulin metabolism. PARFKO (PAFR-knockout) and WT (wild-type) mice were fed on an SD (standard diet) or an HFD (high-fat diet). Glucose and insulin tolerance tests were performed by blood monitoring. ATMs were evaluated by FACS...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (12): 1083–1096.
Published: 13 October 2015
... not necessarily parallel the inflammatory status of metabolic tissues that control blood glucose. In fact, a permissive immune environment in the gut can exacerbate metabolic tissue inflammation. Unravelling these discordant immune responses in different parts of the body and establishing a connection between...
Yun Lin, Amanda Damjanovic, E. Jeffrey Metter, Huy Nguyen, Thai Truong, Kevin Najarro, Christa Morris, Dan L. Longo, Ming Zhan, Luigi Ferrucci, Richard J. Hodes, Nan-ping Weng
Clin Sci (Lond) (2015) 128 (6): 367–377.
Published: 28 November 2014
... of telomere attrition in T-cells with age was explained by a decline in the telomerase activity, decreased naïve cells and the change in physiological conditions such as elevated blood glucose and interleukin (IL)-6 levels. These findings show that changes in the telomere length of the PBMCs with age in vivo...
Includes: Supplementary data
Clin Sci (Lond) (2009) 117 (9): 321–330.
Published: 01 September 2009
... of the glucose- and amino-acid-responsive clonal insulin-secreting cell line BRIN-BD11. Aralar1 overexpression increased long-term (24 h) and acute (20 min) glucose- and amino-acid-stimulated insulin secretion, cellular glucose metabolism, L -alanine and L -glutamine consumption, cellular ATP and glutamate...
Ana Jovanovic, Emily Leverton, Bhavana Solanky, Balasubramanian Ravikumar, Johanna E. M. Snaar, Peter G. Morris, Roy Taylor
Clin Sci (Lond) (2009) 117 (3): 119–127.
Published: 02 July 2009
...Ana Jovanovic; Emily Leverton; Bhavana Solanky; Balasubramanian Ravikumar; Johanna E. M. Snaar; Peter G. Morris; Roy Taylor The rise in blood glucose after lunch is less if breakfast has been eaten. The metabolic basis of this second-meal phenomenon remains uncertain. We hypothesized that storage...
Emily M. Segar, Andrew W. Norris, Jian-Rong Yao, Shanming Hu, Stacia L. Koppenhafer, Robert D. Roghair, Jeffrey L. Segar, Thomas D. Scholz
Clin Sci (Lond) (2009) 117 (3): 129–138.
Published: 02 July 2009
...) in pregnant rats on gestational day 13 and was partially controlled by twice-daily injections of insulin. At 2 months of age, ODM had slightly better glucose tolerance than controls ( P <0.05); however, by 6 months of age this trend had reversed. A euglycaemic–hyperinsulinamic clamp revealed insulin...
Juan M. Fernández, Marzo E. da Silva-Grigoletto, Juan A. Ruano-Ruíz, Javier Caballero-Villarraso, Rafael Moreno-Luna, Isaac Túnez-Fiñana, Inmaculada Tasset-Cuevas, Pablo Pérez-Martínez, José López-Miranda, Francisco Pérez-Jiménez
Clin Sci (Lond) (2009) 116 (2): 137–145.
Published: 15 December 2008
... the ingestion of glucose plus fructose is unclear. In the present study, we administered two beverages containing GluF (glucose+fructose) or Glu (glucose alone) in a randomized cross-over design to 20 healthy aerobically trained volunteers to compare the hormonal and lipid responses provoked during aerobic...
Clin Sci (Lond) (2008) 115 (12): 371–378.
Published: 12 November 2008
...Dan Berndtson; Joel Olsson; Robert G. Hahn High-dose intravenous infusion of 5% glucose promotes rebound hypoglycaemia and hypovolaemia in healthy volunteers. To study whether such effects occur in response to glucose/insulin, 12 healthy firemen (mean age, 39 years) received three infusions over 1...
Christian J. F. Holubarsch, Martin Rohrbach, Matthias Karrasch, Erich Boehm, Lech Polonski, Piotr Ponikowski, Siegfried Rhein
Clin Sci (Lond) (2007) 113 (4): 205–212.
Published: 13 July 2007
...Christian J. F. Holubarsch; Martin Rohrbach; Matthias Karrasch; Erich Boehm; Lech Polonski; Piotr Ponikowski; Siegfried Rhein Etomoxir is an inhibitor of mitochondrial CPT1 (carnitine palmitoyltransferase 1) and thereby switches energy metabolism from fatty acids to glucose oxidation...
Clin Sci (Lond) (2005) 109 (5): 439–446.
Published: 24 October 2005
...Biao Xu; Yong Ji; Kang Yao; Yue-Xin Cao; Albert Ferro Endothelial dysfunction, with decreased NO (nitric oxide) biosynthesis, may play a pathophysiological role in diabetic vasculopathy. The aim of the present study was to determine the relative contributions of glucose and AGE (advanced glycation...
Clin Sci (Lond) (2005) 109 (4): 405–411.
Published: 23 September 2005
...% carbohydrates, 20% fat and 35% protein), for breakfast on separate days. The test meals were administered 1 month apart. Blood samples were withdrawn immediately before and at 15, 30, 60, 120 and 180 min after the test meal for measurement of plasma acylated ghrelin, as well as serum glucose, insulin...
Clin Sci (Lond) (2004) 107 (2): 191–196.
Published: 27 July 2004
...Aris SIAFARIKAS; Katie WATTS; Petra BEYE; Timothy W. JONES; Elizabeth A. DAVIS; Daniel J. GREEN The aim of the present study was to investigate the impact of an oral glucose load on circulating insulin and glucose levels and arterial function in healthy non-diabetic subjects. Thirty-nine non-obese...
Clin Sci (Lond) (2004) 107 (2): 213–220.
Published: 27 July 2004
...Ole FRØBERT; Jens P. BAGGER; Ulf SIMONSEN; Sten LUND; Claus H. GRAVHOLT In acute ischaemia, glucose–insulin–potassium administration reduces mortality and β-adrenoceptor antagonists have favourable effects on the outcome of ischaemic heart disease. The present study was designed to investigate...
Hartmut SCHÄCHINGER, Johannes PORT, Stuart BRODY, Lilly LINDER, Frank H. WILHELM, Peter R. HUBER, Daniel COX, Ulrich KELLER
Clin Sci (Lond) (2004) 106 (6): 583–588.
Published: 01 June 2004
... 2004 The Biochemical Society 2004 autonomic nervous system glucose heart rate variability hypoglycaemia impedance cardiography Clinical Science (2004) 106, 583 588 (Printed in Great Britain) 583 Increased high-frequency heart rate variability during insulin-induced hypoglycaemia in healthy...
Clin Sci (Lond) (2004) 106 (5): 527–533.
Published: 01 May 2004
...David M. WOOD; Amanda L. BRENNAN; Barbara J. PHILIPS; Emma H. BAKER Glucose is not detectable in airways secretions of normoglycaemic volunteers, but is present at 1–9 mmol·l -1 in airways secretions from people with hyperglycaemia. These observations suggest the existence of a blood glucose...
Clin Sci (Lond) (2004) 106 (5): 547–548.
Published: 01 May 2004
... studies and those of others, ATBF is much more responsive to nutrients than is skeletal muscle blood flow [3,4]; ATBF may increase 2.5-fold in response to glucose ingestion in a healthy subject . Steinberg  therefore probably underestimates the importance of adipose tissue in the responses observed...
Clin Sci (Lond) (2003) 105 (6): 715–721.
Published: 01 December 2003
... Society 2003 blood flow glucose haemodynamics insulin lipids Clinical Science (2003) 105, 715 721 (Printed in Great Britain) 715 Central and peripheral haemodynamic effects of hyperglycaemia, hyperinsulinaemia, hyperlipidaemia or a mixed meal Andreas FUGMANN, Jonas MILLGA RD, Mahziar SARABI...
Eiichiro NAKAGAWA, Noritoshi NAGAYA, Hiroyuki OKUMURA, Mitsunobu ENOMOTO, Hideo OYA, Fumiaki ONO, Hiroshi HOSODA, Masayasu KOJIMA, Kenji KANGAWA
Clin Sci (Lond) (2002) 103 (3): 325–328.
Published: 15 August 2002
... intake and reducing fat utilization. However, whether glucose influences the release of ghrelin remains unknown. Accordingly, we examined circulating levels of ghrelin and GH in response to the intravenous or oral administration of 50g of glucose in eight healthy humans. After the administration...
Clin Sci (Lond) (2002) 103 (2): 179–189.
Published: 17 July 2002
... by apoptosis, which is important for the effective resolution of the inflammatory response. Both glucose and glutamine are important fuels for neutrophils, yet little has been done to investigate the comparative effects of glucose and glutamine on neutrophil apoptosis. We hypothesized that glucose...
Clin Sci (Lond) (2002) 102 (2): 241–246.
Published: 10 January 2002
...Lars LIND; Andreas FUGMANN; Jonas MILLGÅRD; Christian BERNE; Hans LITHELL In order to evaluate possible differences between men and women with regard to the ability of insulin to induce vasodilatation, promote glucose uptake and enhance endothelium-dependent vasodilatation, 12 young (22-28 years...
Clin Sci (Lond) (2001) 101 (1): 37–43.
Published: 24 May 2001
...Zoltán SZABÓ; Hans ARNQVIST; Erik HÅKANSON; Lennart JORFELDT; Rolf SVEDJEHOLM The effects of glucose–insulin–potassium (GIK) on cardiac metabolism have been studied previously in non-diabetic patients after cardiac surgery. Although patients with diabetes mellitus can be expected to benefit most...
Clin Sci (Lond) (2001) 101 (1): 59–64.
Published: 24 May 2001
... 12 3 2001 3 4 2001 The Biochemical Society and the Medical Research Society © 2001 2001 acetylcholine glucose insulin iontophoresis sodium nitroprusside 59Clinical Science (2001) 101, 59 64 (Printed in Great Britain) Diminished skin blood flow in Type I diabetes: evidence...
Clin Sci (Lond) (2000) 98 (1): 21–30.
Published: 19 November 1999
...H. MERZOUK; S. MADANI; D. CHABANE SARI; J. PROST; M. BOUCHENAK; J. BELLEVILLE The aim of this investigation was to determine the time course of changes in serum glucose, insulin and lipid levels, as well as lipid and protein content and lipolytic activities in insulin target organs (liver, adipose...
Clin Sci (Lond) (1999) 96 (6): 589–595.
Published: 07 May 1999
...-thrombotic therapy in 148 patients with myocardial infarction (MI); 76 patients with unstable angina (UA) pectoris were also studied, together with 27 patients with non-cardiac chest pain (NCP). There were significant progressive increases in the concentrations of catecholamines, cortisol, glucose...
Carolina GARCIA, Tania C. PITHON-CURI, Maria DE LOURDES FIRMANO, Mariza PIRES DE MELO, Philip NEWSHOLME, Rui CURI
Clin Sci (Lond) (1999) 96 (6): 549–555.
Published: 28 April 1999
...-investigated topic. The present study has addressed the effects of adrenaline on the rates of utilization and oxidation of glucose and glutamine, the phagocytic capacity and the rate of superoxide production by rat neutrophils. Incubation of rat neutrophils in the presence of 50 µ M adrenaline caused a marked...
Yasunobu Hirata, Yasuko Suzuki, Hiroshi Hayakawa, Etsu Suzuki, Kenjiro Kimura, Atsuo Goto, Kenji Kangawa, Hisayuki Matsuo, Masao Omata
Clin Sci (Lond) (1995) 88 (4): 413–419.
Published: 01 April 1995
... the effects of administration of glucose, albumin, atrial natriuretic peptide and an atrial natriuretic peptide receptor antagonist on renal function in rats with streptozotocin-induced diabetes mellitus and vehicle-treated control rats. 2. Four weeks after treatment, rats with diabetes mellitus had a higher...
Clin Sci (Lond) (1994) 86 (2): 169–175.
Published: 01 February 1994
... concentrations of plasma triacylglycerol (1510 ± 150 versus 850 ± 80 μmol/l, P < 0.01), blood ketone bodies (151 ± 21 versus 80 ± 10 μmol/l, P < 0.01) and plasma insulin (17 ± 3 versus 7 ± 1 m-units/l, P < 0.01) were elevated compared with the postabsorptive state; plasma glucose and non-esterified...
Clin Sci (Lond) (1994) 86 (1): 15–25.
Published: 01 January 1994
... of blood flow, was r = −0.98 (−0.94 to −0.99) (median and range, n = 6). The corresponding correlation coefficient for 133 Xe clearance was r = 0.97 (0.92–0.98), the correlation coefficient between the ethanol outflow/inflow ratio and 133 Xe clearance being r = −0.92 (−0.89 to −0.94). 4. Dialysate glucose...
Clin Sci (Lond) (1993) 85 (4): 495–500.
Published: 01 October 1993
... gradient by using a hypo-osmolar solution, but this phenomenon has not previously been applied to clinical peritoneal dialysis. 2. The ultrafiltration performances of hypo-osmolar dialysis solutions containing a high-molecular-weight glucose polymer (weight average molecular weight 22 000), isolated...
Clin Sci (Lond) (1993) 85 (3): 337–342.
Published: 01 September 1993
...Peter E. Ballmer; Margaret A. McNurlan; Ian Grant; Peter J. Garlick 1. The influence of an acute-phase reaction on the ability of protein synthesis rates in liver and three different muscles (gastrocnemius, soleus and heart) to respond to a short intravenous infusion of nutrients (glucose plus...
Clin Sci (Lond) (1993) 84 (3): 247–256.
Published: 01 March 1993
...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...
Clin Sci (Lond) (1992) 83 (6): 677–682.
Published: 01 December 1992
...R. F. G. J. King; M. Madan; D. Alexander; A. Boyd; K. Ibrahim; M. J. McMahon; D. Johnston 1. This study was designed to test the hypothesis that three-carbon intermediates can be used in the ‘indirect’ pathway of glycogen synthesis in human liver (i.e. a route additional to the use of glucose...
Clin Sci (Lond) (1992) 83 (5): 607–614.
Published: 01 November 1992
... area is less well characterized. We were specifically interested in substrate flux across the spleen as it is an organ with important immunological functions. 2. Therefore, hindquarter, gut, spleen and liver fluxes of amino acids, ammonia, glucose, lactate and blood gases were measured for 4 days after...
Clin Sci (Lond) (1992) 83 (5): 597–605.
Published: 01 November 1992
.... In cirrhotic patients, 24 h blood glucose profiles showed a worsening of glucose tolerance over breakfast, despite greater insulin secretion compared with other meals, suggesting that the insulin insensitivity of cirrhosis is worse at this time. 3. Cirrhotic patients showed impaired suppression of blood...
Clin Sci (Lond) (1992) 83 (4): 489–494.
Published: 01 October 1992
...Anthony J. Proudler; Carl V. Felton; John C. Stevenson 1. Eighty-six apparently healthy postmenopausal women not receiving hormone replacement therapy were given an intravenous glucose tolerance test. Plasma glucose, insulin and C-peptide concentrations were determined in fasting and post-glucose...
S. Pukrittayakamee, N.J. White, T. M. E. Davis, S. Looareesuwan, W. Supanaranond, V. Desakorn, B. Chaivisuth, D. H. Williamson
Clin Sci (Lond) (1992) 82 (1): 63–70.
Published: 01 January 1992
... clearance was significantly higher in acute disease [1.41 (0.51)] than in convalescence [0.70 (0.34)], largely because of the elevated ratios in severely ill patients [1.48 (0.50)]. 4. The rise in blood glucose concentration after galactose administration was significantly higher during acute illness [1.48...
Clin Sci (Lond) (1992) 82 (1): 77–83.
Published: 01 January 1992
...Ceri J. Green; R. S. Frazer; S. Underhill; Paula Maycock; Judith A. Fairhurst; I. T. Campbell 1. Dobutamine in 5% (w/v) d -glucose was infused at sequential doses of 2, 5 and 10 μg min −1 kg −1 , 45 min at each dose, into eight healthy male subjects, and the effects were compared with those...
Clin Sci (Lond) (1991) 81 (3): 347–355.
Published: 01 September 1991
...M. Salleh M. Ardawi; Sawsan M. Jalalah 1. The metabolism of glucose and glutamine was studied in the small intestine and the colon of rats after 4–5 weeks of hypothyroidism. 2. Hypothyroidism resulted in increases in the plasma concentrations of ketone bodies ( P < 0.05), cholesterol ( P...
Clin Sci (Lond) (1991) 80 (4): 359–365.
Published: 01 April 1991
...M. J. T. Hommes; J. A. Romijn; E. Endert; J. K. M. Eeftinck Schattenkerk; H. P. Sauerwein 1. In eight clinically stable symptomatic human-immunodeficiency-virus-infected patients and in seven healthy control subjects, glucose and fat metabolism were studied, using indirect calorimetry and primed...
Clin Sci (Lond) (1991) 80 (1): 71–76.
Published: 01 January 1991
...R. C. Mühlbauer; H. Fleisch 1. The renal handling of glucose was determined in male X-linked hypophosphataemic ( Hyp/Y ) mice and in control littermates (+/ Y ) aged 4 months. Plasma glucose concentration and urinary glucose excretion were measured before and during stepwise increase in glycaemia...
Clin Sci (Lond) (1990) 79 (6): 605–611.
Published: 01 December 1990
...Cathy J. Regan; R. Duckworth; Judith A. Fairhurst; Paula F. Maycock; K. N. Frayn; I. T. Campbell 1. Dopamine in 5% (w/v) d-glucose was infused into five healthy male volunteers at doses of 2, 5 and 10 μg min −1 kg −1 over three sequential periods of 45 min each. 2. Oxygen consumption, respiratory...
Clin Sci (Lond) (1990) 79 (5): 513–516.
Published: 01 November 1990
... in the presence of euglycaemia (mean glucose concentration 5 mmol/l) and hyperglycaemia (mean glucose concentration 9 mmol/l) with and without triacylglycerol infusions. 2. During euglycaemia, plasma insulin levels rose from baseline values [median (range)] of 13 (6.6–20.6) m-units/l to 89 (74–105) m-units/l...
S. W. Coppack, R. M. Fisher, G. F. Gibbons, S. M. Humphreys, M. J. McDonough, J. L. Potts, K. N. Frayn
Clin Sci (Lond) (1990) 79 (4): 339–348.
Published: 01 October 1990
..., mainly in the form of non-esterified fatty acids. 3. After the meal, arterialized plasma concentrations of glucose and lactate rose sharply (peak at 60 min), whereas those of non-esterified fatty acids and glycerol fell (nadir at 60–120 min). Plasma triacylglycerol concentrations rose slowly to peak...
Clin Sci (Lond) (1990) 79 (3): 201–213.
Published: 01 September 1990
...D. F. Heath 1. My aim was to investigate, by mathematical simulation, the errors inherent in the measurement by the primed infusion method of the rate of appearance of glucose in man when turnover was as low or lower than in overnight-fasted normal subjects (control subjects). The simulations were...
Clin Sci (Lond) (1990) 79 (1): 81–87.
Published: 01 July 1990
... occlusions. 3. The concentrations of glucose, lactate and glycerol, as well as blood gas variables, in arterial and femoral venous blood did not change during the study or decreased so slightly (pH and lactate) that the arteriovenous difference was not influenced. 4. We conclude that the blood flow...
Clin Sci (Lond) (1990) 78 (3): 335–341.
Published: 01 March 1990
...D. Simmons; J. Bomford; L. L. Ng 1. Low intracellular concentrations of myo -inositol in diabetic cells may contribute to the development of tissue damage. The cause of these low levels is unknown, but inhibition of a putative myo -inositol transporter by high concentrations of glucose has been...
Clin Sci (Lond) (1990) 78 (2): 185–191.
Published: 01 February 1990
...L. A. Corr; R. M. Grounds; J. L. Beacham; J. G. Whitwam; M. J. Brown 1. To examine the metabolic effects of increases in circulating endogenous plasma catecholamines, we measured plasma glucose, potassium and magnesium in 14 patients undergoing elective coronary artery bypass grafting. The patients...